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1. 发明申请

WO2007078335A3 BIARYL NITROGEN HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION 审中-公开
标题翻译： LTA4H用于治疗炎症的BIARYL NITROGEN HETEROCYCLE INHIBITORS
公开(公告)号：WO2007078335A3
公开(公告)日：2007-11-29
申请号：PCT/US2006030525
申请日：2006-08-03
申请人： DECODE GENETICS INC , SANDANAYAKA VINCENT , SINGH JASBIR , ZHOU LI-MING , GURNEY MARK
发明人： SANDANAYAKA VINCENT , SINGH JASBIR , ZHOU LI-MING , GURNEY MARK
IPC分类号： C07D295/15 , A61K31/445 , A61K31/495 , A61P9/10 , A61P11/06 , A61P17/06 , A61P29/00 , C07D211/58 , C07D295/033 , C07D295/096 , C07D333/16 , C07D333/28
CPC分类号： C07D295/033 , C07D211/58 , C07D295/096 , C07D295/15 , C07D333/16 , C07D333/28
摘要： The present invention relates to a chemical genus of biaryl nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.
摘要翻译：本发明涉及作为LTA4H（白三烯A4水解酶）抑制剂的联芳基氮连接杂环化学属。它们可用于治疗和预防和预防炎性疾病和病症。

2. 发明申请

WO1998003189A1 USE OF CONANTOKINS 审中-公开
标题翻译：使用组合
公开(公告)号：WO1998003189A1
公开(公告)日：1998-01-29
申请号：PCT/US1997012652
申请日：1997-07-21
申请人： COGNETIX, INC. , McCABE, R., Tyler , ZHOU, Li-Ming , LAYER, Richard, T.
发明人： COGNETIX, INC.
IPC分类号： A61K38/00
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is directed to the use of conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more gamma -carboxyglutamic acid residues, for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents. Neurologic disorders and psychiatric disorders include epilepsy, convulsions, neurotoxic injury (associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drowning, suffocation, perinatal asphyxia, or hypoglycemic events), neurodegeneration (associated with Alzheimer's disease, senile dementia, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson's disease, Huntington's disease, Down's Syndrome, Korsakoff's disease, schizophrenia, AIDS dementia, multi-infarct dementia, Binswanger dementia and neuronal damage associated with uncontrolled seizures), chemical toxicity (such as addiction, morphine tolerance, opiate tolerance, opioid tolerance and barbiturate tolerance), pain (acute, chronic, migraine), anxiety, major depression, manic-depressive illness, obsessive-compulsive disorder, schizophrenia and mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and dystonia (movement disorder), sleep disorder, muscle relaxation and urinary incontinence. In addition, the conantokins are useful for treating HIV infection, ophthalmic indications and memory, learning or cognitive deficits.
摘要翻译：本发明涉及使用具有10-30个氨基酸（包括优选两个或更多个γ-羧基谷氨酸残基）的用于治疗神经系统和神经系统疾病的柯南多诺肽，柯南多肽衍生物和柯南多肽嵌合体精神障碍，如抗惊厥剂，神经保护剂或止痛剂。神经系统疾病和精神疾病包括癫痫，抽搐，神经毒性损伤（与缺氧，缺氧或局部缺血的症状相关，典型地是中风，脑血管意外，脑或脊髓创伤，心肌梗塞，身体创伤，溺水，窒息，围产期窒息或低血糖事件），神经变性（与阿尔茨海默病，老年性痴呆，肌萎缩性侧索硬化，多发性硬化症，帕金森病，亨廷顿病，唐氏综合征，柯萨科夫病，精神分裂症，AIDS痴呆，多发性梗塞性痴呆，Binswanger痴呆和神经元损伤有关不安全的癫痫发作），化学毒性（如成瘾，吗啡耐受，阿片剂耐受，阿片样物质耐受和巴比妥耐受），疼痛（急性，慢性，偏头痛），焦虑，主要抑郁症，躁狂抑郁症，强迫症，精神分裂症和情绪障碍（如双相情感障碍，单极压抑离子，心境恶劣和季节性有效障碍）和肌张力障碍（运动障碍），睡眠障碍，肌肉松弛和尿失禁。此外，凝血因子可用于治疗艾滋病毒感染，眼科指征和记忆，学习或认知缺陷。

3. 发明申请

WO2017132178A3 SALTS OF 5-AMINOLEVULINIC ACID AND DERIVATIVES 审中-公开
标题翻译： 5-氨基冰片酸和衍生物的盐
公开(公告)号：WO2017132178A3
公开(公告)日：2017-08-03
申请号：PCT/US2017/014791
申请日：2017-01-24
申请人： ZHAO, Ming , ZHOU, Li-Ming
发明人： ZHAO, Ming , ZHOU, Li-Ming
IPC分类号： C07C227/00 , A61K31/197 , C07C229/22
摘要： The present disclosure provides new salts of 5-aminolevulinic acid (5-ALA) and new salts of 5-ALA esters, their preparation, formulation and use as photosensitizing agents in photodynamic therapy, diagnosis and cosmetic cares.
摘要翻译：本公开提供5-氨基乙酰丙酸（5-ALA）的新盐和5-ALA酯的新盐，其制备，制剂和作为光敏剂在光动力治疗，诊断和美容护理中的用途

