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1. 发明申请

WO2009052392A1 IMMUNOASSAYS AND KITS FOR THE DETECTION OF NGAL 审中-公开
标题翻译：用于检测NGAL的免疫测定和试剂盒
公开(公告)号：WO2009052392A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080331
申请日：2008-10-17
申请人： ABBOTT LABORATORIES , BIRKENMEYER, Larry G. , DESAI, Suresh M. , GRENIER, Frank C. , HAWKSWORTH, David J. , OLEJNICZAK, Edward T. , RUAN, Qiaoqiao , SIEGEL, Robert W. , TETIN, Sergey Y. , TIEMAN, Bryan C. , TU, Bailin , TYNER, Joan D. , WORKMAN, Ryan F. , ZIEMANN, Robert N.
发明人： BIRKENMEYER, Larry G. , DESAI, Suresh M. , GRENIER, Frank C. , HAWKSWORTH, David J. , OLEJNICZAK, Edward T. , RUAN, Qiaoqiao , SIEGEL, Robert W. , TETIN, Sergey Y. , TIEMAN, Bryan C. , TU, Bailin , TYNER, Joan D. , WORKMAN, Ryan F. , ZIEMANN, Robert N.
IPC分类号： C07K14/47 , C07K16/18
CPC分类号： C07K14/47 , C07K2317/56 , C07K2317/92 , Y10T436/105831
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
摘要翻译：本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。

2. 发明申请

WO2021026403A1 METHODS FOR DETECTING ASSAY INTERFERENTS AND INCREASING DYNAMIC RANGE 审中-公开
公开(公告)号：WO2021026403A1
公开(公告)日：2021-02-11
申请号：PCT/US2020/045297
申请日：2020-08-06
申请人： ABBOTT LABORATORIES
发明人： POPE, Mark R. , HERSHBERGER, Stefan J. , RUAN, Qiaoqiao , SWIFT, Kerry M. , TETIN, Sergey Y. , MACDONALD, Patrick , HAACK, Richard A.
IPC分类号： G01N33/58
摘要： The disclosure provides kits and methods for detecting a substance that interferes with detection of an analyte in a sample and for expanding the dynamic range and reducing the hook effect of an immunoassay. The kits and methods employ two conjugates with two different detectable labels, at least one of which is a chemiluminescent compound of Formula (I).

3. 发明申请

WO2014143323A1 ASSAY WITH INTERNAL CALIBRATION 审中-公开
标题翻译：测量与内部校准
公开(公告)号：WO2014143323A1
公开(公告)日：2014-09-18
申请号：PCT/US2013/077073
申请日：2013-12-20
申请人： ABBOTT LABORATORIES
发明人： GAYDA, Susan , RUAN, Qiaoqiao , SKINNER, Joseph P. , TETIN, Sergey Y.
IPC分类号： G01N33/543
CPC分类号： G01N35/00693 , G01N33/54306
摘要： Provided herein are kits and methods for assays with internal calibration.
摘要翻译：本文提供了用于具有内部校准的测定的试剂盒和方法。

4. 发明申请

WO2012170428A1 SPATIALLY RESOLVED LIGAND-RECEPTOR BINDING ASSAYS 审中-公开
标题翻译：空间分辨的配体 - 受体结合测定
公开(公告)号：WO2012170428A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/040925
申请日：2012-06-05
申请人： ABBOTT LABORATORIES , QIAOQIAO, Ruan , SALDANA, Silvia C. , SKINNER, Joseph P. , TETIN, Sergey Y.
发明人： QIAOQIAO, Ruan , SALDANA, Silvia C. , SKINNER, Joseph P. , TETIN, Sergey Y.
IPC分类号： G01N33/543 , G01N21/64
CPC分类号： G01N21/6456
摘要： A method for analysing the results of a ligand-receptor binding assay wherein a traditional washing step is avoided comprising: combining reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample or at a concentration that is inversely proportional to the amount of analyte present in the sample. Providing a digital image of the sedimented/immobilised support at two different types of illumiation and subtracting the images digitally in order to only identify binding events and not components of the reaction. Quantification of intensity of images so produced being compared to a standard curve in order to provide concentration of analyte.
摘要翻译：一种用于分析配体 - 受体结合测定结果的方法，其中避免传统的洗涤步骤，包括：组合试剂，其中附着于固体支持物的受体，怀疑含有配体的样品和包含标记的缀合物形成复合物其中标记以与样品中存在的配体的量成正比的浓度存在，或以与样品中存在的分析物的量成反比的浓度存在。以两种不同类型的照明提供沉积/固定的支持物的数字图像，并以数字方式减去图像，以便仅识别结合事件而不是反应的组成部分。将如此产生的图像的强度的量化与标准曲线进行比较，以提供分析物的浓度。

