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1. 发明申请

WO2018044795A1 COMPOSITIONS AND METHODS FOR PROGRAMMING ADULT CELLS WITH PLATELET RICH FRACTION OF BLOOD CONTAINING PLATELET-LIKE CELLS 审中-公开
标题翻译：用含血小板样细胞的含血小板富含成分编程成人细胞的组合物和方法
公开(公告)号：WO2018044795A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/048907
申请日：2017-08-28
申请人： ZHAO, Yong
发明人： ZHAO, Yong
IPC分类号： C12N5/074 , C12N5/078 , C12N5/095
摘要： The described invention provides a method of functionally reprogramming adult cells to an immature cell type that expresses one or more embryonic biomarkers. The reprogramming is accomplished by contacting the adult cells with a platelet rich fraction comprising platelet-like cells from umbilical cord blood or peripheral blood, and expanding the immature cell type in vitro under culture conditions to generate an insulin-producing cell population that expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells. Without being limited by theory, platelet-like cells and their released mitochondria display immune tolerance-associated markers that may modulate the function and differentiation of immune cells. The described invention further provides a pharmaceutical composition comprising a cell product containing a therapeutic amount of an insulin-producing cell population derived from functionally reprogrammed adult cells, wherein the insulin-producing cell population expresses human beta-cell specific transcription factors and is functionally equivalent to human pancreatic beta-cells.
摘要翻译：所描述的发明提供了将成体细胞功能性重编程为表达一种或多种胚胎生物标志物的不成熟细胞类型的方法。通过将成体细胞与包含来自脐带血或外周血的血小板样细胞的富含血小板的部分接触，并在培养条件下体外扩增未成熟细胞类型以产生表达人β的产胰岛素细胞群来完成重编程细胞特异性转录因子，在功能上等同于人类胰腺β细胞。不受理论限制，血小板样细胞及其释放的线粒体显示可调节免疫细胞的功能和分化的免疫耐受相关标记。所述发明进一步提供了一种药物组合物，其包含细胞产物，所述细胞产物含有治疗量的源自功能性重编程成体细胞的产生胰岛素的细胞群体，其中产生胰岛素的细胞群体表达人类β-细胞特异性转录因子并且在功能上等同于人类胰腺β细胞。

2. 发明申请

WO2012154832A2 OBJECT TRACKING 审中-公开
标题翻译：对象追踪
公开(公告)号：WO2012154832A2
公开(公告)日：2012-11-15
申请号：PCT/US2012/037094
申请日：2012-05-09
申请人： GOOGLE INC. , GOSSWEILER III, Richard, C. , ZHAO, Yong
发明人： GOSSWEILER III, Richard, C. , ZHAO, Yong
IPC分类号： G06T7/20
CPC分类号： G06K9/00241 , G06K9/00261
摘要： In general, the subject matter described in this specification can be embodied in methods, systems, and program products. A computing system accesses an indication of a first template that includes a region of a first image. The region of the first image includes a graphical representation of a face. The computing system receives a second image. The computing system identifies indications of multiple candidate templates. Each respective candidate template from the multiple candidate templates includes a respective candidate region of the second image. The computing system compares at least the first template to each of the multiple candidate templates, to identify a matching template from among the multiple candidate templates that includes a candidate region that matches the region of the first image that includes the graphical representation of the face.
摘要翻译：通常，本说明书中描述的主题可以体现在方法，系统和程序产品中。计算系统访问包括第一图像的区域的第一模板的指示。第一图像的区域包括面部的图形表示。计算系统接收第二个图像。计算系统识别多个候选模板的指示。来自多个候选模板的每个候选模板包括第二图像的相应候选区域。所述计算系统至少将所述第一模板与所述多个候选模板中的每一个进行比较，以从所述多个候选模板中识别匹配模板，所述匹配模板包括与包括所述面部的图形表示的所述第一图像的区域相匹配的候选区域。

