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1. 发明申请

WO2006118605A2 8A, 9-DIHYDRO-4A-H-ISOTHIAZOLO[5,4-B] QUINOLINE-3, 4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译： 8A，9-二氢-4A-H-异噻唑并[5,4-B]喹啉-3,4-二酮和作为抗感染剂的相关化合物
公开(公告)号：WO2006118605A2
公开(公告)日：2006-11-09
申请号：PCT/US2005/040725
申请日：2005-11-10
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , DESHPANDE, Milind , PUCCI, Michael, John , WANG, Qiuping , WILES, Jason, Allan , SONG, Yongsheng , HASHIMOTO, Akihiro , LUCIEN, Edlaine
发明人： BRADBURY, Barton, James , DESHPANDE, Milind , PUCCI, Michael, John , WANG, Qiuping , WILES, Jason, Allan , SONG, Yongsheng , HASHIMOTO, Akihiro , LUCIEN, Edlaine
IPC分类号： C07D513/04 , A61K31/437 , A61P31/04 , A61P33/02
CPC分类号： C07D513/04 , C07D513/14
摘要： The invention provides compounds and salts of Formula I and Formula II which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables n, m, p, R A , R B , A 1 , R 2 , R 3 , R 5 , R 6 , R 7 , A 8 and R 9 are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and /or selective inhibitors of bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in eukaryotes.
摘要翻译：本发明提供了具有抗微生物活性的式I和式II的化合物和盐。本发明还提供了用于制备式I和式II化合物的新型合成中间体。变量n，m，p，R A，R B，A 1，R 2，R 1， R 3，R 5，R 6，R 7，A 8和R 9各自独立地是氢，在此定义。本文公开的某些式I和式II化合物是细菌复制的有效和/或选择性抑制剂。本发明还提供了包含一种或多种式I或式II化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有式I或式II的化合物作为唯一的活性剂或可以含有式I或式II的化合物与一种或多种其他活性剂的组合。本发明还提供了治疗真核生物微生物感染的方法。

2. 发明申请

WO2008131415A1 4-SUBSTITUTED-1H-ISOTHIAZOLO[5,4-B][1,4]OXAZINO[2,3,4-IJ]QUINOLINE-7,8(2H,9H)-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译： 4-取代的1H-异亮氨酸[5,4-B] [1,4]氧杂嗪[2,3,4-I]喹啉-7,8（2H，9H） - 和相关化合物作为抗感染剂
公开(公告)号：WO2008131415A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/061263
申请日：2008-04-23
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , DESHPANDE, Milind , HASHIMOTO, Akihiro , KIM, Ha, Young , LUCIEN, Edlaine , PAIS, Godwin Clarence, Gilroy , PUCCI, Michael, John , WANG, Qiuping , WILES, Jason, Allan
发明人： BRADBURY, Barton, James , DESHPANDE, Milind , HASHIMOTO, Akihiro , KIM, Ha, Young , LUCIEN, Edlaine , PAIS, Godwin Clarence, Gilroy , PUCCI, Michael, John , WANG, Qiuping , WILES, Jason, Allan
IPC分类号： C07D513/04
CPC分类号： C07D513/16
摘要： 4-Substituted-lH-Isothiazolo[5,4-b][l,4]Oxazino[2,3,4-ij]Quinoline-7,8(2H,9H)-Diones (see Formula).The present invention provides compounds of the formula that possess antimicrobial activity. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity. Particular compounds provided herein are also potent and/or selective inhibitors of microbial DNA synthesis and reproduction. The invention provides anti-microbial compositions, including pharmaceutical compositions, containing a compound of the invention and one or more or more carriers. The invention provides pharmaceutical compositions containing a 4-substituted-lH- isothiazolo[5,4-b][l,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound as the only active agent or in combination with one or more other active agents. The invention provides methods for treating or preventing microbial infections, preferably animals, by administering an effective amount of a 4-substituted-lH-isothiazolo[5,4-b][l,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound to an organism suffering from or susceptible to microbial infection. The invention also provides methods of inhibiting microbial growth and survival by applying an effective amount of a 4-substituted-lH-isothiazolo[5,4-b][l,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound.
摘要翻译： 4-取代的-1H-异噻唑并[5,4-b] [1,4]恶嗪并[2,3,4-ij]喹啉-7,8（2H，9H） - 二酮（参见式）具有抗微生物活性的配方化合物。本文提供的某些化合物具有有效的抗细菌，抗原生动物或抗真菌活性。本文提供的具体化合物也是微生物DNA合成和繁殖的有效和/或选择性抑制剂。本发明提供包含本发明化合物和一种或多种或多种载体的抗微生物组合物，包括药物组合物。本发明提供含有4-取代的1H-异噻唑并[5,4-b] [1,4]恶嗪并[2,3,4-ij]喹啉-7,8（2H，9H） - 二酮或相关的化合物作为唯一的活性剂或与一种或多种其它活性剂组合。本发明提供了通过施用有效量的4-取代-1H-异噻唑并[5,4-b] [1,4]恶嗪并[2,3,4-ij]的方法来治疗或预防微生物感染，优选动物，喹啉-7,8（2H，9H） - 二酮或相关化合物与患有或易感微生物感染的生物体接触。本发明还提供了通过施用有效量的4-取代的1H-异噻唑并[5,4-b] [1,4]恶嗪并[2,3,4-ij]喹啉-7 ，8（2H，9H） - 二酮或相关化合物。

