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1. 发明申请

WO2010126653A1 ANTIBODIES AGAINST DELTA-5 DESATURASE AND USES THEREOF 审中-公开
标题翻译：抗逆转录酶5抗体及其用途
公开(公告)号：WO2010126653A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/027085
申请日：2010-03-12
申请人： ABBOTT LABORATORIES , PEREIRA, Suzette , KRISHNAN, Padmavathy , DAS, Tapas , MUKERJI, Pradip
发明人： PEREIRA, Suzette , KRISHNAN, Padmavathy , DAS, Tapas , MUKERJI, Pradip
IPC分类号： C07K16/14 , C07K16/40
CPC分类号： C07K16/14 , C07K16/40 , C07K2319/23
摘要： Disclosed are antibodies that specifically recognize Δ5-desaturase, methods of producing the antibodies, nucleotides and polypeptides for producing the antibodies, and methods of using the antibodies. The Δ5-desaturase-specific antibodies provide improved methods of detecting Δ5- desaturase in a sample.
摘要翻译：公开了特异性识别α5-去饱和酶的抗体，产生抗体的方法，用于产生抗体的核苷酸和多肽，以及使用该抗体的方法。 α5-去饱和酶特异性抗体提供了在样品中检测α5去饱和酶的改进方法。

2. 发明申请

WO2011008803A2 NOVEL Δ9-ELONGASE FOR PRODUCTION OF POLYUNSATURATED FATTY ACID-ENRICHED OILS 审中-公开
标题翻译：用于生产多不饱和脂肪酸富集油的新型Δ9-延胡索酸酶
公开(公告)号：WO2011008803A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/041893
申请日：2010-07-14
申请人： ABBOTT LABORATORIES , PEREIRA, Suzette , DAS, Tapas , KRISHNAN, Padmavathy , MUKERJI, Pradip
发明人： PEREIRA, Suzette , DAS, Tapas , KRISHNAN, Padmavathy , MUKERJI, Pradip
IPC分类号： C12N9/00 , C12N9/02 , C12N15/82
CPC分类号： C12N9/0071 , C12N9/93 , C12N15/8247
摘要： The present disclosure relates to isolated polynucleotides encoding a delta 9-elongase, delta 9-elongases encoded by the isolated polynucleotides, expression vectors comprising the isolated polynucleotides, host cells comprising the expression vectors, and methods for producing delta 9-elongase and polyunsaturated fatty acids.
摘要翻译：本发明涉及编码由分离的多核苷酸编码的δ9延伸酶，Δ9延伸酶的分离的多核苷酸，包含分离的多核苷酸的表达载体，包含表达载体的宿主细胞以及产生三角洲9延长酶和多不饱和脂肪酸。

3. 发明申请

WO2008064096A2 ELONGASE GENE AND USES THEREOF 审中-公开
标题翻译： ELONGASE基因及其用途
公开(公告)号：WO2008064096A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/084902
申请日：2007-11-16
申请人： ABBOTT LABORATORIES , DAS, Tapas , MUKERJI, Pradip , KRISHNAN, Padmavathy , LEONARD, Amanda, E. , PEREIRA, Suzette, L.
发明人： DAS, Tapas , MUKERJI, Pradip , KRISHNAN, Padmavathy , LEONARD, Amanda, E. , PEREIRA, Suzette, L.
IPC分类号： C07K14/43
CPC分类号： C12N15/8247 , C12N9/1029
摘要： The subject invention relates to the identification of a gene involved in the elongation of polyunaturated fatty acids containing unsaturation at the carbon 9 position ( i.e. , "Δ9-elongase") and to uses thereof. In particular, Δ9-elongase may be utilized, for example, in the conversion of linoleic acid (LA, 18:2n-6) to eicosadienoic acid (EDA, 20:2n-6). The production of dihomo-y-linolenic acid (DGLA, 20:3n-6) from eicosadienoic acid (EDA, 20:2n-6), and arachidonic acid (AA, 20:4n-6) from dihomo-y-linolenic acid (DGLA, 20:3n-6) is then catalyzed by Δ8-desaturase and Δ5-desaturase, respectively. AA or polyunsafurated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
摘要翻译：本发明涉及鉴定涉及在碳9位置处含有不饱和度的多不饱和脂肪酸延伸（即Δ9-延长酶）的基因并涉及其用途。特别地，Δ9-延长酶可用于例如亚油酸（LA，18：2n-6）向二十碳二烯酸（EDA，20：2n-6）的转化。由二高-γ-亚麻酸制备二十碳三烯酸（EDA，20：2n-6）和花生四烯酸（AA，20：4n-6）的二高-γ-亚麻酸（DGLA，20：3n- （DGLA，20：3n-6）分别被Δ8-去饱和酶和Δ5-去饱和酶催化。由其生产的AA或聚不饱和脂肪酸可以加入到药物组合物，营养组合物，动物饲料以及其他产品如化妆品中。