3. 发明申请

WO2007044314A3 ISOLATED EMBRYONIC-LIKE STEM CELLS DERIVED FROM HUMAN UMBILICAL CORD BLOOD 审中-公开
标题翻译：来自人脐带血的分离的胚胎样干细胞
公开(公告)号：WO2007044314A3
公开(公告)日：2007-09-13
申请号：PCT/US2006038524
申请日：2006-10-03
申请人： UNIV ILLINOIS , ZHAO YONG , MAZZONE THEODORE
发明人： ZHAO YONG , MAZZONE THEODORE
IPC分类号： C12N5/074 , C12N5/0783
CPC分类号： C12N5/0607 , A61K2035/122 , C12N5/0636 , C12N2501/23 , C12N2501/59 , C12N2502/03
摘要： The present invention is related generally to embryonic-like stem cells isolated from human umbilical cord blood, designated herein as cord blood-stem cells (CB-SCs), which display the characteristics of embryonic stem cells and hematopoietic cells. These cells have the capability of proliferation and are able to differentiate to multiple types of cells. In addition, the CB-SC display low immunogenicity and immune regulation. These cells are, therefore, suitable for use in stem cell-based therapies for the treatment of diseases such as Parkinson's disease, diabetes, spinal cord damage, multiple sclerosis, cardiovascular disease, stroke and birth defects.
摘要翻译：本发明一般涉及从人脐带血分离的胚胎样干细胞，本文称为脐带血干细胞（CB-SC），其显示胚胎干细胞和造血细胞的特征。这些细胞具有增殖能力并能够分化为多种类型的细胞。此外，CB-SC显示低免疫原性和免疫调节。因此，这些细胞适用于基于干细胞的治疗，用于治疗诸如帕金森病，糖尿病，脊髓损伤，多发性硬化症，心血管疾病，中风和出生缺陷等疾病。

4. 发明申请

WO2005046570A3 HUMAN STEM CELL MATERIALS AND METHODS 审中-公开
标题翻译：人类细胞材料和方法
公开(公告)号：WO2005046570A3
公开(公告)日：2006-12-07
申请号：PCT/US2004016790
申请日：2004-05-26
申请人： UNIV CHICAGO , HUBERMAN ELIEZER , ZHAO YONG
发明人： HUBERMAN ELIEZER , ZHAO YONG
IPC分类号： A61K35/28 , A61K20060101 , A61K35/26 , A61K48/00 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/074 , C12N5/0783 , C12N5/0786 , C12N5/0793 , E02D27/42 , G01N33/53
CPC分类号： C12N5/0635 , A61K35/12 , A61K2035/124 , C12N5/0607 , C12N5/0619 , C12N5/0636 , C12N5/0645 , C12N5/067 , C12N5/069 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/165 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2501/52 , C12N2501/599 , C12N2503/02 , C12N2506/03 , C12N2506/115 , G01N33/5073
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals are provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease including disorders or diseases associated with platelets.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其差异衍生物的方法。这些生物材料的用途包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状（包括与血小板相关的疾病或疾病）的方法。

