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1. 发明申请

WO2009103046A4 MEDICAL IMAGE REPORTING SYSTEM AND METHOD 审中-公开
标题翻译：医学图像报告系统及方法
公开(公告)号：WO2009103046A4
公开(公告)日：2010-01-07
申请号：PCT/US2009034197
申请日：2009-02-16
申请人： PENN STATE RES FOUND , HIGGINS WILLIAM E , GIBBS JASON D , YU KUN-CHANG , GRAHAM MICHAEL W , LU KONGKUO
发明人： HIGGINS WILLIAM E , GIBBS JASON D , YU KUN-CHANG , GRAHAM MICHAEL W , LU KONGKUO
IPC分类号： A61B6/00 , G05F1/00
CPC分类号： G06T7/162 , G06T7/12 , G06T2207/20044 , G06T2207/30061
摘要： This invention relates generally to medical imaging and, in particular, to a method and system for I) reconstructing a model path through a branched tubular organ, II) automatic lymph node station mapping, and III) automatic path or route report generation. Novel methodologies and systems segment and define accurate endoluminal surfaces in airway trees, including small peripheral bronchi. An automatic algorithm is described that searches the entire lung volume for airway branches and poses airway-tree segmentation as a global graph-theoretic optimization problem. A suite of interactive segmentation tools for cleaning and extending critical areas of the automatically segmented result is disclosed. A model path is reconstructed through the airway tree. Additionally, a computer-based system for automatically locating the central chest lymph -node stations in a 3D MDCT image is described. Automated analysis methods extract the airway tree, airway-tree centerlines, aorta, pulmonary artery, lungs, key skeletal structures, and major-airway labels. Geometrical and anatomical cues arising from the extracted structures are used to localize the major nodal stations. The system calculates and displays the nodal stations in 3D. Visualization tools within the system enable the user to interact with the stations to locate visible lymph nodes. Additionally, a method and apparatus for producing and previewing a report for peripheral bronchoscopic procedures using patient-specific MDCT chest scans is disclosed. The report provides quantitative data about the route and both static and dynamic previews of the procedure. Static previews consist of virtual bronchoscopic endoluminal renderings at bifurcations encountered along the route, renderings of the airway tree and ROI at the suggested biopsy location, and three-dimensional cues as to the location for the biopsy.
摘要翻译：本发明一般涉及医学成像，特别涉及一种用于I）通过分支管状器官重建模型路径的方法和系统，II）自动淋巴结站映射，以及III）自动路径或路线报告生成。新颖的方法和系统在气道树中分割和定义准确的腔内表面，包括小型外周支气管。描述了一种自动算法，用于搜索整个肺体积以进行气道分支，并将气道树分割作为全局图理论优化问题。公开了一套用于清理和扩展自动分段结果的关键区域的交互式分割工具。通过气道树重建模型路径。另外，描述了一种用于在3D MDCT图像中自动定位中央胸部淋巴结站的基于计算机的系统。自动分析方法提取气道树，气道树中心线，主动脉，肺动脉，肺，关键骨骼结构和主要气道标签。提取的结构产生的几何和解剖学线索用于本地化主要节点。系统以3D方式计算和显示节点站。系统内的可视化工具使用户能够与站点进行交互来定位可见的淋巴结。另外，公开了一种用于使用患者特异性MDCT胸部扫描来生产和预览用于外周支气管镜手术的报告的方法和装置。该报告提供有关路线的定量数据，以及程序的静态和动态预览。静态预览包括在路线上遇到的分叉处的虚拟支气管镜腔内效果图，气道树的渲染和建议的活检位置处的ROI，以及针对活检位置的三维线索。

