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1. 发明申请

WO2005019191A2 ANTI-INFECTIVE AGENTS 审中-公开
标题翻译：抗感染药物
公开(公告)号：WO2005019191A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/027000
申请日：2004-08-19
申请人： ABBOTT LABORATORIES , HUTCHINSON, Douglas, K. , BELLETTINI, John, R. , BETEBENNER, David, A. , BISHOP, Richard, D. , BORCHARDT, Thomas, B. , BOSSE, Todd, D. , CINK, Russell, D. , FLENTGE, Charles, A. , GATES, Bradley, D. , GREEN, Brian, E. , HINMAN, Mira, M. , HUANG, Peggy, P. , KLEIN, Larry, L. , KRUEGER, Allan, C. , LARSON, Daniel, P. , LEANNA, M., Robert , LIU, Dachun , MADIGAN, Darold, L. , MCDANIEL, Keith, F. , RANDOLPH, John, T. , ROCKWAY, Todd, W. , ROSENBERG, Teresa, A. , STEWART, Kent, D. , STOLL, Vincent, S. , WAGNER, Rolf , YEUNG, Ming, C.
发明人： HUTCHINSON, Douglas, K. , BELLETTINI, John, R. , BETEBENNER, David, A. , BISHOP, Richard, D. , BORCHARDT, Thomas, B. , BOSSE, Todd, D. , CINK, Russell, D. , FLENTGE, Charles, A. , GATES, Bradley, D. , GREEN, Brian, E. , HINMAN, Mira, M. , HUANG, Peggy, P. , KLEIN, Larry, L. , KRUEGER, Allan, C. , LARSON, Daniel, P. , LEANNA, M., Robert , LIU, Dachun , MADIGAN, Darold, L. , MCDANIEL, Keith, F. , RANDOLPH, John, T. , ROCKWAY, Todd, W. , ROSENBERG, Teresa, A. , STEWART, Kent, D. , STOLL, Vincent, S. , WAGNER, Rolf , YEUNG, Ming, C.
IPC分类号： C07D285/00
CPC分类号： C07D417/12 , C07D285/24 , C07D285/30 , C07D513/04
摘要： Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
摘要翻译：具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。还公开了用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，用于制备化合物的方法和在该方法中使用的合成中间体。

2. 发明申请

WO2005061450A2 HIV PROTEASE INHIBITING COMPOUNDS 审中-公开
标题翻译： HIV蛋白酶抑制化合物
公开(公告)号：WO2005061450A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/037745
申请日：2004-11-10
申请人： ABBOTT LABORATORIES , FLENTGE, Charles, A. , CHEN, Hui-Ju , DEGOEY, David, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , HUANG, Peggy, P. , KEMPF, Dale, J. , KLEIN, Larry, L. , KRUEGER, Allan, C. , MADIGAN, Darold, L. , RANDOLPH, John, T. , SUN, Minghua , YEUNG, Ming, C. , ZHAO, Chen
发明人： FLENTGE, Charles, A. , CHEN, Hui-Ju , DEGOEY, David, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , HUANG, Peggy, P. , KEMPF, Dale, J. , KLEIN, Larry, L. , KRUEGER, Allan, C. , MADIGAN, Darold, L. , RANDOLPH, John, T. , SUN, Minghua , YEUNG, Ming, C. , ZHAO, Chen
IPC分类号： C07D
CPC分类号： C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
摘要： A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：式（I）的化合物被公开为HIV蛋白酶抑制剂。还公开了抑制HIV感染的方法和组合物。

3. 发明申请

WO2008027932A2 CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF 审中-公开
标题翻译： CYTOCHROME P450氧化酶抑制剂及其用途
公开(公告)号：WO2008027932A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/077046
申请日：2007-08-29
申请人： ABBOTT LABORATORIES , KLEIN, Larry, L. , CHEN, Hui-Ju , YEUNG, Ming, C. , FLENTGE, Charles, A. , RANDOLPH, John, T. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J.
发明人： KLEIN, Larry, L. , CHEN, Hui-Ju , YEUNG, Ming, C. , FLENTGE, Charles, A. , RANDOLPH, John, T. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J.
IPC分类号： C07D277/24 , C07D417/12 , A61K31/427 , A61K31/426 , A61P43/00
CPC分类号： A61K31/5377 , A61K31/4164 , A61K31/4178 , A61K31/4439 , A61K31/4525 , A61K31/496 , A61K31/506 , A61K45/06 , C07D213/79 , C07D277/24 , C07D277/30 , C07D277/593 , C07D417/12
摘要： The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.
摘要翻译：本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。

