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1. 发明申请

WO2021174545A1 SWITCH, CONTACT PROTECTION ASSEMBLY AND MANUFACTURING METHOD THEREOF 审中-公开
公开(公告)号：WO2021174545A1
公开(公告)日：2021-09-10
申请号：PCT/CN2020/078263
申请日：2020-03-06
申请人： ABB POWER GRIDS SWITZERLAND AG , ZHANG, Jian , LV, Zhangang , ZHANG, Weidong
发明人： ZHANG, Jian , LV, Zhangang , ZHANG, Weidong
IPC分类号： H01H31/02 , H01H31/28 , H01H1/64
摘要： Provided are a switch (200), a contact protection assembly (100) for a switch (200) and a manufacturing method thereof. The contact protection assembly (100) comprises a protection cover assembly (101) rotatably coupled to a moveable blade (201) of the switch (200), the moveable blade (201) being rotatable about a first shaft (203) of the switch (200) to change an engagement status of contact fingers (2011) of the moveable blade (201) with a fixed contact (202); a second shaft (103) arranged at a distance from the first shaft (203); and an actuation rod (102) coupled between the protection cover assembly (101) and the second shaft (103) and configured to be rotatable about the second shaft (103) with a rotation of the moveable blade (201), wherein the second shaft (103) is arranged parallel to the first shaft (203) to enable the actuation rod (102) to push or pull the protection cover assembly (101) to rotate between a covering position and an exposing position, wherein the protection cover assembly (101) covers the contact fingers (2011) at the covering position and exposes the contact fingers (2011) at the exposing position. With the contact protection assembly (100), foreign objects like ice covering the contact fingers (2011) can be easily removed with the rotation of the protection cover assembly (101). This arrangement makes the switch (200) such as an earthing switch meet requirements of relevant standards, which require that the engagement of contact fingers (2011) with the fixed contact (202) cannot be affected in a case where the contact fingers (2011) are covered by a 20mm ice layer. In this way, the stability of the switch (200) is improved.

2. 发明申请

WO2021159334A1 BALANCE SPRING ASSEMBLY FOR DISCONNECTOR 审中-公开
公开(公告)号：WO2021159334A1
公开(公告)日：2021-08-19
申请号：PCT/CN2020/074930
申请日：2020-02-12
申请人： ABB POWER GRIDS SWITZERLAND AG , YAN, Jiaquan , LI, Shengqiang , LV, Zhangang , ZHANG, Weidong
发明人： YAN, Jiaquan , LI, Shengqiang , LV, Zhangang , ZHANG, Weidong
IPC分类号： H01H71/10 , H01H3/30
摘要： A balance spring assembly for a disconnector(200). The balance spring assembly comprises a push rod (101)partially and coaxially arranged in a blade (201)of the disconnector(200) which is rotatable about a first shaft(103) to change an operation status of the disconnector(200), a first end of the push rod(101) fixed to a second shaft(202) so that the push rod (101)is rotatable about the second shaft(202); and a spring(102) arranged in the blade (201)and around the push rod(101), the spring(102) held between a second end of the push rod(101)and an end of the blade (201)adjacent to the first shaft(103), wherein the second shaft(202) is arranged parallel to the first shaft (103)to enable the push rod(101)to axially move in the blade(201) with a rotation of the blade(201) to thereby compress or decompress the spring(102). By arranging the balance spring assembly at least in part in the blade(201) of the disconnector(200), only one set of the spring(102) is needed. Furthermore, extra components such as the protective tube, the auxiliary spring and some connection elements are no longer needed. In this way, the manufacturing and assembling costs are significantly reduced. Furthermore, with this arrangement, the spring(102) can fully work during the whole process when the blade(201) is rotated from the open position to the close position.

3. 发明申请

WO2011005593A3 SCHISTOSOMIASIS VACCINE COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2011005593A3
公开(公告)日：2011-01-13
申请号：PCT/US2010/039707
申请日：2010-06-23
申请人： TEXAS TECH UNIVERSITY SYSTEM , SIDDIQUI, Afzal, A. , AHMAD, Gul , ZHANG, Weidong
发明人： SIDDIQUI, Afzal, A. , AHMAD, Gul , ZHANG, Weidong
IPC分类号： A61K38/20 , A61K38/22 , A61K38/16 , A61K31/711 , C12N15/85 , A61P33/12
摘要： No effective vaccine exists for the devastating parasitic disease of Schistosomiasis. The present invention focuses on Sm-p80, a functionally important antigen of Schistosoma mansoni that plays a pivotal role in the schistosome immune evasion process. When used in a novel vaccine formulation, Sm-p80 demonstrates consistent immunogenicity, protective potential, and antifecundity effects. Two novel DNA constructs were made for immunization purposes. Sm- p80 coding sequence was cloned into VR 1020. Additionally, Sm-p80 coding sequence was cloned into pcDNA3.1 with flanking CpG motifs on each end of the Sm-p80 sequence. When used in different vaccine formulations, both of the constructs demonstrate the superior antifecundity and anti-worm effects of Sm-p80, which has great potential as an important vaccine candidate for the reduction of the morbidity associated with schistosome infection.

