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1. 发明申请

WO2023035005A2 DUAL INHIBITOR OF HISTONE DEACETYLASE 6 AND HEAT SHOCK PROTEIN 90 审中-公开
公开(公告)号：WO2023035005A2
公开(公告)日：2023-03-09
申请号：PCT/US2022/075962
申请日：2022-09-06
申请人： TAIPEI MEDICAL UNIVERSITY , YEN, Yun
发明人： CHUANG, Kuo-Hsiang , LIOU, Jing-Ping
IPC分类号： C07C39/04 , C07C259/06 , C07C259/04 , A61P35/00 , C07C259/10 , C07D295/192
摘要： The present invention provides a dual inhibitor that inhibits histone deacetylase 6 (HDAC6) and heat shock protein 90 (HSP90) for amelioration and/or treatment of tumors through removal of immune suppression from tumor microenvironments or stimulation of an immune system against tumors. Pharmaceutical compositions comprising the dual inhibitor and uses thereof are also provided.

2. 发明申请

WO2017074317A1 INDOLINE DERIVATIVES FOR TREATMENT AND/OR PREVENTION OF FIBROSIS DISEASES 审中-公开
标题翻译：吲哚啉衍生物治疗和/或预防纤维化疾病
公开(公告)号：WO2017074317A1
公开(公告)日：2017-05-04
申请号：PCT/US2015/057600
申请日：2015-10-27
申请人： TAIPEI MEDICAL UNIVERSITY , YEN, Yun
发明人： LIN, Chien, Huang , LIOU, Jing, Ping , PAN, Shiou, Lin , TENG, Che-Ming
IPC分类号： C07D209/08 , A61K31/404
CPC分类号： A61K31/404 , A61K31/192 , A61K31/4412 , C07D209/08 , A61K2300/00
摘要： The invention relates to the use of Indoline derivatives, and their effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.
摘要翻译：本发明涉及吲哚啉衍生物及其在预防和/或治疗纤维化疾病中的有效剂量的用途。该化合物可以有效地预防和/或治疗纤维化疾病而没有细胞毒性或遗传毒性。

3. 发明申请

WO2011034954A1 TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：WO2011034954A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/048973
申请日：2010-09-15
申请人： CERULEAN PHARMA INC. , CALANDO PHARMACEUTICALS, INC. , CITY OF HOPE , YEN, Yun , SCHLUEP, Thomas , RYAN, John
发明人： YEN, Yun , SCHLUEP, Thomas , RYAN, John
IPC分类号： C07D471/00
CPC分类号： A61K47/6851 , A61K39/3955 , A61K45/06 , A61K47/61 , C07D491/22
摘要： Provided are methods relating to compositions that include a CDP- topoisomerase inhibitor, e.g., a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.
摘要翻译：提供了涉及包括CDP-拓扑异构酶抑制剂，例如CDP-喜树碱或喜树碱衍生物缀合物例如CRLX101的组合物的方法。

4. 发明申请

WO2010083203A3 NON-EMBRYONIC STEM CELLS AND USES THEREOF 审中-公开
标题翻译：非胚胎干细胞及其用途
公开(公告)号：WO2010083203A3
公开(公告)日：2010-11-25
申请号：PCT/US2010020884
申请日：2010-01-13
申请人： STEMBIOS TECHNOLOGIES INC , WANG JAMES , YEN YUN
发明人： WANG JAMES , YEN YUN
IPC分类号： C12N5/074 , A61K35/12 , A61P25/16 , A61P35/00 , A61P37/00 , C12N5/02 , C12N15/12
CPC分类号： A61K35/545 , C12N5/0607 , G01N33/5073 , G01N2333/4712 , G01N2333/90203
摘要： Disclosed are novel stem cells of non-embryonic origins and the uses thereof.
摘要翻译：公开了非胚胎起源的新型干细胞及其用途。

