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1. 发明申请

WO2005039648A3 USE OF METAL TRICARBONYL COMPLEXES AS RADIOTHERAPEUTIC CHEMOTOXIC AGENTS 审中-公开
公开(公告)号：WO2005039648A3
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011953
申请日：2004-10-20
申请人： UNIVERSITÄT ZÜRICH , ALBERTO, Roger , ZOBI, Fabio
发明人： ALBERTO, Roger , ZOBI, Fabio
IPC分类号： A61K51/04
摘要： The invention relates to the use of metal tricarbonyl compounds of the general formula [M(CO),L,]', wherein M is rhenium or technetium or an isotope thereof and L is a ligand, for the preparation of a medicament for the treatment of cancer that is both radiotherapeutic and chemotoxic when a radioactive metal is used and chemotoxic when cold rhenium or macroscopic amounts of long-lived Tc-99 is used. The medicament is in particular chemotoxic by causing intrastrand linkages in DNA. In a specific embodiment at least one of L is not OH2. The invention further relates to novel compounds of the general formula IM(CO)3XIX2X3]+and their use, wherein M is rhenium or technetium or an isotope thereof and at least one of X1. X2 and X3 is a monodentate ligand; or two of X, X2 and X3 are part of a bidentate ligand and the other one is optionally a monodentate ligand.

2. 发明申请

WO2005039648A2 USE OF METAL TRICARBONYL COMPLEXES AS RADIOTHERAPEUTIC CHEMOTOXIC AGENTS 审中-公开
标题翻译：金属三羰基复合物作为放射治疗药物代谢物的使用
公开(公告)号：WO2005039648A2
公开(公告)日：2005-05-06
申请号：PCT/EP2004011953
申请日：2004-10-20
申请人： UNIV ZUERICH , ALBERTO ROGER , ZOBI FABIO
发明人： ALBERTO ROGER , ZOBI FABIO
IPC分类号： A61K33/24 , A61K51/04 , A61K51/08 , A61P35/00
CPC分类号： A61K51/0476 , A61K33/24 , A61K51/0478
摘要： The invention relates to the use of metal tricarbonyl compounds of the general formula [M(CO),L,]', wherein M is rhenium or technetium or an isotope thereof and L is a ligand, for the preparation of a medicament for the treatment of cancer that is both radiotherapeutic and chemotoxic when a radioactive metal is used and chemotoxic when cold rhenium or macroscopic amounts of long-lived Tc-99 is used. The medicament is in particular chemotoxic by causing intrastrand linkages in DNA. In a specific embodiment at least one of L is not OH2. The invention further relates to novel compounds of the general formula IM(CO)3XIX2X3]+and their use, wherein M is rhenium or technetium or an isotope thereof and at least one of X1. X2 and X3 is a monodentate ligand; or two of X, X2 and X3 are part of a bidentate ligand and the other one is optionally a monodentate ligand.
摘要翻译：本发明涉及通式[M（CO），L，]'的金属三羰基化合物的用途，其中M是铼或锝或其同位素，L是配体，用于制备治疗药物当放射性金属被使用时既放射治疗又具有化学毒性，并且当使用冷铼或宏观量的长寿命Tc-99时具有化学毒性。该药物特别是通过在DNA中引起链内连锁的化学毒性。在具体实施方案中，L中的至少一个不是OH 2。本发明还涉及通式为IM（CO）3 XIX 2 X 3] +的新化合物及其用途，其中M为铼或锝或其同位素和X1中的至少一种。 X2和X3是单齿配体; X，X 2和X 3中的两个是二齿配体的一部分，另一个是任选的单齿配体。

3. 发明申请

WO2011110315A1 CARBON MONOXIDE RELEASING RHENIUM COMPOUNDS FOR MEDICAL USE 审中-公开
标题翻译：一氧化碳释放铑化合物用于医疗用途
公开(公告)号：WO2011110315A1
公开(公告)日：2011-09-15
申请号：PCT/EP2011/001077
申请日：2011-03-04
申请人： UNIVERSITY OF ZURICH , ZOBI, Fabio , ALBERTO, Roger , KROMER, Lukas
发明人： ZOBI, Fabio , ALBERTO, Roger , KROMER, Lukas
IPC分类号： C07F13/00 , A61K31/28
CPC分类号： A61K33/24 , A61K31/555 , C07F13/00 , C07F13/005
摘要： The present invention relates to new rhenium compounds of formula (I) with medical utility, corresponding pharmaceutical compositions as well as medical uses thereof.
摘要翻译：本发明涉及具有医疗效用的新的式（I）铼化合物，相应的药物组合物及其医疗用途。

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