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1. 发明申请

WO2018227102A1 OPTIMIZED DEFERRED LIGHTING AND FOVEAL ADAPTATION OF PARTICLES AND SIMULATION MODELS IN A FOVEATED RENDERING SYSTEM 审中-公开
公开(公告)号：WO2018227102A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036679
申请日：2018-06-08
申请人： SONY INTERACTIVE ENTERTAINMENT INC. , YOUNG, Andrew
发明人： YOUNG, Andrew , HO, Chris , STAFFORD, Jeffrey, Roger
IPC分类号： A63F13/5255 , A63F13/25 , A63F13/211 , A63F13/212 , A63F13/55 , G06T15/50
摘要： A method for implementing a graphics pipeline. The method includes determining a plurality of light sources affecting a virtual scene. Geometries of objects of an image of the scene is projected onto a plurality of pixels of a display from a first point-of-view. The pixels are partitioned into a plurality of tiles. A foveal region of highest resolution is defined for the image as displayed, wherein a first subset of pixels is assigned to the foveal region, and wherein a second subset of pixels is assigned to a peripheral region that is outside of the foveal region. A first set of light sources is determined from the plurality of light sources that affect one or more objects displayed in a first tile that is in the peripheral region. At least two light sources from the first set is clustered into a first aggregated light source affecting the first tile when rendering the image in pixels of the first tile.

2. 发明申请

WO2018227029A1 TEMPORAL SUPERSAMPLING FOR FOVEATED RENDERING SYSTEMS 审中-公开
公开(公告)号：WO2018227029A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036569
申请日：2018-06-07
申请人： SONY INTERACTIVE ENTERTAINMENT INC. , YOUNG, Andrew
发明人： YOUNG, Andrew , HO, Chris , STAFFORD, Jeffrey, Roger
IPC分类号： G06T3/40 , G06T15/50 , G06T11/00
摘要： Methods and systems are provided for using temporal supersampling to increase a displayed resolution associated with peripheral region of a foveated rendering view. A method for enabling reconstitution of higher resolution pixels from a low resolution sampling region for fragment data is provided. The method includes an operation for receiving a fragment from a rasterizer of a GPU and for applying temporal supersampling to the fragment with the low resolution sampling region over a plurality of prior frames to obtain a plurality of color values. The method further includes an operation for reconstituting a plurality of high resolution pixels in a buffer that is based on the plurality of color values obtained via the temporal supersampling. Moreover, the method includes an operation for sending the plurality of high resolution pixels for display.

3. 发明申请

WO2009067236A1 METHODS AND KITS FOR MAKING FLEXIBLE DENTAL GUARDS 审中-公开
标题翻译：用于制造柔性牙科护理的方法和工具
公开(公告)号：WO2009067236A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/012971
申请日：2008-11-20
申请人： DENTSPLY INTERNATIONAL INC. , SUN, Benjamin, Jiemin , SHAFFER, Scott, Earl , YOUNG, Andrew, Matthias
发明人： SUN, Benjamin, Jiemin , SHAFFER, Scott, Earl , YOUNG, Andrew, Matthias
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F2005/563
摘要： Dental guards (36), particularly night guards, used by patients to protect their teeth against the effects of grinding and bruxism are provided. Methods and kits for making such dental guards are also included. A light-curable polymerizable arch material is used to fabricate the dental guard. Preferably, the material contains polymerizable acrylic compounds, color-changing cure indicator, and particulate filler. The material is molded to conform to the shape of a dental arch of a patient and light-cured to form the dental guard.
摘要翻译：提供了护理人员（36名），特别是夜间护士，由患者用来保护牙齿免受研磨和磨牙症的影响。还包括制作这种护卫的方法和工具包。可光固化的可聚合拱形材料用于制造牙科防护装置。优选地，该材料包含可聚合的丙烯酸化合物，变色固化指示剂和颗粒填料。该材料被模塑以符合患者的牙弓的形状并且被光固化以形成牙科保护。