5. 发明申请

WO2003099947A1 JETTABLE COMPOSITIONS 审中-公开
标题翻译：可口的组合
公开(公告)号：WO2003099947A1
公开(公告)日：2003-12-04
申请号：PCT/GB2003/002273
申请日：2003-05-23
申请人： VANTICO AG , PATEL, Ranjana, Chhaganhbi , ZHAO, Yong , PEACE, Richard, John
发明人： PATEL, Ranjana, Chhaganhbi , ZHAO, Yong , PEACE, Richard, John
IPC分类号： C09D11/10
CPC分类号： C09D11/36 , B33Y40/00 , B33Y70/00 , C09D11/101
摘要： A fully curable jettable composition having a viscosity less than 30cps at a temperature within the range of 15-180 °C, more preferably at a temperature of 15-100 °C, e.g. 60-80 °C the composition comprising: (A) at least one low viscosity reactive resin selected from the group consisting of compounds containing an oxetane ring, cycloaliphatic epoxy resins, tetrahydrofurans, hexahydropyrans and mono-functional (meth)acrylates, said resin having a molecular weight of not greater than 300 Daltons, e.g. 250 Daltons or less, and a viscosity at a temperature in the said range of less than 30 cps, e.g. 5 to 15 cps; (B) at least one higher viscosity resin selected from the group consisting of epoxy resins, compounds containing an oxetane ring and acrylates, which resin acts to thicken the low viscosity resin and strengthen a jetted deposit of the composition, the higher viscosity resin having: a viscosity greater than twice that of the low viscosity resin at the said temperature in the range stated above, and a functionality of greater than or equal to 2; (C) at least one curable toughener, preferably having a functionality of at least 2, such as hydroxy, epoxy, acrylic or other reactive functionalised polymer/oligomer (e.g. derived by functionalising poly(tetrahydrofuran), polycaprolactone, polycarbonate diol, or a dendrimeric polyol; (D) at least one initiator for the polymerisation of the resins, and (E) at least one stabiliser for delaying the curing of the resins of the composition; wherein the low viscosity resin is slower to react than the higher viscosity resin and acts to solvate the higher viscosity resin prior to curing and at least partly during curing and wherein at least 30 % of the components A and B are cationically curable resins. The composition can be jetted from piezo electric printing heads under the control of a computer program to form a multi-layered article, e.g. a three dimensional article, in which the adjacent droplets merge and are cured homogeneously together.
摘要翻译：一种完全可固化的可喷射组合物，其粘度在15-180℃范围内，更优选在15-100℃温度下具有小于30cps的粘度。 60-80℃的组合物包含：（A）至少一种选自含有氧杂环丁烷环的化合物，脂环族环氧树脂，四氢呋喃，六氢吡喃和单官能（甲基）丙烯酸酯的低粘度反应性树脂，所述树脂具有分子量不大于300道尔顿，例如 250道尔顿或更低，并且在所述范围内的温度下的粘度小于30cps，例如。 5至15厘泊; （B）选自环氧树脂，含有氧杂环丁烷环的化合物和丙烯酸酯的至少一种较高粘度的树脂，该树脂用于增稠低粘度树脂并加强组合物的喷射沉积物，该高粘度树脂具有：在上述范围内的所述温度下的粘度大于所述低粘度树脂的粘度的两倍以上，并且官能度大于或等于2; （C）至少一种可固化增韧剂，优选具有至少2的官能度，例如羟基，环氧，丙烯酸或其它反应性官能化聚合物/低聚物（例如通过官能化聚（四氢呋喃），聚己内酯，聚碳酸酯二醇或树枝状聚合物多元醇;（D）至少一种用于树脂聚合的引发剂，和（E）至少一种用于延迟组合物树脂固化的稳定剂;其中低粘度树脂比较高粘度的树脂反应慢，在固化之前至少部分地固化期间溶解高粘度树脂，并且其中至少30％的组分A和B是阳离子可固化树脂。组合物可以在计算机程序的控制下从压电印刷头喷射以形成多层制品，例如三维制品，其中相邻的液滴合并并均匀地固化在一起。

6. 发明申请

WO2002064354A1 THREE-DIMENSIONAL STRUCTURED PRINTING 审中-公开
标题翻译：三维结构打印
公开(公告)号：WO2002064354A1
公开(公告)日：2002-08-22
申请号：PCT/GB2002/000615
申请日：2002-02-12
申请人： VANTICO LIMITED , PATEL, Ranjana, C. , PEACE, Richard, J. , ZHAO, Yong , POWELL, Jeremy, H. , RHODES, Michael
发明人： PATEL, Ranjana, C. , PEACE, Richard, J. , ZHAO, Yong , POWELL, Jeremy, H. , RHODES, Michael
IPC分类号： B29C67/00
CPC分类号： B29C64/165 , B29K2105/162 , B33Y10/00 , B33Y30/00 , B33Y70/00
摘要： A process for forming a three-dimensional article in sequential layers in accordance with a digital model of the article. The process comprises the steps of defining a layer of powder material, applying a liquid reagent to the powder layer in a pattern corresponding to the digital model, and repeating these steps to form successive layers. The powder comprises a first reactive component and the liquid includes a second active component capable of reacting with the first reactive component so that the article is built up in layers.
摘要翻译：根据制品的数字模型在连续层中形成三维制品的方法。该方法包括以下步骤：定义一层粉末材料，以对应于数字模型的图案将液体试剂施加到粉末层，并重复这些步骤以形成连续的层。粉末包括第一反应性组分，并且液体包括能够与第一反应性组分反应的第二活性组分，使得制品层压成型。

