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1. 发明申请

WO2010041021A2 GENE REGULATION USING RNA 审中-公开
标题翻译：使用RNA进行基因调控
公开(公告)号：WO2010041021A2
公开(公告)日：2010-04-15
申请号：PCT/GB2009/002411
申请日：2009-10-08
申请人： ARK THERAPEUTICS LTD. , TURUNEN, Mikko, P. , YLÄ-HERTTUALA, Seppo
发明人： TURUNEN, Mikko, P. , YLÄ-HERTTUALA, Seppo
IPC分类号： C12N15/11
CPC分类号： C12N15/1136 , C12N2310/14
摘要： The present invention is a vector for use in therapy effected by expression of a gene product, wherein the vector comprises a nucleotide sequence that can be transcribed to give RNA that can form a double-stranded RNA hairpin construct, wherein the RNA comprises: (i) a first sequence identical or complementary to a target sequence within a promoter area of the gene which encodes the gene product; (ii) a loop sequence; (iii) a sequence complementary to the first sequence; and (iv) a termination codon. The present invention may also be a system comprising an oligonucleotide and an oligonucleotide delivery system, which can generate an RNA construct.
摘要翻译：本发明是用于通过表达基因产物进行治疗的载体，其中所述载体包含可转录以产生可形成双链RNA发夹构建体的RNA的核苷酸序列，其中所述RNA包含：（i ）与编码基因产物的基因的启动子区域内的靶序列相同或互补的第一序列; （ii）循环序列; （iii）与第一序列互补的序列; 和（iv）终止密码子。本发明还可以是包含可以产生RNA构建体的寡核苷酸和寡核苷酸递送系统的系统。

2. 发明申请

WO1998020027A2 THERAPEUTIC USE OF GROWTH FACTOR, AND DELIVERY DEVICE, ESPECIALLY FOR THE TREATMENT OF INTIMAL HYPERPLASIA 审中-公开
标题翻译：生长因子和输送装置的治疗用途，特别适用于治疗原发性高血压
公开(公告)号：WO1998020027A2
公开(公告)日：1998-05-14
申请号：PCT/GB1997003015
申请日：1997-11-03
申请人： EUROGENE LIMITED , MARTIN, John, Francis , YLÄ-HERTTUALA, Seppo , BARKER, Stephen, George, Edward
发明人： EUROGENE LIMITED
IPC分类号： C07K14/00
CPC分类号： A61K38/44 , A61F2/06 , A61F2250/0067 , A61K38/1866 , A61K48/00 , C12Y114/13039
摘要： Vascular endothelial growth factor (VEGF) has utility in the treatment of intimal hyperplasia, hypertension and atherosclerosis, and of conditions susceptible to treatment with agents that produce nitric oxide or prostacyclin. Instead of VEGF, an equivalent agent such as an agonist of VEGF receptors may be given, as may nucleic acid encoding such an agonist. The agent may successfully be administered via the adventitial surface of a blood vessel, e.g. using a device which defines a reservoir between the body wall and the vessel's adventitial surface, the reservoir being at least part-filled by a pharmaceutical formulation containing the agent to be delivered.
摘要翻译：血管内皮生长因子（VEGF）可用于治疗内膜增生，高血压和动脉粥样硬化，以及易于用产生一氧化氮或前列环素的药物治疗的病症。代替VEGF，可以给出等同的试剂，例如VEGF受体的激动剂，编码这种激动剂的核酸也可以。该试剂可以成功地通过血管的外膜表面施用，例如，使用在体壁和容器的外膜表面之间限定储存器的装置，储存器至少由含有待递送剂的药物制剂部分填充。

3. 发明申请

WO2008146023A1 VEGF-D MUTANTS AND THEIR USE 审中-公开
标题翻译： VEGF-D突变体及其用途
公开(公告)号：WO2008146023A1
公开(公告)日：2008-12-04
申请号：PCT/GB2008/001873
申请日：2008-06-02
申请人： ARK THERAPEUTICS LTD. , TOIVANEN, Pyry , AIRENNE, Kari, Juchani , YLÄ-HERTTUALA, Seppo
发明人： TOIVANEN, Pyry , AIRENNE, Kari, Juchani , YLÄ-HERTTUALA, Seppo
IPC分类号： C07K14/52 , A61K38/19
CPC分类号： C07K14/52 , A61K38/00
摘要： The present invention is a VEGF-D protein, containing one or more amino acid mutations at the dimer interface, and their use in therapy, particularly in the promotion of angiogenesis.
摘要翻译：本发明是在二聚体界面含有一个或多个氨基酸突变的VEGF-D蛋白，以及它们在治疗中的用途，特别是在促进血管发生中。

