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1. 发明申请

WO2014035361A1 IL-1β INHIBITOR COMPOSITION AND USE THEREOF 审中-公开
标题翻译： IL-1beta抑制剂组合物及其用途
公开(公告)号：WO2014035361A1
公开(公告)日：2014-03-06
申请号：PCT/US2012/052415
申请日：2012-08-26
申请人： R-PHARM, CJSC (Closed Joint Stock Company) , LAVROVSKY, Yan , XU, Ting , REPIK, Alexey , XU, Tao , IGNATIEV, Vasily , SAMSONOV, Mikhail
发明人： LAVROVSKY, Yan , XU, Ting , REPIK, Alexey , XU, Tao , IGNATIEV, Vasily , SAMSONOV, Mikhail
IPC分类号： C07K14/715 , C07K19/00 , C07K16/18 , C12N15/62 , C12N15/63 , A61K38/17 , A61P19/00 , A61P9/10 , A61P27/14
CPC分类号： A61K38/17 , C07K14/7155 , C07K2319/30 , C07K2319/32
摘要： A therapeutic composition is described that can be used for treating or prevention of diseases association with modulation of activity of human IL-Ιβ. In certain aspects, the disclosed invention is based, on engineering of a heterodimeric protein assembly that is capable of binding to human IL-Ιβ and attenuating its function. The heterodimeric protein assembly comprises an extracellular portions of human IL1-R1 and of human IL-1RAcP, or their functional fragments. Each, the IL1-R1 portion and the IL-1RAcP portion, is fused to a distinct mutant of Fc portion of the human Ig Gamma-1. The two distinct Fc mutants in the heterodimeric protein assembly are engineered as to favor the heteromeric dimer formation between the two Fc mutants over any homomeric assembly. DNA expression vectors and expression systems for overproducing the polypeptides in mammalian cells are also provided for.
摘要翻译：描述了可用于治疗或预防与调节人IL-Iotabeta的活性相关的疾病的治疗组合物。在某些方面，所公开的发明基于能够结合人IL-Iotabeta并衰减其功能的异二聚体蛋白组装的工程。异二聚体蛋白组合包含人IL1-R1和人IL-1RAcP的细胞外部分或其功能片段。每个IL1-R1部分和IL-1RAcP部分融合到人Ig Gamma-1的Fc部分的不同突变体。工程改造异二聚体蛋白组装中的两种不同的Fc突变体，以促进两种Fc突变体之间异源二聚体在任何同源组装上形成。也提供了用于在哺乳动物细胞中过量产生多肽的DNA表达载体和表达系统。

2. 发明申请

WO2008131255A1 SERVICE REGULATOR WITH IMPROVED BOOST PERFORMANCE 审中-公开
标题翻译：具有改进性能的服务调节器
公开(公告)号：WO2008131255A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060872
申请日：2008-04-18
申请人： FISHER CONTROLS INTERNATIONAL LLC , ZHANG, Jun, Ya , HAWKINS, James, Chester , XU, Ting
发明人： ZHANG, Jun, Ya , HAWKINS, James, Chester , XU, Ting
IPC分类号： G05D16/06
CPC分类号： G05D16/0683 , Y10T29/49407 , Y10T137/5109 , Y10T137/7794 , Y10T137/7831 , Y10T137/7922
摘要： A regulator comprises a regulator valve and an actuator. The regulator valve comprises a valve body equipped with a customized valve port. That is, the valve seat is designed to have a customized seat height depending on a diameter of an orifice through the valve port, a longitudinal dimension of an orifice through the valve port, and/or a flow capacity of the valve port. Such a design advantageously maximizes the efficiency at which gas flows through the regulator. The actuator is coupled to the valve body and comprises a valve disc disposed within the valve body and adapted for displacement between a closed position engaging the valve seat and an open position spaced from the valve seat.
摘要翻译：调节器包括调节阀和致动器。调节阀包括配有定制阀口的阀体。也就是说，阀座被设计成具有取决于通过阀口的孔的直径，通过阀口的孔的纵向尺寸和/或阀口的流量的定制的座椅高度。这种设计有利地使气体流过调节器的效率最大化。致动器联接到阀体并且包括设置在阀体内并适于在与阀座接合的关闭位置和与阀座间隔开的打开位置之间的位移的阀盘。

