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1. 发明申请

WO2017161046A1 NUCLEIC ACID AMPLIFICATION AND DETECTION DEVICES, SYSTEMS AND METHODS 审中-公开
标题翻译：核酸扩增和检测装置，系统和方法
公开(公告)号：WO2017161046A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022588
申请日：2017-03-15
申请人： ABBOTT LABORATORIES , YEATON, Eric D. , GIRAUD, Michael , PATNO, Timothy J. , ATTARWALLA, Ali , KHAN, Dean
发明人： YEATON, Eric D. , GIRAUD, Michael , PATNO, Timothy J. , ATTARWALLA, Ali , KHAN, Dean , NANA, Sonal Sadaria , SHAIN, Eric B. , HAZELL, Michael S. , HAYES, Matthew J.
IPC分类号： C12M1/34 , G01N33/48
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/0609 , B01L2300/0645 , B01L2300/0654 , B01L2300/12 , B01L2300/16 , B01L2300/1822 , B01L2300/1894
摘要： The instant disclosure provides nucleic acid amplification systems and multi-reaction analysis systems useful in the efficient processing of samples, including clinical samples. Integrated systems that include nucleic acid amplification devices functionally combined with multi-reaction analysis systems are also included. Also provided are methods for monitoring multiple concurrent nucleic acid amplification reactions that include the use of devices and systems described herein.
摘要翻译：本公开提供用于有效处理样品（包括临床样品）的核酸扩增系统和多反应分析系统。包括功能上与多反应分析系统结合的核酸扩增装置的集成系统也包括在内。还提供了用于监测多个同时的核酸扩增反应的方法，其包括使用本文所述的装置和系统。

2. 发明申请

WO2013116204A3 REAGENT BOTTLE 审中-公开
标题翻译：试剂瓶
公开(公告)号：WO2013116204A3
公开(公告)日：2015-05-14
申请号：PCT/US2013023611
申请日：2013-01-29
申请人： THERMO SHANDON LTD , YEATON ERIC D , NOLET CHRISTOPHER J
发明人： YEATON ERIC D , NOLET CHRISTOPHER J
IPC分类号： B65D39/00
CPC分类号： B01L3/52 , B01L3/0275 , B01L2200/025 , B01L2200/026 , B01L2300/049 , G01N1/31 , G01N35/1002
摘要： A reagent bottle includes a reservoir adapted to contain a reagent, a pipette tip defining a fluid channel extending into the reservoir and a resilient seal fixedly disposed within the reservoir and surrounding the pipette tip, the seal functioning to reduce reagent loss when the pipette tip is withdrawn from the reagent bottle. The fluid channel of the pipette tip is defined by the pipette tip being in direct fluid communication, or interrupted fluid communication, with the exterior of the reagent bottle, the pipette tip being directly or indirectly engageable through a fluid-tight fitting with a pipette. A base member of the reagent bottle is adapted for selective engagement with one or more rotation pin and has an indexing feature for properly aligning the reagent bottle within an automated system. The base member adapted for selective engagement with one or more spring pins for raising and lowering the reagent bottle.
摘要翻译：试剂瓶包括适于容纳试剂的储存器，限定延伸到储存器中的流体通道的移液管尖端和固定地设置在储存器内并围绕移液管末端的弹性密封件，该密封件用于当移液管吸头为从试剂瓶中取出。移液管尖端的流体通道由移液管尖端与试剂瓶的外部直接流体连通或中断的流体连通限定，移液管末端通过与移液管的流体密封配件直接或间接接合。试剂瓶的基底构件适于与一个或多个旋转销的选择性接合，并且具有用于在自动化系统内适当地对准试剂瓶的分度特征。基座构件适于与用于升高和降低试剂瓶的一个或多个弹簧销选择性地接合。