4. 发明申请

WO2008146019A8 METHOD FOR BACULOVIRUS GENERATION FROM INSECT CELLS IN HIGH-TROUGHPUT PLATES 审中-公开
公开(公告)号：WO2008146019A8
公开(公告)日：2008-12-04
申请号：PCT/GB2008/001867
申请日：2008-06-02
申请人： ARK THERAPEUTICS LTD. , AIRENNE, Kari, Juhani , YLÄ-HERTTUALA, Seppo , KÄRKKÄINEN, Hanna-Riikka , LAITINEN, Olli
发明人： AIRENNE, Kari, Juhani , YLÄ-HERTTUALA, Seppo , KÄRKKÄINEN, Hanna-Riikka , LAITINEN, Olli
IPC分类号： C12N15/866 , C12P21/00
摘要： The present invention is a method of baculovirus generation from insect cells, using a high-throughput plate, wherein the insect cells are transfected or infected by a virus construct, in suspension, and wherein the plate comprises wells which have a substantially square cross-section.

5. 发明申请

WO2003092727A1 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2003092727A1
公开(公告)日：2003-11-13
申请号：PCT/SE2003/000713
申请日：2003-04-30
申请人： FIT BIOTECH OYJ PLC , LEPPÄNEN, Olli-Pekka , YLÄ-HERTTUALA, Seppo , LAUKKANEN, Mikko , LAHTINEN, Mika
发明人： LEPPÄNEN, Olli-Pekka , YLÄ-HERTTUALA, Seppo , LAUKKANEN, Mikko , LAHTINEN, Mika
IPC分类号： A61K38/44
CPC分类号： A61K38/446
摘要： The present invention relates to the use of a gene transfer product to reduce hyperplastic connective tissue growth after tissue trauma or implantation of a medical device. The present invention also relates to a medical device with improved biological properties for an at least partial contact with blood, bodily fluids and/or tissues when introduced in a mammalian body, which device comprises a core and a nucleic acid, encoding a product capable of leading to production of extracellular superoxide dismutase present in a biologically compatible medium. Said nucleic acid encodes a translation or transcription product, which is capable of inhibiting hyperplastic connective tissue growth and promoting endothelialisation in vivo at least partially on a synthetic surface of said core. The present invention also relates to a method of producing a medical device according to the invention.
摘要翻译：本发明涉及基因转移产物在组织创伤或植入医疗器械后减少增生性结缔组织生长的用途。本发明还涉及一种具有改善的生物学特性的医疗装置，其在引入哺乳动物体内时与血液，体液和/或组织至少部分接触，该装置包含核心和核酸，其编码能够导致存在于生物相容介质中的细胞外超氧化物歧化酶的产生。所述核酸编码翻译或转录产物，其能够至少部分地在所述核心的合成表面上抑制增生性结缔组织生长并促进体内内皮化。本发明还涉及根据本发明的医疗器械的制造方法。

6. 发明申请

WO2008099148A1 PRODUCTION OF LENTIVIRAL VECTORS 审中-公开
标题翻译：生产活力矢量
公开(公告)号：WO2008099148A1
公开(公告)日：2008-08-21
申请号：PCT/GB2008/000464
申请日：2008-02-11
申请人： ARK THERAPEUTICS LTD. , LESCH, Hanna, P. , AIRENNE, Kari, J. , Ylä-HERTTUALA, Seppo
发明人： LESCH, Hanna, P. , AIRENNE, Kari, J. , Ylä-HERTTUALA, Seppo
IPC分类号： C12N15/79
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2710/14021 , C12N2710/14043 , C12N2710/14051 , C12N2740/15043 , C12N2740/15051 , C12N2740/16022 , C12N2740/16043 , C12N2740/16045 , C12N2740/16051 , C12N2810/6081
摘要： The present invention is a method of generating a lentivirus vector, comprising cloning each of a lentivirus transfer construct, gag, pol , an envelope protein and rev respectively into the same or different baculoviruses, and transducing a producer cell with the or each baculovirus.
摘要翻译：本发明是产生慢病毒载体的方法，其包括将慢病毒转运构建体，gag，pol，包膜蛋白和rev的各自分别克隆到相同或不同的杆状病毒中，并用每个杆状病毒转导生产细胞。

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