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1. 发明申请

WO2019165232A1 INHIBITORS OF PHOSPHOLIPID SYNTHESIS AND METHODS OF USE 审中-公开
公开(公告)号：WO2019165232A1
公开(公告)日：2019-08-29
申请号：PCT/US2019/019185
申请日：2019-02-22
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GOUW, Arvin , FELSHER, Dean W. , JIN, Feng , ZARE, Richard N. , MARGULIS, Katherine , SCHOW, Steven R. , GREENHOUSE, Robert , LOUGHHEAD, David Garrett , RICHARDS, Steven
发明人： GOUW, Arvin , FELSHER, Dean W. , JIN, Feng , ZARE, Richard N. , MARGULIS, Katherine , SCHOW, Steven R. , GREENHOUSE, Robert , LOUGHHEAD, David Garrett , RICHARDS, Steven
IPC分类号： A61K31/18 , A61K31/196 , C07C311/21 , A61P3/00
摘要： Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome and hyperlipidemia.

2. 发明申请

WO2011097014A1 DOPED GRAPHENE ELECTRONIC MATERIALS 审中-公开
标题翻译： DOPED GRAPHENE电子材料
公开(公告)号：WO2011097014A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/000187
申请日：2011-02-02
申请人： SEARETE LLC , BOWERS, Jeffrey, A. , HYDE, Roderick, A. , ISHIKAWA, Muriel, Y. , KARE, Jordin, T. , TEGREENE, Clarence, T. , TOYOKUNI, Tatsushi , ZARE, Richard, N.
发明人： BOWERS, Jeffrey, A. , HYDE, Roderick, A. , ISHIKAWA, Muriel, Y. , KARE, Jordin, T. , TEGREENE, Clarence, T. , TOYOKUNI, Tatsushi , ZARE, Richard, N.
IPC分类号： H01B5/00
CPC分类号： H01L29/1606 , H01L21/2225 , H01L21/2236 , H01L29/76 , H01L29/92
摘要： A graphene substrate is doped with one or more functional groups to form an electronic device.
摘要翻译：石墨烯衬底掺杂有一个或多个官能团以形成电子器件。

3. 发明申请

WO2007133750A3 ENCAPSULATED NANOPARTICLES FOR DRUG DELIVERY 审中-公开
公开(公告)号：WO2007133750A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/011581
申请日：2007-05-14
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , JACOBSON, Gunilla B. , ZARE, Richard N. , MARKIDES, Karin E. , SHINDE, Rajesh R. , CONTAG, Christopher H.
发明人： JACOBSON, Gunilla B. , ZARE, Richard N. , MARKIDES, Karin E. , SHINDE, Rajesh R. , CONTAG, Christopher H.
IPC分类号： A61K9/14
摘要： Compositions and methods are provided for preparing nanosized biologically active agents, including agents formulated for target specific drug delivery. The nanosized agents are prepared with supercritical carbon dioxide as an antisolvent, providing nanoparticles whose size, shape, and surroundings are well-controlled. The nanoparticles are made of small molecules, e.g. drugs, anti-oxidants, luciferin, polypeptides, e.g. oligopeptides; polynucleotides, e.g. siRNA, antisense oligonucleotides, etc. In some embodiments, the nanoparticles comprise a polymer coating, which can provide for controlled delivery, targeting, controlled release, and the like. In other embodiments, the nanoparticles comprise a target specific tag for targeting the nanoparticles to a site of interest, e.g. tissue, cell, etc.

4. 发明申请

WO2012125552A3 METHODS OF ELECTRIC FIELD INDUCED DELIVERY OF COMPOUNDS, COMPOSITIONS USED IN DELIVERY, AND SYSTEM OF DELIVERY 审中-公开
标题翻译：化合物的电场诱导方法，交付中使用的组合物和递送系统的方法
公开(公告)号：WO2012125552A3
公开(公告)日：2012-11-29
申请号：PCT/US2012028758
申请日：2012-03-12
申请人： UNIV LELAND STANFORD JUNIOR , ZARE RICHARD N , GE JUN
发明人： ZARE RICHARD N , GE JUN
IPC分类号： A61K9/16 , A61K9/14 , A61K47/30 , A61K47/48
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0024 , A61K9/06 , A61K9/5138 , A61M2037/0007
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of delivering a compound, a composition, and the like.
摘要翻译：根据本公开的目的，如本文所体现和广泛描述的，本公开的实施例在一方面涉及递送化合物，组合物等的方法。