4. 发明申请

WO2004076664A2 VECTORS FOR REGULATING GENE EXPRESSION 审中-公开
标题翻译：用于调节基因表达的载体
公开(公告)号：WO2004076664A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005566
申请日：2004-02-23
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , ZHANG, Weidong
发明人： MOHAPATRA, Shyam, S. , ZHANG, Weidong
IPC分类号： C12N15/11
CPC分类号： C12N15/111 , A61K48/005 , A61K48/0058 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2750/14143
摘要： The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression cassette encodes a polypeptide of interest, and wherein the gene suppressing cassette encodes a short interfering RNA (siRNA) molecule that reduces expression of a target gene by RNA interference. The present invention further includes vectors that contain suppressor cassettes in conjunction with cassettes upregulating gene expression regulated by either a constitutive promoter, such as a general CMV promoter, or a tissue specific promoter. The present invention further includes vectors that contain Dengue virus gene suppression cassettes. The present invention further includes pharmaceutical compositions containing such vectors, methods of modulating the expression of genes in a host using such vectors, and method of producing such vectors.
摘要翻译：本发明涉及用于调节基因表达的载体，所述载体具有至少一个表达基因的盒和至少一个基因抑制盒，其中所述基因表达盒编码目的多肽，并且其中所述基因抑制盒编码短干扰RNA（siRNA）通过RNA干扰降低靶基因表达的分子。本发明还包括载体，其含有与上调由组成型启动子如一般CMV启动子或组织特异性启动子调节的基因表达的盒结合的抑制盒。本发明还包括含有登革热病毒基因抑制盒的载体。本发明还包括含有这些载体的药物组合物，使用这种载体调节宿主中基因表达的方法，以及生产这种载体的方法。

5. 发明申请

WO2005056021A1 POLYNUCLEOTIDES FOR REDUCING RESPIRATORY SYNCYTIAL VIRUS GENE EXPRESSION 审中-公开
标题翻译：用于减少呼吸道同源病毒基因表达的多核苷酸
公开(公告)号：WO2005056021A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/040727
申请日：2004-12-06
申请人： UNIVERSITY OF SOUTH FLORIDA , MOHAPATRA, Shyam, S. , ZHANG, Weidong
发明人： MOHAPATRA, Shyam, S. , ZHANG, Weidong
IPC分类号： A61K31/70
CPC分类号： A61K31/713 , A61K31/70 , C07H21/02 , C07H21/04 , C12N15/1131 , C12N2310/111 , C12N2310/14
摘要： This invention pertains to polynucleotides, such as small interfering RNA (siRNA), useful for reducing the expression of respiratory syncytial virus (RSV) genes within a subject; and methods for treating a patient suffering from, or at risk of developing, an RSV infection by administering such polynucleotides to the subject.
摘要翻译：本发明涉及可用于减少受试者内呼吸道合胞病毒（RSV）基因表达的多核苷酸，例如小干扰RNA（siRNA）; 以及通过向受试者施用这种多核苷酸来治疗患有或有发展为RSV感染风险的患者的方法。

6. 发明申请

WO2013173462A1 SYSTEM AND METHODS TO PRESENT EXPERIENCE DATA 审中-公开
标题翻译：系统和方法提供经验数据
公开(公告)号：WO2013173462A1
公开(公告)日：2013-11-21
申请号：PCT/US2013/041153
申请日：2013-05-15
申请人： CHIEN, Hsin-Yi , MACLAURIN, Matthew, Bret , TAHIR, Marie, Jeanette, Floyd , CYPHER, Healey , HANEGBY, Ori , ZHANG, Weidong , ORON, Dan, A. , SKORUPSKI, James, Ross , WOLFE, Jesse
发明人： CHIEN, Hsin-Yi , MACLAURIN, Matthew, Bret , TAHIR, Marie, Jeanette, Floyd , CYPHER, Healey , HANEGBY, Ori , ZHANG, Weidong , ORON, Dan, A. , SKORUPSKI, James, Ross , WOLFE, Jesse
IPC分类号： G06Q30/06
CPC分类号： G06Q30/0639 , G06Q30/0207
摘要： A method and a system to present a personal shopping experience are provided. A plurality of items assigned to a category inputted by a user is identified. The plurality of items is available for sale at a plurality of corresponding locations within a pre-defined geographical area. A selection of at least one item of the plurality of items, the category, or a region within the pre-defined geographical area is received from a user. A path from a first location corresponding to a first item of the plurality of items to a second location corresponding to a second item of the plurality of items is determined. The path is within the pre-defined geographical area where the system is located. Discount information for the first item and discount information for the second item are identified. A path from the first location to the second location is displayed to the user. Discount information for the first item and the second item are provided to the user.
摘要翻译：提供了呈现个人购物体验的方法和系统。识别分配给由用户输入的类别的多个项目。多个项目可在预定义的地理区域内的多个对应位置处出售。从用户接收到对多个项目，类别或预定义地理区域内的区域中的至少一个项目的选择。确定从对应于多个项目中的第一项目的第一位置到对应于多个项目中的第二项目的第二位置的路径。该路径位于系统所在的预定义的地理区域内。识别第一个项目的折扣信息和第二个项目的折扣信息。从第一位置到第二位置的路径被显示给用户。向用户提供第一个项目和第二个项目的折扣信息。

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