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1. 发明申请

WO2019035983A1 INTELLIGENT DOWNLOAD OF CONTENT 审中-公开
公开(公告)号：WO2019035983A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/000262
申请日：2018-08-17
申请人： WOOD, Anthony, John
发明人： WOOD, Anthony, John
IPC分类号： H04N21/4402 , H04N21/466 , H04N21/462
摘要： Intelligently downloading content to user devices is described herein. According to an embodiment, a user request for content is received. In response to the request, a low quality version of the content is downloaded and played to the user. Then, a higher quality version of the content is downloaded (this may occur during or after the download or playback of the low quality version of the content). Playback of the low quality version is discontinued. Then, playback of the higher quality version begins at the point where playback of the low quality version was discontinued. In some embodiments, the low quality version and the higher quality version of the requested content (among all the versions of the requested content) are identified via crowdsourcing.

2. 发明申请

WO2011137317A1 METHODS AND COMPOSITIONS FOR PROTECTING AGAINST NEUROTOXIC AGENTS 审中-公开
标题翻译：用于防治神经毒性试剂的方法和组合物
公开(公告)号：WO2011137317A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034508
申请日：2011-04-29
申请人： REVALESIO CORPORATION , WATSON, Richard L. , WOOD, Anthony, B. , ARCHAMBEAU, Gregory, J.
发明人： WATSON, Richard L. , WOOD, Anthony, B. , ARCHAMBEAU, Gregory, J.
IPC分类号： A01N39/00
CPC分类号： A61K31/58 , A61K9/0019 , A61K31/522 , A61K31/56 , A61K38/13 , A61K41/0004 , A61K45/06 , A61K2300/00
摘要： Provided are methods for protecting against or reducing neurotoxicity of exposure to a neurotoxic agent, comprising administering an electrokinetically altered aqueous fluid as provided herein in an amount sufficient to provide for neuroprotection against the neurotoxic agent, preferably where protecting against or reducing loss of motor coordination in the subject exposed to the neurotoxin is afforded. In certain aspects, protecting or reducing neurotoxin-mediated neuronal apoptosis is afforded, and/or activating or inducing at least one of PI-3 kinase and Akt phosphorylation in neurons is afforded. Preferably, administering the fluid comprises administering the fluid prior to exposure to the neurotoxic agent. Additionally provided are methods for preserving or improving motor coordination in a subject having a neurodegenerative condition or disease, comprising administering an electrokinetically altered aqueous fluid as provided herein in an amount sufficient to provide for preserving or improving motor coordination in the subject.
摘要翻译：提供了用于防止或减少暴露于神经毒性试剂的神经毒性的方法，其包括以足以提供对神经毒性剂的神经保护作用的量给予本文所提供的电动改变的水性流体，优选地在保护或减少运动协调丧失的情况下给予暴露于神经毒素的受试者。在某些方面，提供保护或减少神经毒素介导的神经细胞凋亡，和/或激活或诱导神经元中的PI-3激酶和Akt磷酸化中的至少一种。优选地，施用流体包括在暴露于神经毒性试剂之前施用流体。另外提供了用于保持或改善具有神经变性病症或疾病的受试者的运动协调的方法，包括以足以提供保护或改善受试者运动协调的量给予本文提供的电动改变的水性液体。

