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1. 发明申请

WO2016109541A1 METHOD FOR TREATING INFLUENZA A VIRUS INFECTION 审中-公开
标题翻译：用于治疗流感病毒感染的方法
公开(公告)号：WO2016109541A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/067870
申请日：2015-12-29
申请人： ACADEMIA SINICA , LIANG, Chi-Ming
发明人： HSIEH, Shie-Liang , CHANG, Yung-Chi , HUANG, Ming-Ting
IPC分类号： A61K38/00
CPC分类号： A61K38/177 , C07K14/70578 , C07K2319/30
摘要： Disclosed herein is a method of treating influenza A virus (IAV) infection by a fusion protein. According to some embodiments of the present disclosure, the fusion protein comprises a HBD peptide and a IgG1 Fc region. According to other embodiments of the present disclosure, the fusion protein comprises a DcR3 protein and a IgG1 Fc region. The present fusion protein is found to possess inhibitory effects on IAV-induced secretion of the inflammatory cytokine, and IAV-induced infiltration of inflammatory cell into the lung tissue. Accordingly, the fusion protein is useful for developing a medicament for the treatment or prophylaxis of IAV infection and/or ameliorating pulmonary injury caused by excessive inflammation associated with IAV infection in a subject.
摘要翻译：本文公开了一种通过融合蛋白治疗甲型流感病毒（IAV）感染的方法。根据本公开的一些实施方案，融合蛋白包含HBD肽和IgG1 Fc区。根据本公开的其它实施方案，融合蛋白包含DcR3蛋白和IgG1 Fc区。发现本发现的融合蛋白具有对IAV诱导的炎症细胞因子分泌的抑制作用，并且IAV诱导的炎性细胞浸润到肺组织中。因此，融合蛋白可用于开发用于治疗或预防IAV感染和/或改善由受试者中与IAV感染相关的过度炎症引起的肺损伤的药物。

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