2. 发明申请

WO2009103046A3 MEDICAL IMAGE REPORTING SYSTEM AND METHOD 审中-公开
标题翻译：医学图像报告系统和方法
公开(公告)号：WO2009103046A3
公开(公告)日：2009-11-19
申请号：PCT/US2009034197
申请日：2009-02-16
申请人： PENN STATE RES FOUND , HIGGINS WILLIAM E , GIBBS JASON D , YU KUN-CHANG , GRAHAM MICHAEL W , LU KONGKUO
发明人： HIGGINS WILLIAM E , GIBBS JASON D , YU KUN-CHANG , GRAHAM MICHAEL W , LU KONGKUO
IPC分类号： A61B6/00 , G05F1/00
CPC分类号： G06T7/162 , G06T7/12 , G06T2207/20044 , G06T2207/30061
摘要： This invention relates generally to medical imaging and, in particular, to a method and system for I) reconstructing a model path through a branched tubular organ, II) automatic lymph node station mapping, and III) automatic path or route report generation. Novel methodologies and systems segment and define accurate endoluminal surfaces in airway trees, including small peripheral bronchi. An automatic algorithm is described that searches the entire lung volume for airway branches and poses airway-tree segmentation as a global graph-theoretic optimization problem. A suite of interactive segmentation tools for cleaning and extending critical areas of the automatically segmented result is disclosed. A model path is reconstructed through the airway tree. Additionally, a computer-based system for automatically locating the central chest lymph -node stations in a 3D MDCT image is described. Automated analysis methods extract the airway tree, airway-tree centerlines, aorta, pulmonary artery, lungs, key skeletal structures, and major-airway labels. Geometrical and anatomical cues arising from the extracted structures are used to localize the major nodal stations. The system calculates and displays the nodal stations in 3D. Visualization tools within the system enable the user to interact with the stations to locate visible lymph nodes. Additionally, a method and apparatus for producing and previewing a report for peripheral bronchoscopic procedures using patient-specific MDCT chest scans is disclosed. The report provides quantitative data about the route and both static and dynamic previews of the procedure. Static previews consist of virtual bronchoscopic endoluminal renderings at bifurcations encountered along the route, renderings of the airway tree and ROI at the suggested biopsy location, and three-dimensional cues as to the location for the biopsy.
摘要翻译：本发明一般涉及医学成像，尤其涉及一种方法和系统，用于I）重建通过分支管状器官的模型路径，II）自动淋巴结站映射，以及III）自动路径或路径报告生成。新的方法和系统在气道树中分割并确定准确的腔内表面，包括小的外周支气管。描述了一种自动算法，其搜索整个肺体积以寻找气道分支并将气道树分割作为全局图论优化问题。公开了一套用于清洁和扩展自动分割结果的关键区域的交互式分割工具。模型路径通过气道树重建。另外，描述了用于自动定位3D MDCT图像中央胸部淋巴结站的基于计算机的系统。自动分析方法提取气道树，气道树中心线，主动脉，肺动脉，肺部，关键骨骼结构和主要气道标签。从提取的结构中产生的几何和解剖线索被用于定位主要的节点站。系统将以三维方式计算并显示节点电台。系统中的可视化工具使用户能够与站点进行交互以定位可见的淋巴结。另外，公开了一种用于使用患者特异性MDCT胸部扫描产生和预览外周支气管镜检查程序的报告的方法和设备。该报告提供关于路线的静态和动态预览的定量数据。静态预览包括沿路线遇到的分叉处的虚拟支气管镜腔内渲染，建议的活检位置处的气道树和ROI的渲染，以及关于活检位置的三维线索。

3. 发明申请

WO2009103046A2 MEDICAL IMAGE REPORTING SYSTEM AND METHOD 审中-公开
标题翻译：医学图像报告系统及方法
公开(公告)号：WO2009103046A2
公开(公告)日：2009-08-20
申请号：PCT/US2009/034197
申请日：2009-02-16
申请人： THE PENN STATE RESEARCH FOUNDATION , HIGGINS, William, E. , GIBBS, Jason, D. , YU, Kun-chang , GRAHAM, Michael, W. , LU, Kongkuo
发明人： HIGGINS, William, E. , GIBBS, Jason, D. , YU, Kun-chang , GRAHAM, Michael, W. , LU, Kongkuo
IPC分类号： A61B6/00
CPC分类号： G06T7/162 , G06F19/00 , G06T7/12 , G06T2207/20044 , G06T2207/30061
摘要： This invention relates generally to medical imaging and, in particular, to a method and system for I) reconstructing a model path through a branched tubular organ, II) automatic lymph node station mapping, and III) automatic path or route report generation. Novel methodologies and systems segment and define accurate endoluminal surfaces in airway trees, including small peripheral bronchi. An automatic algorithm is described that searches the entire lung volume for airway branches and poses airway-tree segmentation as a global graph-theoretic optimization problem. A suite of interactive segmentation tools for cleaning and extending critical areas of the automatically segmented result is disclosed. A model path is reconstructed through the airway tree. Additionally, a computer-based system for automatically locating the central chest lymph -node stations in a 3D MDCT image is described. Automated analysis methods extract the airway tree, airway-tree centerlines, aorta, pulmonary artery, lungs, key skeletal structures, and major-airway labels. Geometrical and anatomical cues arising from the extracted structures are used to localize the major nodal stations. The system calculates and displays the nodal stations in 3D. Visualization tools within the system enable the user to interact with the stations to locate visible lymph nodes. Additionally, a method and apparatus for producing and previewing a report for peripheral bronchoscopic procedures using patient-specific MDCT chest scans is disclosed. The report provides quantitative data about the route and both static and dynamic previews of the procedure. Static previews consist of virtual bronchoscopic endoluminal renderings at bifurcations encountered along the route, renderings of the airway tree and ROI at the suggested biopsy location, and three-dimensional cues as to the location for the biopsy.
摘要翻译：本发明一般涉及医学成像，特别是涉及I）通过分支管状器官重建模型路径的方法和系统，II）自动淋巴结站映射，以及III）自动路径或路线报告生成。新颖的方法和系统在气道树中划分并定义精确的内腔表面，包括小型外周支气管。描述了一种自动算法，其搜索整个肺体积以进行气道分支，并将气道树分割作为全局图理论优化问题。公开了一套用于清理和扩展自动分段结果关键区域的交互式分割工具。通过气道树重建模型路径。另外，描述了一种用于在3D MDCT图像中自动定位中央胸部淋巴结站的基于计算机的系统。自动分析方法提取气道树，气道树中心线，主动脉，肺动脉，肺，关键骨骼结构和主要气道标签。提取的结构产生的几何和解剖学线索用于本地化主要节点。系统以3D形式计算和显示节点站。系统中的可视化工具使用户能够与站点进行交互，以定位可见的淋巴结。另外，公开了一种用于使用患者特异性MDCT胸部扫描来生产和预览用于外周支气管镜手术的报告的方法和装置。该报告提供有关路线的定量数据，以及程序的静态和动态预览。静态预览包括在路线上遇到的分叉处的虚拟支气管镜腔内效果图，气道树的渲染和建议的活检位置处的ROI，以及针对活检位置的三维线索。

