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1. 发明申请

WO2020128797A1 METHOD FOR TESTING A CHROMATOGRAPHY DEVICE USED FOR ION EXCHANGE 审中-公开
公开(公告)号：WO2020128797A1
公开(公告)日：2020-06-25
申请号：PCT/IB2019/060866
申请日：2019-12-16
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： HESTER, Jonathan F. , OLSON, Eric J. , PORBENI, Francis E. , VAIL, Andrew W. , VOLOSHIN, Alexei M.
IPC分类号： G01N30/88 , G01N30/96
摘要： Described herein is method for testing an ion exchange chromatography device. The method includes monitoring both a binding and a non-binding species and determining their breakthrough point to determine a net breakthrough value. The method can be used to determine the integrity of the chromatography device, ensure that the chromatography device possesses the expected adsorbent capacity, and/or determine viral clearance of the chromatography device.

2. 发明申请

WO2018125798A1 ARTICLE AND METHODS TO DETERMINE EFFICACY OF DISINFECTION PROCESS 审中-公开
公开(公告)号：WO2018125798A1
公开(公告)日：2018-07-05
申请号：PCT/US2017/068176
申请日：2017-12-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BENNAARS-EIDEN, Assumpta A. G. , BONILLA, Tonya D. , CONNELL, Jodi L. , SCHMIDT, John J. , VAIL, Andrew W. , SGOLASTRA, Federica
IPC分类号： A47L13/17 , C11D17/04 , A01N47/44
摘要： An article is provided. The article comprises a nonwoven substrate having a copolymer grafted thereto, and a dried coating adhered to the substrate. The copolymer comprises interpolymerized monomer units of a quaternary ammonium-containing ligand monomer, an amide monomer, and an oxy monomer. The coating comprises a plurality of test microorganisms. Optionally, the coating further comprises a water-soluble or water-dispersible polymeric binding agent. A process challenge device comprising a body having a hollow channel with said article fixed disposed therein is also provided. Methods of using the article or the process challenge device for determining the efficacy of a disinfection process are also provided.

3. 发明申请

WO2018025207A1 BIOLOGICAL INDICATOR FOR DISINFECTION PROCESS CHALLENGE DEVICE 审中-公开
标题翻译：消毒过程挑战装置的生物指示剂
公开(公告)号：WO2018025207A1
公开(公告)日：2018-02-08
申请号：PCT/IB2017/054737
申请日：2017-08-02
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BENNAARS-EIDEN, Assumpta A. G. , BOMMARITO, G. Marco , BONILLA, Tonya D. , CONNELL, Jodi L. , DUDA, Ruthann R. , SGOLASTRA, Federica , VAIL, Andrew W.
IPC分类号： A61L2/28
CPC分类号： A61L2/28 , C12Q1/02 , C12Q1/18 , C12Q1/22 , G01N2333/37 , G01N2333/38 , G01N2333/385
摘要： A method of verifying the efficacy of a disinfection process is provided. The method includes flowing a liquid disinfectant into an indicator device that has a plurality of indicator microorganisms disposed therein, the indicator microorganisms comprising or capable of producing a detectable enzyme activity; contacting the indicator microorganisms with the liquid disinfectant for a predetermined minimum first period of time at a first temperature; after contacting the indicator microorganisms with the liquid disinfectant for the first period of time at the first temperature, contacting the indicator microorganisms for a second period of time with a detection medium comprising a detection reagent; and during or after the second period of time, detecting a quantity of the detectable enzyme activity that was not inactivated by the contact with the disinfectant. The indicator device is also provided.
摘要翻译：提供了验证消毒过程的功效的方法。该方法包括使液体消毒剂流入其中设置有多个指示微生物的指示装置中，指示微生物包含或能够产生可检测的酶活性; 在第一温度下使指示微生物与液体消毒剂接触预定的最小第一时间段; 在第一温度下使指示微生物与液体消毒剂接触第一段时间后，使指示微生物与包含检测试剂的检测介质接触第二段时间; 并且在第二时间段期间或之后，检测通过与消毒剂接触未被灭活的可检测酶活性的量。指示装置也提供。