3. 发明申请

WO2013116207A2 SLIDE POCKET 审中-公开
标题翻译：幻灯片
公开(公告)号：WO2013116207A2
公开(公告)日：2013-08-08
申请号：PCT/US2013023615
申请日：2013-01-29
申请人： THERMO SHANDON LTD , DOWLING JAMES L , NOLET CHRISTOPHER J , VON BUEREN ERICO , YEATON ERIC D
发明人： DOWLING JAMES L , NOLET CHRISTOPHER J , VON BUEREN ERICO , YEATON ERIC D
IPC分类号： G01N1/31
CPC分类号： G01N1/31 , G01N1/312
摘要： A slide pocket includes a first shell portion having a slide well with a depth suitable for accepting a sample-containing portion of a slide thereby positioning a sample affixed to the sample-containing portion of the slide within the slide well. The slide well has a plurality of beveled interior walls, the beveled portions functioning to prevent the sample affixed to the sample-containing portion of the slide from contacting any surface of the slide well during insertion. The slide pocket has a second shell portion, mateable in fluid tight engagement with the first shell portion. The second shell portion has a slide well. The first and second shell portions engage to define a single continuous slide chamber, a fluid input channel and fluid input port in communication with the single continuous slide chamber, and a fluid output channel and fluid output port in communication with the single continuous slide chamber.
摘要翻译：滑动袋包括具有滑动井的第一壳体部分，其具有适于接收滑动件的样品容纳部分的深度，从而将固定在载玻片上的载玻片的样品容纳部分的样品定位。滑动井具有多个倾斜的内壁，所述斜面部分用于防止在插入期间固定到载玻片的样品容纳部分的样品接触滑动孔的任何表面。滑动口袋具有第二壳体部分，可与第一壳体部分流体密封地接合。第二壳体部分具有滑动孔。第一和第二壳体部分接合以限定与单个连续滑动室连通的单个连续滑动室，流体输入通道和流体输入端口，以及与单个连续滑动室连通的流体输出通道和流体输出端口。

4. 发明申请

WO2013016035A1 SAMPLE TRANSPORT SYSTEMS AND METHODS 审中-公开
标题翻译：样本运输系统和方法
公开(公告)号：WO2013016035A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/046726
申请日：2012-07-13
申请人： CONSTITUTION MEDICAL, INC. , MCKEEN, Brian, J. , YEATON, Eric D. , DOWLING, James L.
发明人： MCKEEN, Brian, J. , YEATON, Eric D. , DOWLING, James L.
IPC分类号： G01N1/31 , G01N35/00
CPC分类号： G01N35/04 , G01N1/31 , G01N35/00029 , G01N35/0099 , G01N35/02 , G01N2035/00039 , G01N2035/041
摘要： Sample transport systems are described that move a sample carrier from one station to a next station in a sample processing systems. The systems include: a translating member; two or more sample carrier retaining devices attached to the translating member, wherein each of the two or more sample carrier retaining devices can include a retainer portion to temporarily retain one or more sample carriers; and a movement mechanism to move the translating member and the attached sample carrier retaining devices between a first position and a second position; wherein the sample carrier retaining devices are controlled and moved simultaneously to retain a sample carrier when the translating member reaches the first position and to release a sample carrier when the translating member reaches the second position to successively advance sample carriers in the sample processing systems.
摘要翻译：描述了样本传送系统，其将样本载体从样本处理系统中的一个站移动到下一个站。系统包括：翻译成员; 两个或更多个样品载体保持装置附接到平移构件，其中两个或更多个样品载体保持装置中的每一个可以包括暂时保持一个或多个样品载体的保持器部分; 以及移动机构，用于在第一位置和第二位置之间移动所述平移构件和附接的样品载体保持装置; 其中当所述平移构件到达所述第一位置时，所述样品载体保持装置被同时控制和移动以保持样品载体，并且当所述平移构件到达所述第二位置时释放样品载体，以连续地提取所述样品处理系统中的样品载体。

