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1. 发明申请

WO9857666A8 USE OF ACOUSTO-OPTICAL AND SONOLUMINESCENCE CONTRAST AGENTS 审中-公开
标题翻译： ACOUSTO-OPTICAL和SONOLUMINESCENCE对比剂的使用
公开(公告)号：WO9857666A8
公开(公告)日：2000-01-20
申请号：PCT/GB9801438
申请日：1998-05-19
申请人： NYCOMED IMAGING AS , TOWLER PHILIP DEAN , HENRICHS PAUL MARK , WOLFE HENRY RAPHAEL
发明人： HENRICHS PAUL MARK , WOLFE HENRY RAPHAEL
IPC分类号： A61K49/00 , A61K49/22
CPC分类号： A61K49/0043 , A61K49/0002 , A61K49/0013 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0041 , A61K49/0065 , A61K49/0078 , A61K49/0084 , A61K49/0093 , A61K49/0438 , A61K49/0466 , A61K49/22 , A61K49/223 , A61K49/227
摘要： The invention relates inter alia to a method of generating information from an animate human or non-human animal body which method comprises: administering to said body a physiologically tolerable material capable of absorbing, scattering or emitting light at a wavelength in the range 300 to 1300 nm; subjecting at least a portion of said body to ultrasound irradiation; detecting light in the wavelength range 300 to 1300 nm from said portion of said body; and manipulating the detected light to generate said information.
摘要翻译：本发明特别涉及从动物人或非人动物体产生信息的方法，该方法包括：向所述身体施用能够吸收，散射或发射波长在300至1300范围内的光的生理上可耐受的材料纳米; 对所述身体的至少一部分进行超声波照射; 从所述主体的所述部分检测在300至1300nm的波长范围内的光; 并操纵检测到的光以产生所述信息。

2. 发明申请

WO9909417A3 METHOD OF DRUG SELECTION 审中-公开
公开(公告)号：WO9909417A3
公开(公告)日：1999-08-12
申请号：PCT/GB9802510
申请日：1998-08-20
申请人： NYCOMED IMAGING AS , COCKBAIN JULIAN , WOLFE HENRY RAPHAEL
发明人： WOLFE HENRY RAPHAEL
IPC分类号： G01N33/50 , A61K38/00 , C07K1/04 , C40B30/04 , G01N20060101 , G01N33/15 , G01N33/566 , G01N33/68
CPC分类号： C40B30/04 , C07K1/047 , G01N33/6845 , G01N2333/245
摘要： The invention provides a method for selecting a candidate drug compound, said method comprising i) identifying a starting oligopeptide having a binding affinity for a cell surface or other receptor site; ii) generating a plurality of homologous oligopeptides having single site amino acid modifications relative to said starting oligopeptide; iii) identifying components of said starting oligopeptide responsible for the secondary structure thereof; iv) for modification sites identified in step (ii) selecting a set of amino acids; v) for components identified in step (iii) selecting at least one non-natural amino acid which mimics the secondary structure of the component; vi) generating a first combinatorial library of oligopeptides having at said identified modification sites amino acid residues corresponding to said selected sets of amino acids; vii) identifying members of said first library having a binding affinity value above a predetermined minimum and generating a further combinatorial library of oligopeotides having members not present in said first library, and identifying members of said further library having improved binding affinity values relative to the identified members of said first library, and with the proviso that at least one of said first and further libraries contains oligopeptides containing residues of said non-natural amino acid or acids; and (viii) selecting from the identified members of said library or library a drug candidate.

