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1. 发明申请

WO2010130832A3 AMINO ACID SEQUENCES DIRECTED AGAINST DICKKOPF-1 AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH BONE LOSS AND/OR OSTEOLYTIC LESIONS 审中-公开
公开(公告)号：WO2010130832A3
公开(公告)日：2010-11-18
申请号：PCT/EP2010/056659
申请日：2010-05-14
申请人： ABLYNX N.V. , CROMIE, Karen , DOMBRECHT, Bruno , VERHEESEN, Peter , SABATAKOS, Georgios
发明人： CROMIE, Karen , DOMBRECHT, Bruno , VERHEESEN, Peter , SABATAKOS, Georgios
IPC分类号： C07K16/18
摘要： Amino acid sequences are provided that are directed against Dickkopf-1 (Dkk-1), as well as compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, compounds, constructs and/or polypeptides, and to uses of such amino acid sequences, compounds, constructs, polypeptides, and/or compositions, for prevention and/or treatment of diseases and disorders associated with bone loss and/or osteolytic lesions.

2. 发明申请

WO2008071447A2 AMINO ACID SEQUENCES THAT MODULATE THE INTERACTION BETWEEN CELLS OF THE IMMUNE SYSTEM 审中-公开
标题翻译：调节免疫系统细胞之间的相互作用的氨基酸序列
公开(公告)号：WO2008071447A2
公开(公告)日：2008-06-19
申请号：PCT/EP2007/011057
申请日：2007-12-17
申请人： ABLYNX N.V. , HERMANS, Guy , VERHEESEN, Peter , DOLK, Edward , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus , SAUNDERS, Michael John Scott , DE HAARD, Johannes Joseph Wilhelmus , DE BRUIN, Renee
发明人： HERMANS, Guy , VERHEESEN, Peter , DOLK, Edward , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus , SAUNDERS, Michael John Scott , DE HAARD, Johannes Joseph Wilhelmus , DE BRUIN, Renee
IPC分类号： C07K14/43
CPC分类号： C07K16/2818 , A61K47/643 , C07K14/76 , C07K16/2803 , C07K16/2827 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a T-cell. More particularly, the present invention relates to amino acid sequences that are directed against (as defined herein) a target on an APC (also referred to herein as "APC target") or a target on a T-cell (also referred to herein as "T-cell target"). The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences
摘要翻译：本发明涉及阻断抗原呈递细胞（APC）上的靶标（APC）和（T细胞上的靶标）之间的相互作用的氨基酸序列。更具体地，本发明涉及针对（如本文所定义）APC上的靶（本文中也称为“APC靶”）或T细胞上的靶（本文也称为“靶”）的氨基酸序列 “T细胞靶”）。本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽

3. 发明申请

WO2008068280A1 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS 审中-公开
标题翻译：能够与血清蛋白结合的肽
公开(公告)号：WO2008068280A1
公开(公告)日：2008-06-12
申请号：PCT/EP2007/063348
申请日：2007-12-05
申请人： ABLYNX N.V. , REVETS, Hilde Adi Pierrette , KOLKMAN, Joost Alexander , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus , VERHEESEN, Peter , STAELENS, Stephanie
发明人： REVETS, Hilde Adi Pierrette , KOLKMAN, Joost Alexander , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus , VERHEESEN, Peter , STAELENS, Stephanie
IPC分类号： C07K16/18 , C07K14/435
CPC分类号： C07K16/18 , C07K16/32 , C07K2317/22 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2319/31 , G01N33/5047 , G01N33/6857
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译：本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。

4. 发明申请

WO2008101985A2 AMINO ACID SEQUENCES DIRECTED AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF CONDITIONS AND DISEASES CHARACTERIZED BY EXCESSIVE AND/OR PATHOLOGICAL ANGIOGENESIS OR NEOVASCULARIZATION 审中-公开
标题翻译：用于治疗血管内皮生长因子的氨基酸序列和包含其的用于治疗由过度和/或病理性血管发生或新血管化表征的病症和疾病的多肽
公开(公告)号：WO2008101985A2
公开(公告)日：2008-08-28
申请号：PCT/EP2008/052119
申请日：2008-02-21
申请人： ABLYNX N.V. , MERCHIERS, Pascal Gerard , VERHEESEN, Peter , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus
发明人： MERCHIERS, Pascal Gerard , VERHEESEN, Peter , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , C07K2317/22 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to amino acid sequences that are directed against vascular endothelial growth factor (VEGF), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization.
摘要翻译：本发明涉及针对血管内皮生长因子（VEGF）的氨基酸序列以及化合物或构建体，特别是蛋白质和多肽，其包含一种或基本上由一种或更多这样的氨基酸序列。氨基酸序列，化合物和构建体可用于预防，治疗或诊断目的，例如用于治疗以过度和/或病理性血管生成或新血管形成为特征的病症和疾病。