3. 发明申请

WO2007014308A1 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译： 8-甲氧基-9H-异亮氨酸[5,4-B]喹啉-3,4-二酮及相关化合物作为抗感染剂
公开(公告)号：WO2007014308A1
公开(公告)日：2007-02-01
申请号：PCT/US2006/029302
申请日：2006-07-27
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , WILES, Jason, Allan , WANG, Qiuping , HASHIMOTO, Akihiro , LUCIEN, Edlaine , PAIS, Godwin, Clarence, Gilroy , DESHPANDE, Milind , PUCCI, Michael, John , KIM, Ha, Young
发明人： BRADBURY, Barton, James , WILES, Jason, Allan , WANG, Qiuping , HASHIMOTO, Akihiro , LUCIEN, Edlaine , PAIS, Godwin, Clarence, Gilroy , DESHPANDE, Milind , PUCCI, Michael, John , KIM, Ha, Young
IPC分类号： C07D513/04 , A61K31/4365 , A61P33/00
CPC分类号： C07D495/04 , C07D498/04 , C07D513/04 , C07D513/14
摘要： The invention provides compound and salts of Formula (I) and (II), disclosed herein, which includes compounds of Formula (A) and Formula (B) such compounds possess useful antimicrobial activity. The variables R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 shown in Formula A and B are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and/ or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
摘要翻译：本发明提供了本文公开的式（I）和（II）的化合物和盐，其包括式（A）和式（B）的化合物，该化合物具有有用的抗微生物活性。变量R 2，R 3，R 5，R 6，R 7和/或N >，并且式A和B中所示的R 9是本文定义的。本文公开的某些式（I）和式（II）化合物是细菌DNA合成和细菌复制的有效和/或选择性抑制剂。本发明还提供包含一种或多种式（I）或式（II）化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有作为唯一活性剂的式（I）或式（II）的化合物，或者可以含有式I或式II化合物与一种或多种其它活性剂的组合。本发明还提供了治疗动物微生物感染的方法。

4. 发明申请

WO2008036420A2 9-(HETEROARYL)-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译： 9-（异丁基） - 异噻唑并[5,4-B]喹啉-3,4-二酮及其相关化合物作为抗感染剂
公开(公告)号：WO2008036420A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/020611
申请日：2007-09-21
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , WANG, Qiuping , WILES, Jason, Allan , HASHIMOTO, Akihiro , LUCIEN, Edlaine , PAIS, Godwin, Clarence, Gilroy , KIM, Ha, Young
发明人： BRADBURY, Barton, James , WANG, Qiuping , WILES, Jason, Allan , HASHIMOTO, Akihiro , LUCIEN, Edlaine , PAIS, Godwin, Clarence, Gilroy , KIM, Ha, Young
IPC分类号： C07D513/04 , A61K31/428 , A61P31/04
CPC分类号： C07D513/04
摘要： The invention provides compounds and salts of Formula (I) and Formula (II); which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables R 2 , R 3 , R 5 , R 6 , R 7 , A 8 and R 9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula (I) or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
摘要翻译：本发明提供式（I）和式（II）的化合物和盐; 具有抗菌活性。本发明还提供了可用于制备式（I）和式（II）的化合物的新型合成中间体。变量R 2，R 3，R 5，R 6，R 7和/或N >，＆lt; 8＆gt;和＆lt; 9＆gt;在本文中定义。本文公开的某些式（I）和式（II）化合物是细菌DNA合成和细菌复制的有效和/或选择性抑制剂。本发明还提供包含一种或多种式（I）或式（II）化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有作为唯一活性剂的式（I）或式（II）的化合物或可以含有式（I）或式（II）的化合物与一种或多种其它活性剂的组合。本发明还提供了治疗动物微生物感染的方法。