3. 发明申请

WO2011139785A3 DISPLAY DEVICE HAVING PLASMONIC COLOR FILTERS AND PHOTOVOLTAIC CAPABILITIES 审中-公开
标题翻译：具有等离子色彩过滤器和照相能力的显示设备
公开(公告)号：WO2011139785A3
公开(公告)日：2012-04-12
申请号：PCT/US2011034174
申请日：2011-04-27
申请人： UNIV MICHIGAN , GUO LINGJIE JAY , XU TING
发明人： GUO LINGJIE JAY , XU TING
IPC分类号： G02B5/20 , G02F1/1335
CPC分类号： G02B5/288 , G02B5/008 , G02F1/133516 , G02F1/133533 , G02F1/13439 , G02F2001/13324 , G02F2203/10
摘要： A plasmonic optical spectrum filtering device is provided that filters electromagnetic waves by optical resonance, for example, by selective conversion between the free-space waves and spatially confined modes in plasmonic nano-resonators. Frequency-selective transmission and reflection spectra are engineered and can be used as spectrum filters for display and imaging applications. A thin film stack color filter is further disclosed, which can be designed to either function as a transmission color filter with efficiency twice that of conventional colorant based color filter; or as a reflective color filter for display devices (e.g., used in an energy harvesting reflective display). In other variations, a novel reflective colored display is viewable under direct sunlight, and can simultaneously harvest both incident light and generate electrical power. Methods of making such plamonic optical spectrum filtering devices are also provided.
摘要翻译：提供了等离子体激发光谱滤波装置，其通过光谐振来对电磁波进行滤波，例如通过在等离子体激元纳米谐振器中的自由空间波和空间限制模式之间的选择性转换。频率选择性传输和反射光谱被设计并且可以用作用于显示和成像应用的频谱滤波器。进一步公开了一种薄膜堆叠滤色器，其可以被设计成作为传统滤色器的功能，效率是传统的基于着色剂的滤色器的两倍; 或用作显示设备的反射滤色器（例如，用于能量收集反射显示器）。在其他变型中，新颖的反射彩色显示器可在直射的阳光下观看，并且可以同时收集入射光并产生电力。还提供了制造这种同谱光谱滤波装置的方法。

4. 发明申请

WO2011139785A2 DISPLAY DEVICE HAVING PLASMONIC COLOR FILTERS AND PHOTOVOLTAIC CAPABILITIES 审中-公开
标题翻译：具有等离子色彩过滤器和照相能力的显示设备
公开(公告)号：WO2011139785A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034174
申请日：2011-04-27
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , GUO, Lingjie Jay , XU, Ting
发明人： GUO, Lingjie Jay , XU, Ting
IPC分类号： G02B5/20 , G02F1/1335
CPC分类号： G02B5/288 , G02B5/008 , G02F1/133516 , G02F1/133533 , G02F1/13439 , G02F2001/13324 , G02F2203/10
摘要： A plasmonic optical spectrum filtering device is provided that filters electromagnetic waves by optical resonance, for example, by selective conversion between the free-space waves and spatially confined modes in plasmonic nano-resonators. Frequency-selective transmission and reflection spectra are engineered and can be used as spectrum filters for display and imaging applications. A thin film stack color filter is further disclosed, which can be designed to either function as a transmission color filter with efficiency twice that of conventional colorant based color filter; or as a reflective color filter for display devices (e.g., used in an energy harvesting reflective display). In other variations, a novel reflective colored display is viewable under direct sunlight, and can simultaneously harvest both incident light and generate electrical power. Methods of making such plamonic optical spectrum filtering devices are also provided.
摘要翻译：提供了等离子体激发光谱滤波装置，其通过光谐振来对电磁波进行滤波，例如通过在等离子体激元纳米谐振器中的自由空间波和空间限制模式之间的选择性转换。频率选择性传输和反射光谱被设计并且可以用作用于显示和成像应用的频谱滤波器。进一步公开了一种薄膜堆叠滤色器，其可以被设计成作为传统滤色器的功能，效率是传统的基于着色剂的滤色器的两倍; 或用作显示设备的反射滤色器（例如，用于能量收集反射显示器）。在其他变型中，新颖的反射彩色显示器可在直射的阳光下观看，并且可以同时收集入射光并产生电力。还提供了制造这种同谱光谱滤波装置的方法。

