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1. 发明申请

WO2012131109A2 PEPTIDES AND PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT BY NASAL ADMINISTRATION OF PATIENTS SUFFERING FROM ANXIETY AND SLEEP DISORDERS 审中-公开
标题翻译：鼻炎和药物组合物用于治疗来自放射性疾病和睡眠障碍患者的NASAL治疗
公开(公告)号：WO2012131109A2
公开(公告)日：2012-10-04
申请号：PCT/EP2012/056002
申请日：2012-04-02
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFT E.V. , YEN, Yi-Chun , STEIGER, Axel , HOLSBOER, Florian , LANDGRAF, Rainer , IONESCU, Irina, Alexandra , SCHMIDT, Ulrike
发明人： YEN, Yi-Chun , STEIGER, Axel , HOLSBOER, Florian , LANDGRAF, Rainer , IONESCU, Irina, Alexandra , SCHMIDT, Ulrike
IPC分类号： A61K38/00
CPC分类号： A61K38/2271 , A61K9/0043 , A61K38/10 , A61K38/22 , C07K14/57545
摘要： The present invention provides peptides for use in a medicament which is administered nasally, wherein the peptide is an agonist of neuropeptide S receptor (NPSR), of the receptor TGR23 and/or of vasopressin receptor-related receptor 1 (VRR1) or for use in the treatment of a patient by causing, promoting or increasing relieve or healing of phobic anxiety, avoidance anxiety, dissociative anxiety such as flashbacks, depersonalisation, derealisation, intrusions, vegetative symptoms related to anxiety symptoms, especially in panic attacks, in posttraumatic stress disorder, in generalised anxiety disorder and in anxiety accompanying depressive, or psychotic episodes, arousal, awakening, alertness, activity, spontaneous movement, an anxiolytic effect or a combination thereof in the patient, wherein the peptide is administered nasally or for use in the prophylaxis and/or treatment of an anxiety or sleep disorder, especially in any type of hypersomnia like idiopathic hypersomnia, wherein the peptide is administered nasally. Further provided are pharmaceutical compositions for nasal administration comprising at least one of said peptides, uses of said peptide or said pharmaceutical composition. The invention also provides a method for identifying target neurons of a peptide in an animal, wherein the peptide is administered nasally.
摘要翻译：本发明提供用于鼻内给药的药物中的肽，其中肽是受体TGR23和/或加压素受体相关受体1（VRR1）的神经肽S受体（NPSR）的激动剂或用于通过引发，促进或增加恐惧焦虑的缓解或愈合，避免焦虑，离散焦虑如反光，人格解体，脱发，入侵，与焦虑症状相关的营养症状，特别是恐慌发作，创伤后应激障碍，广泛性焦虑症和伴随着患者的抑郁或精神病发作，觉醒，觉醒，警觉，活动，自发运动，抗焦虑作用或其组合的焦虑，其中所述肽经鼻给药或用于预防和/ 或治疗焦虑或睡眠障碍，特别是在任何类型的特发性睡眠过度睡眠中的睡眠过多，其中p 耳鼻喉管还提供了用于鼻腔给药的药物组合物，其包含至少一种所述肽，所述肽或所述药物组合物的用途。本发明还提供了一种用于鉴定动物中肽的靶神经元的方法，其中所述肽经鼻施用。

2. 发明申请

WO2012131109A3 PEPTIDES AND PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT BY NASAL ADMINISTRATION OF PATIENTS SUFFERING FROM ANXIETY AND SLEEP DISORDERS 审中-公开
标题翻译：鼻炎和药物组合物用于治疗由放射性疾病和睡眠障碍患者的NASAL治疗
公开(公告)号：WO2012131109A3
公开(公告)日：2013-03-28
申请号：PCT/EP2012056002
申请日：2012-04-02
申请人： MAX PLANCK GESELLSCHAFT , YEN YI-CHUN , STEIGER AXEL , HOLSBOER FLORIAN , LANDGRAF RAINER , IONESCU IRINA ALEXANDRA , SCHMIDT ULRIKE
发明人： YEN YI-CHUN , STEIGER AXEL , HOLSBOER FLORIAN , LANDGRAF RAINER , IONESCU IRINA ALEXANDRA , SCHMIDT ULRIKE
IPC分类号： A61K38/00 , A61P25/22
CPC分类号： A61K38/2271 , A61K9/0043 , A61K38/10 , A61K38/22 , C07K14/57545
摘要： The present invention provides peptides for use in a medicament which is administered nasally, wherein the peptide is an agonist of neuropeptide S receptor (NPSR), of the receptor TGR23 and/or of vasopressin receptor-related receptor 1 (VRR1) or for use in the treatment of a patient by causing, promoting or increasing relieve or healing of phobic anxiety, avoidance anxiety, dissociative anxiety such as flashbacks, depersonalisation, derealisation, intrusions, vegetative symptoms related to anxiety symptoms, especially in panic attacks, in posttraumatic stress disorder, in generalised anxiety disorder and in anxiety accompanying depressive, or psychotic episodes, arousal, awakening, alertness, activity, spontaneous movement, an anxiolytic effect or a combination thereof in the patient, wherein the peptide is administered nasally or for use in the prophylaxis and/or treatment of an anxiety or sleep disorder, especially in any type of hypersomnia like idiopathic hypersomnia, wherein the peptide is administered nasally. Further provided are pharmaceutical compositions for nasal administration comprising at least one of said peptides, uses of said peptide or said pharmaceutical composition. The invention also provides a method for identifying target neurons of a peptide in an animal, wherein the peptide is administered nasally.
摘要翻译：本发明提供用于鼻内给药的药物中的肽，其中肽是受体TGR23和/或加压素受体相关受体1（VRR1）的神经肽S受体（NPSR）的激动剂或用于通过引发，促进或增加恐惧焦虑的缓解或愈合，避免焦虑，离散焦虑如反光，人格解体，脱发，入侵，与焦虑症状相关的营养症状，特别是恐慌发作，创伤后应激障碍，广泛性焦虑症和伴随着患者的抑郁或精神病发作，觉醒，觉醒，警觉，活动，自发运动，抗焦虑作用或其组合的焦虑，其中所述肽经鼻给药或用于预防和/ 或治疗焦虑或睡眠障碍，特别是在任何类型的特发性睡眠过度睡眠中的睡眠过多，其中p 耳鼻喉管还提供了用于鼻腔给药的药物组合物，其包含至少一种所述肽，所述肽或所述药物组合物的用途。本发明还提供了一种用于鉴定动物中肽的靶神经元的方法，其中所述肽经鼻施用。

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