7. 发明申请

WO2015048365A1 NOVEL 20(S)-SULFONYLAMIDINE DERIVATIVES OF CAMPTOTHECIN AND THE USE THEREOF AS A POTENT ANTITUMOR AGENT 审中-公开
标题翻译：氨茶碱的新二十（S） - 磺酰胺衍生物及其作为抗肿瘤剂的用途
公开(公告)号：WO2015048365A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/057575
申请日：2014-09-26
申请人： LEE, Kuo-Hsiung , QIAN, Keduo , YANG, Xiaoming , GOTO, Masuo , LIU, Ying-Qian , ZHAO, Yong-Long , YANG, Liu , WANG, Mei-Juan , ZHANG, Zhi-Jun , WU, Tian-Shung , TENG, Che-Ming , WANG, Chih-Ya , PAN, Shiow-Lin , KUO, Sheng-Chu , HUNG, Hsin-Yi , CHANG, Ling-Chu , WU, Yang-Chang , HSIEH, Min-Tsang , HSU, Chung Y. , SHYU, Woei-Cherng , LIN, Chen-Huan
发明人： LEE, Kuo-Hsiung , QIAN, Keduo , YANG, Xiaoming , GOTO, Masuo , LIU, Ying-Qian , ZHAO, Yong-Long , YANG, Liu , WANG, Mei-Juan , ZHANG, Zhi-Jun , WU, Tian-Shung , TENG, Che-Ming , WANG, Chih-Ya , PAN, Shiow-Lin , KUO, Sheng-Chu , HUNG, Hsin-Yi , CHANG, Ling-Chu , WU, Yang-Chang , HSIEH, Min-Tsang , HSU, Chung Y. , SHYU, Woei-Cherng , LIN, Chen-Huan
IPC分类号： C07D491/12 , C07D471/04 , A61K31/4745 , A61K35/00
CPC分类号： C07D491/22 , C07F7/0812 , C07F9/6561
摘要： The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.
摘要翻译：本发明涉及喜树碱（1）的新型20-磺酰脒衍生物，其合成方法及其作为抗肿瘤剂的用途，例如用于治疗鼻咽癌，肺癌，乳腺癌或前列腺癌的抗肿瘤剂。

8. 发明申请

WO2012154832A3 OBJECT TRACKING 审中-公开
标题翻译：对象追踪
公开(公告)号：WO2012154832A3
公开(公告)日：2013-03-21
申请号：PCT/US2012037094
申请日：2012-05-09
申请人： GOOGLE INC , GOSSWEILER III RICHARD C , ZHAO YONG
发明人： GOSSWEILER III RICHARD C , ZHAO YONG
IPC分类号： G06T7/20
CPC分类号： G06K9/00241 , G06K9/00261
摘要： In general, the subject matter described in this specification can be embodied in methods, systems, and program products. A computing system accesses an indication of a first template that includes a region of a first image. The region of the first image includes a graphical representation of a face. The computing system receives a second image. The computing system identifies indications of multiple candidate templates. Each respective candidate template from the multiple candidate templates includes a respective candidate region of the second image. The computing system compares at least the first template to each of the multiple candidate templates, to identify a matching template from among the multiple candidate templates that includes a candidate region that matches the region of the first image that includes the graphical representation of the face.
摘要翻译：通常，本说明书中描述的主题可以体现在方法，系统和程序产品中。计算系统访问包括第一图像的区域的第一模板的指示。第一图像的区域包括面部的图形表示。计算系统接收第二个图像。计算系统识别多个候选模板的指示。来自多个候选模板的每个候选模板包括第二图像的相应候选区域。所述计算系统至少将所述第一模板与所述多个候选模板中的每一个进行比较，以从所述多个候选模板中识别匹配模板，所述匹配模板包括与包括所述面部的图形表示的所述第一图像的区域相匹配的候选区域。

