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    • 4. 发明申请
    • DISTENDER DEVICE AND METHOD FOR TREATMENT OF OBESITY AND METABOLIC AND OTHER DISEASES
    • 用于治疗肥胖和代谢疾病及其他疾病的减轻器具及方法
    • WO2008028037A2
    • 2008-03-06
    • PCT/US2007/077239
    • 2007-08-30
    • YOUNG, Andrew
    • YOUNG, Andrew
    • A61F2/04A61M29/00
    • A61F5/0076A61F2/04
    • A gastrointestinal implant device is positioned in a patient's small intestine or rectum and produces an outward force that itself produces a distension signal which is a therapeutically useful neural or humoral signal that evokes satiogenic or weight loss effects by itself. The device may advantageously be placed in the duodenum adjacent the pylorus or in the jejunum, ileum or rectum. The distension signals may amplify chemosensory or mechanosensory signals such as enteroendochne secretions within the patient. The device may be a mesh and include a low material density that allows for unrestricted chyme absorption within the small intestine and unrestricted chyme flow through the gastrointestinal system. A method includes inserting the device into the patient then either retrieving the device after treatment is complete or allowing a device formed of a biodegradable material to degrade in time after treatment is complete.
    • 胃肠道植入装置定位在患者的小肠或直肠中,并产生向外的力,其本身产生扩张信号,其是治疗上有用的神经或体液信号,其本身唤起饱腹感或体重减轻作用。 该装置可以有利地放置在邻近幽门或在空肠,回肠或直肠中的十二指肠中。 膨胀信号可以放大患者体内的化学感觉或机械感觉信号,如肠内分泌物。 该装置可以是网状物并且包括低材料密度,其允许在小肠内不受限制的食糜吸收和通过胃肠系统的不受限制的食糜流。 一种方法包括将装置插入患者,然后在治疗完成之后取回装置,或允许由可生物降解的材料形成的装置在治疗完成后在时间上降解。