5. 发明申请

WO2011112999A2 LIPID-PEPTIDE-POLYMER CONJUGATES AND NANOPARTICLES THEREOF 审中-公开
标题翻译：脂质 - 肽 - 聚合物缀合物及其纳米颗粒
公开(公告)号：WO2011112999A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/028198
申请日：2011-03-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , XU, Ting , DONG, He , SHU, Jessica
发明人： XU, Ting , DONG, He , SHU, Jessica
IPC分类号： C07K14/47
CPC分类号： C07K14/435 , A61K47/42 , A61K47/542 , A61K47/60 , A61K47/6907 , B82Y5/00 , Y10S977/773 , Y10S977/906
摘要： The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
摘要翻译：本发明提供了具有约10至约100个氨基酸的肽的缀合物，其中所述肽采用螺旋结构。缀合物还包括共价连接至肽的第一聚合物和共价连接至肽的N-末端的疏水部分，其中疏水部分包含第二聚合物或脂质部分。本发明还提供了通过自组装所述缀合物形成的螺旋束以及通过自组装所述螺旋束而形成的粒子。还提供了制备螺旋束和颗粒的方法。

6. 发明申请

WO2011028829A3 ORGANIC ELECTRONIC DEVICES AND POLYMERS, INCLUDING PHOTOVOLTAIC CELLS AND DIKETONE-BASED AND DIKETOPYRROLOPYRROLE-BASED POLYMERS 审中-公开
标题翻译：有机电子器件和聚合物，包括光伏电池和基于二酮的和二酮基吡咯并吡咯基聚合物
公开(公告)号：WO2011028829A3
公开(公告)日：2011-05-26
申请号：PCT/US2010047567
申请日：2010-09-01
申请人： PLEXTRONICS INC , BROWN CHRISTOPHER T , LANDIS CHAD , GRENIER CHRISTOPHE RENE GASTON , SHEINA ELENA E , XU TING
发明人： BROWN CHRISTOPHER T , LANDIS CHAD , GRENIER CHRISTOPHE RENE GASTON , SHEINA ELENA E , XU TING
IPC分类号： C08G61/12 , C07D487/04 , C07D519/00 , C08L65/00 , H01L51/00 , H01L51/42
CPC分类号： C08L65/00 , C07D487/04 , C07D495/04 , C07D519/00 , C07F7/0816 , C08G61/12 , C08G61/126 , C08G2261/124 , C08G2261/18 , C08G2261/226 , C08G2261/228 , C08G2261/3223 , C08G2261/334 , C08G2261/344 , C08G2261/364 , C08G2261/414 , C09B57/004 , C09B69/008 , C09B69/109 , C09D165/00 , H01L51/0036 , H01L51/0043 , H01L51/0069 , H01L51/0077 , H01L51/4253 , Y02E10/549 , Y10S428/917
摘要： Polymers which can be used in p-type materials for organic electronic devices and photovoltaic cells. Compounds, monomers, dimers, trimers, and polymers comprising formula (I) and/or formula (VIII); wherein A1 and A2 each independently comprise a fused ring system comprising at least two fused rings directly covalently linked to the pyrrole rings. Good photovoltaic efficiency and lifetime can be achieved. The R group can provide solubility, environmental stability, and fine tuning of spectroscopic and/or electronic properties. Different polymer microstructures can be prepared which encourage multiple band gaps and broad and strong absorptions. The carbonyl can interact with adjacent thiophene rings to provide backbone with rigidity, induce planarity, and reduce and/or eliminate intramolecular chain twisting defects.
摘要翻译：可用于有机电子器件和光伏电池的p型材料的聚合物。包含式（I）和/或式（VIII）的化合物，单体，二聚体，三聚体和聚合物; 其中A 1和A 2各自独立地包含稠环系统，所述稠环系统包含至少两个直接共价连接至吡咯环的稠合环。可以实现良好的光伏效率和使用寿命。 R基团可以提供溶解性，环境稳定性和光谱和/或电子性质的微调。可以制备不同的聚合物微结构，其鼓励多重带隙和宽而强的吸收。羰基可以与邻近的噻吩环相互作用以提供具有刚性的主链，引起平面性，并减少和/或消除分子内链扭曲缺陷。