5. 发明申请

WO2013016034A1 FLUID SAMPLE PREPARATION SYSTEMS AND METHODS 审中-公开
标题翻译：流体样品制备系统和方法
公开(公告)号：WO2013016034A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/046713
申请日：2012-07-13
申请人： CONSTITUTION MEDICAL, INC. , MCKEEN, Brian J. , YEATON, Eric D. , DOWLING, James L.
发明人： MCKEEN, Brian J. , YEATON, Eric D. , DOWLING, James L.
IPC分类号： G01N1/31 , G01N35/00 , G01N35/10
CPC分类号： G01N1/312 , G01N1/30 , G01N35/00029 , G01N35/0099 , G01N35/10 , G01N35/1004
摘要： Sample application systems can include an extraction mechanism to remove a sample from sample containers, a sample vessel disposed on a deployment mechanism, where the deployment mechanism is arranged to move the sample vessel to receive a sample, an extraction mechanism washing station to wash the extraction mechanism, a sample applicator to remove a portion of the sample in the sample vessel and apply it onto a sample carrier, where the deployment mechanism can move the sample vessel to a sample application position, a sample vessel washing station to wash the sample vessel, where the deployment mechanism can move the sample vessel to the sample vessel washing station, a sample applicator washing station to wash the sample applicator after the sample has been dispensed onto the sample carrier, and a fluid control system to control flow of a fluid provided to the extraction mechanism and the sample applicator.
摘要翻译：样品应用系统可以包括从样品容器中除去样品的提取机构，设置在展开机构上的样品容器，其中布置机构被布置成移动样品容器以接收样品，提取机构洗涤站以洗涤提取机构，样品施加器以移除样品容器中的一部分样品并将其施加到样品载体上，其中所述展开机构可将样品容器移动到样品施加位置，样品容器清洗站以洗涤样品容器，其中展开机构可以将样品容器移动到样品容器清洗站;样品施加器清洗站，用于在将样品分配到样品载体上之后洗涤样品施加器;以及流体控制系统，用于控制提供给提取机构和样品施加器。

6. 发明申请

WO2012064873A1 AUTOMATED SYSTEMS AND METHODS FOR PREPARING BIOLOGICAL SPECIMENS FOR EXAMINATION 审中-公开
标题翻译：自动化系统和准备生物样本检验的方法
公开(公告)号：WO2012064873A1
公开(公告)日：2012-05-18
申请号：PCT/US2011/060028
申请日：2011-11-09
申请人： CONSTITUTION MEDICAL, INC. , LAPEN, Daniel , ZAHNISER, David , LICARI, Mark , MCKEEN, Brian J. , YEATON, Eric D. , POOLE, Dennis
发明人： LAPEN, Daniel , ZAHNISER, David , LICARI, Mark , MCKEEN, Brian J. , YEATON, Eric D. , POOLE, Dennis
IPC分类号： G01N1/31 , G01N35/00 , G01N35/10
CPC分类号： G01N1/312 , G01N1/30 , G01N35/00029 , G01N35/0099 , G01N2035/00079 , G01N2035/00138 , G01N2035/00524 , G01N2035/1037
摘要： The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation cycles for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining biological specimens.
摘要翻译：本文公开的系统和方法允许自动化制备生物标本进行检查。所公开的系统和方法使用最少量的流体提供快速，有效和高度均匀的样品处理。所述方法至少包括用于将生物样本固定到诸如显微镜载玻片的基底的固定阶段，用于染色样本的染色阶段和用于冲洗样本的漂洗阶段。定影，染色和漂洗阶段中的一种或多种包括一个或多个搅拌循环，用于均匀均匀地分布试剂。这些系统可以作为一个独立设备来实现，也可以作为一个更大的系统中用于准备和检查生物标本的组件。

7. 发明申请

WO2017161056A1 SAMPLE PREPARATION CARTRIDGES AND METHODS FOR USING SAME 审中-公开
标题翻译：样品制备盒和使用它的方法
公开(公告)号：WO2017161056A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022601
申请日：2017-03-15
申请人： ABBOTT LABORATORIES , YEATON, Eric D.
发明人： YEATON, Eric D. , HENNING, Timothy P. , SKINNER, Joseph P. , KECK, Jody L. , DUNN, Chadwick M. , ADDISON II, Wesley W. , PATNO, Timothy J. , NANA, Sonal Sadaria , TALMER, Mark , LINES, Austin , HARRIS, Daniel J.
IPC分类号： B01L3/00 , B01L3/14 , C12Q1/00 , G01N1/00
摘要： Aspects of the present disclosure include sample preparation cartridges including a frame the includes a plurality of wells integrated therewith, where the plurality of wells have a closed bottom and an open top. The frame further includes an opening within the frame having a reaction vessel (RV) or RV cap removably disposed therein, where the plurality of wells and the opening are linearly arranged relative to each other. Also provided are sample preparation cartridges that include a frame, two or more cartridge separation projections on a top side of the frame, and two or more cartridge separation projections on a bottom side of the frame. The cartridge separation projections separate the cartridge and a different cartridge when the cartridge and different cartridge are stacked. Methods of using the sample preparation cartridges, as well as nucleic acid sample preparation units that include the sample preparation cartridges, are also provided.
摘要翻译：本公开的方面包括样品制备盒，所述样品制备盒包括框架，所述框架包括与其集成的多个井，其中所述多个井具有封闭的底部和敞开的顶部。框架还包括框架内的开口，该开口具有可移除地设置在其中的反应容器（RV）或RV帽，其中多个孔和开口相对于彼此线性地布置。还提供了样本制备盒，其包括框架，框架顶侧上的两个或更多个盒分离突起，以及框架底侧上的两个或更多个盒分离突起。当盒子和不同的盒子堆叠时，盒子分离突起将盒子和不同的盒子分开。还提供了使用样品制备盒的方法以及包括样品制备盒的核酸样品制备单元。

