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1. 发明申请

WO2013001505A2 SULPHONAMIDE DERIVATIVES OF ALICYCLIC AMINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 审中-公开
标题翻译：用于治疗中枢神经系统疾病的亚胺胺磺酰胺衍生物
公开(公告)号：WO2013001505A2
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053318
申请日：2012-06-29
申请人： ADAMED SP. Z O.O. , KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KRUKOWSKI, Andrzej , RUSIECKI, Rafał , SIWEK, Agata Magdalena , WOLAK, Małgorzata Anna
发明人： KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KRUKOWSKI, Andrzej , RUSIECKI, Rafał , SIWEK, Agata Magdalena , WOLAK, Małgorzata Anna
IPC分类号： C07D403/06
CPC分类号： C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Sulphonamide derivatives of alicyclic amines of formula (I), wherein A represents naphthyl or 9- or 10-membered bicyclic group, consisting of benzene ring fused with -or 6-membered heterocyclic ring; D represents phenyl, naphthyl, 5-membered aromatic heterocyclic group, bicyclic group consisting of a ring selected from benzene and pyridine, fused with aromatic or non-aromatic 5-membered heterocyclic ring; r represents 0 or 1; x, z independently represent 1 or 2; n represents 3 and p represents 0, or n represents 2 and p represents 1;and enantiomers, pharmaceutically acceptable salts and solvates thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders (Formula I).
摘要翻译：式（I）脂环族胺的磺酰胺衍生物，其中A代表萘基或9-或10-元双环基团，由与6-或6-元杂环稠合的苯环组成; D代表苯基，萘基，5元芳族杂环基团，由选自苯和吡啶的环组成的双环基团，与芳族或非芳族5-元杂环稠合; r代表0或1; x，z独立地表示1或2; n表示3且p表示0，或者n表示2且p表示1;以及其对映异构体，可药用盐和溶剂合物。该化合物可用于治疗和/或预防中枢神经系统疾病（式I）。

2. 发明申请

WO2013001499A1 INDOLEAMINE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 审中-公开
标题翻译：用于治疗中枢神经系统疾病的吲哚胺衍生物
公开(公告)号：WO2013001499A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053309
申请日：2012-06-28
申请人： ADAMED SP. Z O.O. , KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KAZEK, Grzegorz , BEDNARSKI, Marek , WESOŁOWSKA, Anna
发明人： KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , PAWŁOWSKI, Maciej , KAZEK, Grzegorz , BEDNARSKI, Marek , WESOŁOWSKA, Anna
IPC分类号： C07D209/30 , C07D403/04 , C07D413/04 , A61K31/404
CPC分类号： C07D401/12 , C07D209/08 , C07D209/30 , C07D403/04 , C07D413/04
摘要： Indoleamine derivatives of formula (IA), wherein R 1 represents benzyl unsubstituted or substituted with halogen atom, -OH, or C 1 -C 3 -alkyl; phenylsulphonyl unsubstituted or substituted in the phenyl ring with halogen atom, -OH or C 1 -C 3 -alkyl; G 1 represents phenoxyalkyl, heteroaryloxyalkyl- or heterocyclyloxyalkyl-piperazine moiety; and pharmaceutically acceptable salts and solvates thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.
摘要翻译：式（IA）的吲哚胺衍生物，其中R 1表示未取代或被卤素原子取代的苄基，-OH或C 1 -C 3 - 烷基; 在苯环中未被取代或取代的苯基磺酰基与卤素原子，-OH或C 1 -C 3 - 烷基; G1表示苯氧基烷基，杂芳氧基烷基或杂环基烷基 - 哌嗪部分; 及其药学上可接受的盐和溶剂化物。所述化合物可用于治疗和/或预防中枢神经系统疾病。

3. 发明申请

WO2012035123A1 ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES 审中-公开
标题翻译：用于治疗CNS疾病的ARYLOSULFONAMIDES
公开(公告)号：WO2012035123A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/066054
申请日：2011-09-16
申请人： ADAMED SP. Z O.O. , KOŁACZKOWSKI, Marcin , KOWALSKI, Piotr , JAŚKOWSKA, Jolanta , MARCINKOWSKA, Monika , MITKA, Katarzyna , BUCKI, Adam , WESOŁOWSKA, Anna , PAWŁOWSKI, Maciej
发明人： KOŁACZKOWSKI, Marcin , KOWALSKI, Piotr , JAŚKOWSKA, Jolanta , MARCINKOWSKA, Monika , MITKA, Katarzyna , BUCKI, Adam , WESOŁOWSKA, Anna , PAWŁOWSKI, Maciej
IPC分类号： C07D209/40 , C07D235/30 , C07D275/04 , C07D319/20 , C07D413/12 , A61K31/496 , A61P25/00
CPC分类号： C07D401/04 , C07D209/40 , C07D235/30 , C07D263/58 , C07D275/04 , C07D277/82 , C07D319/20 , C07D401/02 , C07D403/02 , C07D405/12 , C07D409/02 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Arylsulphonamide derivatives of formula (I) and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of disorders of the central nervous system.
摘要翻译：式（I）的芳基磺酰胺衍生物及其药学上可接受的盐。所述化合物可用于治疗和/或预防中枢神经系统疾病。

