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1. 发明申请

WO2007148774A1 環状アミン化合物审中-公开
标题翻译：循环胺化合物
公开(公告)号：WO2007148774A1
公开(公告)日：2007-12-27
申请号：PCT/JP2007/062562
申请日：2007-06-22
申请人：第一三共株式会社 , 宮崎正二郎 , 中村勇二 , 永山貴弘 , 徳井太郎 , 小川泰之
发明人：宮崎正二郎 , 中村勇二 , 永山貴弘 , 徳井太郎 , 小川泰之
IPC分类号： C07D241/06 , A61K31/495 , A61K31/496 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , C07D241/08 , C07D401/04 , C07D403/04 , C07D409/04
CPC分类号： C07D401/04 , C07D211/18 , C07D211/22 , C07D211/70 , C07D241/04 , C07D241/08
摘要： Disclosed is an excellent drug for treatment of hypertension. Specifically disclosed is a pharmaceutical agent containing a compound represented by the general formula (I) below or the like. [In the formula, R 1 represents H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted cyclic hydrocarbon, an optionally substituted heterocyclyl or the like; R 2 represents H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted cycloalkyl or the like; R 3 and R 4 independently represent H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted cycloalkyl or the like; R 5 and R 6 independently represent H, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted alkoxy or the like; R 7 and R 8 independently represent H, an optionally substituted alkyl, an optionally substituted cycloalkyl or the like; X represents a group represented by the above formula (II) or the like; A represents an optionally substituted cyclic hydrocarbon, an optionally substituted heterocyclyl or the like; Y represents a single bond, an optionally substituted alkylene, an optionally substituted alkenylene, -(CH 2 ) a -X 1 -(CH 2 ) b - (wherein X 1 represents -NH-, -O- or the like, and a and b respectively represent a number of 0-5) or the like; and B represents an optionally substituted cyclic hydrocarbon, an optionally substituted heterocyclyl or the like.]
摘要翻译：公开了治疗高血压的优良药物。具体公开了含有下述通式（I）表示的化合物等的药剂。 [式中，R 1表示H，可以具有取代基的烷基，可以具有取代基的烯基，任意取代的环状烃，任意取代的杂环基等; R 2表示H，任选取代的烷基，任选取代的烯基，任选取代的环烷基等; R 3和R 4独立地表示H，任选取代的烷基，任选取代的烯基，任选取代的环烷基等; R 5和R 6独立地表示H，任选取代的烷基，任选取代的环烷基，任选取代的烷氧基等; R 7和R 8独立地表示H，任选取代的烷基，任选取代的环烷基等; X表示由上述式（II）表示的基团等; A表示任选取代的环状烃，任选取代的杂环基等; Y表示单键，任选取代的亚烷基，任选取代的亚烯基， - （CH 2）n - （CH 2）（其中X 1表示-NH-，-O-等，a和b分别表示0的整数） -5）等; 和B代表任选取代的环烃，任选取代的杂环基等。]

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