4. 发明申请

WO2010042510A1 DELTA-8 DESATURASE GENES, ENZYMES ENCODED THEREBY AND USES THEREOF 审中-公开
标题翻译： DELTA-8去饱和基因，编码的酶及其用途
公开(公告)号：WO2010042510A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/059689
申请日：2009-10-06
申请人： ABBOTT LABORATIRES , DAS, Tapas , MUKERJI, Pradip , PEREIRA, Suzette , KRISHNAN, Padmavathy
发明人： DAS, Tapas , MUKERJI, Pradip , PEREIRA, Suzette , KRISHNAN, Padmavathy
IPC分类号： C12N9/02
CPC分类号： C12N15/8247 , C12N9/0083 , C12P7/6427
摘要： The present invention is related to isolated polynucleotides encoding a delta-8 desaturase, delta-8 desaturases encoded by the isolated polynucleotides, expression vectors containing the isolated polynucleotides, host cells containing the expression vectors and methods for producing delta-8 desaturases and polyunsaturated fatty acids.
摘要翻译：本发明涉及编码由分离的多核苷酸编码的δ-8去饱和酶，δ-8去饱和酶的分离的多核苷酸，含有分离的多核苷酸的表达载体，含有表达载体的宿主细胞和用于产生δ-8去饱和酶和多不饱和脂肪酸的方法。

5. 发明申请

WO2007075605A2 METHOD OF USING β-HYDROXY-β-METHYLBUTYRATE 审中-公开
标题翻译：使用β-羟基-β-甲基丁酸酯的方法
公开(公告)号：WO2007075605A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048303
申请日：2006-12-19
申请人： ABBOTT LABORATORIES , THOMAS, Debra, L. , MUKERJI, Pradip
发明人： THOMAS, Debra, L. , MUKERJI, Pradip
IPC分类号： A61K31/19 , A61P37/08 , A61P35/00 , A61P31/00
CPC分类号： A61K31/19 , A23L33/10 , A23L33/40 , Y10S514/826 , Y10S514/885
摘要： Disclosed are methods of treating an individual having a condition characterized by an imbalance in type (1) and type (2) cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type (1) to type (2) cytokines, including an increase in the ratio of type (1) to type (2) cytokines without a corresponding increase in type (2) cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type (1) cytokines without a corresponding increase in type (2) cytokines.
摘要翻译：公开的是治疗具有以类型（1）和类型（2）细胞因子产生不平衡为特征的个体的个体的方法，其中所述方法包括向个体施用一定量的有效成分的β-羟基-β-甲基丁酸酯（HMB）调节或以其他方式引起类型（1）与类型（2）细胞因子的比例的增加，包括类型（1）与类型（2）细胞因子的比例增加，而类型（2）细胞因子水平没有相应的增加。还公开了使用HMB治疗哮喘和过敏的方法。本发明的方法基于以下发现：HMB调节细胞因子产生，最典型地通过增加类型（1）细胞因子而没有类型（2）细胞因子的相应增加。

6. 发明申请

WO2005102301A2 HMB COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： HMB组合物及其用途
公开(公告)号：WO2005102301A2
公开(公告)日：2005-11-03
申请号：PCT/US2005/007951
申请日：2005-03-14
申请人： ABBOTT LABORATORIES , BAXTER, Jeffrey, H , MUKERJI, Pradip , VOSS, Anne, C , TISDALE, Michael, J
发明人： BAXTER, Jeffrey, H , MUKERJI, Pradip , VOSS, Anne, C , TISDALE, Michael, J
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 w-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and subtantially lacking in free amino acids.
摘要翻译：本发明涉及预防和治疗慢性炎性疾病，癌症和非自愿减肥的方法。在本发明的实践中，患者是单独的肠道给药HMB，或者与二十碳五烯酸（20:5w-3），FOS，肉碱及其混合物组合。可以将HMB加入含有富含大中性氨基酸的氨基氮源如亮氨酸，异亮氨酸，缬氨酸，酪氨酸，苏氨酸和苯丙氨酸并且在游离氨基酸中不足的氨基氮源的食品中。

7. 发明申请

WO1995032728A1 INHIBITION OF ATTACHMENT OF H. INFLUENZAE TO HUMAN CELLS 审中-公开
标题翻译：抑制H.HIV对人类细胞的影响
公开(公告)号：WO1995032728A1
公开(公告)日：1995-12-07
申请号：PCT/US1995003789
申请日：1995-04-18
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MUKERJI, Pradip , SEO, Amanda, Eun-Yeong , ANDERSON, Steven, Neal , HARVEY, Linda, Ann
IPC分类号： A61K38/17
CPC分类号： C07K14/4732 , A23L33/19 , A61K38/018 , A61K38/1709
摘要： The attachment of H. influenzae to human cells, such as oropharyngeal cells, may be inhibited by native human beta -casein, a recombinant form of human beta -casein, and hydrolysates of both. The human beta -casein or hydrolysate may be contained in a liquid enteral nutritional product such as an infant formula. The enteral nutritional product may be used, for example, in the prevention and treatment of otitis media in infants. The human beta -casein or hydrolysate may also be administered as a throat spray or nasally using drops or a spray.
摘要翻译：流感嗜血杆菌对人细胞如口咽细胞的附着可被天然人β-酪蛋白，人β-酪蛋白的重组形式和两者的水解产物所抑制。人β-酪蛋白或水解产物可以包含在液体肠内营养产品如婴儿配方奶粉中。肠内营养产品可用于例如预防和治疗婴幼儿中耳炎。人类β-酪蛋白或水解产物也可以作为喉部喷雾剂或使用滴剂或喷雾剂鼻部施用。

