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1. 发明申请

WO2009066876A3 THE CO-CULTURE METHOD OF SPHINGOMONAS SP. BACTERIAL STRAIN AND ASPERGILLUS SP. FUNGUS STRAIN, NEW ANTI-CANCER AND ANTIBIOTIC GLIONITRINS DERIVED FROM THIS CO-CULTURE METHOD, AND PHARMACEUTICAL COMPOSITION CONTAINING GLIONITRINS OR PHARMACEUTICALLY AC 审中-公开
标题翻译： SPHINGOMONAS SP的共培养方法细菌菌株和ASPERGILLUS SP。真菌菌株，新型抗癌剂和来自该文化方法的抗生素药物，以及含有葡萄糖苷或药物AC的药物组合物
公开(公告)号：WO2009066876A3
公开(公告)日：2009-08-13
申请号：PCT/KR2008006275
申请日：2008-10-23
申请人： KOREA INST SCI & TECH , YANG HYUN OK , KWON HAK CHEOL , PARK HYUN-BONG , YOO JI-HYE
发明人： YANG HYUN OK , KWON HAK CHEOL , PARK HYUN-BONG , YOO JI-HYE
IPC分类号： C12N1/20
CPC分类号： C12R1/66 , A23L29/065 , A23L33/10 , A23L33/135 , C12N1/14 , C12N1/20 , C12P17/182 , C12P17/185 , C12P39/00 , C12R1/01
摘要： The present invention relates to a co-culture method of Sphingomonas sp. bacterial strain and Aspergillus sp. fungus strain, in which the novel Sphingomonas sp. bacterial strain KMK-001 is cultured in a liquid medium and the novel Aspergillus sp. strain KMC-901 separately cultured in another liquid medium is added to the above culture solution, a novel glionitrin biosynthesized therefrom and a pharmaceutical composition comprising the said glionitrin or its pharmaceutically acceptable salt as an active ingredient. The glionitrin herein has strong cytotoxic effect on cancer cells and has antibiotic effect on 10 pathogenic bacteria including the novel Sphingomonas sp. bacterial strain KMK-001, so that it can be effectively applied in antibiotics or anti-cancer agents.
摘要翻译：本发明涉及鞘氨醇单胞菌属的共培养方法。细菌菌株和曲霉菌真菌菌株，其中新型鞘氨醇单胞菌细菌菌株KMK-001在液体培养基中培养，新型曲霉菌将在另一种液体培养基中分别培养的菌株KMC-901加入到上述培养液中，由其生物合成的新型glionitrin和包含所述的格列rin嗪或其药学上可接受的盐作为活性成分的药物组合物。本发明的幽门螺杆菌对癌细胞具有强烈的细胞毒作用，对10种致病菌具有抗菌作用，包括新型鞘氨醇单胞菌细菌菌株KMK-001，使其可有效应用于抗生素或抗癌剂中。

2. 发明申请

WO2007120008A1 EXTRACT OF CHRYSANTHEMUM ZAWADSKII REMOVING HANGOVER ACTIVITY 审中-公开
标题翻译：提取枸杞子除草活性
公开(公告)号：WO2007120008A1
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001869
申请日：2007-04-17
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YANG, Hyun Ok , YOO, Ji-Hye , KIM, Young-Joo , KIM, Su-Jeong , SUH, Jong-Teak , JUNG, Sang Hoon , CHA, Kwang-Hyun , KIM, Su-Nam , NHO, Chu Won , LEE, Saet Byoul , MOON, Kil Choo
发明人： YANG, Hyun Ok , YOO, Ji-Hye , KIM, Young-Joo , KIM, Su-Jeong , SUH, Jong-Teak , JUNG, Sang Hoon , CHA, Kwang-Hyun , KIM, Su-Nam , NHO, Chu Won , LEE, Saet Byoul , MOON, Kil Choo
IPC分类号： A61K36/287
CPC分类号： A61K36/287
摘要： The present invention relates to use of the extract of Chrysanthemum zawadskii that is extracted using water, alcohol or a mixture thereof. Particularly, the extract of Chrysanthemum zawadskii can be used for an ant i- hangover agent because it can reduce alcohol density and acetaldehyde density in blood by promoting in vivo alcohol metabolism through improving activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), and present radical removal ability. The extract of Chrysanthemum zawadskii of the present invention can be used as an anti -hangover agent and health food for removing hangover because it can get rid of hangover more efficiently than hangover removing beverages in the market.
摘要翻译：本发明涉及使用水，醇或其混合物提取菊苣提取物的用途。特别地，菊花提取物可用于蚂蚁中毒剂，因为它可以通过改善醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）的活性来促进体内酒精代谢，从而降低血液中的酒精密度和乙醛密度，并具有根本的清除能力。本发明的菊花提取物可以用作抗脱水剂和用于去除宿醉的保健食品，因为它可以比在市场上去除饮料的宿醉更有效地摆脱宿醉。