5. 发明申请

WO2009127691A1 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开
标题翻译：能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽
公开(公告)号：WO2009127691A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054533
申请日：2009-04-16
申请人： ABLYNX N.V. , REVETS, Hilde Adi Pierrette , BOUTTON, Carlo , STAELENS, Stephanie , VERHEESEN, Peter
发明人： REVETS, Hilde Adi Pierrette , BOUTTON, Carlo , STAELENS, Stephanie , VERHEESEN, Peter
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to human serum albumin; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译：本发明涉及能够结合人血清白蛋白的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。

6. 发明申请

WO2012025602A1 INSECT BINDING ANTIBODIES 审中-公开
标题翻译： INSECT BINDING抗体
公开(公告)号：WO2012025602A1
公开(公告)日：2012-03-01
申请号：PCT/EP2011/064663
申请日：2011-08-25
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , JONGEDIJK, Erik , JONGEDIJK, Erik , VERHEESEN, Peter
发明人： JONGEDIJK, Erik , VERHEESEN, Peter
IPC分类号： C07K16/18 , G01N33/53
CPC分类号： C07K16/18 , A01N37/44 , A01N37/46 , A01N63/00 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to a binding domain, preferably an antigen binding domain, more preferably an antigen binding domain that specifically binds a binding site on an insect. More specifically, it relates to antigen binding domains comprising an amino acid sequence that comprises 4 framework regions and 3 complementary determining regions, whereby said antigen binding domains are capable to bind specifically to an insect as a whole, preferably to a binding site on the insect surface. The invention relates further to the use of said binding domain to deliver a compound, preferably a biologically active agent to the insect, and to insecticidal compositions comprising said binding domain.
摘要翻译：本发明涉及结合域，优选抗原结合结构域，更优选涉及特异性结合昆虫上的结合位点的抗原结合结构域。更具体地，本发明涉及包含包含4个构架区和3个互补决定区的氨基酸序列的抗原结合结构域，其中所述抗原结合结构域能够特异性结合昆虫作为整体，优选结合昆虫的结合位点表面。本发明进一步涉及所述结合结构域向昆虫递送化合物，优选生物活性剂的用途以及包含所述结合结构域的杀虫组合物。

7. 发明申请

WO2012025619A1 CHITINOUS POLYSACCHARIDE ANTIGEN BINDING PROTEINS 审中-公开
标题翻译： CHITINOUS多糖抗原结合蛋白
公开(公告)号：WO2012025619A1
公开(公告)日：2012-03-01
申请号：PCT/EP2011/064734
申请日：2011-08-26
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , JONGEDIJK, Erik , VERHEESEN, Peter , DE JONGHE, Chris , JONGEDIJK, Erik
发明人： VERHEESEN, Peter , DE JONGHE, Chris , JONGEDIJK, Erik
IPC分类号： C07K16/44 , C07K16/14 , C07K16/18
CPC分类号： A01N37/46 , C07K16/14 , C07K16/16 , C07K16/18 , C07K2317/22 , C07K2317/569 , G01N33/56961
摘要： The present invention relates to an antigen binding protein, preferably comprising an amino acid sequence that comprises 4 framework regions and 3 complementary determining regions, wherein said antigen binding protein is capable of binding a chitinous polysaccharide, and uses thereof.
摘要翻译：本发明涉及抗原结合蛋白，优选包含含有4个构架区和3个互补决定区的氨基酸序列，其中所述抗原结合蛋白能够结合几丁质多糖及其应用。

8. 发明申请

WO2011124612A1 SPECIFIC DELIVERY OF AGROCHEMICALS 审中-公开
标题翻译：农业特定交付
公开(公告)号：WO2011124612A1
公开(公告)日：2011-10-13
申请号：PCT/EP2011/055358
申请日：2011-04-06
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , JONGEDIJK, Erik , JONGEDIJK, Erik , VERHEESEN, Peter
发明人： JONGEDIJK, Erik , VERHEESEN, Peter
IPC分类号： A01N25/00 , C07K16/00
CPC分类号： A01N25/28 , A01N25/00 , A61K47/48507 , A61K47/6835 , C07K16/16 , C07K2317/35 , C07K2317/569 , C07K2317/92 , A01N25/24 , A01N53/00
摘要： The present invention relates to specific delivery of agrochemicals to plants. More specifically, it relates to a composition, essentially consisting of a targeting agent comprising at least one binding domain that specifically binds to a binding site on an intact living plant and an agrochemical or a combination of agrochemicals. The present invention relates further to a binding domain that specifically binds said binding site on an intact living plant. More specifically, it relates to binding domains comprising an amino acid sequence that comprises 4 framework regions and 3 complementary determining regions, or any suitable fragment thereof, whereby said binding domains are capable to bind or retain a carrier onto a plant. In one preferred embodiment, the invention relates to binding domains which specifically bind trichomes, stomata, cuticle, lenticels, thorns, spines, root hairs, or wax layer. The invention relates further to a method for delivery of agrochemicals to a plant, for improving the deposition of agrochemicals on a plant,and for retaining said agrochemicals on a plant, using targeting agents comprising said binding domains, and to a method for protecting a plant against biotic or abiotic stress or controlling plant growth using the same. Also, the invention relates to a method for manufacturing a specifically targeting agrochemical carrier.
摘要翻译：本发明涉及农药对植物的具体递送。更具体地说，本发明涉及一种组合物，其基本上由包含至少一个结合结构域的靶向剂组成，所述结合结构域特异性结合完整活体植物上的结合位点，以及农业化学品或农用化学品的组合。本发明还涉及特异性结合完整活的植物上的结合位点的结合结构域。更具体地说，本发明涉及包含包含4个构架区和3个互补决定区的氨基酸序列或其任何合适的片段的结合域，其中所述结合结构域能够将载体结合或保留在植物上。在一个优选的实施方案中，本发明涉及特异性结合毛状体，气孔，角质层，微孔，刺，刺，根毛或蜡层的结合结构域。本发明还涉及一种用于将植物递送至植物的方法，用于改善农业化学品在植物上的沉积，以及使用包含所述结合结构域的靶向剂将植物上的所述农业化学品保留，以及保护植物的方法针对生物或非生物胁迫或使用该胁迫控制植物生长。此外，本发明涉及一种制造特异性靶向农药载体的方法。