3. 发明申请

WO9909417A9 METHOD OF DRUG SELECTION 审中-公开
标题翻译：药物选择方法
公开(公告)号：WO9909417A9
公开(公告)日：1999-05-27
申请号：PCT/GB9802510
申请日：1998-08-20
申请人： NYCOMED IMAGING AS , COCKBAIN JULIAN , WOLFE HENRY RAPHAEL
发明人： WOLFE HENRY RAPHAEL
IPC分类号： G01N33/50 , A61K38/00 , C07K1/04 , C40B30/04 , G01N20060101 , G01N33/15 , G01N33/566 , G01N33/68
CPC分类号： C40B30/04 , C07K1/047 , G01N33/6845 , G01N2333/245
摘要： The invention provides a method for selecting a candidate drug compound, said method comprising i) identifying a starting oligopeptide having a binding affinity for a cell surface or other receptor site; ii) generating a plurality of homologous oligopeptides having single site amino acid modifications relative to said starting oligopeptide; iii) identifying components of said starting oligopeptide responsible for the secondary structure thereof; iv) for modification sites identified in step (ii) selecting a set of amino acids; v) for components identified in step (iii) selecting at least one non-natural amino acid which mimics the secondary structure of the component; vi) generating a first combinatorial library of oligopeptides having at said identified modification sites amino acid residues corresponding to said selected sets of amino acids; vii) identifying members of said first library having a binding affinity value above a predetermined minimum and generating a further combinatorial library of oligopeotides having members not present in said first library, and identifying members of said further library having improved binding affinity values relative to the identified members of said first library, and with the proviso that at least one of said first and further libraries contains oligopeptides containing residues of said non-natural amino acid or acids; and (viii) selecting from the identified members of said library or library a drug candidate.
摘要翻译：本发明提供了用于选择候选药物化合物的方法，所述方法包括：i）鉴定对细胞表面或其他受体位点具有结合亲和力的起始寡肽; ii）产生相对于所述起始寡肽具有单位点氨基酸修饰的多个同源寡肽; iii）鉴定负责其二级结构的所述起始寡肽的组分; iv）在步骤（ii）中鉴定的修饰位点选择一组氨基酸; v）对于步骤（iii）中鉴定的组分，选择至少一种模拟组分二级结构的非天然氨基酸; vi）产生寡肽的第一组合文库，其在所述鉴定的修饰位点处具有对应于所述选择的氨基酸组的氨基酸残基; vii）鉴定具有高于预定最小值的结合亲和力值的所述第一文库的成员，并产生具有不存在于所述第一文库中的成员的寡核苷酸的另一组合文库，并鉴定所述另外文库相对于所鉴定的具有改善的结合亲和力值的成员所述第一文库的成员，并且附带条件是所述第一文库和其他文库中的至少一个包含含有所述非天然氨基酸残基的寡肽; 和（viii）从所述图书馆或图书馆的特定成员中选择候选药物。

4. 发明申请

WO9955383A3 IMPROVEMENTS IN OR RELATING TO DIAGNOSTIC/THERAPEUTIC AGENTS 审中-公开
标题翻译：诊断/治疗药物的改善或相关
公开(公告)号：WO9955383A3
公开(公告)日：2000-07-06
申请号：PCT/GB9901247
申请日：1999-04-22
申请人： NYCOMED IMAGING AS , CUTHBERTSON ALAN , SOLBAKKEN MAGNE , WOLFE HENRY RAPHAEL
发明人： CUTHBERTSON ALAN , SOLBAKKEN MAGNE , WOLFE HENRY RAPHAEL
IPC分类号： A61K49/00 , A61K20060101 , A61K41/00 , A61K47/48 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/12 , C07K4/00
CPC分类号： A61K41/0028 , A61K47/60 , A61K47/62 , A61K49/1806 , A61K49/223 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Novel membrane-forming amphiphilic lipopeptides comprising one or more peptide moieties containing 2-50 aminoacyl residues and one or more hydrocarbon chains containing 5-50 carbon atoms. Such lipopeptides may be used in the formation of stabilised gas microbubble dispersions suitable for use as diagnostic and/or therapeutic agents, for example as ultrasound contrast agents.
摘要翻译：包含一个或多个含有2-50个氨基酰基残基和一个或多个含有5-50个碳原子的烃链的肽部分的新型膜形成两亲性脂肽。这种脂肽可用于形成适合用作诊断和/或治疗剂（例如超声造影剂）的稳定气体微泡分散体。

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