4. 发明申请

WO2008028037A2 DISTENDER DEVICE AND METHOD FOR TREATMENT OF OBESITY AND METABOLIC AND OTHER DISEASES 审中-公开
标题翻译：用于治疗肥胖和代谢疾病及其他疾病的减轻器具及方法
公开(公告)号：WO2008028037A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/077239
申请日：2007-08-30
申请人： YOUNG, Andrew
发明人： YOUNG, Andrew
IPC分类号： A61F2/04 , A61M29/00
CPC分类号： A61F5/0076 , A61F2/04
摘要： A gastrointestinal implant device is positioned in a patient's small intestine or rectum and produces an outward force that itself produces a distension signal which is a therapeutically useful neural or humoral signal that evokes satiogenic or weight loss effects by itself. The device may advantageously be placed in the duodenum adjacent the pylorus or in the jejunum, ileum or rectum. The distension signals may amplify chemosensory or mechanosensory signals such as enteroendochne secretions within the patient. The device may be a mesh and include a low material density that allows for unrestricted chyme absorption within the small intestine and unrestricted chyme flow through the gastrointestinal system. A method includes inserting the device into the patient then either retrieving the device after treatment is complete or allowing a device formed of a biodegradable material to degrade in time after treatment is complete.
摘要翻译：胃肠道植入装置定位在患者的小肠或直肠中，并产生向外的力，其本身产生扩张信号，其是治疗上有用的神经或体液信号，其本身唤起饱腹感或体重减轻作用。该装置可以有利地放置在邻近幽门或在空肠，回肠或直肠中的十二指肠中。膨胀信号可以放大患者体内的化学感觉或机械感觉信号，如肠内分泌物。该装置可以是网状物并且包括低材料密度，其允许在小肠内不受限制的食糜吸收和通过胃肠系统的不受限制的食糜流。一种方法包括将装置插入患者，然后在治疗完成之后取回装置，或允许由可生物降解的材料形成的装置在治疗完成后在时间上降解。

5. 发明申请

WO2007112069A3 ENDOTHELIN AND ENDOTHELIN RECEPTOR AGONISTS IN THE TREATMENT OF METABOLIC DISEASES 审中-公开
公开(公告)号：WO2007112069A3
公开(公告)日：2007-10-04
申请号：PCT/US2007/007376
申请日：2007-03-23
申请人： AMYLIN PHARMACEUTICALS, INC. , PITTNER, Richard , YOUNG, Andrew
发明人： PITTNER, Richard , YOUNG, Andrew
IPC分类号： A61K38/22 , A61K38/16 , A61K38/04 , A61P3/00 , A61P3/04 , A61P3/10
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an endothelin or an endothelin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

6. 发明申请

WO2007055728A1 TREATMENT OF OBESITY AND RELATED DISORDERS 审中-公开
标题翻译：治疗肥胖和相关疾病
公开(公告)号：WO2007055728A1
公开(公告)日：2007-05-18
申请号：PCT/US2006/017529
申请日：2006-05-03
申请人： AMYLIN PHARMACEUTICALS, INC. , ROTH, Jonathan , ANDERSON, Christen M. , BARON, Alain , PARKES, David , YOUNG, Andrew
发明人： ROTH, Jonathan , ANDERSON, Christen M. , BARON, Alain , PARKES, David , YOUNG, Andrew
IPC分类号： A61K45/06 , A61K38/17 , A61K38/22 , A61P3/00
CPC分类号： A61K45/06 , A61K31/137 , A61K31/454 , A61K38/22 , A61K38/2264 , A61K38/2278 , A61K2300/00
摘要： Methods for treating obesity or obesity related disorders are disclosed. These methods include the use of anti-obesity agents directed to the forebrain in combination with anti-obesity agents directed to the hindbrain.
摘要翻译：公开了治疗肥胖或肥胖相关疾病的方法。这些方法包括使用针对前脑的抗肥胖剂与针对后脑的抗肥胖剂的组合。

7. 发明申请

WO2007050628A2 BILIARY/PANCREATIC SHUNT DEVICE AND METHOD FOR TREATMENT OF METABOLIC AND OTHER DISEASES 审中-公开
标题翻译：双重/胰腺分流装置及其治疗代谢和其他疾病的方法
公开(公告)号：WO2007050628A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041521
申请日：2006-10-24
申请人： YOUNG, Andrew
发明人： YOUNG, Andrew
IPC分类号： A61M25/00
CPC分类号： A61M27/002 , A61F2002/041 , A61M27/008
摘要： Provided is a shunt device that promotes stimulation of secretion of intestinal L-cells and other enteroendocrine cell types. Enteroendocrine secretion is stimulated directly or indirectly by shunting bile and/or pancreatic secretion to segments of the gut more distal than would normally occur. The shunt device may be a flexible catheter that is impervious to such secretions, with a proximal end draining the pancreatic/bile duct, and a distal end residing distally within the lumen of the small or large intestine. The shunt may be inserted with minimally invasive techniques, such as by endoscopy.
摘要翻译：提供了促进肠L细胞和其他肠内分泌细胞类型的分泌刺激的分流装置。肠内分泌物通过将胆汁和/或胰腺分泌物直接或间接地刺激到比通常发生的更远端的肠段。分流装置可以是不透过这种分泌物的柔性导管，其中近端排出胰管/胆管，远端位于小肠或大肠的内腔内。分流可以用微创技术插入，例如通过内窥镜检查。