5. 发明申请

WO2005059537A1 IMMOBILIZED-ENZYME MICROREACTOR DEVICES FOR CHARACTERIZATION OF BIOMOLECULAR ANALYTES AND ASSOCIATED METHODS 审中-公开
标题翻译：用于表征生物分子分析仪和相关方法的固定化酶微生物装置
公开(公告)号：WO2005059537A1
公开(公告)日：2005-06-30
申请号：PCT/US2004/041640
申请日：2004-12-13
申请人： THE BOARD OF TRUSTEES FOR THE LELAND STANFORD JUNIOR UNIVERSITY , ZARE, Richard N. , DULAY, Maria T. , BACA, Quentin J. , TRAPP, Gabriele S.
发明人： ZARE, Richard N. , DULAY, Maria T. , BACA, Quentin J. , TRAPP, Gabriele S.
IPC分类号： G01N27/447
CPC分类号： G01N33/573 , C12N11/08 , C12N11/14 , C12Q1/37 , G01N27/44747 , G01N33/54353 , G01N33/553 , G01N2030/528
摘要： A method that comprises providing a polymerized sol-gel material (PSG) and linking an enzyme to a surface of the PSG via covalent linkage is provided. The surface of the PSG is derivatized with a linker that comprises a functional group for linking itself to the surface of the PSG and a functional group for linking itself with then enzyme. The linked-enzyme PSG, or microreactor, is an effective means of at least partially digesting a substrate, such as a biological substrate. The activity of the enzyme of the microreactor may be significantly enhanced, up to 200-fold for example, relative to the activity of the enzyme free of the microreactor. The microreactor is thus an effective vehicle for digesting a substrate such as a biomolecule, a protein, an oligonucleotide, a peptide, a steroid, and/or an organic acid, after which, any remaining substrate and one or more digestion product(s) may be separated and detected. Microreactors and integrated devices that incorporate microreactors, such as columns, pipet tips, wells, and well-plates, are also provided.
摘要翻译：提供了一种包括提供聚合的溶胶 - 凝胶材料（PSG）并通过共价键将酶与PSG的表面连接的方法。 PSG的表面用包含用于将其自身连接到PSG表面的官能团的接头衍生化，以及将其自身与酶连接的官能团。连接酶PSG或微反应器是至少部分消化底物如生物底物的有效手段。相对于不含微反应器的酶的活性，微反应器的酶的活性可以显着增强，例如高达200倍。因此，微反应器是用于消化诸如生物分子，蛋白质，寡核苷酸，肽，类固醇和/或有机酸的底物的有效载体，之后，任何残留的底物和一种或多种消化产物，可能被分离和检测。还提供了包含微反应器的微反应器和集成器件，例如色谱柱，移液管吸头，孔和孔板。

6. 发明申请

WO2006034347A3 SEPARATION OF COMPLEX MIXTURES BY SHEARING 审中-公开
公开(公告)号：WO2006034347A3
公开(公告)日：2006-03-30
申请号：PCT/US2005/033836
申请日：2005-09-21
申请人： PETROSHEAR CORPORATION , ZARE, Richard, N.
发明人： ZARE, Richard, N.
IPC分类号： C10G15/00 , C10G7/00
摘要： A more energy-efficient method of processing crude oil is achieved by viscoelastic shearing in order to increase the vapor pressure of the crude oil. This change in vapor pressure allows a more efficient separation of volatile components from non-volatile components in the crude oil. By optimizing the energy expenditure for shearing and the energy expenditure for separating the volatile components from the non-volatile components of the crude oil, while simultaneously removing the volatile components by distillation, one can reduce the overall energy input for the separation. Alternatively, it is possible to affect the distillation at a reduced temperature.

7. 发明申请

WO2006034347A2 SEPARATION OF COMPLEX MIXTURES BY SHEARING 审中-公开
标题翻译：通过剪切分离复杂混合物
公开(公告)号：WO2006034347A2
公开(公告)日：2006-03-30
申请号：PCT/US2005033836
申请日：2005-09-21
申请人： PETROSHEAR CORP , ZARE RICHARD N
发明人： ZARE RICHARD N
IPC分类号： C10G15/00 , C10G7/00
CPC分类号： C10G31/00 , C10G15/00
摘要： A more energy-efficient method of processing crude oil is achieved by viscoelastic shearing in order to increase the vapor pressure of the crude oil. This change in vapor pressure allows a more efficient separation of volatile components from non-volatile components in the crude oil. By optimizing the energy expenditure for shearing and the energy expenditure for separating the volatile components from the non-volatile components of the crude oil, while simultaneously removing the volatile components by distillation, one can reduce the overall energy input for the separation. Alternatively, it is possible to affect the distillation at a reduced temperature.
摘要翻译：通过粘弹性剪切实现原油加工的更加节能的方法，以便增加原油的蒸汽压力。蒸气压的这种变化可以使挥发性组分与原油中的非挥发性组分更有效地分离。通过优化用于剪切的能量消耗和从原油的非挥发性组分中分离挥发性组分的能量消耗，同时通过蒸馏除去挥发性组分，可以减少分离的总能量输入。或者，可以在降低的温度下影响蒸馏。

