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1. 发明申请

WO2010048332A2 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼部疾病和病症的化合物
公开(公告)号：WO2010048332A2
公开(公告)日：2010-04-29
申请号：PCT/US2009061545
申请日：2009-10-21
申请人： ACUCELA INC , SCOTT IAN L , KUKSA VLADIMIR A , HONG FENG , KUBOTA RYO , GAGE JENNIFER
发明人： SCOTT IAN L , KUKSA VLADIMIR A , HONG FENG , KUBOTA RYO , GAGE JENNIFER
IPC分类号： C07C311/33 , A61K31/167 , A61K31/18 , A61P27/02 , C07C237/20 , C07C311/08 , C07C311/36
CPC分类号： C07C233/25 , A61K31/167 , A61K31/18 , C07B59/001 , C07B2200/05 , C07C211/49 , C07C211/52 , C07C215/08 , C07C215/14 , C07C215/42 , C07C215/68 , C07C217/08 , C07C217/10 , C07C217/58 , C07C225/06 , C07C225/22 , C07C233/36 , C07C233/43 , C07C233/62 , C07C275/40 , C07C311/08 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/24 , C07C335/18 , C07C2601/08 , C07C2601/14 , C07D277/28
摘要： Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译：提供了使用所述化合物和组合物的化合物，其药物组合物以及使用所述化合物和组合物治疗眼科疾病和病症（例如年龄相关性黄斑变性和斯塔加特病）的方法。

2. 发明申请

WO2007089673A8 COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼科疾病和病症的组合物和方法
公开(公告)号：WO2007089673A8
公开(公告)日：2008-04-10
申请号：PCT/US2007002330
申请日：2007-01-26
申请人： ACUCELA INC , KUBOTA RYO , FAWZI AHMAD , SCOTT IAN LESLIE , KUKSA VLADIMIR A
发明人： KUBOTA RYO , FAWZI AHMAD , SCOTT IAN LESLIE , KUKSA VLADIMIR A
IPC分类号： A61K31/21 , A61K31/16 , A61K31/215
CPC分类号： A61K31/137
摘要： Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy.
摘要翻译：本文提供了用于治疗眼科疾病和病症的组合物和方法。包含本文提供的视黄胺衍生物化合物的组合物可用于治疗和预防眼科疾病和病症，包括糖尿病视网膜病变糖尿病黄斑病变，糖尿病性黄斑水肿，视网膜缺血，缺血再灌注相关视网膜损伤和代谢性视神经病变。

3. 发明申请

WO2007089673A3 COMPOSITIONS AND METHODS FOR TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼病和疾病的组合物和方法
公开(公告)号：WO2007089673A3
公开(公告)日：2008-02-28
申请号：PCT/US2007002330
申请日：2007-01-26
申请人： ACUCELA INC , KUBOTA RYO , FAWZI AHMAD , SCOTT IAN LESLIE , KUKSA VLADIMIR A
发明人： KUBOTA RYO , FAWZI AHMAD , SCOTT IAN LESLIE , KUKSA VLADIMIR A
IPC分类号： A61K31/21 , A61K31/16 , A61K31/215
CPC分类号： A61K31/137
摘要： Provided herein are compositions and methods for treating ophthalmic diseases and disorders. Compositions comprising retinylamine derivative compounds provided herein are useful for treating and preventing ophthalmic diseases and disorders, including diabetic retinopathy diabetic maculopathy, diabetic macular edema, retinal ischemia, ischemia-reperfusion related retinal injury, and metabolic optic neuropathy.
摘要翻译：本文提供了用于治疗眼科疾病和病症的组合物和方法。包含本文提供的视黄醇衍生物化合物的组合物可用于治疗和预防眼科疾病和病症，包括糖尿病性视网膜病，糖尿病性黄斑变性，糖尿病性黄斑水肿，视网膜缺血，缺血再灌注相关的视网膜损伤和代谢性视神经病变。

4. 发明申请

WO2011003103A3 PHARMACOLOGY OF VISUAL CYCLE MODULATORS 审中-公开
标题翻译：视频循环调制器的药理学
公开(公告)号：WO2011003103A3
公开(公告)日：2011-05-26
申请号：PCT/US2010040983
申请日：2010-07-02
申请人： ACUCELA INC , KUBOTA RYO , BOMAN NANCY , BAVIK CLAES , SCOTT IAN L
发明人： KUBOTA RYO , BOMAN NANCY , BAVIK CLAES , SCOTT IAN L
IPC分类号： A61K31/195 , A61K31/166 , A61K31/19 , A61P27/02
CPC分类号： A61K31/166 , A61K9/0048 , A61K9/5078 , A61K31/19 , A61K31/195
摘要： Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators.
摘要翻译：本文描述了治疗眼科疾病或病症的方法，其包括施用非类视黄醇视觉循环调节剂。