4. 发明申请

WO2008095068A1 METHOD AND APPARATUS FOR CONTINUOUS GUIDANCE OF ENDOSCOPY 审中-公开
标题翻译：连续指导内镜的方法和装置
公开(公告)号：WO2008095068A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/052589
申请日：2008-01-31
申请人： THE PENN STATE RESEARCH FOUNDATION , HIGGINS, William, E. , MERRITT, Scott, A. , RAI, Lav , GIBBS, Jason, D. , YU, Kun-chang
发明人： HIGGINS, William, E. , MERRITT, Scott, A. , RAI, Lav , GIBBS, Jason, D. , YU, Kun-chang
IPC分类号： A61B1/00
CPC分类号： A61B1/0005 , A61B1/00009 , A61B34/20 , A61B34/25 , A61B90/36 , A61B90/361 , A61B2034/105 , A61B2034/107 , A61B2090/365
摘要： Methods and apparatus provide continuous guidance of endoscopy during a live procedure. A data-set based on 3D image data is pre-computed including reference information representative of a predefined route through a body organ to a final destination. A plurality of live real endoscopic (RE) images are displayed as an operator maneuvers an endoscope within the body organ. A registration and tracking algorithm registers the data-set to one or more of the RE images and continuously maintains the registration as the endoscope is locally maneuvered. Additional information related to the final destination is then presented enabling the endoscope operator to decide on a final maneuver for the procedure. The reference information may include 3D organ surfaces, 3D routes through an organ system, or 3D regions of interest (ROIs), as well as a virtual endoscopic (VE) image generated from the precomputed data-set. The preferred method includes the step of superimposing one or both of the 3D routes and ROIs on one or both of the RE and VE images. The 3D organ surfaces and routes may correspond to the surfaces and paths of a tracheobronchial airway tree extracted, for example, from 3D MDCT images of the chest.
摘要翻译：方法和装置在实时程序中提供内窥镜检查的连续指导。基于3D图像数据的数据集被预先计算，包括表示通过身体器官到最终目的地的预定义路线的参考信息。多个实时内窥镜（RE）图像作为操作者显示在身体器官内的内窥镜。注册和跟踪算法将数据集注册到一个或多个RE图像，并且在内窥镜被局部操纵时连续地保持注册。然后呈现与最终目的地相关的附加信息，使得内窥镜操作者能够决定该程序的最终操纵。参考信息可以包括3D器官表面，通过器官系统的3D路线或感兴趣的3D区域（ROI）以及从预先计算的数据集生成的虚拟内窥镜（VE）图像。优选的方法包括将一个或两个3D路线和ROI叠加在RE和VE图像中的一个或两个上的步骤。 3D器官表面和路线可以对应于例如从胸部的3D MDCT图像提取的气管支气管气道树的表面和路径。

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