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1. 发明申请

WO2011097522A3 COMBINATION METHODS FOR TREATMENT OF DISEASE 审中-公开
公开(公告)号：WO2011097522A3
公开(公告)日：2011-08-11
申请号：PCT/US2011/023804
申请日：2011-02-04
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , RAHL, Peter, B. , YOUNG, Richard, A.
发明人： RAHL, Peter, B. , YOUNG, Richard, A.
IPC分类号： A61K31/445 , A61K31/453 , A61K31/506 , A61P35/00
摘要： In some aspects, the invention provides compositions and methods of use for treating a variety of diseases. In some aspect, the compositions and methods involve combined modulation of transcriptional modulators.

2. 发明申请

WO2010017518A3 CONNECTING MICRORNA GENES TO THE CORE TRANSCRIPTIONAL REGULATORY CIRCUITRY OF EMBRYONIC STEM CELLS 审中-公开
标题翻译：将微阵列基因连接到胚胎干细胞的核心转录调控电路
公开(公告)号：WO2010017518A3
公开(公告)日：2010-06-03
申请号：PCT/US2009053214
申请日：2009-08-07
申请人： WHITEHEAD BIOMEDICAL INST , JAENISCH RUDOLPH , YOUNG RICHARD A , MARSON ALEXANDER , LEVINE STUART
发明人： JAENISCH RUDOLPH , YOUNG RICHARD A , MARSON ALEXANDER , LEVINE STUART
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G06F19/18 , C12N15/1089
摘要： The present invention provides, among other things, promoters for mouse and human microRNA genes and methods of use thereof.
摘要翻译：本发明尤其提供了用于小鼠和人microRNA基因的启动子及其使用方法。

3. 发明申请

WO2009002988A1 MEDICATION CONTAINER WITH FRESNEL LENS 审中-公开
标题翻译：含有FRESNEL镜片的药物容器
公开(公告)号：WO2009002988A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/068055
申请日：2008-06-24
申请人： WANG, Tom Y. , YOUNG, Richard A. , TRUONG, David
发明人： WANG, Tom Y. , YOUNG, Richard A. , TRUONG, David
IPC分类号： B65D1/00
CPC分类号： B65D75/522 , A61J1/03 , B65D2201/00 , G01N21/01
摘要： A medication container with a Fresnel lens formed on its surface is described. The Fresnel lens provides a magnified view of the medication content of the container so that a user such as a pharmacist or a patient can accurately determine the medication content without opening the container. In one embodiment, the medication container is generally cylindrical in shape and a Fresnel lens is formed on the bottom of the container. In other embodiments, the Fresnel lens is formed on the cap of a middle component located between the cap and the body of the container.
摘要翻译：描述了在其表面上形成有菲涅耳透镜的药物容器。菲涅尔透镜提供容器的药物含量的放大视图，使得诸如药剂师或患者的用户可以在不打开容器的情况下准确地确定药物含量。在一个实施例中，药物容器的形状通常为圆柱形，并且在容器的底部上形成菲涅尔透镜。在其他实施例中，菲涅尔透镜形成在位于盖和容器主体之间的中间部件的盖上。

4. 发明申请

WO2007064898A3 METHODS FOR MAPPING SIGNAL TRANSDUCTION PATHWAYS TO GENE EXPRESSION PROGRAMS 审中-公开
标题翻译：用于映射信号传输路径的方法来表达表达程序
公开(公告)号：WO2007064898A3
公开(公告)日：2008-08-21
申请号：PCT/US2006046016
申请日：2006-12-01
申请人： WHITEHEAD BIOMEDICAL INST , POKHOLOK DMITRY K , YOUNG RICHARD A
发明人： POKHOLOK DMITRY K , YOUNG RICHARD A
IPC分类号： C12Q1/68
CPC分类号： G01N33/5308 , C12Q1/6804 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2523/101 , C12Q2522/101
摘要： The invention relates to improved methods of identifying the gene expression programs that are regulated by a signal transduction pathway. The invention also provides methods of identifying agents which modulate signal transduction pathway. The invention also provides improved methods of isolating DNA fragments to which a protein of interest is bound, and genome-wide location analysis methods employing these improved isolation methods.
摘要翻译：本发明涉及鉴定由信号转导途径调节的基因表达程序的改进方法。本发明还提供鉴定调节信号转导途径的试剂的方法。本发明还提供了分离目的蛋白质结合的DNA片段的改进方法，以及使用这些改进的分离方法的全基因组位置分析方法。

