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1. 发明申请

WO2013083569A1 NASAL FORMULATION 审中-公开
标题翻译： NASAL公式
公开(公告)号：WO2013083569A1
公开(公告)日：2013-06-13
申请号：PCT/EP2012/074374
申请日：2012-12-04
申请人： TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC. , ZENG, Xian-Ming , LY, Jade Ching-Ying , DALVI, Mukul C
发明人： ZENG, Xian-Ming , LY, Jade Ching-Ying , DALVI, Mukul C
IPC分类号： A61K31/55 , A61K31/573 , A61K9/00 , A61K9/12 , A61P27/14 , A61M15/08
CPC分类号： A61K31/573 , A61K9/0043 , A61K9/008 , A61K9/12 , A61K9/124 , A61K31/55 , A61M11/04 , A61M11/06 , A61M15/0065 , A61M15/009 , A61M15/08 , A61K2300/00
摘要： This invention relates to a solution formulation for nasal administration comprising azelastine, beclomethasone dipropionate, a co-solvent, an acid and an HFA propellant.
摘要翻译：本发明涉及用于鼻内给药的溶液制剂，其包含阿斯匹丁，二丙酸倍氯米松，共溶剂，酸和HFA推进剂。

2. 发明申请

WO2009007687A2 AN INHALABLE MEDICAMENT 审中-公开
标题翻译：不耐烦的药物
公开(公告)号：WO2009007687A2
公开(公告)日：2009-01-15
申请号：PCT/GB2008/002294
申请日：2008-07-03
申请人： NORTON HEALTHCARE LIMITED , ZENG, Xian-Ming
发明人： ZENG, Xian-Ming
IPC分类号： A61K9/12 , A61K31/46 , A61P11/06
CPC分类号： A61K9/19 , A61K9/0075 , A61K9/1694 , A61K31/439 , A61K47/26
摘要： This invention relates to an inhalable medicament and in particular to a new solid-state form of tiotropium bromide, namely solid amorphous particles comprising an intimate admixture of tiotropium bromide together with a pharmaceutically acceptable co-solid having a glass transition temperature of at least -5O°C, such as a sugar and/or a sugar derivative.
摘要翻译：本发明涉及可吸入药物，特别涉及一种新的固态噻托溴铵，即固体无定形颗粒，其包含噻托溴铵与药学上可接受的共固体的混合物，玻璃化转变温度至少为-5O ℃，例如糖和/或糖衍生物。

3. 发明申请

WO2013092237A1 AN INHALABLE MEDICAMENT COMPRISING TIOTROPIUM 审中-公开
标题翻译：包含生物学的可吸入药物
公开(公告)号：WO2013092237A1
公开(公告)日：2013-06-27
申请号：PCT/EP2012/074690
申请日：2012-12-06
申请人： TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC. , ZENG, Xian-Ming
发明人： ZENG, Xian-Ming
IPC分类号： A61K31/46 , A61K9/00 , A61K9/12 , A61P11/00
CPC分类号： A61K47/12 , A61K9/008 , A61K31/439 , A61K31/46 , A61K47/10 , A61M15/009
摘要： This invention relates to a solution formulation comprising a tiotropium salt, 12-20% ethanol, 0.1-1.5% of water, 0.05-0.10% citric acid (or other organic acid) and an HFA propellant, wherein the percentages are percentages by weight based on the total weight of the formulation. The invention also provides a p MDI comprising a canister containing the formulation.
摘要翻译：本发明涉及包含噻托铵盐，12-20％乙醇，0.1-1.5％水，0.05-0.10％柠檬酸（或其它有机酸）和HFA推进剂的溶液制剂，其中百分比是基于关于制剂的总重量。本发明还提供一种包含含有该制剂的罐的p MDI。

4. 发明申请

WO2009010770A2 DRY-POWDER MEDICAMENT 审中-公开
标题翻译：干粉药
公开(公告)号：WO2009010770A2
公开(公告)日：2009-01-22
申请号：PCT/GB2008/002473
申请日：2008-07-18
申请人： NORTON HEALTHCARE LTD , ZENG, Xian-Ming , MARTIN, Gary, Peter , MARRIOTT, Christopher , TAKI, Mohammed
发明人： ZENG, Xian-Ming , MARTIN, Gary, Peter , MARRIOTT, Christopher , TAKI, Mohammed
IPC分类号： A61K9/00 , A61K31/00
CPC分类号： A61K9/0075 , A61K31/00 , A61K45/06 , A61K2300/00
摘要： This invention relates to a dry powder medicament and particularly to a medicament which provides improved fine particle fraction. The method for preparing the inhalable dry-powder medicament comprises the steps of: (i) fractionating a particulate active ingredient based on aerodynamic particle size, (ii) recovering at least one fraction of the particulate active ingredient and (iii) combining the recovered fraction with a carrier to provide the inhalable dry-powder medicament. A dry-powder medicament per se is also described.
摘要翻译：本发明涉及一种干粉药物，特别涉及提供改进的细颗粒级分的药物。制备可吸入干粉药物的方法包括以下步骤：（i）基于空气动力学粒径分级颗粒活性成分，（ii）回收至少一部分的颗粒活性成分，和（iii）将回收的级分用载体提供可吸入的干粉药物。还描述了干粉药物本身。