4. 发明申请

WO2007078335A2 BIARYL NITROGEN HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的LTA4H双氮杂氮杂环化合物抑制剂
公开(公告)号：WO2007078335A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/030525
申请日：2006-08-03
申请人： DECODE GENETICS, INC. , SANDANAYAKA, Vincent , SINGH, Jasbir , ZHOU, Li-Ming , GURNEY, Mark
发明人： SANDANAYAKA, Vincent , SINGH, Jasbir , ZHOU, Li-Ming , GURNEY, Mark
IPC分类号： C07D295/15 , C07D295/033 , C07D295/096 , C07D211/58 , C07D333/16 , C07D333/28 , A61K31/495 , A61K31/445 , A61P29/00 , A61P9/10 , A61P11/06 , A61P17/06
CPC分类号： C07D295/033 , C07D211/58 , C07D295/096 , C07D295/15 , C07D333/16 , C07D333/28
摘要： The present invention relates to a chemical genus of biaryl nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.
摘要翻译：本发明涉及作为LTA4H（白三烯A4水解酶）抑制剂的联芳基氮连接杂环的化学属。它们可用于治疗和预防和预防炎症性疾病和病症。

5. 发明申请

WO1998003541A1 CONANTOKINS 审中-公开
公开(公告)号：WO1998003541A1
公开(公告)日：1998-01-29
申请号：PCT/US1997012618
申请日：1997-07-21
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , COGNETIX, INC. , ABOGADIE, Fe, C. , CRUZ, Lourdes, J. , OLIVERA, Baldomero, M. , WALKER, Craig , COLLEDGE, Clark , HILLYARD, David, R. , JIMENEZ, Elsie , LAYER, Richard, T. , ZHOU, Li-Ming , SHEN, Gregory, S. , McCABE, R., Tyler , RIVIER, Jean, E.
发明人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , COGNETIX, INC.
IPC分类号： C07K05/00
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more gamma -carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.
摘要翻译：本发明涉及具有10-30个氨基酸，包括优选两个或更多个γ-羧基谷氨酸残基的组合蛋白肽，柯南酮肽衍生物和柯南鸟肽嵌合体，统称为聚对二聚体。凝血因子可用于治疗神经和精神疾病，例如抗惊厥剂，神经保护剂或止痛剂。

6. 发明申请

WO2019104247A1 ARTEMISININ-DERIVED TRIMERS AND TETRAMERS AND THEIR USE THEREOF 审中-公开
公开(公告)号：WO2019104247A1
公开(公告)日：2019-05-31
申请号：PCT/US2018/062356
申请日：2018-11-21
申请人： ZHAO, Ming , ZHOU, Li-Ming
发明人： ZHAO, Ming , ZHOU, Li-Ming
IPC分类号： A61K31/357 , A61K31/44 , A61K31/554 , A61K31/635
CPC分类号： C07D519/00 , C07D493/18
摘要： The present disclosure provides compositions comprising artemisinin-derived trimers and tetramers; methods of preparing these compositions; and methods for their use as medicaments.

7. 发明申请

WO2017132178A2 SALTS OF 5-AMINOLEVULINIC ACID AND DERIVATIVES 审中-公开
公开(公告)号：WO2017132178A2
公开(公告)日：2017-08-03
申请号：PCT/US2017/014791
申请日：2017-01-24
申请人： ZHAO, Ming , ZHOU, Li-Ming
发明人： ZHAO, Ming , ZHOU, Li-Ming
IPC分类号： A61K31/44 , A61K31/401
CPC分类号： A61K31/197 , A61K9/0009 , A61K9/0014 , A61K9/006 , A61K9/06 , A61K9/08 , A61K41/0061 , A61K45/06 , A61K47/12 , C07C53/16 , C07C229/22 , A61K2300/00
摘要： The present disclosure provides new salts of 5-aminolevulinic acid (5-ALA) and new salts of 5-ALA esters, their preparation, formulation and use as photosensitizing agents in photodynamic therapy, diagnosis and cosmetic cares.

8. 发明申请

WO2017124045A1 COMPOSITION CONTAINING ARTESUNATE 审中-公开
标题翻译：含有青蒿琥酯的组合物
公开(公告)号：WO2017124045A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013576
申请日：2017-01-13
申请人： ZHAO, Ming , ZHOU, Li-Ming
发明人： ZHAO, Ming , ZHOU, Li-Ming
IPC分类号： A61K31/357 , A61K47/18 , A61K47/22
CPC分类号： A61K31/357 , A61K9/0019 , A61K47/18 , A61K47/22 , Y02A50/411 , Y02A50/423
摘要： The present disclosure provides a composition of artesunate, a process of preparing the same, and a method of treatment.
摘要翻译：本公开提供了青蒿琥酯的组合物，其制备方法和治疗方法。

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