专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005111237A1 DETECTION OF CHROMOSOMAL DISORDERS 审中-公开
标题翻译：检测染色体异常
公开(公告)号：WO2005111237A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/013070
申请日：2005-04-18
申请人： BIOCEPT, INC. , XIE, Zhiyi , HAHN, Soonkap , WATANASKUL, Tim
发明人： XIE, Zhiyi , HAHN, Soonkap , WATANASKUL, Tim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2537/143 , C12Q2531/113
摘要： Methods for detecting in a single assay any one of multiple chromosomal disorders that result from aneuploidy or certain mutations, particularly mic;rodeletions, and kits for use therein. A poly erase chain reaction (PCR) is carried out to amplify eukaryotic genomic DNA using a plurality of primer oligonucleotide pairs wherein one primer of each pair has a detecta~ a label attached 5 thereto. A plurality of the primer pairs are targeted to DNA segments of different chromosomes of interest which are indicative of potential chromosomal disorders, and one pair is targeted for a control gene. The amplified PCR products are purified, and single-stranded DNA having the detecta+e labels is obtained therefrom and hybridized with spots on a microarray that each contain DNA oligonucleotide probes having nucleotide sequences complementary to a nucleotide sequence of one strand of each segment. The microarray is imaged for presence of labels on its respective spots, and the absence or presence of chromosomal disorders as indicated by one or more of the targeted DNA segments of interest is diagnosed by first comparing the imaging results to the imaging of spots specific to the control gene and then to results obtained from imaging normal DNA.
摘要翻译：用于在单次测定中检测由非整倍体或某些突变，特别是麦克风，滚球和其中使用的试剂盒引起的多种染色体紊乱中的任何一种的方法。进行多重擦除链反应（PCR）以使用多个引物寡核苷酸对扩增真核基因组DNA，其中每对的一个引物具有附着于其上的标记5。多个引物对靶向不同染色体的DNA片段，其指示潜在的染色体病症，一对靶向对照基因。纯化扩增的PCR产物，从中获得具有检测+ e标记的单链DNA，并与微阵列上的斑点杂交，每个点含有具有与每个片段的一条链的核苷酸序列互补的核苷酸序列的DNA寡核苷酸探针。成像微阵列以在其各自的斑点上存在标记，并且通过首先将成像结果与成像特异性的斑点的成像进行比较来诊断由一个或多个目标DNA片段指示的染色体病症的不存在或存在控制基因，然后从成像正常DNA获得的结果。

2. 发明申请

WO2006134482A8 PROCESS FOR PRODUCING ATORVASTATIN, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND INTERMEDIATES THEREOF 审中-公开
标题翻译：生产ATORVASTATIN的方法，其药学上可接受的盐及其中间体
公开(公告)号：WO2006134482A8
公开(公告)日：2008-03-06
申请号：PCT/IB2006001613
申请日：2006-06-06
申请人： PFIZER , HU SHANGHUI , TAO JUNHUA , XIE ZHIYI
发明人： HU SHANGHUI , TAO JUNHUA , XIE ZHIYI
IPC分类号： C12P17/10
CPC分类号： C12P17/10
摘要： A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agents.
摘要翻译：描述了使用醛缩酶制备阿伐他汀，其药学上可接受的盐及其中间体的新方法。如此制备的化合物可用作HMG-CoA还原酶的抑制剂，因此可用作降血脂药和降血胆固醇药。

3. 发明申请

WO2006134482A1 PROCESS FOR PRODUCING ATORVASTATIN, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND INTERMEDIATES THEREOF 审中-公开
标题翻译：生产ATORVASTATIN的方法，其药学上可接受的盐及其中间体
公开(公告)号：WO2006134482A1
公开(公告)日：2006-12-21
申请号：PCT/IB2006/001613
申请日：2006-06-06
申请人： PFIZER INC. , HU, Shanghui , TAO, Junhua , XIE, Zhiyi
发明人： HU, Shanghui , TAO, Junhua , XIE, Zhiyi
IPC分类号： C12P17/10
CPC分类号： C12P17/10
摘要： A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agents.
摘要翻译：描述了使用醛缩酶制备阿托伐他汀，其药学上可接受的盐及其中间体的新方法。如此制备的化合物可用作HMG-CoA还原酶的抑制剂，因此可用作降血脂药和低胆固醇血症药。

4. 发明申请

WO2003000898A1 PLANT GENES INVOLVED IN DEFENSE AGAINST PATHOGENS 审中-公开
标题翻译：参与防治病虫害的植物基因
公开(公告)号：WO2003000898A1
公开(公告)日：2003-01-03
申请号：PCT/IB2001/001105
申请日：2001-06-22
申请人： SYNGENTA PARTICIPATIONS AG , CHANG, Hur-Song , CHEN, Wenqiong , COOPER, Bret , GLAZEBROOK, Jane , GOFF, Stephen, Arthur , HOU, Yu-Ming , KATAGIRI, Fumiaki , QUAN, Sheng , TAO, Yi , WHITHAM, Steve , XIE, Zhiyi , ZHU, Tong , ZOU, Guangzhou
发明人： CHANG, Hur-Song , CHEN, Wenqiong , COOPER, Bret , GLAZEBROOK, Jane , GOFF, Stephen, Arthur , HOU, Yu-Ming , KATAGIRI, Fumiaki , QUAN, Sheng , TAO, Yi , WHITHAM, Steve , XIE, Zhiyi , ZHU, Tong , ZOU, Guangzhou
IPC分类号： C12N15/29
CPC分类号： C12Q1/6895 , C07K14/415 , C12N15/8279 , C12Q2600/158
摘要： Methods to identify genes, the expression of which are altered in response to pathogen infection, are provided, as well as the genes identified thereby and their corresponding promoters.
摘要翻译：提供了识别基因，其表达被响应于病原体感染而改变的方法，以及由此鉴定的基因及其相应的启动子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式