7. 发明申请

WO2012145677A3 SPECTRUM FILTERING FOR VISUAL DISPLAYS AND IMAGING HAVING MINIMAL ANGLE DEPENDENCE 审中-公开
标题翻译：用于视觉显示的光谱滤波和具有最小角度依赖性的成像
公开(公告)号：WO2012145677A3
公开(公告)日：2013-01-17
申请号：PCT/US2012034526
申请日：2012-04-20
申请人： UNIV MICHIGAN , GUO LINGJIE JAY , XU TING
发明人： GUO LINGJIE JAY , XU TING
IPC分类号： G02B5/20 , G02F1/1335
CPC分类号： G02F1/216 , G02B5/201 , G02B5/288 , G02F2001/133521 , G02F2001/213 , G02F2201/346 , G02F2202/30 , G02F2202/32
摘要： An optical spectrum filtering device, e.g., color filter, having reduced angle dependence is provided that comprises an interference filter assembly comprising a high refractive index dielectric material, such as a Fabry-Perot based resonator structure. The filter assembly is capable of transmitting a portion of an electromagnetic spectrum into the dielectric material to generate a filtered output with a predetermined range of wavelengths that displays minimal angle dependence, when viewed from a range of incidence angles ranging from normal (0) to 90. Methods of making minimal angle dependent optical spectrum filters and reducing angle dependence for such devices are also provided.
摘要翻译：提供了具有减小的角度依赖性的光谱滤波装置，例如滤色器，其包括包括高折射率介电材料的干涉滤光器组件，例如基于法布里 - 珀罗的谐振器结构。当从正常（0）到90度的入射角度范围内观察时，过滤器组件能够将电磁光谱的一部分传输到电介质材料中以产生具有显示最小角度依赖性的预定波长范围的滤波输出还提供了使最小角度相关的光谱滤波器和减小这种装置的角度依赖性的方法。

8. 发明申请

WO2012145677A2 SPECTRUM FILTERING FOR VISUAL DISPLAYS AND IMAGING HAVING MINIMAL ANGLE DEPENDENCE 审中-公开
标题翻译：用于视觉显示的光谱滤波和具有最小角度依赖性的成像
公开(公告)号：WO2012145677A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/034526
申请日：2012-04-20
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , GUO, Lingjie Jay , XU, Ting
发明人： GUO, Lingjie Jay , XU, Ting
IPC分类号： G02B5/20 , G02F1/1335
CPC分类号： G02F1/216 , G02B5/201 , G02B5/288 , G02F2001/133521 , G02F2001/213 , G02F2201/346 , G02F2202/30 , G02F2202/32
摘要： An optical spectrum filtering device, e.g., color filter, having reduced angle dependence is provided that comprises an interference filter assembly comprising a high refractive index dielectric material, such as a Fabry-Perot based resonator structure. The filter assembly is capable of transmitting a portion of an electromagnetic spectrum into the dielectric material to generate a filtered output with a predetermined range of wavelengths that displays minimal angle dependence, when viewed from a range of incidence angles ranging from normal (0) to 90. Methods of making minimal angle dependent optical spectrum filters and reducing angle dependence for such devices are also provided.
摘要翻译：提供具有减小的角度依赖性的光谱滤波装置，例如滤色器，其包括包括高折射率介电材料的干涉滤光器组件，例如基于法布里 - 珀罗的谐振器结构。当从正常（0）到90度的入射角度范围内观察时，过滤器组件能够将电磁光谱的一部分传输到电介质材料中以产生具有显示最小角度依赖性的预定波长范围的滤波输出还提供了制造最小角度依赖的光谱滤波器并减小这种装置的角度依赖性的方法。

