会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 9. 发明申请
    • DRUG FOR THE PREVENTION AND TREATMENT OF AUTO-IMMUNE AND VIRAL DISEASES, AND DIAGNOSTIC AGENTS FOR DETECTING SAID DISEASES
    • 用于预防和治疗药品和诊断检测自身免疫性疾病和病毒性疾病
    • WO1996009395A2
    • 1996-03-28
    • PCT/EP1995003726
    • 1995-09-21
    • MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.MEYER, Thomas, Franz, FerdinandPOHLNER, JohannesBECK, Susanne, ChristineJOSE, JoachimWÖLK, UweLORENZEN, Dirk, R.OETZELBERGER, Karin, Brigitte
    • MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    • C12N15/57
    • C12N9/52A61K35/74A61K39/00A61K39/095A61K2039/58C07K14/22C07K14/47C07K16/12G01N33/564G01N33/56983G01N33/6893G01N2800/102
    • The present invention concerne drugs and diagnostic agents as well as diagnostic, therapeutic and preventive methods for treating auto-immune and viral diseases in humans, these diseases being caused by pathogenic bacteria which are, in particular, micro-organisms colonizing human mucus membranes and secreting given exoproteins which display structural similarities to human proteins. Proteins similar to IgA protease which are absorbed particularly well by cells and present as antigens on MHC molecules are of particular significance in this respect. The IgA protease polyprotein (IPP) of pathogenic Neisseriae has a particularly marked homology to human proteins. For example, a given IPP peptide has marked homology to the articular proteins link and aggrekan. It is thus proven, for example, that the IPP is an etiological agent of rheumatoid arthritis (RA). The auto-immune reaction is further encouraged by other properties of the IPP-producing Neisseriae and IPPs. A particularly important property is the ability of the IPP to activate viruses and viral elements. This concerns in particular the activation of proviral retroviruses and endogenic retroviruses in humans. Further auto-immune reactions are induced in humans owing to the activation of viruses and viral elements. The development of acquired immune deficiency syndrome (AIDS) is also explained by the IPP-dependent activation of the HIV provirus. The properties according to the invention of the pathogenic Neisseriae and the IPPs formed thereby give rise to numerous novel diagnostic, therapeutic and preventive processes.
    • 本发明涉及药物和诊断剂,以及对人类的自身免疫疾病和病毒疾病,由病原性细菌的诊断,治疗和预防方法。 这些细菌,在定殖人类和某些外蛋白分泌具有结构亲和力的人类蛋白质的粘膜特定微生物。 特别重要的是附接至由细胞特别好地吸收并且被呈现为在MHC分子的抗原的IgA蛋白酶样蛋白。 特别显着的同源性具有致病奈瑟氏球菌的IgA蛋白酶(IPP)的多聚蛋白的人类蛋白质。 例如,IPP的特定肽具有广泛的同源性的铰链连杆和蛋白质聚集蛋白聚糖。 因此,例如 检测执行,使得该IPP是类风湿性关节炎(RA)的病原。 自身免疫反应也由IPP生产奈瑟和电力企业的其它特征变得容易。 一个特别重要的特征是IPP的激活病毒和病毒元素的能力。 这尤其涉及前病毒逆转录病毒和人类内源性逆转录病毒的激活。 由于病毒和病毒元件的激活的人其它自身免疫反应被诱导。 由HIV前病毒的IPP依赖性激活获得性免疫缺陷综合征的发展(AIDS)是超越解释。 从致病奈瑟氏球菌和由它们形成的独立发电的新性质,许多新的诊断,治疗和预防方法导出。