5. 发明申请

WO2010127294A3 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：WO2010127294A3
公开(公告)日：2010-11-04
申请号：PCT/US2010/033246
申请日：2010-04-30
申请人： ABBOTT LABORATORIES , GHAYUR, Tariq , BROPHY, Susan E. , DEVARE, Sushil G. , GRENIER, Frank C. , MOORE, Jeffrey A. , RUAN, Qiaoqiao , TETIN, Sergey Y. , STEINHAUS, Jennifer M. , LIU, Junjian , ALI, Salman , SYED, Hina, N.
发明人： GHAYUR, Tariq , BROPHY, Susan E. , DEVARE, Sushil G. , GRENIER, Frank C. , MOORE, Jeffrey A. , RUAN, Qiaoqiao , TETIN, Sergey Y. , STEINHAUS, Jennifer M. , LIU, Junjian , ALI, Salman , SYED, Hina, N.
IPC分类号： A61K39/00 , C12P21/06
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

6. 发明申请

WO2021026402A1 CHEMILUMINESCENT COMPOUNDS FOR MULTIPLEXING 审中-公开
公开(公告)号：WO2021026402A1
公开(公告)日：2021-02-11
申请号：PCT/US2020/045296
申请日：2020-08-06
申请人： ABBOTT LABORATORIES
发明人： HERSHBERGER, Stefan J. , HAACK, Richard A. , RUAN, Qiaoqiao , BEST, Quinn , BAX, Brian M. , SWIFT, Kerry M. , TETIN, Sergey Y.
IPC分类号： C09B11/22 , C09B11/24 , C09B11/28 , C09B15/00 , C09B19/00 , C09B23/04 , C09B23/06 , C09B57/08 , C09B57/10 , C09K11/07 , G01N33/58
摘要： Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

7. 发明申请

WO2020140071A1 DIRECT DETECTION OF SINGLE MOLECULES ON MICROPARTICLES 审中-公开
公开(公告)号：WO2020140071A1
公开(公告)日：2020-07-02
申请号：PCT/US2019/068801
申请日：2019-12-27
申请人： ABBOTT LABORATORIES
发明人： RUAN, Qiaoqiao , MACDONALD, Patrick J. , SWIFT, Kerry M. , TETIN, Sergey Y. , CALFIN, Brenda , LIN, Zhen , HAACK, Richard , POPE, Mark R. , PROSTKO, John , QIU, Xiaoxing , BOGDAN, Felicia
IPC分类号： G01N33/543 , G01N33/566 , G01N33/58
摘要： The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.

8. 发明申请

WO2014149111A1 ASSAY WITH INCREASED DYNAMIC RANGE 审中-公开
标题翻译：测定动态范围增加
公开(公告)号：WO2014149111A1
公开(公告)日：2014-09-25
申请号：PCT/US2013/077063
申请日：2013-12-20
申请人： ABBOTT LABORATORIES
发明人： DOWELL, Barry L. , GAYDA, Susan , RUAN, Qiaoqiao , SKINNER, Joseph P. , TETIN, Sergey Y.
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54393 , G01N33/5306 , G01N33/54306
摘要： Provided herein are assays and kits useful for avoiding "prozone phenomenon" or "hook effect" and which expand the range of accurately measurable analyte concentrations.
摘要翻译：本文提供了可用于避免“前区现象”或“钩效应”的测定和试剂盒，并扩大了可精确测量的分析物浓度的范围。

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