5. 发明申请

WO2010099044A2 TREATMENT OF IMMUNOSUPPRESSION-RELATED DISORDERS 审中-公开
标题翻译：治疗免疫抑制相关疾病
公开(公告)号：WO2010099044A2
公开(公告)日：2010-09-02
申请号：PCT/US2010024735
申请日：2010-02-19
申请人： STEMBIOS TECHNOLOGIES INC , WANG JAMES , CHANG LUFEN , YEN YUN
发明人： WANG JAMES , CHANG LUFEN , YEN YUN
IPC分类号： A61K35/12 , A61P29/00 , A61P37/00
CPC分类号： A61K35/545 , A61K35/15 , C12N5/0607 , C12N5/0634
摘要： Disclosed are methods of using blastomere-like stem cells to treat a number of immunodeficiency disorders.
摘要翻译：公开了使用卵裂球样干细胞来治疗许多免疫缺陷障碍的方法。

6. 发明申请

WO2010083203A2 NON-EMBRYONIC STEM CELLS AND USES THEREOF 审中-公开
标题翻译：非胚胎干细胞及其用途
公开(公告)号：WO2010083203A2
公开(公告)日：2010-07-22
申请号：PCT/US2010/020884
申请日：2010-01-13
申请人： STEMBIOS TECHNOLOGIES, INC. , WANG, James , YEN, Yun
发明人： WANG, James , YEN, Yun
IPC分类号： C12N5/074 , C12N5/02 , C12N15/12 , A61K35/12 , A61P25/16 , A61P35/00 , A61P37/00
CPC分类号： A61K35/545 , C12N5/0607 , G01N33/5073 , G01N2333/4712 , G01N2333/90203
摘要： Disclosed are novel stem cells of non-embryonic origins and the uses thereof.
摘要翻译：公开了非胚胎来源的新型干细胞及其用途。

7. 发明申请

WO2005094485A3 DRUG SCREENING 审中-公开
标题翻译：药物筛选
公开(公告)号：WO2005094485A3
公开(公告)日：2007-03-01
申请号：PCT/US2005009639
申请日：2005-03-23
申请人： YEN YUN
发明人： YEN YUN
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/02 , C12N9/06 , C12N15/09
CPC分类号： C12N9/0093 , C12Q1/6886 , C12Q2600/136
摘要： An isolated polypeptide containing (i) an immunogenic fragment of an RNR subunit (SEQ ID NO: 1 or 15) spanning Y162 or Y369 of SEQ ID NO: 1, or Y124 or Y331 of SEQ ID NO: 15, or (ii) a mutant fragment of SEQ ID NO: 1 or 15 in which at least one of the aforementioned Y residues is replaced by a non-tyrosine residue. Disclosed are related nucleic acids, expression vectors, host cells, reconstituted RNR enzymes, preparation methods, and compound screening methods. Also disclosed are RNAi agents for inhibiting expression of a gene encoding SEQ ID NO: 1 or 15. Within the scope of this invention are methods of treating a cell proliferation-associated disorder.
摘要翻译：一种分离的多肽，其包含（i）跨越SEQ ID NO：1的Y162或Y369或SEQ ID NO：15的Y124或Y331的RNR亚基（SEQ ID NO：1或15）的免疫原性片段，或（ii） SEQ ID NO：1或15的突变体片段，其中至少一个上述Y残基被非酪氨酸残基替代。公开了相关的核酸，表达载体，宿主细胞，重建的RNR酶，制备方法和化合物筛选方法。还公开了用于抑制编码SEQ ID NO：1或15的基因表达的RNAi剂。在本发明的范围内，是治疗细胞增殖相关病症的方法。