4. 发明申请

WO2005061487A1 HIV PROTEASE INHIBITING COMPOUNDS 审中-公开
公开(公告)号：WO2005061487A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/037711
申请日：2004-11-10
申请人： ABBOTT LABORATORIES , RANDOLPH, John, T. , CHEN, Hui-Ju , DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C.
发明人： RANDOLPH, John, T. , CHEN, Hui-Ju , DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , HUANG, Peggy, P. , HUTCHINSON, Douglas, K. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C.
IPC分类号： C07D401/14
CPC分类号： C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
摘要： A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

5. 发明申请

WO2005058841A2 HIV PROTEASE INHIBITING COMPOUNDS 审中-公开
标题翻译：艾滋病病毒蛋白抑制化合物
公开(公告)号：WO2005058841A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/041658
申请日：2004-12-09
申请人： ABBOTT LABORATORIES , DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C. , RANDOLPH, John, T. , WANG, Xiu, C. , YU, Su
发明人： DEGOEY, David, A. , FLENTGE, Charles, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , KEMPF, Dale, J. , KLEIN, Larry, L. , YEUNG, Ming, C. , RANDOLPH, John, T. , WANG, Xiu, C. , YU, Su
IPC分类号： C07D233/00
CPC分类号： C07D401/06 , C07D213/30 , C07D213/40 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
摘要： A compound of the formula (I) is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式（I）化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

6. 发明申请

WO2006014282A3 PRODRUGS OF HIV PROTEASE INHIBITORS 审中-公开
公开(公告)号：WO2006014282A3
公开(公告)日：2006-02-09
申请号：PCT/US2005/023047
申请日：2005-06-29
申请人： ABBOTT LABORATORIES , DEGOEY, David, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , KLEIN, Larry, L. , KEMPF, Dale, J. , WANG, Xiu, C.
发明人： DEGOEY, David, A. , FLOSI, William, J. , GRAMPOVNIK, David, J. , KLEIN, Larry, L. , KEMPF, Dale, J. , WANG, Xiu, C.
IPC分类号： C07F9/09 , A61K31/661 , A61P35/00
摘要： A compound of the formula , or is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions or inhibiting HIV protease activity and treating HIV infection are also disclosed.

7. 发明申请

WO1998006745A1 AMINO-LIPOPEPTIDE ANTIFUNGAL AGENTS 审中-公开
标题翻译：氨基磷脂抗真菌药物
公开(公告)号：WO1998006745A1
公开(公告)日：1998-02-19
申请号：PCT/US1997014053
申请日：1997-08-11
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , LARTEY, Paul, A. , LI, Leping , KLEIN, Larry, L. , LEONE, Christine, L. , THOMAS, Sheela, A. , YEUNG, Ming, C. , DEGOEY, David, A. , GRAMPOVNIK, David, J.
IPC分类号： C07K07/56
CPC分类号： C07K7/56 , A61K38/00
摘要： Disclosed are novel antifungal agents having formula (I) or a pharmaceutically acceptable acid, ester or prodrug thereof, wherein preferred compounds include those compounds wherein R1 is selected from the group consisting of -NH2; R2 is selected from the group consisting of hydrogen, fluoro, and hydroxyl; R3 is selected from the group consisting of -CH2(p-C6H4)3O(CH2)3CH3, -CH2(p-C6H4)O(CH2)6CH3, -COO(p-C6H4)O(CH2)6CH3, -CO(Piperazinyl)(p-C6H4)2OCH3, -CO(p-C6H4)O(CH2)6CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)O(CH2)4CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)O(CH2)6CH3, -CO(p-C6H4)(Piperazinyl)(p-C6H4)OCH3, and -CO(p-C6H4)(Piperazinyl)O(CH2)6CH3; et R4 is selected from the group consisting of -CH(OH)CH3, -CH2OH, -CH2CH3, -CH2CH2CH2NH2, -CH2(CH2)NH2, -CH2NH2, -CH2(CH2)2(NH)C=(NH)-NH2, -CH3, -CH2(Ph)OH, hydrogen, -CH2CH2COOH, and -CH2COOH. Also disclosed are pharmaceutical compositions containing such compounds and the use of the same in the treatment of fungal infections.
摘要翻译：公开了具有式（I）的新型抗真菌剂或其药学上可接受的酸，酯或前药，其中优选的化合物包括其中R 1选自-NH 2; R2选自氢，氟和羟基; R 3选自-CH 2（对-C 6 H 4）3 O（CH 2）3 CH 3，-CH 2（对-C 6 H 4）O（CH 2）6 CH 3，-COO（对-C 6 H 4）O（CH 2）6 CH 3，-CO（哌嗪基）（对-C 6 H 4）2 OCH 3，-CO（p-C 6 H 4）O（CH 2）6 CH 3，-CO（p-C 6 H 4）（哌嗪基）（对-C 6 H 4）O（CH 2）4 CH 3，-CO（p-C 6 H 4）（哌嗪基）（p-C6H4）O（CH2）6CH3，-CO（对-C6H4）（哌嗪基）（对-C 6 H 4）OCH 3和-CO（对-C 6 H 4）（哌嗪基）O（CH 2）其中R 4选自-CH（OH）CH 3，-CH 2 OH，-CH 2 CH 3，-CH 2 CH 2 CH 2 NH 2，-CH 2（CH 2）NH 2，-CH 2 NH 2，-CH 2（CH 2）2（NH）C =（NH） NH 2，-CH 3，-CH 2（Ph）OH，氢，-CH 2 CH 2 COOH和-CH 2 COOH。还公开了含有这些化合物的药物组合物及其在治疗真菌感染中的用途。