5. 发明申请

WO2008131368A3 STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗眼底疾病和疾病的苯乙烯衍生化合物
公开(公告)号：WO2008131368A3
公开(公告)日：2008-12-24
申请号：PCT/US2008061073
申请日：2008-04-21
申请人： ACUCELA INC , SCOTT IAN LESLIE , KUKSA VLADIMIR ALEKSANDROVICH , GALL ANNA , ORME MARK W , GAGE JENNIFER , LITTLE THOMAS L JR , JIANG QIN , ROSSITER LANA MICHELE , MCGEE KEVIN F JR , KUBOTA RYO
发明人： SCOTT IAN LESLIE , KUKSA VLADIMIR ALEKSANDROVICH , GALL ANNA , ORME MARK W , GAGE JENNIFER , LITTLE THOMAS L JR , JIANG QIN , ROSSITER LANA MICHELE , MCGEE KEVIN F JR , KUBOTA RYO
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译：本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。本文提供了苯乙烯衍生物化合物，包括但不限于二苯乙烯衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和Stargardt氏病。

6. 发明申请

WO2010028088A3 SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS 审中-公开
标题翻译：用于治疗非典型疾病和疾病的硫化合物
公开(公告)号：WO2010028088A3
公开(公告)日：2010-06-17
申请号：PCT/US2009055785
申请日：2009-09-02
申请人： ACUCELA INC , SCOTT IAN L , KUKSA VLADIMIR ALEKSANDROVICH , KUBOTA RYO
发明人： SCOTT IAN L , KUKSA VLADIMIR ALEKSANDROVICH , KUBOTA RYO
IPC分类号： C07C323/32 , A61K31/10 , A61K31/18 , A61P27/02 , C07C311/37 , C07C317/32
CPC分类号： C07C323/32 , C07B2200/05 , C07C311/37 , C07C317/22 , C07C317/32 , C07C323/20 , C07C323/41 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18
摘要： Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译：提供硫化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。

7. 发明申请

WO2006105215A3 THE USE OF A SPIN TRAP FOR ENHANCING RETINAL CELL SURVIVAL AND TREATING RETINAL DEGENERATIVE DISEASES 审中-公开
标题翻译：用于增强视网膜细胞存活和治疗视网膜变性疾病
公开(公告)号：WO2006105215A3
公开(公告)日：2007-07-12
申请号：PCT/US2006011497
申请日：2006-03-28
申请人： ACUCELA INC , KUBOTA RYO
发明人： KUBOTA RYO
IPC分类号： A61K31/15
CPC分类号： A61K31/15
摘要： A method for treating neurodegenerative diseases and conditions, particularly retinal neurodegenerative diseases by administering a spin-trap antioxidant compound is provided. In one embodiment, the compound is a spin-trap antioxidant such as alpha-phenyl-N-tert-butyl nitrone (PBN), a derivative or analogue thereof, that enhances survival of photoreceptor cells and may be used for treatment of retinal neurodegenerative diseases, including the dry form of macular degeneration. Also provided are methods for identifying and measuring the activity of spin-trap antioxidant compounds that enhance survival of retinal neuronal cells, such as photoreceptor cells.
摘要翻译：提供了通过施用自旋捕获抗氧化剂治疗神经变性疾病和病症，特别是视网膜神经变性疾病的方法。在一个实施方案中，化合物是自旋捕获抗氧化剂，例如α-苯基-N-叔丁基硝酮（PBN），其衍生物或类似物，其可增强感光细胞的存活并且可用于治疗视网膜神经变性疾病，包括干燥形式的黄斑变性。还提供了用于鉴定和测量增强视网膜神经细胞如感光细胞的存活的自旋捕获抗氧化剂化合物的活性的方法。