9. 发明申请

WO2012025621A1 COMPOSITIONS FOR SEED TREATMENT 审中-公开
标题翻译：种子处理组合物
公开(公告)号：WO2012025621A1
公开(公告)日：2012-03-01
申请号：PCT/EP2011/064740
申请日：2011-08-26
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , JONGEDIJK, Erik , VERHEESEN, Peter , DE JONGHE, Chris , JONGEDIJK, Erik
发明人： VERHEESEN, Peter , DE JONGHE, Chris , JONGEDIJK, Erik
IPC分类号： C07K16/16
CPC分类号： A01N37/46 , C07K16/14 , C07K16/16 , C07K16/18 , C07K2317/22 , C07K2317/569 , G01N33/56961
摘要： The present invention relates to a composition for seed treatment comprising a plant seed binding protein, preferably an antigen binding plant seed binding protein. In a preferred embodiment, the seed binding protein is binding a polysaccharide, preferably pectin. The invention relates further to the use of a plant seed binding protein to bind a plant enhancing agent to a plant seed, and to a method for treating plant seeds.
摘要翻译：本发明涉及用于种子处理的组合物，其包含植物种子结合蛋白，优选抗原结合植物种子结合蛋白。在优选的实施方案中，种子结合蛋白结合多糖，优选果胶。本发明还涉及植物种子结合蛋白将植物增强剂与植物种子结合的用途以及用于处理植物种子的方法。

10. 发明申请

WO2010043650A2 AMINO ACID SEQUENCES DIRECTED AGAINST CELLULAR RECEPTORS FOR VIRUSES AND BACTERIA 审中-公开
标题翻译：针对病毒和细菌的细胞受体指导的氨基酸序列
公开(公告)号：WO2010043650A2
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063411
申请日：2009-10-14
申请人： ABLYNX NV , BLANCHETOT, Cristoph , SMIT, Martine , LEURS, Regorius , JÄHNICHEN, Sven , SCHOLS, Dominique , SAUNDERS, Michael John Scott , DE HAARD, Johannes Joseph Wilhelmus , VANLANDSCHOOT, Peter , VERHEESEN, Peter
发明人： BLANCHETOT, Cristoph , SMIT, Martine , LEURS, Regorius , JÄHNICHEN, Sven , SCHOLS, Dominique , SAUNDERS, Michael John Scott , DE HAARD, Johannes Joseph Wilhelmus , VANLANDSCHOOT, Peter , VERHEESEN, Peter
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/39533 , A61K2039/505 , C07K16/2812 , C07K2317/21 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2319/31 , Y10S530/866
摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. Nanobodies specifically recognizing hCD4, hCXCR4, hCCR5. hTLR4, human alphaV integrin, human beta3 integrin, human betal integrin, human alpha2 integrin, hCD81, hSR-Bl, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. Said amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.
摘要翻译：本发明涉及针对（如本文定义的）病毒和/或细菌的人细胞受体的氨基酸序列，例如，纳米抗体专门识别hCD4，hCXCR4，hCCR5。 hTLR4，人αV整联蛋白，人β3整联蛋白，人betal整联蛋白，人α2整联蛋白，hCD81，hSR-B1，hClaudin-1，hClaudin-6和hClaudin-9，以及化合物或构建体，特别是蛋白质和多肽，其包含或基本上由一个或多个这样的氨基酸序列组成。所述氨基酸序列可用于预防HIV，HCV，腺病毒，汉坦病毒，疱疹病毒，回波病毒1等的人细胞进入。

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