3. 发明申请

WO2010048455A1 COMPOSITIONS AND METHODS FOR TREATING MATRIX METALLOPROTEINASE 9 (MMP9)-MEDIATED CONDITIONS 审中-公开
标题翻译：用于治疗基质金属蛋白酶9（MMP9）的受体条件的组合物和方法
公开(公告)号：WO2010048455A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/061744
申请日：2009-10-22
申请人： REVALESIO CORPORATION , WATSON, Richard, L. , WOOD, Anthony, B. , ARCHAMBEAU, Gregory, J.
发明人： WATSON, Richard, L. , WOOD, Anthony, B. , ARCHAMBEAU, Gregory, J.
IPC分类号： A61K31/74
CPC分类号： A61K31/00 , A61K9/0078 , A61K45/06
摘要： Provided are methods for treating an MMP9-mediated condition or disease, comprising administration of an electrokinetically altered aqueous fluid comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures substantially having an average diameter of less than about 100 nanometers and stably configured in the ionic aqueous fluid in an amount sufficient for treating an MMP9-mediated condition or disease. The chargestabilized oxygen-containing nanostructures are preferably stably configured in the fluid in an amount sufficient to provide for modulation of cellular membrane potential and/or conductivity.
摘要翻译：提供了用于治疗MMP9介导的病症或疾病的方法，包括施用电动改变的含水流体，其包含基本上具有小于约100纳米的平均直径的电荷稳定的含氧纳米结构的离子水溶液，并稳定地配置在离子水溶液的量足以治疗MMP9介导的病症或疾病。充电稳定的含氧纳米结构优选地稳定地配置在流体中，其量足以提供细胞膜电位和/或电导率的调节。

4. 发明申请

WO2009055824A1 COMPOSITIONS AND METHODS FOR TREATING ASTHMA AND LUNG DISORDERS 审中-公开
标题翻译：用于治疗哮喘和肺疾病的组合物和方法
公开(公告)号：WO2009055824A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081386
申请日：2008-10-27
申请人： REVALESIO CORPORATION , WATSON, Richard L. , WOOD, Anthony B. , ARCHAMBEAU, Gregory J.
发明人： WATSON, Richard L. , WOOD, Anthony B. , ARCHAMBEAU, Gregory J.
IPC分类号： A61K45/00
CPC分类号： A61K33/00 , A61K31/43 , A61K31/431 , A61K45/06 , A61K2300/00
摘要： Provided are compositions and methods for treating or preventing lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis (e.g. nose respiratory tract), and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically generated fluid (including gas-enriched electrokinetically generated fluids) as disclosed herein, the electrokinetically altered aqueous fluid suitable to alter cellular membrane structure or function sufficient to provide for modulation of intracellular signal transduction, wherein treating a lung disorder or a symptom thereof is thereby afforded. Additional aspects relate to therapeutic compositions, and combination treatment methods comprising administration of at least one electrokinetically generated fluid in combination with at least one additional therapeutic agent.
摘要翻译：提供用于治疗或预防肺或呼吸系统疾病或由气流阻塞或限制或其症状（例如，哮喘，鼻炎，过敏性鼻炎（例如鼻呼吸道）和慢性阻塞性肺病（COPD））的症状的组合物和方法，和COPD相关的病症（例如，支气管炎，肺气肿，肺气肿，肺炎，支气管炎，流行性感冒，SARS，肺结核和百日咳（百日咳）等）在有需要的受试者中通过施用治疗组合物，至少一种电动产生的流体（包括富含气体的电动产生的流体），如本文所公开的，电动改变的水性流体适于改变足以提供细胞内信号转导调节的细胞膜结构或功能，其中治疗肺病或症状由此得到。另外的方面涉及治疗组合物和组合治疗方法，其包括与至少一种另外的治疗剂组合施用至少一种电动产生的流体。

5. 发明申请

WO2009055729A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的组合物和方法
公开(公告)号：WO2009055729A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081202
申请日：2008-10-24
申请人： REVALESIO CORPORATION , WATSON, Richard L. , WOOD, Anthony B. , ARCHAMBEAU, Gregory J.
发明人： WATSON, Richard L. , WOOD, Anthony B. , ARCHAMBEAU, Gregory J.
IPC分类号： A61K39/395
CPC分类号： C12N13/00 , G01N33/6872
摘要： Provided are electrokinetically-generated fluids ( e.g. , gas-enriched electrokinetic fluids or solutions), and therapeutic compositions and methods for use in treating inflammation or at least one symptom of inflammation. The electrokinetically-generated fluids or therapeutic compositions and methods include electrokinetically-generated aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions ( e.g. , tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-generated fluids ( e.g. , electrokinetically-generated gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动产生的流体（例如，富气电动液或溶液），以及用于治疗炎症或至少一种炎症症状的治疗组合物和方法。电动产生的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动产生的水性流体。特定方面提供通过调节细胞膜，膜电位，膜蛋白如膜受体，包括但不限于G-蛋白偶联受体（GPCR）和细胞间的细胞膜中的至少一种来调节或调节与炎性反应相关的细胞内信号转导交界处（例如，紧密连接处，间隙连接处，粘合层和脱水垫）。其它实施方案包括用于电动产生的流体（例如，电动产生的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