3. 发明申请

WO2009142458A3 FUNCTIONAL HEALTH FOOD COMPOSITION FOR PREVENTING CARCINOGENESIS CONTAINING ASTER KORAIENSIS EXTRACT,ASTER KORAIENSIS FRACTIONS, GYMNASTERKOREAYNES DERIVATIVES SEPARATED THEREFROM OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS EFFECTIVE INGREDIENTS 审中-公开
标题翻译：功能性健康食品组合物，用于预防含有ASTER KORAIENSIS提取物，ASTER KORAIENSIS提取物，GYMNASTERKOREAYNES衍生物或其药物作为有效成分的药物代谢产物的致癌物质
公开(公告)号：WO2009142458A3
公开(公告)日：2010-03-04
申请号：PCT/KR2009002723
申请日：2009-05-22
申请人： KOREA INST SCI & TECH , NHO CHU WON , LEE SAET BYOUL , KWON HAK CHEOL , YANG HYUN OK , UM BYUNG HUN , KIM CHUL YOUNG , PAN CHEOL-HO , CHA KWANG-HYUN , KIM MYUNG SOO
发明人： NHO CHU WON , LEE SAET BYOUL , KWON HAK CHEOL , YANG HYUN OK , UM BYUNG HUN , KIM CHUL YOUNG , PAN CHEOL-HO , CHA KWANG-HYUN , KIM MYUNG SOO
IPC分类号： A23L1/29
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/308 , A23V2250/21
摘要： The present invention relates to a functional health food composition for preventing carcinogenesis containing Aster koraiensis extract,Aster koraiensis fractions, and Gymnasterkoreaynes derivatives separated therefrom or pharmaceutically acceptable salts thereof as effective ingredients. Gymnasterkoreaynes B, separated from Aster koraiensis extract, induces quinone reductase activity which is a marker enzyme for prevention of cancer, and thus, compositions according to the present invention can be used for preventing cancer.
摘要翻译：本发明涉及一种用于预防癌症发生的功能保健食品组合物，其含有菊酯提取物，白菊科部分和与其分离的Gymnasterkoreaynes衍生物或其药学上可接受的盐作为有效成分。与菊科提取物分离的Gymnasterkoreaynes B诱导醌还原酶活性，其是用于预防癌症的标记酶，因此根据本发明的组合物可用于预防癌症。

4. 发明申请

WO2009066876A2 THE CO-CULTURE METHOD OF SPHINGOMONAS SP. BACTERIAL STRAIN AND ASPERGILLUS SP. FUNGUS STRAIN, NEW ANTI-CANCER AND ANTIBIOTIC GLIONITRINS DERIVED FROM THIS CO-CULTURE METHOD, AND PHARMACEUTICAL COMPOSITION CONTAINING GLIONITRINS OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE INGREDIENT 审中-公开
标题翻译： SPHINGOMONAS SP的共培养方法细菌菌株和ASPERGILLUS SP。由该共培养方法衍生的新的抗癌和抗生素类药物，以及含有作为活性成分的糖皮质激素或药物可接受的盐的药物组合物
公开(公告)号：WO2009066876A2
公开(公告)日：2009-05-28
申请号：PCT/KR2008/006275
申请日：2008-10-23
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YANG, Hyun Ok , KWON, Hak Cheol , PARK, Hyun-Bong , YOO, Ji-Hye
发明人： YANG, Hyun Ok , KWON, Hak Cheol , PARK, Hyun-Bong , YOO, Ji-Hye
IPC分类号： C12N1/20
CPC分类号： C12R1/66 , A23L29/065 , A23L33/10 , A23L33/135 , C12N1/14 , C12N1/20 , C12P17/182 , C12P17/185 , C12P39/00 , C12R1/01
摘要： The present invention relates to a co-culture method of Sphingomonas sp. bacterial strain and Aspergillus sp. fungus strain, in which the novel Sphingomonas sp. bacterial strain KMK-001 is cultured in a liquid medium and the novel Aspergillus sp. strain KMC-901 separately cultured in another liquid medium is added to the above culture solution, a novel glionitrin biosynthesized therefrom and a pharmaceutical composition comprising the said glionitrin or its pharmaceutically acceptable salt as an active ingredient. The glionitrin herein has strong cytotoxic effect on cancer cells and has antibiotic effect on 10 pathogenic bacteria including the novel Sphingomonas sp. bacterial strain KMK-001, so that it can be effectively applied in antibiotics or anti-cancer agents.
摘要翻译：本发明涉及鞘氨醇单胞菌（Sphingomonas sp。）的共培养方法。细菌菌株和曲霉菌属。真菌菌株，其中新型鞘氨醇单胞菌属将细菌菌株KMK-001在液体培养基中培养，并将新型曲霉属菌株在另一种液体培养基中分别培养的菌株KMC-901加入到上述培养液中，由其生物合成新的glionitrin以及包含所述glionitrin或其药学上可接受的盐作为活性成分的药物组合物。本发明的glionitrin对癌细胞具有强烈的细胞毒性作用，并且对包括新型鞘氨醇单胞菌属在内的10种致病菌具有抗生素作用。细菌菌株KMK-001，因此可以有效应用于抗生素或抗癌药物。