8. 发明申请

WO2007022503A3 ADHESIVE AND METHOD FOR BONDING ARTIFICIAL PLASTIC TEETH 审中-公开
公开(公告)号：WO2007022503A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/032580
申请日：2006-08-18
申请人： DENTSPLY INTERNATIONAL INC. , WEBER, Frederick, J. , SUN, Benjamin, Jieman , GHERGULESCU, Camilia Maria , YOUNG, Andrew, Mathias , DEEBEL, Michelle
发明人： WEBER, Frederick, J. , SUN, Benjamin, Jieman , GHERGULESCU, Camilia Maria , YOUNG, Andrew, Mathias , DEEBEL, Michelle
IPC分类号： A61K6/00 , A61K6/083
摘要： The present invention is directed toward an adhesive for and a method for bonding artificial plastic teeth to a denture base. The adhesive employs a number of adhesion promoter monomers, dimers or oligomers and a cure package, as well as methyl acetate as a solvent. The method according to the invention includes exposing a plastic tooth to the adhesive and allowing the plastic to soften (not dissolve). The adhesion promoter chains infiltrate the plastic tooth matrix, such that upon curing a secure bond is formed.

9. 发明申请

WO2007014051A2 USE OF AMYLIN AND AMYLIN AGONISTS AS CARDIOPROTECTIVE OR MYOPROTECTIVE AGENTS 审中-公开
标题翻译：使用作为心脏保护剂或维生素A的AMYLIN和AMYLIN AGONISTS
公开(公告)号：WO2007014051A2
公开(公告)日：2007-02-01
申请号：PCT/US2006028410
申请日：2006-07-21
申请人： AMYLIN PHARMACEUTICALS INC , YOUNG ANDREW A
发明人： YOUNG ANDREW A
IPC分类号： A61K38/17 , A61P9/00 , A61P21/00
CPC分类号： A61K38/22 , A61K45/06 , A61K2300/00
摘要： Methods for provided for the use of amylin and amylin agonists as a cardioprotective agent. Compounds of the invention are used to reduce, prevent, or delay the mortality and/or morbidity associated with heart disease. Compounds of the invention are useful for treating or preventing cardiac and/or cardiovascular diseases. Compounds of the invention are useful for increasing or promoting the health of the heart.
摘要翻译：用于将胰岛淀粉样多肽和胰岛淀粉样多肽激动剂用作心脏保护剂的方法。本发明的化合物用于减少，预防或延迟与心脏病相关的死亡率和/或发病率。本发明的化合物可用于治疗或预防心脏和/或心血管疾病。本发明的化合物可用于增加或促进心脏的健康。

10. 发明申请

WO2006086769A2 GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES 审中-公开
标题翻译： GIP类似物和具有可选性质的杂合多肽
公开(公告)号：WO2006086769A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/005020
申请日：2006-02-10
申请人： AMYLIN PHARMACEUTICALS, INC. , LEVY, Odile Esther , HANLEY, Michael R. , JODKA, Carolyn M. , LEWIS, Diana Y. , SOARES, Christopher J. , GHOSH, Soumitra S. , D'SOUZA, Lawrence J. , PARKES, David G. , MACK, Christine M. , SRIVASTAVA, Ved , JANSSEN, Samuel , BARON, Alain D. , YOUNG, Andrew A. , PITTNER, Richard A. , ERICKSON, Mary
发明人： LEVY, Odile Esther , HANLEY, Michael R. , JODKA, Carolyn M. , LEWIS, Diana Y. , SOARES, Christopher J. , GHOSH, Soumitra S. , D'SOUZA, Lawrence J. , PARKES, David G. , MACK, Christine M. , SRIVASTAVA, Ved , JANSSEN, Samuel , BARON, Alain D. , YOUNG, Andrew A. , PITTNER, Richard A. , ERICKSON, Mary
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , C07K14/605 , C07K2319/00
摘要： The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
摘要翻译：本发明一般涉及具有可选特性的新型GIP类似物和GIP杂合多肽，其可用作治疗和预防代谢性疾病和病症的药剂，例如可通过控制血浆葡萄糖水平，胰岛素水平和/或胰岛素分泌，正性肌力作用，分解代谢作用的减少，胃排空减慢。此类病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，危重病护理，胰岛素抵抗，肥胖和任何种类的糖尿病，包括1型，2型和妊娠糖尿病。 / p>

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