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1. 发明申请

WO2013023070A3 PLANTS WITH ALTERED GLUCURONOXYLAN METHYL TRANSFERASE ACTIVITY AND METHODS OF USE 审中-公开
标题翻译：具有改变的葡萄糖醛酸甲基转移酶活性的植物和使用方法
公开(公告)号：WO2013023070A3
公开(公告)日：2013-07-11
申请号：PCT/US2012050166
申请日：2012-08-09
申请人： UNIV GEORGIA , PENA MARIA , URBANOWICZ BREEANNA , BACKE JASON , O'NEILL MALCOM A , YORK WILLIAM S
发明人： PENA MARIA , URBANOWICZ BREEANNA , BACKE JASON , O'NEILL MALCOM A , YORK WILLIAM S
IPC分类号： A01H5/00 , C07K14/415 , C12N15/29 , C12N15/82 , D21H11/00
CPC分类号： C12N15/8246 , C12N9/1007 , D21H11/00
摘要： Provided herein are plants having altered glucuronoxylan methyl transferase (GXMT) activity, including reduced GXMT activity. In one embodiment the plant is a transgenic plant. Also provided herein are methods for using such plants, including methods for processing a part of a plant to result in a pulp, methods for hydrolyzing a pulp, and methods for producing a metabolic product. Further provided herein is plant material from a plant having altered GXMT activity, and pulp from a plant having altered GXMT activity.
摘要翻译：本文提供具有改变的葡糖醛酸甲酯转移酶（GXMT）活性的植物，包括降低的GXMT活性。在一个实施方案中，植物是转基因植物。本文还提供了使用这种植物的方法，包括用于处理植物的一部分以产生纸浆的方法，水解纸浆的方法和用于产生代谢产物的方法。本文进一步提供了具有改变的GXMT活性的植物的植物材料和来自具有改变的GXMT活性的植物的纸浆。

2. 发明申请

WO2011123837A2 METHOD AND SYSTEM USING COMPUTER SIMULATION FOR THE QUANTITATIVE ANALYSIS OF GLYCAN BIOSYNTHESIS 审中-公开
标题翻译：使用计算机模拟方法和系统进行GLYCAN生物分析的定量分析
公开(公告)号：WO2011123837A2
公开(公告)日：2011-10-06
申请号：PCT/US2011/031022
申请日：2011-04-01
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , YORK, William, S. , MILLER, John, A. , HAN, Jun , KOCHUT, Krzysztof, J. , WELLS, Lance
发明人： YORK, William, S. , MILLER, John, A. , HAN, Jun , KOCHUT, Krzysztof, J. , WELLS, Lance
IPC分类号： G01N33/60 , G06F19/28 , G06F17/10
CPC分类号： G06F19/12 , G01N33/5308 , G01N2400/00 , G01N2458/15 , G01N2560/00 , G06F19/24
摘要： This invention relates to methods and systems for the quantitative analysis of glycan biosynthesis along meta pathways, and more particularly, to using a computer simulation for comparing a computer generated spectrum to experimental data to quantitatively track the biosynthesis. Computer simulating the mass spectra of isotopic detection of aminosugars with glutamine experiments allows modeling the glycan biosynthesis over time, via changes in the 14N and 15N isotope abundance levels, so as to estimate the relative abundance of molecules involved in glycan biosynthesis, from experimental mass spectra collected from different time points. The proposed approach utilizes gradient search optimization to maximize the coefficient of determination between the experimental spectrum and the simulated spectrum. These relative abundances are then fed into a pathway simulation model to analyze glycan biosynthesis. Using a computer for simulating a mass spectrum allows reconfirming the identification, quantifying the isotopic configurations and obtaining the relative abundance of each as samples are taken at periodic intervals. This information can then be organized into time-series data allowing tracking the changes in abundance levels over time. These changes can then be used to analyze the data properties of glycan biosynthesis.
摘要翻译：本发明涉及用于沿着元途径定量分析聚糖生物合成的方法和系统，更具体地说，涉及使用计算机模拟来比较计算机产生的光谱与实验数据以定量跟踪生物合成。使用谷氨酰胺实验模拟氨基糖同位素检测质谱的计算机模拟聚糖生物合成随着时间的推移，通过14N和15N同位素丰度水平的变化，从实验质谱估计参与聚糖生物合成的分子的相对丰度从不同的时间点收集。所提出的方法利用梯度搜索优化来最大化实验光谱和模拟光谱之间的确定系数。然后将这些相对丰度加入到通路模拟模型中以分析聚糖生物合成。使用计算机模拟质谱允许重新确认识别，量化同位素构型，并获得每个样本的相对丰度，因为采样周期性间隔。然后可以将该信息组织成时间序列数据，从而跟踪随时间的丰度水平的变化。然后可以使用这些变化来分析聚糖生物合成的数据性质。