5. 发明申请

WO2007066928A1 USE OF THE EXTRACT OF CAESALPINIA SAPPAN L. AND COMPOUNDS THEREFROM 审中-公开
标题翻译：芍药提取物的使用及其化合物
公开(公告)号：WO2007066928A1
公开(公告)日：2007-06-14
申请号：PCT/KR2006/005084
申请日：2006-11-29
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YANG, Hyun Ok , KIM, Min Young , KWON, Young-Guen , CHOI, Yeon Hee
发明人： YANG, Hyun Ok , KIM, Min Young , KWON, Young-Guen , CHOI, Yeon Hee
IPC分类号： A61K36/48 , A61K31/352 , A23L1/29 , A61P19/02 , A61P17/00 , A61P25/28 , A61P3/04 , A61P35/00 , A61P27/02
CPC分类号： A61K36/48 , A23L33/105 , A61K2300/00
摘要： The present invention relates to an extract of Caesalpinia sappan L. having an angiogenesis inhibition activity and a use of the compound isolated therefrom, more precisely an extract of Caesalpinia sappan L. extracted by using water, alcohol or a mixture thereof , and a use of brazilin, sappanchalcone and brazilein isolated from the extract as an angiogenesis inhibitor. The extract of Caesalpinia sappan L. of the invention and a compound isolated therefrom have angiogenesis inhibition activity, so that they can be effectively used for the prevention and treatment of angiogenesis associated diseases such as vascular diseases, cardiovascular diseases, ophthalmic diseases, chronic inflammatory diseases, dermatological diseases, Alzheimer's disease, obesity and cancer.
摘要翻译：本发明涉及具有血管生成抑制活性的Caesalpinia sappan L.的提取物和使用从其分离的化合物，更准确地说，是使用水，醇或其混合物提取的Caesalpinia sappan L.提取物，以及使用巴西，sappanchalcone和brazilein作为血管发生抑制剂从提取物中分离出来。本发明的Caesalpinia sappan L.提取物及其分离的化合物具有血管生成抑制活性，因此可有效地用于预防和治疗血管生成相关疾病如血管疾病，心血管疾病，眼科疾病，慢性炎性疾病，皮肤病，阿尔茨海默病，肥胖症和癌症。

6. 发明申请

WO2011052968A3 COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE NEUROLOGICAL DISORDER, CONTAINING OLEANONIC ACID 审中-公开
标题翻译：用于预防或治疗退化性神经系统疾病的组合物，含有奥利康酸
公开(公告)号：WO2011052968A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007377
申请日：2010-10-26
申请人： KOREA INST SCI & TECH , YANG HYUN-OK , KWON HAK-CHEOL , CHUNG SUNG-KWON , PARK JIN-SOO , YANG MIN-CHEOL , CHUN YOON-SUN
发明人： YANG HYUN-OK , KWON HAK-CHEOL , CHUNG SUNG-KWON , PARK JIN-SOO , YANG MIN-CHEOL , CHUN YOON-SUN
IPC分类号： A61K31/56 , A23L1/30 , A61K36/84 , A61P25/28
CPC分类号： A61K31/56 , A23L33/10 , A61K36/748 , A61K36/84
摘要： The present invention relates to a use of oleanonic acid for preventing and/or treating dementia. Oleanonic acid can inhibit the generation of ß-amyloid which is known as a material causing dementia, particularly Alzheimer's disease, and thus can be effectively used for preventing and/or treating degenerative neurological disorders including dementia.
摘要翻译：本发明涉及齐墩果酸预防和/或治疗痴呆的用途。齐墩果酸可以抑制已知为引起痴呆症的物质，特别是阿尔茨海默病的β-淀粉样蛋白的产生，因此可以有效地用于预防和/或治疗包括痴呆在内的退行性神经障碍。

