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1. 发明申请

WO1993010212A1 THIN MEMBRANE SENSOR WITH BIOCHEMICAL SWITCH 审中-公开
标题翻译：薄膜传感器与生物化学开关
公开(公告)号：WO1993010212A1
公开(公告)日：1993-05-27
申请号：PCT/US1992009607
申请日：1992-11-12
申请人： CASE, George, D. , WORLEY, Jennings, F., III
IPC分类号： C12M01/34
CPC分类号： G01N33/5438 , Y10S435/817
摘要： A modular biosensor system for chemical or biological agent detection utilizes electrochemical measurement of an ion current across a gate membrane (4) triggered by the reaction of the target agent with a recognition protein conjugated to a channel blocker (2). The sensor system includes a bioresponse simulator or "biochemical switch" module (1) which contains the recognition protein-channel blocker conjugate (2), and in which the detection reaction occurs, and a transducer module (3) which contains a gate membrane (4) and a measuring electrode (5), and in which the presence of agent is sensed electrically. A self-contained direct current voltage source (6) and an indicator means output (7) are connected in a biosensor circuit by means of a poised polarizing electrode (8). The biosensor has applications for environmental, medical, and industrial use.
摘要翻译：用于化学或生物试剂检测的模块化生物传感器系统利用由靶物质与与通道阻断剂（2）缀合的识别蛋白质的反应触发的栅极膜（4）的离子电流的电化学测量。传感器系统包括生物反应模拟器或包含识别蛋白质通道阻断剂共轭体（2）的生物反应模拟器或其中发生检测反应的“生物化学开关”模块（1）和包含栅极膜的换能器模块（3） 4）和测量电极（5），并且其中电性检测试剂的存在。独立的直流电压源（6）和指示装置输出（7）通过一个稳定的极化电极（8）连接在生物传感器电路中。生物传感器适用于环境，医疗和工业用途。

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