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1. 发明申请

WO2010127712A1 INFLUENZA A AND B VIRUS REPLICATION-INHIBITING PEPTIDES 审中-公开
标题翻译：流感病毒A和B病毒复制抑制肽
公开(公告)号：WO2010127712A1
公开(公告)日：2010-11-11
申请号：PCT/EP2009/055632
申请日：2009-05-08
申请人： PIKE PHARMA GMBH , KESSLER, Ulrich , MAYER, Daniel , WUNDERLICH, Kerstin , RANADHEERA, Charlene , SCHWEMMLE, Martin
发明人： KESSLER, Ulrich , MAYER, Daniel , WUNDERLICH, Kerstin , RANADHEERA, Charlene , SCHWEMMLE, Martin
IPC分类号： C07K14/11 , A61K38/04
CPC分类号： C07K14/005 , A61K38/00 , C12N2760/16122 , C12N2760/16222
摘要： A synthesized or isolated influenza virus replication-inhibiting peptide that competitively inhibits protein-protein interaction of the PA and PB1 of both influenza Virus Types A and B and novel in vitro binding screen to identify peptides with antiviral activity against influenza viruses of both type A and B is disclosed. In addition to the well-known pandemic influenza A viruses (such as the 1918 "Spanish" flu or H5N1), both type A and B viruses contribute greatly to the annual recurring epidemics that cause the vast majority of human cases and medical cost. Surprisingly, it was found that the novel virus replication-inhibiting, are able to inhibit protein-protein interaction of the PA and PB1 subunits of the heterotrimeric viral RNA polymerase complex of both influenza virus types A and B. The viral polymerase sub- unit interaction domain turned out as an effective target for the new antivirals, as correct assembly of the three viral polymerase subunits PB1, PB2 and PA is required for viral RNA synthesis and infectivity.
摘要翻译：合成或分离的流感病毒复制抑制肽，其竞争性地抑制A型和B型流感病毒的PA和PB1的蛋白质 - 蛋白质相互作用以及新颖的体外结合筛选，以鉴定具有针对A型和A型流感病毒的抗病毒活性的肽 B被公开。除了着名的大流行性甲型流感病毒（例如1918年“西班牙”流感或H5N1）外，A型和B型病毒对导致绝大多数人类病例和医疗费用的年度流行病学事件有很大贡献。令人惊讶的是，发现新型病毒复制抑制能够抑制A型和B型流感病毒的异源三聚病毒RNA聚合酶复合物的PA和PB1亚基的蛋白质 - 蛋白质相互作用。病毒聚合酶亚单元相互作用结构域是新型抗病毒药物的有效靶标，因为病毒RNA合成和感染性需要三种病毒聚合酶亚基PB1，PB2和PA的正确组装。

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