5. 发明申请

WO2005088306A2 BIOLOGICALLY-ACTIVE DNA-BINDING SITES AND RELATED METHODS 审中-公开
标题翻译：生物活性DNA结合位点及相关方法
公开(公告)号：WO2005088306A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007249
申请日：2005-03-03
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , HARBISON, Christopher , YOUNG, Richard, A. , GORDON, David, B. , FRAENKEL, Ernest
发明人： HARBISON, Christopher , YOUNG, Richard, A. , GORDON, David, B. , FRAENKEL, Ernest
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , C12Q2522/00
摘要： The invention relates to the identification of biologically-active DNA-binding sites to which a protein of interest binds in a cell. The invention also relates to the identification of agents and conditions which alter the biologically-active DNA-binding sites to which a protein binds. One aspect of the invention also provides methods for identifying pathways that are regulated by transcriptional regulators and for modulating the activity of the pathways.
摘要翻译：本发明涉及鉴定目的蛋白质在细胞中结合的生物活性DNA结合位点。本发明还涉及改变蛋白质结合的生物活性DNA结合位点的试剂和条件的鉴定。本发明的一个方面还提供了鉴定通过转录调节因子调节并调节途径活性的途径的方法。

6. 发明申请

WO02059371A2 GENOME-WIDE LOCATION AND FUNCTION OF DNA BINDING PROTEINS 审中-公开
标题翻译： DNA结合蛋白的基因组位置和功能
公开(公告)号：WO02059371A2
公开(公告)日：2002-08-01
申请号：PCT/US0150396
申请日：2001-12-21
申请人： WHITEHEAD BIOMEDICAL INST , WYRICK JOHN , YOUNG RICHARD A , REN BING , ROBERT FRANCOIS , SIMON ITAMAR
发明人： WYRICK JOHN , YOUNG RICHARD A , REN BING , ROBERT FRANCOIS , SIMON ITAMAR
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： G01N33/68 , C12Q1/6809 , C12Q2522/10 , C12Q2565/601
摘要： The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed.
摘要翻译：本发明涉及鉴定目的蛋白质结合的细胞的基因组区域（一个或多个）的方法。在本文所述的方法中，将细胞的DNA结合蛋白与细胞的基因组DNA连接（例如共价交联）。在鉴定出的基因组DNA与与基因组DNA互补的序列发生杂交的条件下，除去与DNA结合蛋白连接的基因组DNA，并与包含与细胞的基因组DNA互补的序列的DNA组合或接触。杂交区域是结合蛋白质的细胞的基因组的区域。还包括识别一组基因的方法，其中细胞周期调节器结合与基因表达相关并且识别活细胞中细胞周期转录激活子的基因组靶标。

7. 发明申请

WO2010033920A2 COMPOSITIONS AND METHODS FOR ENHANCING CELL REPROGRAMMING 审中-公开
标题翻译：增强细胞重编程的组合物和方法
公开(公告)号：WO2010033920A2
公开(公告)日：2010-03-25
申请号：PCT/US2009057692
申请日：2009-09-21
申请人： WHITEHEAD BIOMEDICAL INST , YOUNG RICHARD A , BILODEAU STEVEN , KAGEY MICHAEL
发明人： YOUNG RICHARD A , BILODEAU STEVEN , KAGEY MICHAEL
CPC分类号： C12N5/0696 , C12N2501/065
摘要： The invention provides compositions and methods of use to enhance reprogramming of mammalian cells. Certain compositions and methods of the invention are of use to enhance generation of induced pluripotent stem cells by reprogramming somatic cells. Certain compositions and methods of the invention are of use to enhance reprogramming of pluripotent mammalian cells to a differentiated cell type. Certain compositions and methods of the invention are of use to enhance reprogramming of differentiated mammalian cells of a first cell type to differentiated mammalian cells of a second differentiated cell type. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that enhances or contributes to reprogramming mammalian cells. Certain of the inventive compositions and methods relate to inhibiting histone methylation.
摘要翻译：本发明提供了用于增强哺乳动物细胞重编程的组合物和方法。本发明的某些组合物和方法可用于通过重编程体细胞来增强诱导多能干细胞的产生。本发明的某些组合物和方法可用于增强多能哺乳动物细胞重编程为分化细胞类型。本发明的某些组合物和方法可用于增强第一种细胞类型的分化哺乳动物细胞重编程为第二分化细胞类型的分化哺乳动物细胞。重编程的体细胞可用于多种目的，包括治疗或预防个体的医疗状况。本发明还提供了鉴定增强或有助于重编程哺乳动物细胞的试剂的方法。某些本发明的组合物和方法涉及抑制组蛋白甲基化。