6. 发明申请

WO2008052143A3 MIXING DEVICE AND OUTPUT FLUIDS OF SAME 审中-公开
标题翻译：混合装置和输出流体
公开(公告)号：WO2008052143A3
公开(公告)日：2008-10-09
申请号：PCT/US2007082578
申请日：2007-10-25
申请人： REVALESIO CORP , WOOD ANTHONY B , ARCHAMBEAU GREGORY J , WATSON RICHARD L
发明人： WOOD ANTHONY B , ARCHAMBEAU GREGORY J , WATSON RICHARD L
IPC分类号： B01F7/12
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： A mixing device (100) for mixing a first and second material together to create an output mixture. The device includes a first chamber (310) containing the first material coupled to a mixing chamber (330) defined between a rotor (600) and a stator (700). The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump (410) configured to pump the first material from the first chamber into the mixing chamber. At least one of the rotor and stator have a plurality of through-holes (608, 708) through which the second material is provided to the mixing chamber. Optionally, a second chamber (320) coupled to the mixing chamber. The second chamber may house an internal pump (420) configured to pump the output material fro the mixing chamber into the second chamber.
摘要翻译：一种用于将第一和第二材料混合在一起以产生输出混合物的混合装置（100）。该装置包括第一室（310），其包含联接到限定在转子（600）和定子（700）之间的混合室（330）的第一材料。转子设置在定子内部并绕其旋转轴线旋转。第一室容纳内部泵（410），其被构造成将第一材料从第一室泵送到混合室中。转子和定子中的至少一个具有多个通孔（608,708），第二材料通过该通孔提供给混合室。可选地，联接到混合室的第二室（320）。第二室可以容纳内部泵（420），其构造成将来自混合室的输出材料泵入第二室。

7. 发明申请

WO2007034325A1 CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：碳酰胺衍生物作为MUSCARINIC受体拮抗剂
公开(公告)号：WO2007034325A1
公开(公告)日：2007-03-29
申请号：PCT/IB2006/002727
申请日：2006-09-01
申请人： PFIZER LIMITED , GLOSSOP, Paul, Alan , MANTELL, Simon, John , STRANG, Ross, Sinclair , WATSON, Christine, Anne, Louise , WOOD, Anthony
发明人： GLOSSOP, Paul, Alan , MANTELL, Simon, John , STRANG, Ross, Sinclair , WATSON, Christine, Anne, Louise , WOOD, Anthony
IPC分类号： C07D207/12 , C07D413/12 , C07D211/46 , C07D205/04 , A61K31/397 , A61K31/40 , A61K31/4409 , A61P37/00
CPC分类号： C07D207/12 , C07D205/02 , C07D205/04 , C07D207/04 , C07D211/26 , C07D211/46 , C07D413/12
摘要： The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
摘要翻译：本发明涉及式（I）化合物及其制备方法及其中间体，其用作毒蕈碱拮抗剂和含有它们的药物组合物。

