专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003060098A2 METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT BINDING OF NUCLEOCAPSID 7 PROTEIN TO HIV-1 RNA 审中-公开
标题翻译：鉴定化学结合的方法，其中抑制NUCLEOCAPSID 7蛋白与HIV-1 RNA的结合
公开(公告)号：WO2003060098A2
公开(公告)日：2003-07-24
申请号：PCT/US2003/000801
申请日：2003-01-10
申请人： ACHILLION PHARMACEUTICALS, INC. , BEUCHTER, Douglas , HOU, Xiaohong , MARLOR, Christopher, W. , RICE, William, G. , YANG, Wengang
发明人： BEUCHTER, Douglas , HOU, Xiaohong , MARLOR, Christopher, W. , RICE, William, G. , YANG, Wengang
IPC分类号： C12N
CPC分类号： C07K14/005 , C12N2740/16222 , G01N33/56988 , G01N2500/02
摘要： The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labeled HIV-1 psi -site oligonucleotide and an amount of the molecule to be tested under binding conditions; and determining the amount of oligonucleotide bound to the NCp7 polypeptide, wherein a decrease in the amount of oligonucleotide bound in the presence of the molecule compared with the amount of oligonucleotide bound in the absence of the molecule indicates that the molecule inhibits binding of NCp7 polypeptide to the oligonucleotide.
摘要翻译：本发明涉及从抑制人免疫缺陷病毒核衣壳7多肽NCp7与寡核苷酸结合的分子文库中鉴定分子的方法，其包括将NCp7多肽与一个标记的HIV-1psi位点寡核苷酸混合，在结合条件下待测试的分子并测定与NCp7多肽结合的寡核苷酸的量，其中与在分子不存在下结合的寡核苷酸的量相比，在分子存在下结合的寡核苷酸的量的减少表明，该分子抑制NCp7多肽与寡核苷酸的结合。

2. 发明申请

WO2003060098A3 METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT BINDING OF NUCLEOCAPSID 7 PROTEIN TO HIV-1 RNA 审中-公开
公开(公告)号：WO2003060098A3
公开(公告)日：2003-07-24
申请号：PCT/US2003/000801
申请日：2003-01-10
申请人： ACHILLION PHARMACEUTICALS, INC. , BEUCHTER, Douglas , HOU, Xiaohong , MARLOR, Christopher, W. , RICE, William, G. , YANG, Wengang
发明人： BEUCHTER, Douglas , HOU, Xiaohong , MARLOR, Christopher, W. , RICE, William, G. , YANG, Wengang
IPC分类号： G01N33/566
摘要： The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labeled HIV-1 psi -site oligonucleotide and an amount of the molecule to be tested under binding conditions; and determining the amount of oligonucleotide bound to the NCp7 polypeptide, wherein a decrease in the amount of oligonucleotide bound in the presence of the molecule compared with the amount of oligonucleotide bound in the absence of the molecule indicates that the molecule inhibits binding of NCp7 polypeptide to the oligonucleotide.

3. 发明申请

WO2018156578A1 METHODS FOR TREATING PATIENTS WITH HEMATOLOGIC MALIGNANCIES 审中-公开
公开(公告)号：WO2018156578A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/018951
申请日：2018-02-21
申请人： APTOSE BIOSCIENCES INC. , CRYSTALGENOMICS, INC. , RICE, William, G.
发明人： RICE, William, G. , CHO, Joong Myung , HONG, Yongrae
IPC分类号： C07D403/10 , A61K45/06 , A61K31/4178
摘要： The present disclosure comprises a method for administering 2,3-dihydro-isoindole-1-one compound or a pharmaceutically acceptable salt, ester, solvate and/or prodrug thereof, for the treatment of hematological cancers such as acute myeloid leukemia (AML). The present disclosure further relates to reducing or inhibiting cell-proliferation which is activated by wild-type or mutated Fms-like tyrosine kinase-3 receptor (FLT3). The present disclosure further relates to a method of inhibiting or reducing abnormal (e.g., overexpressed) wild-type or mutated BTK activity or expression in a subject in need thereof.

4. 发明申请

WO2019089511A1 ARYL IMIDAZOLES FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2019089511A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058103
申请日：2018-10-30
申请人： APTOSE BIOSCIENCES INC. , RICE, William, G.
发明人： RICE, William, G. , HOWELL, Stephen , TSAI, Cheng-Yu
IPC分类号： A61K31/44 , A61K31/4745 , A61K31/475 , A61K31/496 , A61K31/5377
摘要： The present invention relates to a method of preventing, reducing, or treating cancer in a subject, comprising administering a therapeutically effective amount of or a pharmaceutically acceptable salt, free base, hydrate, complex, or chelate (including metal chelates, such as iron, zinc and others) thereof to the subject, wherein the subject has a mutation in a DNA repair gene.