4. 发明申请

WO2022180572A1 CHARGED DEPTH FILTER FOR THERAPEUTIC BIOTECHNOLOGY MANUFACTURING PROCESS 审中-公开
公开(公告)号：WO2022180572A1
公开(公告)日：2022-09-01
申请号：PCT/IB2022/051648
申请日：2022-02-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： LIN, Kuan-Yin , VAIL, Andrew W. , O'NEAL, Daniel J. , NAKAMURA, Masayuki , HESTER, Jonathan F. , DASHARATHI, Kannan , VOLOSHIN, Alexei M.
IPC分类号： B01D15/08 , B01D15/34 , B01D15/36
摘要： A charged depth filter for removing cells and/or cellular debris from a biopharma feedstock having a first functionalized nonwoven layer having a first calculated pore size and a first dynamic charge capacity; a second functionalized nonwoven layer having a second calculated pore size and a second dynamic charge capacity positioned after the first functionalized nonwoven layer in the direction of the biopharma feedstock flow, and wherein the first calculated pore size is greater than the second calculated pore size, and the first dynamic charge capacity is less than the second dynamic charge capacity.

5. 发明申请

WO2021024075A1 ARTICLES CONTAINING A CROSSLINKED GUANIDINYL-CONTAINING POLYMER AND USES THEREOF 审中-公开
公开(公告)号：WO2021024075A1
公开(公告)日：2021-02-11
申请号：PCT/IB2020/056954
申请日：2020-07-23
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： VAIL, Andrew W. , RASMUSSEN, Jerald K. , SCHMITZ, Robert A.
IPC分类号： A01N47/44 , A01N25/10 , A01N25/34
摘要： An article, and method of use, wherein the article includes: a substrate; a cationic coating bound to the substrate, wherein the cationic coating includes a guanidinyl-containing polymer that is crosslinked on the substrate; wherein the guanidinyl-containing polymer is of the following Formula (I), wherein: R 3 is a H, C 1 -C 12 (hetero)alkyl, C 5 -C 12 (hetero)aryl, or Polymer; each R 4 is independently H, C 1 -C 12 (hetero)alkyl, or C 5 -C 12 (hetero)aryl; each R 5 is H, C 1 -C 12 (hetero)alkyl, C 5 -C 12 (hetero)aryl, or N(R 4 ) 2 ; Polymer is a residue of an aminopolymer chain; m is 1 or 2; and x is an integer of at least 1; and wherein the guanidinyl-containing polymer is crosslinked with an amine-reactive polyepoxy compound having pendant -OH groups.

6. 发明申请

WO2020026061A1 ANTIMICROBIAL FOAM ARTICLES AND METHOD OF MAKING THE SAME 审中-公开
公开(公告)号：WO2020026061A1
公开(公告)日：2020-02-06
申请号：PCT/IB2019/056210
申请日：2019-07-19
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： KOHLER RIEDI, Petra L. , RULE, Joseph D. , KARIM, Naimul , COLAK ATAN, Semra , ZHANG, Wei , VAIL, Andrew W.
IPC分类号： A61F13/00 , A61K9/70
摘要： An article. The article includes a polymer foam having a first major surface and a second major surface; and discrete domains of a therapeutic composition at least partially surrounded by the polymer foam; wherein an exterior surface of each discrete domain substantially conforms to a portion of the first major surface of the polymer foam; wherein the article comprises a first major surface and a second major surface; and wherein a portion of the first major surface of the polymer foam and the exterior surfaces of discrete domains form the first major surface of the article.