8. 发明申请

WO2005094485A2 DRUG SCREENING 审中-公开
标题翻译：药物筛选
公开(公告)号：WO2005094485A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/009639
申请日：2005-03-23
申请人： YEN, Yun
发明人： YEN, Yun
IPC分类号： C07H21/04 , C12N9/02 , C12N9/06 , C12N15/09 , C12Q1/68
CPC分类号： C12N9/0093 , C12Q1/6886 , C12Q2600/136
摘要： An isolated polypeptide containing (i) an immunogenic fragment of an RNR subunit (SEQ ID NO: 1 or 15) spanning Y162 or Y369 of SEQ ID NO: 1, or Y124 or Y331 of SEQ ID NO: 15, or (ii) a mutant fragment of SEQ ID NO: 1 or 15 in which at least one of the aforementioned Y residues is replaced by a non-tyrosine residue. Disclosed are related nucleic acids, expression vectors, host cells, reconstituted RNR enzymes, preparation methods, and compound screening methods. Also disclosed are RNAi agents for inhibiting expression of a gene encoding SEQ ID NO: 1 or 15. Within the scope of this invention are methods of treating a cell proliferation-associated disorder.
摘要翻译：一种分离的多肽，其包含（i）跨越SEQ ID NO：1的Y162或Y369或SEQ ID NO：15的Y124或Y331的RNR亚基（SEQ ID NO：1或15）的免疫原性片段，或（ii） SEQ ID NO：1或15的突变体片段，其中至少一个上述Y残基被非酪氨酸残基替代。公开了相关的核酸，表达载体，宿主细胞，重建的RNR酶，制备方法和化合物筛选方法。还公开了用于抑制编码SEQ ID NO：1或15的基因表达的RNAi剂。在本发明的范围内，是治疗细胞增殖相关病症的方法。

9. 发明申请

WO2004016744A3 TREATMENT OF LIVER DESEASES 审中-公开
标题翻译：治疗肝病
公开(公告)号：WO2004016744A3
公开(公告)日：2004-09-23
申请号：PCT/US0325232
申请日：2003-08-12
申请人： YEN YUN
发明人： YEN YUN
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12Q2600/158
摘要： A method of determining whether a subject is suffering from or at risk for developing a liver disease. The method includes providing a sample from the subject and determining a GADD45beta expression level or a GADD45beta activity level in the sample. If the GADD45beta expression level or the GADD45beta activity level in the sample is lower than that in a sample from a normal subject, it indicates that the subject is suffering from or at risk for developing a liver disease. Also disclosed are a method of identifying a compound for treating a liver disease and a method of treating such a disease.
摘要翻译：确定受试者是否患有或有发生肝病风险的方法。该方法包括从受试者提供样品并确定样品中的GADD45β表达水平或GADD45β活性水平。如果样品中的GADD45beta表达水平或GADD45β活性水平低于正常受试者的样品中的GADD45beta活性水平，则表明该受试者患有发生肝脏疾病或处于发展中的风险。还公开了鉴定用于治疗肝脏疾病的化合物的方法和治疗这种疾病的方法。

10. 发明申请

WO2017087695A1 AMINONAPHTHOQUINONE COMPOUNDS FOR TREATMENT AND/OR PREVENTION OF FIBROSIS DISEASES 审中-公开
标题翻译：用于治疗和/或预防纤维化疾病的氨基H QU酮化合物
公开(公告)号：WO2017087695A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062568
申请日：2016-11-17
申请人： TAIPEI MEDICAL UNIVERSITY , YEN, Yun
发明人： YEN, Yun , LIOU, Jing-ping , LIN, Chien, Huang
IPC分类号： A61K31/4409 , A61K31/122 , A61K31/166 , A61K31/426 , A61K9/20 , A61K9/48
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/20 , A61K9/48 , A61K31/122 , A61K31/166 , A61K31/426 , A61K31/4409 , C07C15/00
摘要： The present disclosure relates to the use of a compound of Formula (I) as described herein and its effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.
摘要翻译：本公开涉及如本文所述的式（I）化合物及其有效剂量在预防和/或治疗纤维化疾病中的用途。该化合物可以有效地预防和/或治疗纤维化疾病而没有细胞毒性或遗传毒性。

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