5. 发明申请

WO2005019228A1 ISOTHIAZOLOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：异烟肼和相关化合物作为抗感染剂
公开(公告)号：WO2005019228A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/025365
申请日：2004-08-04
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , DESHPHANDE, Milind , PUCCI, Michael, John , WANG, Quiping , WILES, Jason, Allan , SONG, Monishing , HASHIMOTO, Akihiro , LUCIEN, Edlaine
发明人： BRADBURY, Barton, James , DESHPHANDE, Milind , PUCCI, Michael, John , WANG, Quiping , WILES, Jason, Allan , SONG, Monishing , HASHIMOTO, Akihiro , LUCIEN, Edlaine
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The invention provides compounds and salts of Formula (I) and Formula (II): which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables A 1 , R 2 , R 3 , R 5 , R 6 , R 7 , A 8 and R 9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula (I) or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
摘要翻译：本发明提供具有抗微生物活性的式（I）和式（II）的化合物和盐。本发明还提供了可用于制备式（I）和式（II）的化合物的新型合成中间体。变量A1，R2，R3，R5，R6，R7，A8和R9在本文中定义。本文公开的某些式（I）和式（II）化合物是细菌DNA合成和细菌复制的有效和选择性抑制剂。本发明还提供包含一种或多种式（I）或式（II）化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有作为唯一活性剂的式（I）或式（II）的化合物或可以含有式（I）或式（II）的化合物与一种或多种其它活性剂的组合。本发明还提供了治疗动物微生物感染的方法。

6. 发明申请

WO2006084053A1 8-N-SUBSTITUTED-2H-ISOTHIAZOLO[5,4-B]QUINOLIZINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTIINFECTIVE AGENTS 审中-公开
标题翻译： 8-N-取代的2H-异亮氨酸[5,4-B]喹啉-3,4-二酮及相关化合物作为抗药剂
公开(公告)号：WO2006084053A1
公开(公告)日：2006-08-10
申请号：PCT/US2006/003710
申请日：2006-02-01
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , WILES, Jason, Allan , DESHPANDE, Millind , WANG, Qiuping , HASHIMOTO, Akihiro , LUCIEN, Edlaine
发明人： BRADBURY, Barton, James , WILES, Jason, Allan , DESHPANDE, Millind , WANG, Qiuping , HASHIMOTO, Akihiro , LUCIEN, Edlaine
IPC分类号： C07D513/14 , C07D513/22 , A61K31/4375 , A61K31/519 , A61P31/00
CPC分类号： C07D513/14 , C07D498/14 , C07D513/22 , C07D519/00
摘要： The invention provides compounds and salts of Formula (I) and Formula (II): which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables A 1 , A 8 , R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of compounds of Formula (I) and/or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.
摘要翻译：本发明提供具有抗微生物活性的式（I）和式（II）的化合物和盐。本发明还提供了可用于制备式（I）和式（II）的化合物的新型合成中间体。变量A 1，A 8，R 2，R 3，R 5，/ 3 >，R 6，R 7和R 9在本文中定义。本文公开的某些式（I）和式（II）化合物是细菌DNA合成和细菌复制的有效和选择性抑制剂。本发明还提供包含一种或多种式（I）或式（II）化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有作为唯一活性剂的式（I）或式（II）的化合物或可以含有式（I）和/或式（II）的化合物与一种或多种其它活性剂的组合。本发明还提供了用于处理动物中的微生物和原生动物感染的方法。