7. 发明申请

WO2018048696A1 FUNCTIONALIZED COPOLYMERS AND USE THEREOF 审中-公开
标题翻译：功能化共聚物及其用途
公开(公告)号：WO2018048696A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/049365
申请日：2017-08-30
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： VAIL, Andrew W. , COLAK ATAN, Semra , RASMUSSEN, Jerald K. , GRIESGRABER, George W. , BOTHOF, Catherine A.
IPC分类号： B01D67/00 , B01D69/02 , B01D71/56
CPC分类号： B01D67/0093 , B01D69/02 , B01D71/56 , B01D2323/385 , B01D2325/14
摘要： An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein the first plurality of pendant groups are different than the second plurality of pendant groups; and wherein a mole ratio of the first plurality of pendant groups to the second plurality of pendant groups is in a range of 95:5 to 5:95.
摘要翻译：包括官能化共聚物的制品及其用途，特别是在用于结合生物材料的方法中，例如用于在生物溶液中将聚集的蛋白质与单体蛋白质分离的方法中; 其中所述制品包括：a）多孔基材; 和b）共价连接到所述多孔基材的共聚物，所述共聚物包含烃骨架和连接到所述烃骨架上的多个侧基，其中1）第一多个侧基中的每一个包含：（a）至少一个酸性其组或盐; 和（b）通过至少6个连接原子的链将所述至少一个酸性基团或其盐直接连接到烃主链上的间隔基团; 和2）多个第二侧基中的每一个包含：（a）至少一种酸性基团或其盐; 和（b）通过至少6个连接原子的链将所述至少一个酸性基团或其盐直接连接到烃主链上的间隔基团; 并且其中所述第一多个侧面组不同于所述第二多个侧面组; 并且其中第一多个侧基与第二多个侧基的摩尔比在95:5至5:95的范围内。

8. 发明申请

WO2023037178A1 METHOD OF HARVESTING BIOLOGICS 审中-公开
公开(公告)号：WO2023037178A1
公开(公告)日：2023-03-16
申请号：PCT/IB2022/057281
申请日：2022-08-04
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： KOEHLER, Kenneth C. , VOLOSHIN, Alexei M. , SUNG, Ki Joo , BHOKISHAM, Narendranath , VAIL, Andrew W. , RICHARDSON, Kristopher E. , HOCHSTEIN, Rebecca A.
IPC分类号： C12M1/26 , C12M1/00 , C12N1/06
摘要： A method. The method includes providing a filter medium comprising a functionalized nonwoven; passing a first fluid containing cells through the filter medium, wherein at least some of the cells are captured by the functionalized nonwoven; passing a second fluid, and optionally a third and/or fourth fluid through the filter medium, wherein the second and/or third and/or fourth fluid disrupts at least one of the captured cells; and recovering an intracellular biological product in the first and/or second and/or third and/or fourth fluid.

9. 发明申请

WO2022043913A1 METHOD OF REMOVING PATHOGENS FROM A SURFACE 审中-公开
公开(公告)号：WO2022043913A1
公开(公告)日：2022-03-03
申请号：PCT/IB2021/057833
申请日：2021-08-26
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： VAIL, Andrew W. , SCHMITZ, Robert A.
IPC分类号： A61L2/00 , A61L2/18
摘要： A method of removing pathogens from a surface is described. In particular, a method including providing a wipe including guanidinyl-containing polymer coating, providing a liquid disinfectant having an associated disinfection time t for at least one pathogen is described. The method may help provide safe levels of disinfection even with a significant associated error in dwell time.

10. 发明申请

WO2021209851A1 FLOW-THROUGH PROCESSES AND DEVICES FOR PURIFYING A TARGET MOLECULE 审中-公开
公开(公告)号：WO2021209851A1
公开(公告)日：2021-10-21
申请号：PCT/IB2021/052739
申请日：2021-04-01
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： VAIL, Andrew W. , ATAN, Semra C. , RASMUSSEN, Jerald K. , VOLOSHIN, Alexei M. , HESTER, Jonathan F.
IPC分类号： C07K1/18 , C07K1/36
摘要： Flow-through processes for purifying a target molecule (e.g., antibodies, enzymes, and hormones, particularly a monoclonal antibody) from a biological solution (e.g., a neutralized viral inactivation pool) in a sample that includes the target molecule, and devices for carrying out such processes.

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