8. 发明申请

WO2005012506A3 EXTENDED PRIMARY RETINAL CELL CULTURE AND STRESS MODELS, AND METHODS OF USE 审中-公开
标题翻译：延长的原发性视网膜细胞培养和应激模型以及使用方法
公开(公告)号：WO2005012506A3
公开(公告)日：2005-10-13
申请号：PCT/US2004024714
申请日：2004-07-30
申请人： ACUCELA INC , KUBOTA RYO
发明人： KUBOTA RYO
IPC分类号： C12N5/0793 , G01N33/50 , C12N5/02 , C12N5/06 , C12N5/08
CPC分类号： C12N5/062 , C12N2503/02 , G01N33/5005 , G01N33/5014
摘要： A cell culture system related to extended in vitro culture of mature retinal cells and methods for preparing the cell culture system are provided. Also provided is a retinal cell culture stress model related to extended in vitro culture of mature retinal cells in the presence of a stressor and methods for using the cell culture stress model. The invention provides a cell culture system comprising a long-term culture of mature retinal cells, without requiring addition of other types of non-retinal cells such as purified glia, or cells isolated from ciliary bodies within the eye, and the addition of a stressor such as light, A2E, cigarette smoke condensate, glutamate, or hydrostatic pressure. Methods for identifying bioactive agents that alter viability, neurodegeneration, or survival of retinal cells using the retinal cell culture stress system are also provided.
摘要翻译：提供了与延长的成熟视网膜细胞的体外培养有关的细胞培养系统和用于制备细胞培养系统的方法。还提供了与在应激物存在下延长成熟视网膜细胞的体外培养相关的视网膜细胞培养应激模型以及使用细胞培养应激模型的方法。本发明提供了细胞培养系统，其包含成熟视网膜细胞的长期培养物，而不需要添加其他类型的非视网膜细胞如纯化的神经胶质细胞或从眼内睫状体分离的细胞，并且加入应激物如光，A2E，香烟烟雾冷凝物，谷氨酸盐或静水压力。还提供了使用视网膜细胞培养应激系统来鉴定改变生存力，神经变性或视网膜细胞存活的生物活性剂的方法。

9. 发明申请

WO2006091796A3 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING RETINAL DISEASES 审中-公开
标题翻译：诊断和治疗视网膜病的组合物和方法
公开(公告)号：WO2006091796A3
公开(公告)日：2006-10-05
申请号：PCT/US2006006561
申请日：2006-02-22
申请人： ACUCELA INC , KUBOTA RYO , PALCZEWSKI KRZYSZTOF , GALL ANNA
发明人： KUBOTA RYO , PALCZEWSKI KRZYSZTOF , GALL ANNA
IPC分类号： C07D213/20 , A61K39/00 , A61P27/02 , C07D213/38 , C07D213/50 , C07D213/56 , C07K16/18
CPC分类号： A61K39/0007 , A61K2039/6031 , C07D213/20 , C07D213/38 , C07D213/50 , C07D213/56 , C07K16/44
摘要： The present invention relates generally to the preparation and use of retinoid N-retinylidene-N-retinyl-ethanolamine (A2E) conjugated to a carrier polypeptide and to the preparation and use of antibodies that bind specifically to A2E. The invention relates to the use of A2E conjugates as immunogens or vaccines and to the use of A2E specific antibodies for treatment of ophthalmic diseases. Provided herein are methods for enhancing retinal neuronal cell survival, including photoreceptor cell survival, using antibodies that specifically bind to A2E or by inducing an immune response using an A2E immunoconjugate. Enhancing survival of photoreceptor cells or decreasing accumulation of A2E in the eye using the A2E immunoconjugates or A2E specific antibodies is useful for treatment of ophthalmic diseases such as macular degeneration.
摘要翻译：本发明一般涉及偶联于载体多肽的类视色素N-亚视黄基-N-视黄基 - 乙醇胺（A2E）的制备和用途以及与A2E特异性结合的抗体的制备和用途。本发明涉及A2E缀合物作为免疫原或疫苗的用途以及A2E特异性抗体用于治疗眼科疾病的用途。本文提供了使用特异性结合A2E的抗体或通过使用A2E免疫缀合物诱导免疫应答来增强视网膜神经细胞存活（包括光感受器细胞存活）的方法。使用A2E免疫缀合物或A2E特异性抗体增强光感受器细胞的存活或减少眼内A2E的积聚可用于治疗眼科疾病，例如黄斑变性。

10. 发明申请

WO2004007749A3 METHODS AND SYSTEMS FOR EXTENDED IN VITRO CULTURE OF NEURONAL CELLS 审中-公开
标题翻译：在神经细胞的体外培养中扩增的方法和系统
公开(公告)号：WO2004007749A3
公开(公告)日：2005-05-06
申请号：PCT/US0321968
申请日：2003-07-11
申请人： UNIV WASHINGTON , KUBOTA RYO , REH THOMAS A , FISCHER ANDREW J
发明人： KUBOTA RYO , REH THOMAS A , FISCHER ANDREW J
IPC分类号： C12N5/02 , C12N5/071 , C12N5/0793 , C12N5/00 , C12N5/06
CPC分类号： C12N5/0621 , C12N5/062 , C12N2502/08 , C12N2503/02
摘要： A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.
摘要翻译：提供了与成熟神经元细胞的延长的体外培养相关的细胞培养系统和用于制备细胞培养系统的方法。在优选的实施方案中，本发明提供了包含成熟神经元视网膜细胞和从睫状体分离的细胞的混合物的细胞培养系统。还提供了用于鉴定改变神经元视网膜细胞神经变性的生物活性剂的方法。

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