9. 发明申请

WO2011087637A1 STEM CELL IMMUNE MODULATION METHODS OF USE AND APPARATUS 审中-公开
标题翻译：干细胞免疫调节方法的使用和设备
公开(公告)号：WO2011087637A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/059522
申请日：2010-12-08
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , ZHAO, Yong
发明人： ZHAO, Yong
IPC分类号： C12M3/00 , C12N5/078 , C12N5/0783 , C12N5/0735 , A61K35/26 , A61P37/00
CPC分类号： A61M1/3489 , A61K2035/122 , A61M1/3472 , A61M2202/0407 , C12M25/08 , C12M35/08 , C12N5/0634 , C12N2502/11
摘要： Methods and apparatus are disclosed co-culturing stem cells with mononuclear cells and/or lymphocytes to modulate their function. The invention also discloses the use of stem cells to educate autoreactive immune cells as a mechanism to treat autoimmune diseases and immune disorder-related diseases, such as diabetes. In one aspect of the invention, bioreactors are disclosed for modulating lymphocytes and suppressing autoreactive T cells. The bioreactors can include a chamber having at least one positively charged and/or hydrophobic substrate surface, a population of stem cells attached to the substrate surface, an inlet conduit for introducing lymphocytes into the chamber, and an outlet conduit for extracting treated lymphocytes following co-culturing with the stem cells.
摘要翻译：公开了与单核细胞和/或淋巴细胞共培养干细胞以调节其功能的方法和装置。本发明还公开了使用干细胞来教育自身免疫细胞作为治疗自身免疫疾病和免疫疾病相关疾病如糖尿病的机制。在本发明的一个方面，公开了用于调节淋巴细胞并抑制自身反应性T细胞的生物反应器。生物反应器可以包括具有至少一个带正电荷和/或疏水底物表面的腔室，连接到基底表面的干细胞群，用于将淋巴细胞引入腔室的入口导管，以及用于在下列处理之后提取处理的淋巴细胞的出口导管用干细胞培养。

10. 发明申请

WO2009122153A3 ELECTROLUMINESCENT DISPLAYS 审中-公开
标题翻译：电致发光显示器
公开(公告)号：WO2009122153A3
公开(公告)日：2010-02-18
申请号：PCT/GB2009000835
申请日：2009-03-27
申请人： PELIKON LTD , ZHAO YONG , EVANS CHRISTOPHER MILES
发明人： ZHAO YONG , EVANS CHRISTOPHER MILES
IPC分类号： G02F1/13357
CPC分类号： G02F1/133603 , G02F1/1334 , G02F2201/50
摘要： An electroluminescent display comprising a mask defining the information to be displayed and an electroluminescent (EL) backlight. The mask compress a layer (13) of physically-stabilised liquid crystal switchable to define the information to be displayed mounted in front of an EL layer (16) of the backlight. At least one pair of electrodes (12, 20) are arranged to generate, in use, an electric field across both the EL layer (16) and the LC layer (13). A barrier layer (15) is provided between the LC layer (13) and the EL layer (16) that restricts migration of liquid crystal from the LC layer (13) to the EL layer (16).
摘要翻译：一种电致发光显示器，其包括限定要显示的信息的掩模和电致发光（EL）背光。掩模压缩物理稳定的液晶层（13），其可切换以限定安装在背光源的EL层（16）前面的要显示的信息。至少一对电极（12,20）被布置成在使用中产生穿过EL层（16）和LC层（13）的电场。阻挡层（15）设置在LC层（13）和EL层（16）之间，其限制液晶从LC层（13）向EL层（16）的迁移。

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