4. 发明申请

WO2013001498A1 AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 审中-公开
标题翻译：用于治疗中枢神经系统疾病的AMIDOALKYLPIPERAZINYL衍生物
公开(公告)号：WO2013001498A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053308
申请日：2012-06-28
申请人： ADAMED SP. Z O.O. , MAJKA, Zbigniew , KOŁACZKOWSKI, Marcin , CZOPEK, Anna , MIODOŃSKI, Andrzej , KAMIŃSKI, Krzysztof , PAWŁOWSKI, Maciej , ZAGÓRSKA, Agnieszka , ZAJDEL, Paweł , KOWALSKI, Piotr , MITKA, Katarzyna , JAŚKOWSKA, Jolanta , WESOŁOWSKA, Anna , MIERZEJEWSKI, Paweł , BIEŃKOWSKI, Przemysław
发明人： MAJKA, Zbigniew , KOŁACZKOWSKI, Marcin , CZOPEK, Anna , MIODOŃSKI, Andrzej , KAMIŃSKI, Krzysztof , PAWŁOWSKI, Maciej , ZAGÓRSKA, Agnieszka , ZAJDEL, Paweł , KOWALSKI, Piotr , MITKA, Katarzyna , JAŚKOWSKA, Jolanta , WESOŁOWSKA, Anna , MIERZEJEWSKI, Paweł , BIEŃKOWSKI, Przemysław
IPC分类号： C07D495/04 , C07D513/04 , A61K31/551 , A61K31/554 , A61P25/00
CPC分类号： C07D495/04 , C07D513/04
摘要： The invention relates to novel amidoalkylpiperazinyl derivatives of tricyclic heterocyclic systems of general formula (I), wherein Z represents -NH- and X represents -S-, or Z represents -S- and X represents >C=C 1 represents H or -CH 3 , R 6 and R 7 both represent H, n is an integer from 0 to 4 inclusive, G represents a cyclic amide or imide moiety, and optical isomers, geometric isomers, and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.
摘要翻译：本发明涉及通式（I）的三环杂环体系的新型酰氨基烷基哌嗪基衍生物，其中Z表示-NH-，X表示-S-，或Z表示-S-，X表示> C = C1表示H或-CH 3， R 6和R 7都表示H，n为0〜4的整数，G表示环状酰胺或酰亚胺部分，旋光异构体，几何异构体及其药学上可接受的盐。所述化合物可用于治疗和/或预防中枢神经系统疾病。

5. 发明申请

WO2013140347A1 SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES 审中-公开
标题翻译：苯甲酰胺用于治疗CNS疾病的磺酰胺衍生物
公开(公告)号：WO2013140347A1
公开(公告)日：2013-09-26
申请号：PCT/IB2013/052204
申请日：2013-03-20
申请人： ADAMED SP. Z O.O.
发明人： KOŁACZKOWSKI, Marcin , MARCINKOWSKA, Monika , BUCKI, Adam , ŁYSAKOWSKI, Tomasz , PAWŁOWSKI, Maciej
IPC分类号： C07C311/21 , C07D403/12 , C07D413/14 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D261/20 , C07D487/04 , C07D209/08 , C07D307/79 , A61K31/18 , A61P25/00
CPC分类号： C07D487/04 , C07C311/21 , C07D209/08 , C07D261/20 , C07D307/79 , C07D319/18 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted;or 9-or 10-membered bicyclic group, linked to –(O) x - (CH 2 ) y -through one of its aromatic carbon atoms,consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5-or 6-membered non-aromaticheterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C 1 -C 3 - alkyls; D represents a group selected from:phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted;thiophene unsubstituted or substituted;bicyclic group consisting of imidazolering fused with5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring;and bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring;R represents H or –CH 3;x is 0 or 1;yis 2 or 3;and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents –CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.
摘要翻译：式（I）的苄胺的磺酰胺衍生物，其中A表示未取代或取代的苯基;或与 - （O）x - （CH 2）y连接的9或10元双环，通过其芳族碳原子之一，由含有1或2个独立地选自N和O的杂原子的含有杂芳环的苯环稠合，其中这样的双环基团是未取代的或取代的，或具有1或2个的5-或6-元非芳族杂环 O原子，其中杂环是未取代的或被一个或多个C 1 -C 3 - 烷基取代; D表示选自以下的基团：未取代或取代的苯基; 未取代或取代的萘基;未取代或取代的噻吩;由5元非芳族碳环稠合的咪唑啉组成的双环; 由与5-元杂芳环稠合的苯环组成的双环基团，具有独立地选自N，O和S的1或2个杂原子，未取代或取代并通过苯环的碳原子连接到磺酰胺部分;和双环由具有1或2个独立选自N和O的未取代或取代的杂原子的6元非芳香杂环稠合的苯环，和通过苯环的碳原子与磺酰胺部分连接的苯环; R表示H或-CH 3; x为0或1; yis 2或3;及其药学上可接受的盐和溶剂合物，条件是如果x为0且y为2，则D为未取代的或被一个卤素取代的萘基原子，如果R表示-CH 3，则A不是未取代的或取代的苯基。所述化合物可用于治疗和/或预防中枢神经系统疾病。

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