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    • 1. 发明申请
    • テトラヒドロピラン化合物の製造方法
    • 生产四氢呋喃化合物的方法
    • WO2007086559A1
    • 2007-08-02
    • PCT/JP2007/051387
    • 2007-01-29
    • 宇部興産株式会社西野 繁栄弘津 健二島 秀好敷田 庄司岩本 圭司原田 崇司
    • 西野 繁栄弘津 健二島 秀好敷田 庄司岩本 圭司原田 崇司
    • C07D309/08C07D309/04C07D309/30
    • C07D309/08
    • Disclosed is a method for producing a 4-cyanotetrahydropyran-4-carboxylic acid ester represented by the general formula (4a) or (4b) below, which is characterized in that a bis(2-halogenoethyl) ether represented by the general formula (1) below, a cyanoacetic acid ester represented by the general formula (2) below and an alkali metal alkoxide represented by the general formula (3) below are reacted in an organic solvent. (1) (In the formula, X represents a halogen atom.) (2) (In the formula, R 1 represents an alkyl group having 2-6 carbon atoms.) (3) (In the formula, R 2 may be the same as or different from R 1 and represents an alkyl group having 1-6 carbon atoms, and M represents an alkali metal atom.) (4a) (4b) (In the formulae, R 1 and R 2 are as defined above.) Also disclosed is a method for producing 4-cyanotetrahydropyran represented by the formula (5), which is characterized in that at least one 4-cyanotetrahydropyran-4-carboxylic acid ester is reacted in a solvent. Further disclosed is a method for producing tetrahydropyran-4-carboxylic acid amide represented by the general formula (6), which is characterized in that the 4-cyanotetrahydropyran and a base are reacted in a solvent.
    • 公开了由下述通式(4a)或(4b)表示的4-氰基四氢吡喃-4-羧酸酯的制备方法,其特征在于由通式(1)表示的双(2-卤代乙基)醚 ),下述通式(2)表示的氰基乙酸酯和下述通式(3)表示的碱金属醇盐在有机溶剂中反应。 (1)(式中,X表示卤素原子)(2)(式中,R 1表示具有2-6个碳原子的烷基)(3)(在 式R 2可以与R 1相同或不同,并且表示具有1-6个碳原子的烷基,M表示碱金属原子。)( 4a)(4b)(式中,R 1和R 2如上所定义。)还公开了一种由式(4)表示的4-氰基四氢吡喃的制备方法, 5),其特征在于至少一种4-氰基四氢吡喃-4-羧酸酯在溶剂中反应。 进一步公开的是通式(6)表示的四氢吡喃-4-羧酸酰胺的制造方法,其特征在于4-氰基四氢吡喃和碱在溶剂中反应。