7. 发明申请

WO2007120007A1 EXTRACT OF ECHINOSOPHORA KOREENSIS REMOVING HANGOVER AND HAVING ANTI-OXIDANT ACTIVITY 审中-公开
标题翻译： OF ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY ITY
公开(公告)号：WO2007120007A1
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001868
申请日：2007-04-17
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YANG, Hyun Ok , MOON, Kil, Choo , LEE, Saet, Byoul , KIM, Su-Nam , CHA, Kwang-Hyun , NAM, Chun, Woo , YOO, Ki-Oug , KIM, Won-Bae
发明人： YANG, Hyun Ok , MOON, Kil, Choo , LEE, Saet, Byoul , KIM, Su-Nam , CHA, Kwang-Hyun , NAM, Chun, Woo , YOO, Ki-Oug , KIM, Won-Bae
IPC分类号： A23L1/30
CPC分类号： A23L33/105
摘要： The present invention relates to use of the extract of Echinosophora koreensis that is extracted using water, alcohol or a mixture thereof. Particularly, the extract of Echinosophora koreensis can be used for an ant i -hangover agent because it can reduce alcohol density and acetaldehyde density in blood by promoting in vivo alcohol metabolism through improving activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). In addition, it can be used as an ant i -oxidizing agent because it presents radical removal ability. The extract of Echinosophora koreensis of the present invention can get rid of hangover more efficiently than hangover removing beverages in the market, and has no side effects as an anti-oxidant activator due to its effective radical removal.
摘要翻译：本发明涉及使用水，醇或其混合物提取的枸杞提取物的用途。特别地，由于可以通过改善醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）的活性来促进体内酒精代谢，因此可以将枸杞提取物用于抗瘙痒剂，因为它可以降低血液中的酒精浓度和乙醛密度。此外，它可以用作蚂蚁氧化剂，因为它具有根除的能力。本发明的Echinosophora koreensis的提取物可以比市售的去除饮料更有效地去除宿醉，并且由于其有效的根除去而没有作为抗氧化剂活化剂的副作用。

8. 发明申请

WO2007066926A1 A MASS PRODUCTION METHOD OF BRAZILEIN FROM CAESALPINIA SAPPAN L 审中-公开
标题翻译：豌豆OF OF A A A。。。。。。。。。。。。。。。。
公开(公告)号：WO2007066926A1
公开(公告)日：2007-06-14
申请号：PCT/KR2006/005082
申请日：2006-11-29
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YANG, Hyun Ok , CHOI, Yeon Hee
发明人： YANG, Hyun Ok , CHOI, Yeon Hee
IPC分类号： C07D311/78 , C07D311/00
CPC分类号： C07D311/94 , Y02P20/544
摘要： The present invention relates to a mass -production method of brazilein from Caesalpinia sappan L. , more precisely a mass-production method of brazilein from Caesalpinia sappan L. which comprises the steps of 1) preparing an extract from Caesalpinia sappan L. by using water, alcohol or a mixture of the two; 2) preparing a crude crystal by concentrating the extract of step 1) ; 3) dissolving the crude crystal of step 2) in alcohol; 4) concentrating the solution of step 3) ; and 5) re- crystallizing the concentrated solution of step 4) . According to the method of the invention, brazilein can be mass-produced from Caesalpinia sappan L. with high purity without column chromatography which has been necessarily performed according to the conventional methods, and thus the method of the invention does not need expensive equipments such as column chromatography, supercritical fluid extractor, HPLC, etc., suggesting that the method is efficient for mass -production of brazilein and industrially applicable.
摘要翻译：本发明涉及来自豌豆an an of of of a a a a a a a ction ction water water water water water water water water water water water water water water water water water water water water water water water water water water water water water water water water water ，酒精或两者的混合物; 2）通过浓缩步骤1）的提取物制备粗晶体; 3）将步骤2）的粗晶体溶于醇中; 4）浓缩步骤3）的溶液; 和5）使步骤4）的浓缩溶液重结晶。根据本发明的方法，可以根据常规方法，必须按照常规方法进行，高纯度的不含柱色谱的Caesalpinia sappan L.可以大量生产丁氯苯酚，因此本发明的方法不需要昂贵的设备，例如柱色谱，超临界流体提取器，HPLC等，表明该方法对于大规模生产巴西林和工业上适用的方法是有效的。

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