8. 发明申请

WO2013116207A3 SLIDE POCKET 审中-公开
公开(公告)号：WO2013116207A3
公开(公告)日：2013-08-08
申请号：PCT/US2013/023615
申请日：2013-01-29
申请人： THERMO SHANDON LIMITED , DOWLING, James, L. , NOLET, Christopher, J. , VON BUEREN, Erico , YEATON, Eric, D.
发明人： DOWLING, James, L. , NOLET, Christopher, J. , VON BUEREN, Erico , YEATON, Eric, D.
IPC分类号： C12M1/00
摘要： A slide pocket includes a first shell portion having a slide well with a depth suitable for accepting a sample-containing portion of a slide thereby positioning a sample affixed to the sample-containing portion of the slide within the slide well. The slide well has a plurality of beveled interior walls, the beveled portions functioning to prevent the sample affixed to the sample-containing portion of the slide from contacting any surface of the slide well during insertion. The slide pocket has a second shell portion, mateable in fluid tight engagement with the first shell portion. The second shell portion has a slide well. The first and second shell portions engage to define a single continuous slide chamber, a fluid input channel and fluid input port in communication with the single continuous slide chamber, and a fluid output channel and fluid output port in communication with the single continuous slide chamber.

9. 发明申请

WO2013116204A2 REAGENT BOTTLE 审中-公开
标题翻译：试剂瓶
公开(公告)号：WO2013116204A2
公开(公告)日：2013-08-08
申请号：PCT/US2013/023611
申请日：2013-01-29
申请人： THERMO SHANDON LIMITED , YEATON, Eric, D. , NOLET, Christopher, J.
发明人： YEATON, Eric, D. , NOLET, Christopher, J.
IPC分类号： B01L3/00
CPC分类号： B01L3/52 , B01L3/0275 , B01L2200/025 , B01L2200/026 , B01L2300/049 , G01N1/31 , G01N35/1002
摘要： A reagent bottle includes a reservoir adapted to contain a reagent, a pipette tip defining a fluid channel extending into the reservoir and a resilient seal fixedly disposed within the reservoir and surrounding the pipette tip, the seal functioning to reduce reagent loss when the pipette tip is withdrawn from the reagent bottle. The fluid channel of the pipette tip is defined by the pipette tip being in direct fluid communication, or interrupted fluid communication, with the exterior of the reagent bottle, the pipette tip being directly or indirectly engageable through a fluid-tight fitting with a pipette. A base member of the reagent bottle is adapted for selective engagement with one or more rotation pin and has an indexing feature for properly aligning the reagent bottle within an automated system. The base member adapted for selective engagement with one or more spring pins for raising and lowering the reagent bottle.
摘要翻译：试剂瓶包括适于容纳试剂的储存器，限定延伸到储存器中的流体通道的移液管尖端和固定地设置在储存器内并围绕移液管末端的弹性密封件，所述密封件用于当移液管吸头为从试剂瓶中取出。移液管尖端的流体通道由移液管尖端与试剂瓶的外部直接流体连通或中断的流体连通限定，移液管末端通过与移液管的流体密封配件直接或间接接合。试剂瓶的基底构件适于与一个或多个旋转销的选择性接合，并且具有用于在自动化系统内适当地对准试剂瓶的分度特征。基座构件适于与用于升高和降低试剂瓶的一个或多个弹簧销选择性地接合。

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