7. 发明申请

WO2008021491A2 METHOD FOR SYNTHESIS OF 8-ALKOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES 审中-公开
标题翻译：合成8-羟基-9-异亮氨酸[5,4-B]喹啉-3,4-二酮的方法
公开(公告)号：WO2008021491A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/018251
申请日：2007-08-16
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , WILES, Jason, Allan , HASHIMOTO, Akihiro , WANG, Qiuping
发明人： BRADBURY, Barton, James , WILES, Jason, Allan , HASHIMOTO, Akihiro , WANG, Qiuping
IPC分类号： C07D215/28 , C07D401/04 , C07D513/04
CPC分类号： C07D215/28 , C07D401/04 , C07D513/04
摘要： The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4- b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. The substituents R, R5, Re, R7, Rg and R9 are defined herein. The invention also provides novel synthetic intermediates useful in the synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4- diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.
摘要翻译：本发明提供8-甲氧基-9H-异噻唑并[5,4-b]喹啉-3,4-二酮和8A,9-二氢-4a-异噻唑并[5,4-b]喹啉-3的合成方法，取代基R，R 5，R 6，R 7，R 9和R 9如本文所定义。本发明还提供了可用于合成8-甲氧基-9H-异噻唑并[5,4-b]喹啉-3,4-二酮和8A,9-二氢-4a-异噻唑并[5,4-b] 喹啉-3,4-二酮。

8. 发明申请

WO2006074317A1 1-THIA-2,4A-DIAZA-CYCLOPENTA[B]NAPHTHALENE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS 审中-公开
标题翻译： 1-THIA-2,4A-DIAZA-CYCLOPENTA [B]萘普生-3,4-二酮及相关化合物作为抗感染剂
公开(公告)号：WO2006074317A1
公开(公告)日：2006-07-13
申请号：PCT/US2006/000371
申请日：2006-01-05
申请人： ACHILLION PHARMACEUTICALS, INC. , BRADBURY, Barton, James , WILES, Jason, Allan
发明人： BRADBURY, Barton, James , WILES, Jason, Allan
IPC分类号： C07D513/14 , A61P31/00
CPC分类号： C07D513/14
摘要： The invention provides compounds and salts of Formula (I) and Formula (II) which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables A 1 , A 8 , R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula (I) or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
摘要翻译：本发明提供具有抗微生物活性的式（I）和式（II）的化合物和盐。本发明还提供了可用于制备式（I）和式（II）的化合物的新型合成中间体。变量A 1，A 8，R 2，R 3，R 5，/ 3 >，R 6，R 7和R 9在本文中定义。本文公开的某些式（I）和式（II）化合物是细菌DNA合成和细菌复制的有效和选择性抑制剂。本发明还提供包含一种或多种式（I）或式（II）化合物和一种或多种载体，赋形剂或稀释剂的抗微生物组合物，包括药物组合物。这样的组合物可以含有作为唯一活性剂的式（I）或式（II）的化合物或可以含有式（I）或式（II）的化合物与一种或多种其它活性剂的组合。本发明还提供了治疗动物微生物感染的方法。

9. 发明申请

WO2021168320A HETEROARYL COMPOUNDS FOR TREATMENT OF COMPLEMENT FACTOR D MEDIATED DISORDERS 审中-公开
公开(公告)号：WO2021168320A
公开(公告)日：2021-08-26
申请号：PCT/US2021/018871
申请日：2021-02-19
申请人： ACHILLION PHARMACEUTICALS, INC. [US]/[US]
发明人： WILES, Jason, Allan , GADHACHANDA, Venkat, Rao
IPC分类号： C07H21/02 , C07H21/04
摘要： Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce the excessive activation of complement.

10. 发明申请

WO2017035409A1 ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS 审中-公开
标题翻译： ARYL，HETEROARYL和用于治疗免疫和炎症疾病的杂环化合物
公开(公告)号：WO2017035409A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/048788
申请日：2016-08-25
申请人： ACHILLION PHARMACEUTICALS, INC.
发明人： WILES, Jason, Allan , PHADKE, Avinash, S. , DESHPANDE, Milind , AGARWAL, Atul , CHEN, Dawei , GADHACHANDA, Venkat, Rao , HASHIMOTO, Akihiro , PAIS, Godwin , WANG, Qiuping , WANG, Xiangzhu , GREENLEE, William
IPC分类号： A61K31/40 , A61K31/167 , A61K31/395 , C07D401/14 , C07D403/14 , C07D471/04
CPC分类号： C07D403/04 , A61P1/16 , A61P29/00 , A61P37/00 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/22 , C07D493/04 , C07D513/04 , C07D519/00 , C07F9/65583
摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and I'" or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.
摘要翻译：提供化合物，使用方法和制备补体因子D的抑制剂的方法，其包含式I，I“和I”“或其药学上可接受的盐或组合物。本文描述的抑制剂靶因子D并抑制或调节补体级联。本文所述因子D的抑制剂减少补体的过度活化。

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