5. 发明申请

WO2018094392A1 MEDICAMENT DISPENSER 审中-公开
公开(公告)号：WO2018094392A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/062792
申请日：2017-11-21
申请人： LUPIN INC. , GUPTA, Abhishek , SHAIKH, Imran , ZENG, Xian-Ming
发明人： GUPTA, Abhishek , SHAIKH, Imran , ZENG, Xian-Ming
IPC分类号： A61M15/00
摘要： A medicament dispenser for dispensing medicament comprising: a diskette assembly (1) comprising: at least one medicament carrier (5) carrying multiple distinct medicament portions; a medicament carrier advancing mechanism for actuating the distinct medicament portions; a flow channel; a lever (2); and an outer cover (3) for said flow channel, wherein the outer cover is adapted to couple with the lever and the medicament carrier advancing mechanism.

6. 发明申请

WO2012048867A1 NASAL SPRAY DEVICE 审中-公开
标题翻译： NASAL喷雾装置
公开(公告)号：WO2012048867A1
公开(公告)日：2012-04-19
申请号：PCT/EP2011/005118
申请日：2011-10-12
申请人： IVAX PHARMACEUTICALS IRELAND , TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC. , WALSH, Declan , ZENG, XIan-Ming , LY, Jade , MORALES, Armando , IVAX RESEARCH, LLC
发明人： WALSH, Declan , ZENG, XIan-Ming , LY, Jade , MORALES, Armando
IPC分类号： A61M15/00 , A61M15/08 , B05B1/00
CPC分类号： A61M15/009 , A61K9/0043 , A61K31/57 , A61M15/08 , B65D83/54
摘要： This invention relates to a nasal spray device (1) for the delivery of a pharmaceutical formulation to the nasal cavity in metered doses. The device comprises: a pressurised aerosol canister (3) including a vial (4) containing a pharmaceutical formulation comprising an active ingredient, a propellant and, optionally, a co- solvent, the aerosol canister further including a metering valve (6) having a valve stem (8); and an actuator (2) for the aerosol canister, the actuator including a stem block (11) having a receptacle into which the valve stem of metering valve of the aerosol canister is received and axially located and being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump (15) extending below the receptacle, the stem block further defining a discharge orifice (19) for the pharmaceutical formulation and a transfer channel (13) through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the discharge orifice. The actuator further comprises a delivery outlet (12) for the aerosol plume, the discharge orifice being arranged to direct the aerosol plume through the delivery outlet, and wherein the device is adapted to produce an aerosol plume for a dispensed dose having a spray force value no greater than 40 mN measured at a distance of 30 mm from the discharge orifice. Use of the term formulation encompasses both solution and suspension formulations.
摘要翻译：本发明涉及一种用于以计量剂量将药物制剂递送至鼻腔的鼻喷雾装置（1）。该装置包括：加压气溶胶罐（3），其包括含有包含活性成分，推进剂和任选的助溶剂的药物制剂的小瓶（4），所述气溶胶罐还包括计量阀（6），其具有阀杆（8）; 和用于气溶胶罐的致动器（2），所述致动器包括具有容器的杆块（11），所述气溶胶罐的计量阀的阀杆被容纳在所述容器中并且被轴向定位并且相对于所述气溶胶小瓶可移位致动所述气溶胶罐的计量阀，在所述容器下方延伸的贮槽（15），所述阀杆块还限定用于所述药物制剂的排出孔（19）和输送通道（13），所述分配剂量药物制剂能够从贮槽通过排放口。所述致动器还包括用于所述气溶胶羽流的输送出口（12），所述排放孔布置成引导所述气溶胶羽流通过所述输送出口，并且其中所述装置适于产生具有喷雾力值的分配剂量的气溶胶羽流在距离排放口30mm的距离处测量不大于40mN。术语制剂的使用包括溶液和悬浮液制剂。

7. 发明申请

WO0158425A3 PHARMACEUTICAL COMPOSITION FOR PULMONARY DELIVERY 审中-公开
标题翻译：用于脉搏递送的药物组合物
公开(公告)号：WO0158425A3
公开(公告)日：2002-01-31
申请号：PCT/GB0100489
申请日：2001-02-07
申请人： KING S COLLEGE LONDON , MARTIN GARY PETER , ZENG XIAN MING
发明人： MARTIN GARY PETER , ZENG XIAN MING
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61K9/16 , A61K31/137 , A61K31/46 , A61K31/557 , A61K31/58 , A61L9/04
CPC分类号： A61K9/0075 , A61K9/1635 , A61K31/137 , A61K31/46 , A61K31/557 , A61K31/569 , A61K31/573 , A61K31/58
摘要： A dry particulate pharmaceutical composition for pulmonary administration is prepared by spray-drying a hydrophobic active agent (e.g. declomethasone dipropionate) with a small quantity of pharmaceutically acceptable hydrophilic polymer (e.g. poly(vinyl)alcohol). This mitigates aggregation of the particles of active agent, which otherwise limits the desirable fine particle dose available.
摘要翻译：通过用少量的药学上可接受的亲水性聚合物（例如聚（乙烯醇））喷雾干燥疏水性活性剂（例如二丙酸倍氯米松）来制备用于肺部给药的干燥颗粒药物组合物。这减轻了活性剂颗粒的聚集，否则限制了所需的可用微粒剂量。