3. 发明申请

WO2009058307A1 IN VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS 审中-公开
标题翻译：用于定量GLYCOMICS的VIVO同位素标记方法
公开(公告)号：WO2009058307A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/012283
申请日：2008-10-29
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , WELLS, Robert, Lance , ORLANDO, Ronald, C. , DALTON, Stephen , MOREMEN, Kelley, W. , PIERCE, J., Michael , ATWOOD, James, A. , TIEMEYER, Michael , YORK, William, S.
发明人： WELLS, Robert, Lance , ORLANDO, Ronald, C. , DALTON, Stephen , MOREMEN, Kelley, W. , PIERCE, J., Michael , ATWOOD, James, A. , TIEMEYER, Michael , YORK, William, S.
IPC分类号： G01N33/534 , G01N33/48 , G01N33/68 , G01N33/532
CPC分类号： G01N33/502 , G01N33/6848 , G01N2400/00 , G01N2400/12 , G01N2400/38 , G01N2458/15
摘要： The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
摘要翻译：本发明涉及同位素标记聚糖并促进生物细胞的糖组成的高通量定量/比较分析方法。该方法特别适用于鉴定分化细胞及其糖基特征，分化条件，疾病和/或治疗进展，诊断疾病状态，确定药物活性，建立制造效率和确定细胞中聚糖的半衰期。

4. 发明申请

WO2013023070A2 PLANTS WITH ALTERED GLUCURONOXYLAN METHYL TRANSFERASE ACTIVITY AND METHODS OF USE 审中-公开
标题翻译：具有改变的葡糖醛酸基转移酶活性的植物和使用方法
公开(公告)号：WO2013023070A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/050166
申请日：2012-08-09
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , PENA, Maria , URBANOWICZ, Breeanna , BACKE, Jason , O'NEILL, Malcom A. , YORK, WIlliam S.
发明人： PENA, Maria , URBANOWICZ, Breeanna , BACKE, Jason , O'NEILL, Malcom A. , YORK, WIlliam S.
IPC分类号： A01H5/00 , C12N15/82 , C12N15/29 , C07K14/415 , D21H11/00 , C12S3/08
CPC分类号： C12N15/8246 , C12N9/1007 , D21H11/00
摘要： Provided herein are plants having altered glucuronoxylan methyl transferase (GXMT) activity, including reduced GXMT activity. In one embodiment the plant is a transgenic plant. Also provided herein are methods for using such plants, including methods for processing a part of a plant to result in a pulp, methods for hydrolyzing a pulp, and methods for producing a metabolic product. Further provided herein is plant material from a plant having altered GXMT activity, and pulp from a plant having altered GXMT activity.
摘要翻译：本文提供具有改变的葡糖醛酸木聚糖甲基转移酶（GXMT）活性，包括降低的GXMT活性的植物。在一个实施方案中，植物是转基因植物。本文还提供了使用这种植物的方法，包括加工一部分植物以产生果肉的方法，水解果肉的方法以及产生代谢产物的方法。本文进一步提供了来自具有改变的GXMT活性的植物和来自具有改变的GXMT活性的植物的纸浆的植物材料。

5. 发明申请

WO2011123837A3 METHOD AND SYSTEM USING COMPUTER SIMULATION FOR THE QUANTITATIVE ANALYSIS OF GLYCAN BIOSYNTHESIS 审中-公开
标题翻译：使用计算机模拟方法和系统进行GLYCAN生物分析的定量分析
公开(公告)号：WO2011123837A3
公开(公告)日：2012-04-26
申请号：PCT/US2011031022
申请日：2011-04-01
申请人： UNIV GEORGIA , YORK WILLIAM S , MILLER JOHN A , HAN JUN , KOCHUT KRZYSZTOF J , WELLS LANCE
发明人： YORK WILLIAM S , MILLER JOHN A , HAN JUN , KOCHUT KRZYSZTOF J , WELLS LANCE
IPC分类号： G01N33/60 , G06F17/10 , G06F19/28
CPC分类号： G06F19/12 , G01N33/5308 , G01N2400/00 , G01N2458/15 , G01N2560/00 , G06F19/24
摘要： This invention relates to methods and systems for the quantitative analysis of glycan biosynthesis along meta pathways, and more particularly, to using a computer simulation for comparing a computer generated spectrum to experimental data to quantitatively track the biosynthesis. Computer simulating the mass spectra of isotopic detection of aminosugars with glutamine experiments allows modeling the glycan biosynthesis over time, via changes in the 14N and 15N isotope abundance levels, so as to estimate the relative abundance of molecules involved in glycan biosynthesis, from experimental mass spectra collected from different time points. The proposed approach utilizes gradient search optimization to maximize the coefficient of determination between the experimental spectrum and the simulated spectrum. These relative abundances are then fed into a pathway simulation model to analyze glycan biosynthesis. Using a computer for simulating a mass spectrum allows reconfirming the identification, quantifying the isotopic configurations and obtaining the relative abundance of each as samples are taken at periodic intervals. This information can then be organized into time-series data allowing tracking the changes in abundance levels over time. These changes can then be used to analyze the data properties of glycan biosynthesis.
摘要翻译：本发明涉及用于沿着元途径定量分析聚糖生物合成的方法和系统，更具体地，涉及使用计算机模拟来比较计算机产生的光谱与实验数据以定量跟踪生物合成。使用谷氨酰胺实验模拟氨基糖同位素检测质谱的计算机模拟聚糖生物合成随着时间的推移，通过14N和15N同位素丰度水平的变化，从实验质谱估计参与聚糖生物合成的分子的相对丰度从不同的时间点收集。所提出的方法利用梯度搜索优化来最大化实验光谱和模拟光谱之间的确定系数。然后将这些相对丰度加入到通路模拟模型中以分析聚糖生物合成。使用计算机模拟质谱允许重新确认识别，定量同位素构型，并获得每个样本的相对丰度，因为采样周期性间隔。然后可以将该信息组织成时间序列数据，从而跟踪随时间的丰富程度的变化。然后可以使用这些变化来分析聚糖生物合成的数据性质。

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