8. 发明申请

WO2005029266A2 APPARATUS AND METHOD FOR PRESENTATION OF PORTABLY-STORED CONTENT ON AN HIGH-DEFINITION DISPLAY 审中-公开
标题翻译：用于在高定义显示器上呈现临时存储内容的装置和方法
公开(公告)号：WO2005029266A2
公开(公告)日：2005-03-31
申请号：PCT/US2004030424
申请日：2004-09-16
申请人： ROKU LLC , WOOD ANTHONY JOHN , WOODWARD DONALD ROBERT JR , SHANNON DOUGLAS GLEN , SLETTEN DANIEL , ELLIS PATRICK MICHAEL , GARNER GREGORY MACK , KOBB MICHAEL JOSEPH
IPC分类号： H04N5/45 , H04N5/58 , H04N5/775 , H04N5/907 , G06F
CPC分类号： H04N21/4184 , H04N5/45 , H04N5/58 , H04N5/775 , H04N5/907 , H04N21/4122 , H04N21/4325 , H04N21/44008 , H04N21/458 , H04N21/8153
摘要： An exemplary HD media player device and a method for presenting HD images to a user, according to a specific embodiment, include a controller configured to manage theprocessing of HD video signals to present images with a resolution similar to at least the 1080i format. In one embodiment, the HD media player detects the presence of portably-stored content and then automatically performs a slideshow or any other multimedia performance. In another embodiment, HD media player includes a screen saver module.
摘要翻译：根据具体实施例的示例性HD媒体播放器设备和用于向用户呈现HD图像的方法包括：控制器，被配置为管理HD视频信号的处理，以以至少1080i格式的分辨率呈现图像。在一个实施例中，HD媒体播放器检测可移动存储的内容的存在，然后自动执行幻灯片或任何其他多媒体演奏。在另一个实施例中，HD媒体播放器包括屏幕保护模块。

9. 发明申请

WO1993023325A1 LIFTING DEVICES 审中-公开
标题翻译：提升装置
公开(公告)号：WO1993023325A1
公开(公告)日：1993-11-25
申请号：PCT/GB1993001000
申请日：1993-05-17
申请人： RIVER DON CASTINGS LIMITED , WOOD, Anthony
发明人： RIVER DON CASTINGS LIMITED
IPC分类号： B66C01/66
CPC分类号： B66C1/66
摘要： A lifting device for a cast steel structure (1) includes a releasable or integrally formed pin (2) to which a shackle (4) or spreader bar assembly can be secured thereby regarding the need for conventional bollards or inset sheaves.
摘要翻译：用于铸钢结构（1）的提升装置包括可释放或整体形成的销（2），由此可以固定钩环（4）或吊杆组件，从而满足对常规护柱或插入轮的需要。

10. 发明申请

WO2012021860A1 COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于治疗心血管疾病的组合物和方法
公开(公告)号：WO2012021860A1
公开(公告)日：2012-02-16
申请号：PCT/US2011/047673
申请日：2011-08-12
申请人： REVALESIO CORPORATION , WATSON, Richard L. , WOOD, Anthony B. , ARCHAMBEAU, Gregory J.
发明人： WATSON, Richard L. , WOOD, Anthony B. , ARCHAMBEAU, Gregory J.
IPC分类号： A61K9/00
CPC分类号： A61K33/00 , A61K9/0009 , A61K9/0019 , A61K9/08 , A61K31/58 , A61K33/40 , A61K2300/00
摘要： Provided are methods for treating cardiovascular diseases and related conditions and symptoms (e.g., cardiac arrhythmia, vascular disease, myocardial infarction, congestive heart failure, myocarditis, atherosclerosis, and restenosis), comprising administering to a subject in need thereof a therapeutically effective amount of an electrokinetically altered aqueous fluid as described herein. In particular aspects, the electrokinetically altered aqueous fluids comprise an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures predominantly having an average diameter of less than about 100 nanometers and sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity. Provided are routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions, along with use of the electrokinetically altered aqueous fluids in surgical contexts, including but not limited to cardiovascular related surgeries. Additionally provided are methods for measuring biological activity of electrokinetically altered fluids.
摘要翻译：提供了治疗心血管疾病及相关病症和症状（例如心律失常，血管疾病，心肌梗塞，充血性心力衰竭，心肌炎，动脉粥样硬化和再狭窄）的方法，其包括向有需要的受试者施用治疗有效量的如本文所述的电动改变的含水流体。在特定方面，电动改变的含水流体包含电荷稳定的含氧纳米结构的离子水溶液，其主要具有小于约100纳米的平均直径，并且足以提供细胞膜电位和细胞膜电导率中的至少一种的调节。提供用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的给药途径或制剂，以及在外科环境中使用电动改变的含水流体，包括但不限于心血管相关手术。另外提供了用于测量电动改变的流体的生物活性的方法。

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