5. 发明申请

WO2003055448A2 ANTIFUNGAL COMPOSITIONS 审中-公开
标题翻译：抗菌成分
公开(公告)号：WO2003055448A2
公开(公告)日：2003-07-10
申请号：PCT/US2002/041196
申请日：2002-12-20
申请人： ACHILLION PHARMACEUTICALS, INC.
发明人： RICE, William, G. , BUECHTER, Douglas, D. , MURPHY, Randall, B.
IPC分类号： A61K
CPC分类号： A61K31/166 , A61K31/00 , C12Q1/18
摘要： Methods for elucidating an antifungal or anti-yeast compound which selectively bind to a fungal or yeast zinc finger-containing protein within a fungus are disclosed. Assays of screening for compounds that are effective for binding to a fungal or yeast zinc ginger-containing protein are also provided. It is also provided a pharmaceutical composition containing an effective amount of a compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods. Fungal and/or yeast infections can be treated or prevented by administering to a patient in need of treatment the pharmaceutical composition containing an effective amount of an compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods.
摘要翻译：公开了在真菌中选择性结合真菌或酵母含锌指蛋白的抗真菌或抗酵母化合物的方法。还提供了筛选对结合真菌或酵母含锌姜蛋白有效的化合物的测定。还提供了含有有效量的化合物或化合物的药物组合物，该化合物被鉴定为使用所公开的方法结合或与真菌或酵母含锌指蛋白结合。真菌和/或酵母菌感染可以通过向需要治疗的患者施用含有有效量的化合物或被鉴定为有效结合或与真菌或酵母含锌指蛋白结合的化合物的化合物来治疗或预防使用所公开的方法。

6. 发明申请

WO2007022474A3 HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF 审中-公开
公开(公告)号：WO2007022474A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/032508
申请日：2006-08-18
申请人： CYLENE PHARMACEUTICALS, INC. , DRYGIN, Denis , MICHELOTTI, Emil , O'BRIEN, Sean , RICE, William, G. , SIDDIQUI-JAIN, Adam , WHITTEN, Jeffrey, P.
发明人： DRYGIN, Denis , MICHELOTTI, Emil , O'BRIEN, Sean , RICE, William, G. , SIDDIQUI-JAIN, Adam , WHITTEN, Jeffrey, P.
IPC分类号： A01N43/04 , A61K31/70 , C07H21/04
摘要： Provided herein are isolated nucleic acids that comprise a human rRNA or rDNA subsequence and related compositions and methods of use.

7. 发明申请

WO2002059123A3 BENZOYLALKYLINDOLEPYRIDINIUM COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS 审中-公开
公开(公告)号：WO2002059123A3
公开(公告)日：2002-08-01
申请号：PCT/US2001/048311
申请日：2001-12-13
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , RICE, William, G. , HUANG, Mingjun , BUCKHEIT, Robert, W., Jr. , COVELL, David, G. , CZERWINSKI, Grzegorz , MICHEJDA, Christopher, J.
发明人： RICE, William, G. , HUANG, Mingjun , BUCKHEIT, Robert, W., Jr. , COVELL, David, G. , CZERWINSKI, Grzegorz , MICHEJDA, Christopher, J.
IPC分类号： C07D471/04
摘要： The design, synthesis and antiviral activity of novel benzoylalkylindole-pyridiniums are disclosed. These compounds inhibit the reverse transcriptase enzymes of several retroviruses, including human immunodeficiency virus types 1 and 2, and simian immunodeficiency virus, and effectively inhibit viral replication thereby. Most of these compounds satisfy formula (1) where R 1 is independently selected from the group consisting of lower alkyl; N 1 is a nitrogen in a ring and is bonded to C 1 by either a single bond or a double bond; C 1 is a carbon atom in a ring, is bonded to N 1 by either a single bond or a double bond, and is bonded to C 2 by either a single bond or a double bond; C 2 is a carbon atom in a ring and is bonded to C 1 by either a single bond or a double bond, and is bonded by either a single bond or a double bond to C 3 ; and R 2 is selected from the group consisting of hydrogen, lower alkyl, lower alkyl amide, and formula (2). Compositions comprising effective amounts of such compounds are also described. These compounds and compositions can be used in a method for inhibiting the replication of retroviruses in a subject comprising administering an effective amount of the compound(s) or composition(s) comprising the compound, to a subject to inhibit retroviral replication.