8. 发明申请

WO1995024495A1 TRANSGENIC PRODUCTION OF OLIGOSACCHARIDES AND GLYCOCONJUGATES 审中-公开
标题翻译：低聚糖和甘氨酸的转基因生产
公开(公告)号：WO1995024495A1
公开(公告)日：1995-09-14
申请号：PCT/US1995000967
申请日：1995-01-24
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , PRIETO, Pedro, Antonio , SMITH, David, Fletcher , CUMMINGS, Richard, Dale , KOPCHIK, John, Joseph , MUKERJI, Pradip , MOREMEN, Kelley, Wilson , PIERCE, James, Michael
IPC分类号： C12N15/85
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/01 , A23C9/20 , C12N9/1077 , Y10S530/832
摘要： The invention relates to the milk of a transgenic non-human mammal. The milk is characterized in that it contains heterologous components produced as the secondary gene products of a heterologous gene contained in the genome of the transgenic non-human mammal. The heterologous gene encodes a heterologous catalytic entity such as a human enzyme selected from the group consisting of glycosyltransferases, phosphorylases, hydroxylases, peptidases and sulfotransferases. Especially useful in the practice of the invention are human glycosyltransferases. The desired heterologous components include oligosaccharides, glycoconjugates. The oligosaccharides and glycoconjugates may be isolated from the milk of the transgenic mammals and used in the preparation of pharmaceuticals, diagnostic kits, nutritional products and the like. The whole transgenic milk may also be used to formulate nutritional products that provide special advantages. The transgenic milk may also be used in the production of specialized enteral nutritional products.
摘要翻译：本发明涉及转基因非人哺乳动物的乳。该乳的特征在于它含有作为转基因非人哺乳动物基因组中含有的异源基因的次要基因产物产生的异源成分。异源基因编码异源催化实体，例如选自由糖基转移酶，磷酸酶，羟化酶，肽酶和磺基转移酶组成的组的人类酶。在本发明的实践中特别有用的是人糖基转移酶。所需的异源成分包括寡糖，糖缀合物。寡糖和糖缀合物可以从转基因哺乳动物的乳中分离并用于制备药物，诊断试剂盒，营养产品等。整个转基因乳也可用于配制提供特殊优点的营养产品。转基因奶也可用于生产专门的肠内营养产品。

9. 发明申请

WO2002081668A3 DESATURASE GENES AND USES THEREOF 审中-公开
公开(公告)号：WO2002081668A3
公开(公告)日：2002-10-17
申请号：PCT/US2002/001924
申请日：2002-01-24
申请人： ABBOTT LABORATORIES
发明人： MUKERJI, Pradip , HUANG, Yung-Sheng , DAS, Tapas , THURMOND, Jennifer , PEREIRA, Suzette, L.
IPC分类号： C12N9/02
摘要： The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., "Δ5-desaturase") and at carbon 6 (i.e., "Δ6-desaturase") and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-g-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20: 4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to g-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

10. 发明申请

WO1996027017A1 A METHOD FOR EXPRESSING MODIFIED RECOMBINANT PROTEINS IN A BACTERIAL SYSTEM 审中-公开
标题翻译：一种在细菌体系中表达改性重组蛋白的方法
公开(公告)号：WO1996027017A1
公开(公告)日：1996-09-06
申请号：PCT/US1996002623
申请日：1996-02-27
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MUKERJI, Pradip , THURMOND, M., Jennifer , HANSSON, L., Stig
IPC分类号： C12N15/64
CPC分类号： C12N9/12 , A61K38/00 , C07K14/4732 , C07K2319/02 , C12N15/62 , C12N15/64 , C12N15/70
摘要： The present invention provides a method of producing a modified recombinant protein in a host cell using a single vector containing in tandem both the nucleotide sequence encoding an exogenous protein and an enzyme specific for modification of that protein. The invention also specifically provides a method of producing a recombinant phosphorylated human protein in a bacterial system using a single vector containing in tandem the nucleotide sequence encoding the human protein and a human kinase specific for phosphorylation of that protein.
摘要翻译：本发明提供了使用包含编码外源蛋白的核苷酸序列和对该蛋白质进行修饰的特异性酶的单一载体在宿主细胞中产生修饰的重组蛋白质的方法。本发明还具体提供了在细菌系统中使用单一载体同时编码编码人蛋白质的核苷酸序列和对该蛋白质的磷酸化特异的人类激酶的生物质重组磷酸化人类蛋白质的方法。

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