9. 发明申请

WO2014126582A1 IL-1β INHIBITOR COMPOSITION AND USE THEREOF 审中-公开
标题翻译： IL-1＆BGR; 抑制剂组合物及其用途
公开(公告)号：WO2014126582A1
公开(公告)日：2014-08-21
申请号：PCT/US2013/026349
申请日：2013-02-15
申请人： R-PHARM, CJSC (CLOSED JOINT STOCK COMPANY) , LAVROVSKY, Yan , XU, Ting , REPIK, Alexey , XU, Tao , IGNATIEV, Vasily , SAMSONOV, Mikhail
发明人： LAVROVSKY, Yan , XU, Ting , REPIK, Alexey , XU, Tao , IGNATIEV, Vasily , SAMSONOV, Mikhail
IPC分类号： C07K14/00 , C07K14/545 , C07K19/00 , C12N15/09 , C12N15/117 , C12N15/66 , A61K38/16 , A61K38/20 , A61P19/02 , A61P9/06 , A61P3/10
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/30
摘要： A therapeutic composition is described that can be used for treating or prevention of diseases association with modulation of activity of human IL-1β. In certain aspects, the disclosed invention is based, on engineering of a heterodimeric protein assembly that is capable of binding to human IL-1β and attenuating its function. The heterodimeric protein assembly comprises an extracellular portions of human IL1-R1 and of human IL-1RAcP, or their functional fragments. Each, the IL1-R1 portion and the IL-1RAcP portion, is fused to a distinct mutant of Fc portion of the human Ig Gamma-1. The two distinct Fc mutants in the heterodimeric protein assembly are engineered as to favor the heteromeric dimer formation between the two Fc mutants over any homomeric assembly. DNA expression vectors and expression systems for overproducing the polypeptides in mammalian cells are also provided for.
摘要翻译：描述了可用于治疗或预防与调节人IL-1和bgr的活性相关的疾病的治疗组合物。在某些方面，所公开的发明基于能够结合人IL-1和bgr的异二聚体蛋白组装的工程化; 并衰减其功能。异二聚体蛋白组合包含人IL1-R1和人IL-1RAcP的细胞外部分或其功能片段。每个IL1-R1部分和IL-1RAcP部分融合到人Igγ-1的Fc部分的不同突变体。将异二聚体蛋白组装中的两种不同的Fc突变体设计为有利于两种Fc突变体之间的异聚二聚体在任何同源组装上形成。还提供了用于在哺乳动物细胞中过量产生多肽的DNA表达载体和表达系统。

10. 发明申请

WO2012082893A2 FLUORO MONOMERS, OLIGOMERS, AND POLYMERS FOR INKS AND ORGANIC ELECTRONIC DEVICES 审中-公开
标题翻译：墨水单体，低聚物和聚合物，用于墨水和有机电子设备
公开(公告)号：WO2012082893A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064907
申请日：2011-12-14
申请人： PLEXTRONICS, INC. , BROWN, Christopher T. , SHEINA, Elena , XU, Ting
发明人： BROWN, Christopher T. , SHEINA, Elena , XU, Ting
IPC分类号： C08G61/12 , C07D285/14
CPC分类号： C08G61/123 , C07D285/14 , C07D495/04 , C07D513/04 , C08G61/126 , C08G2261/124 , C08G2261/1412 , C08G2261/146 , C08G2261/18 , C08G2261/3243 , C08G2261/3246 , C08G2261/414 , C08G2261/91 , C09B57/00 , C09B69/109 , H01L51/0043 , H01L51/4253 , Y02E10/549
摘要： High performance organic photovoltaic cells based on donor acceptor polymers in the active layer. A composition comprising: at least one copolymer comprising at least one first donor moiety and at least one first acceptor moiety in the copolymer backbone, wherein the first acceptor moiety comprises at least one first ring which is bivalently linked to the copolymer backbone and at least one second ring fused to the first ring and not bivalently linked to the copolymer backbone, wherein the first ring or the second ring comprises two adjacent fluoro ring substituents, and optionally, wherein the donor comprises at least one fused ring system. High efficiency, high Voc, and a combination of both can be achieved.
摘要翻译：基于活性层中供体受体聚合物的高性能有机光伏电池。一种组合物，其包含：至少一种包含共聚物主链中至少一个第一供体部分和至少一个第一受体部分的共聚物，其中第一受体部分包含至少一个与共聚物主链二元连接的第一环和至少一个第二环与第一环稠合并且不是二价连接到共聚物主链，其中第一环或第二环包含两个相邻的氟环取代基，并且任选地，其中所述供体包含至少一个稠环体系。可以实现高效率，高Voc和两者的组合。

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