8. 发明申请

WO2010017518A2 CONNECTING MICRORNA GENES TO THE CORE TRANSCRIPTIONAL REGULATORY CIRCUITRY OF EMBRYONIC STEM CELLS 审中-公开
标题翻译：将MICRORNA基因连接到胚胎干细胞核心转录调节回路
公开(公告)号：WO2010017518A2
公开(公告)日：2010-02-11
申请号：PCT/US2009/053214
申请日：2009-08-07
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , JAENISCH, Rudolph , YOUNG, Richard, A. , MARSON, Alexander , LEVINE, Stuart
发明人： JAENISCH, Rudolph , YOUNG, Richard, A. , MARSON, Alexander , LEVINE, Stuart
IPC分类号： C12Q1/68
CPC分类号： G06F19/18 , C12N15/1089
摘要： The present invention provides, among other things, promoters for mouse and human microRNA genes and methods of use thereof.
摘要翻译：本发明尤其提供了用于小鼠和人类微RNA基因的启动子及其使用方法。

9. 发明申请

WO2007025190A3 NOVEL METHODS FOR GENOME-WIDE LOCATION ANALYSIS 审中-公开
公开(公告)号：WO2007025190A3
公开(公告)日：2007-03-01
申请号：PCT/US2006/033325
申请日：2006-08-25
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , HARBISON, Christopher , YOUNG, Richard, A. , POKHOLOK, Dmitry, K.
发明人： HARBISON, Christopher , YOUNG, Richard, A. , POKHOLOK, Dmitry, K.
IPC分类号： C12Q1/68
摘要： The invention relates to improved methods of identifying the genomic regions to which a protein of interest binds, and in particular, to methods that use tiled arrays. The invention also provides methods of identifying the transcriptional rate of the gene in a cell. The invention also relates to methods of performing genome-wide location analysis, and ChIP-CHIP analysis, using histones and modified histones.

10. 发明申请

WO2005054461A3 TRANSCRIPTIONAL REGULATORS AND METHODS THEREOF 审中-公开
标题翻译：转录调节因子及其方法
公开(公告)号：WO2005054461A3
公开(公告)日：2005-09-09
申请号：PCT/US2004039805
申请日：2004-11-23
申请人： WHITEHEAD BIOMEDICAL INST , ODOM DUNCAN T , YOUNG RICHARD A
发明人： ODOM DUNCAN T , YOUNG RICHARD A
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6804 , C12Q1/6837 , C12Q2565/501 , C12Q2525/143
摘要： The invention relates to transcriptional regulators and related methods thereof. The invention further relates to the identification of genes regulated by transcriptional regulators, to the treatment of diseases associated with abnormal function of a transcriptional regulator and to the modulation of gene expression, including genes expressed in hepatocytes or pancreatic cells, through the modulation of transcriptional regulator activity.
摘要翻译：本发明涉及转录调节因子及其相关方法。本发明进一步涉及由转录调节因子调节的基因的鉴定，通过调节转录调节因子来治疗与转录调节因子的异常功能相关的疾病和调节基因表达，包括在肝细胞或胰腺细胞中表达的基因活动。

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