8. 发明申请

WO2014093448A1 UNOBTRUSIVE ACTIVE EYE INTERROGATION 审中-公开
标题翻译：独特的活跃眼影
公开(公告)号：WO2014093448A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/074313
申请日：2013-12-11
申请人： BROWN, Allen, L., Jr. , BURGER, Douglas, C. , HORVITZ, Eric , HYDE, Roderick, A. , JUNG, Edward, K., Y. , LEUTHARDT, Eric, C. , KARE, Jordin, T. , KARKANIAS, Chris, Demetrios , MANFERDELLI, John, L. , MUNDIE, Craig, J. , MYHRVOLD, Nathan, P. , PELL, Barney , TEGREENE, Clarence, T. , WATTENBURG, Willard, H. , WHITMER, Charles , WOOD, Lowell, L., Jr. , ZARE, Richard, N.
发明人： BROWN, Allen, L., Jr. , BURGER, Douglas, C. , HORVITZ, Eric , HYDE, Roderick, A. , JUNG, Edward, K., Y. , LEUTHARDT, Eric, C. , KARE, Jordin, T. , KARKANIAS, Chris, Demetrios , MANFERDELLI, John, L. , MUNDIE, Craig, J. , MYHRVOLD, Nathan, P. , PELL, Barney , TEGREENE, Clarence, T. , WATTENBURG, Willard, H. , WHITMER, Charles , WOOD, Lowell, L., Jr. , ZARE, Richard, N.
IPC分类号： A61B3/113
CPC分类号： A61B3/113 , A61B5/01 , A61B5/024 , A61B5/1103 , A61B5/14532 , A61B5/7289 , A61M2210/0612 , G06K9/0061
摘要： Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The physiological parameter is determined from a signal sensed from the eye of a subject when the eye of the subject is properly aligned with regard to an interrogation signal source and/or response signal sensor.
摘要翻译：描述了用光学信号通过询问对象的眼睛来确定对象的生理参数的方法和系统。询问是不引人注意的。当对象的眼睛相对于询问信号源和/或响应信号传感器正确对准时，从从被检者的眼睛感测的信号确定生理参数。

9. 发明申请

WO2012125552A2 METHODS OF ELECTRIC FIELD INDUCED DELIVERY OF COMPOUNDS, COMPOSITIONS USED IN DELIVERY, AND SYSTEM OF DELIVERY 审中-公开
标题翻译：电场诱导递送化合物的方法，用于递送的组合物和递送系统
公开(公告)号：WO2012125552A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/028758
申请日：2012-03-12
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , ZARE, Richard, N. , GE, Jun
发明人： ZARE, Richard, N. , GE, Jun
IPC分类号： A61K9/16 , A61K9/14 , A61K47/30 , A61K47/48
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0024 , A61K9/06 , A61K9/5138 , A61M2037/0007
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of delivering a compound, a composition, and the like.
摘要翻译：根据本公开的目的，如在此具体化和广泛描述的，本公开的实施方案在一个方面涉及递送化合物，组合物和类似的。

10. 发明申请

WO2007133750A2 ENCAPSULATED NANOPARTICLES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的包封纳米颗粒
公开(公告)号：WO2007133750A2
公开(公告)日：2007-11-22
申请号：PCT/US2007011581
申请日：2007-05-14
申请人： UNIV LELAND STANFORD JUNIOR , JACOBSON GUNILLA B , ZARE RICHARD N , MARKIDES KARIN E , SHINDE RAJESH R , CONTAG CHRISTOPHER H
发明人： JACOBSON GUNILLA B , ZARE RICHARD N , MARKIDES KARIN E , SHINDE RAJESH R , CONTAG CHRISTOPHER H
IPC分类号： A61M36/00 , A61N5/00
CPC分类号： A61K9/5153 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5192 , A61K47/6935 , A61K47/6937 , A61K49/0093 , B82Y5/00
摘要： Compositions and methods are provided for preparing nanosized biologically active agents, including agents formulated for target specific drug delivery. The nanosized agents are prepared with supercritical carbon dioxide as an antisolvent, providing nanoparticles whose size, shape, and surroundings are well-controlled. The nanoparticles are made of small molecules, e.g. drugs, anti-oxidants, luciferin, polypeptides, e.g. oligopeptides; polynucleotides, e.g. siRNA, antisense oligonucleotides, etc. In some embodiments, the nanoparticles comprise a polymer coating, which can provide for controlled delivery, targeting, controlled release, and the like. In other embodiments, the nanoparticles comprise a target specific tag for targeting the nanoparticles to a site of interest, e.g. tissue, cell, etc.
摘要翻译：提供组合物和方法用于制备纳米尺寸生物活性剂，包括配制用于靶特异性药物递送的试剂。用超临界二氧化碳作为反溶剂制备纳米尺寸剂，提供其尺寸，形状和环境受到良好控制的纳米颗粒。纳米颗粒由小分子制成。药物，抗氧化剂，荧光素，多肽等。寡肽; 多核苷酸，例如 siRNA，反义寡核苷酸等。在一些实施方案中，纳米颗粒包含可提供受控递送，靶向，控制释放等的聚合物涂层。在其它实施方案中，纳米颗粒包含靶标特异性标签，用于将纳米颗粒靶向感兴趣的位点。组织，细胞等

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