8. 发明申请

WO2004030609A2 ANTIFUNGAL COMPOSITIONS 审中-公开
标题翻译：抗菌成分
公开(公告)号：WO2004030609A2
公开(公告)日：2004-04-15
申请号：PCT/US2002/031069
申请日：2002-06-27
申请人： ACHILLION PHARMACEUTICALS, INC.
发明人： RICE, William, G. , BUECHTER, Douglas, D. , PUCCI, Michael, J.
IPC分类号： A61K
CPC分类号： A01N43/32 , A01N37/40 , A01N37/44 , A01N43/50 , A01N43/80 , A01N47/34 , A01N61/00
摘要： Compositions formed of one or more antifungal compounds which selectively bind to a fungal zinc finger-containing protein and an appropriate carrier for pharmaceutical, industrial or agricultural use are disclosed. Methods for assaying the antifungal activity of a compound are described, either manually or by automation, by reacting the compound with the fungal zinc finger-containing protein and measuring the level of zinc ejection or loss of function of the protein. A disorder caused by one or more fungi can be treated or prevented by administering to an organism the composition. The organism can be an animal or a plant. The animal is preferably a mammal, most preferably a human being
摘要翻译：公开了由一种或多种抗真菌化合物形成的组合物，其选择性地结合含有真菌含锌指蛋白质的蛋白质和适用于药物，工业或农业用途的载体。通过使化合物与真菌含锌指蛋白质反应并测量锌排出水平或蛋白质功能丧失来描述化合物的抗真菌活性的手段或自动化方法。可以通过向生物体施用组合物来治疗或预防由一种或多种真菌引起的病症。生物体可以是动物或植物。动物优选为哺乳动物，最优选为人

9. 发明申请

WO2003055448A3 ANTIFUNGAL COMPOSITIONS 审中-公开
公开(公告)号：WO2003055448A3
公开(公告)日：2003-07-10
申请号：PCT/US2002/041196
申请日：2002-12-20
申请人： ACHILLION PHARMACEUTICALS, INC.
发明人： RICE, William, G. , BUECHTER, Douglas, D. , MURPHY, Randall, B.
IPC分类号： A61K31/00
摘要： Methods for elucidating an antifungal or anti-yeast compound which selectively bind to a fungal or yeast zinc finger-containing protein within a fungus are disclosed. Assays of screening for compounds that are effective for binding to a fungal or yeast zinc ginger-containing protein are also provided. It is also provided a pharmaceutical composition containing an effective amount of a compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods. Fungal and/or yeast infections can be treated or prevented by administering to a patient in need of treatment the pharmaceutical composition containing an effective amount of an compound or compounds identified as effective for binding to or associating with a fungal or yeast zinc finger-containing protein using the disclosed methods.

10. 发明申请

WO2015051302A1 COMPOSITIONS AND METHODS FOR TREATING CANCERS 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2015051302A1
公开(公告)日：2015-04-09
申请号：PCT/US2014/059140
申请日：2014-10-03
申请人： APTOSE BIOSCIENCES INC. , RICE, William, G.
发明人： RICE, William, G.
IPC分类号： A61K31/475 , A61K31/496 , A61K31/5377
CPC分类号： C12Q1/6886 , A61K31/4745 , A61K31/706 , A61K45/06 , A61K49/0004 , C07D471/14 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
摘要： The present invention relates to compositions and methods for treating of cancer. In some embodiments, the invention relates to the use of agents that can modulate a component in the CDX2-KLF4 signaling pathway to treat myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), adult T-cell leukaemia (ATLL), lymphoma, gastric cancer, multiple myeloma, or combinations thereof, or a condition associated with abnormal activity of the CDX2-KLF4 signaling pathway.
摘要翻译：本发明涉及治疗癌症的组合物和方法。在一些实施方案中，本发明涉及可以调节CDX2-KLF4信号传导途径中的组分以治疗骨髓增生异常综合征（MDS），急性骨髓性白血病（AML），急性淋巴细胞性白血病（ALL），成人T细胞白血病（ATLL），淋巴瘤，胃癌，多发性骨髓瘤或其组合，或与CDX2-KLF4信号传导途径异常活动相关的病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式