8. 发明申请

WO2013092345A1 AN INHALER COMPRISING A TIOTROPIUM-CONTAINING-COMPOSITION 审中-公开
标题翻译：包含含有组分的吸收剂
公开(公告)号：WO2013092345A1
公开(公告)日：2013-06-27
申请号：PCT/EP2012/075230
申请日：2012-12-12
申请人： TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC. , ZENG, Xian-Ming , FENLON, Derek
发明人： ZENG, Xian-Ming , FENLON, Derek
IPC分类号： A61K31/46 , A61K9/12 , A61P11/00
CPC分类号： A61M15/009 , A61K9/008 , A61K9/12 , A61K9/124 , A61K31/46 , A61K31/535 , A61K47/10 , A61K47/12 , A61M11/04 , A61M15/0095
摘要： This invention relates to a pressurised metered dose inhaler comprising a canister, wherein the canister contains a formulation comprising a tiotropium salt and an HFA propellant, wherein the inhaler is an inhalation-actuated inhaler.
摘要翻译：本发明涉及包含罐的加压计量剂量吸入器，其中所述罐包含含有噻托铵盐和HFA推进剂的制剂，其中所述吸入器是吸入致动的吸入器。

9. 发明申请

WO2011054527A1 AIRFLOW ADAPTOR FOR A BREATH-ACTUATED DRY POWDER INHALER 审中-公开
标题翻译：用于呼吸干燥粉末吸入器的气流适配器
公开(公告)号：WO2011054527A1
公开(公告)日：2011-05-12
申请号：PCT/EP2010/006744
申请日：2010-11-05
申请人： NORTON HEALTHCARE LIMITED , BLAIR, Julian, Alexander , BUCK, Daniel , HAZENBERG, Jan, Geert , ZENG, Xian-Ming
发明人： BLAIR, Julian, Alexander , BUCK, Daniel , HAZENBERG, Jan, Geert , ZENG, Xian-Ming
IPC分类号： A61M15/00
CPC分类号： A61M15/0086 , A61K9/0075 , A61K31/137 , A61K31/56 , A61M15/0065 , A61M15/0091 , A61M2202/064 , A61M2206/16
摘要： An airflow adaptor (200) for a breath-actuated dry powder inhaler. The airflow adaptor comprises a conduit (202) having a proximal end (201) and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further comprises means (204, 205, 206, 210, 211, 212) for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.
摘要翻译：用于呼吸致动干粉吸入器的气流适配器（200）。气流适配器包括具有近端（201）和远端的导管（202），其中近端允许从解聚器出口端口到导管的远端的流体连通，并且其中气流适配器还包括装置 204,205,206,210,211,212），用于当呼吸诱导的低压被施加到远端时允许空气从适配器的近端流到适配器的远端，而不管导管中的气流的气流适配器。

10. 发明申请

WO2009010770A3 DRY-POWDER MEDICAMENT 审中-公开
标题翻译：干粉药
公开(公告)号：WO2009010770A3
公开(公告)日：2010-01-07
申请号：PCT/GB2008002473
申请日：2008-07-18
申请人： NORTON HEALTHCARE LTD , ZENG XIAN-MING , MARTIN GARY PETER , MARRIOTT CHRISTOPHER , TAKI MOHAMMED
发明人： ZENG XIAN-MING , MARTIN GARY PETER , MARRIOTT CHRISTOPHER , TAKI MOHAMMED
IPC分类号： A61K9/00 , A61K31/00 , A61K31/31
CPC分类号： A61K9/0075 , A61K31/00 , A61K45/06 , A61K2300/00
摘要： This invention relates to a dry powder medicament and particularly to a medicament which provides improved fine particle fraction. The method for preparing the inhalable dry-powder medicament comprises the steps of: (i) fractionating a particulate active ingredient based on aerodynamic particle size, (ii) recovering at least one fraction of the particulate active ingredient and (iii) combining the recovered fraction with a carrier to provide the inhalable dry-powder medicament. A dry-powder medicament per se is also described.
摘要翻译：本发明涉及一种干粉药物，特别涉及提供改进的细颗粒级分的药物。制备可吸入干粉药物的方法包括以下步骤：（i）基于空气动力学粒径分级颗粒活性成分，（ii）回收至少一部分的颗粒活性成分，和（iii）将回收的级分用载体提供可吸入的干粉药物。还描述了干粉药物本身。

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