8. 发明申请

WO1996021670A2 ANTIFUNGAL FUSACANDINS 审中-公开
标题翻译：抗真菌FUSACANDINS
公开(公告)号：WO1996021670A2
公开(公告)日：1996-07-18
申请号：PCT/US1996000225
申请日：1996-01-03
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ALDER, Lisa, A. , BURRES, Neal, S. , HOCHLOWSKI, Jill, E. , JACKSON, Marianna , McALPINE, James, B. , KLEIN, Larry, L. , LARTEY, Paul, A. , YEUNG, Clinton
IPC分类号： C07H15/10
CPC分类号： C07H15/10 , A01N43/16
摘要： Novel antifungal agents having formula (I), wherein R is hydrogen or -C(O)-R1 wherein R1 is alkenyl, C2-C12-alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
摘要翻译：具有式（I）的新型抗真菌剂，其中R是氢或-C（O）-R1，其中R 1是烯基，C 2 -C 12 - 烷基，芳基，芳基烯基，芳基烷基，芳基 - 芳基 - ，芳基烷氧基 - 芳基 - ，芳氧基 - 芳基 - ，芳基 - 芳基 - 芳基 - 或芳基烷氧基 - 芳基 - 芳基 - 或其药学上可接受的盐，酯或前药，以及（i）包含这些化合物的药物组合物，（ii）使用这些化合物的治疗方法，（iv）有用的方法和真菌培养物。

9. 发明申请

WO1993021173A1 TAXOL DERIVATIVES 审中-公开
标题翻译： TAXOL衍生物
公开(公告)号：WO1993021173A1
公开(公告)日：1993-10-28
申请号：PCT/US1993003532
申请日：1993-04-14
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , GUNAWARDANA, Geewananda, P. , KLEIN, Larry, L. , McALPINE, James, B.
IPC分类号： C07D305/14
CPC分类号： C07D493/06 , C07D305/14
摘要： Compounds having formula (I) wherein -OR comprises the C-13 side-chain of taxol and R comprises hydrogen, as well as a method for the preparation thereof.
摘要翻译：具有式（I）的化合物，其中-OR 1包含紫杉醇的C-13侧链和R 3包含氢，以及其制备方法。

10. 发明申请

WO1993013780A1 4''-DEOXYERYTHROMYCIN DERIVATIVES 审中-公开
标题翻译： 4“ - 脱氧葡萄糖衍生物
公开(公告)号：WO1993013780A1
公开(公告)日：1993-07-22
申请号：PCT/US1993000468
申请日：1993-01-19
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , LARTEY, Paul, A. , NELLANS, Hugh, N. , KLEIN, Larry, L. , FAGHIH, Ramin
IPC分类号： A61K31/70
CPC分类号： C07H17/08
摘要： 4''-Deoxy derivatives of erythromycin having formula (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.
摘要翻译： 4' - 具有式（I）的红霉素的脱氧衍生物及其药学上可接受的盐，其是胃动力的增强剂但具有最小的抗菌活性，以及含有其的药物组合物及其使用和制备方法。

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