专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011091423A3 COMBINED ULTRASONIC- PHOTOACOUSTIC IMAGING DEVICES AND METHODS 审中-公开
标题翻译：组合超声波照相成像装置及方法
公开(公告)号：WO2011091423A3
公开(公告)日：2011-09-15
申请号：PCT/US2011022420
申请日：2011-01-25
申请人： UNIV ARIZONA STATE , WITTE RUSSELL S , MONTILLA LEONARDO GABRIEL , OLAFSSON RAGNAR , INGRAM CHARLES M , WANG ZHAOHUI , NORWOOD ROBERT A , GREENLEE CHARLES
发明人： WITTE RUSSELL S , MONTILLA LEONARDO GABRIEL , OLAFSSON RAGNAR , INGRAM CHARLES M , WANG ZHAOHUI , NORWOOD ROBERT A , GREENLEE CHARLES
IPC分类号： G01N21/17 , G01N29/24
CPC分类号： G01S7/52017 , A61B5/0093 , A61B5/0095 , A61B5/7257 , A61B8/08 , A61B8/0825 , G01N21/1702 , G01N29/0672 , G01N29/2418 , G01N2291/02475 , G01S7/52 , G01S15/02
摘要： Devices are disclosed for obtaining data of a sample, particularly data capable of being processed to produce an image of a region of the sample. An exemplary device includes a light-beam source (102), an acoustic -wave source (106), an optical element (104), and an acoustic detector (106). The optical element (104) is transmissive to a light beam (110) produced by the light-beam source (102) and reflective to acoustic waves (114) produced by the acoustic -wave source (106). The optical element is situated to direct the transmitted light beam (111) and reflected acoustic wave (116) simultaneously along an optical axis to be incident at a situs in or on a sample (112) to cause the sample to produce acoustic echoes (118) from the incident acoustic waves while also producing photoacoustic waves (118) from the incident light beam photoacoustically interacting with the situs. The acoustic detector (106) is placed to receive and detect the acoustic echoes and the photoacoustic waves from the situs. The device allows to carry out simultaneously ultrasonic, e.g. pulse-echo, imaging and photoacoustic imaging. The acoustic detector can comprise one or more hydrophones exploiting the acousto - electric effect.
摘要翻译：公开了用于获取样本数据的装置，特别是能够被处理以产生样本区域的图像的数据。示例性装置包括光束源（102），声波源（106），光学元件（104）和声学检测器（106）。光学元件（104）对由光束源（102）产生并对由声波源（106）产生的声波（114）反射的光束（110）是透射的。光学元件被定位成沿着光轴同时引导透射光束（111）和反射声波（116）入射到样品（112）中或其上的位置，以使样品产生声学回波（118 ），同时从与该位置光声学相互作用的入射光束产生光声波（118）。声学检测器（106）被放置成接收和检测来自地点的声学回声和光声波。该装置允许同时进行超声波，例如脉冲回波，成像和光声成像。声学检测器可以包括利用声电效应的一个或多个水听器。

2. 发明申请

WO2011091423A2 ULTRASONIC/PHOTOACOUSTIC IMAGING DEVICES AND METHODS 审中-公开
标题翻译：超声/摄影成像装置及方法
公开(公告)号：WO2011091423A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/022420
申请日：2011-01-25
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , WITTE, Russell, S. , MONTILLA, Leonardo, Gabriel , OLAFSSON, Ragnar , INGRAM, Charles, M. , WANG, Zhaohui , NORWOOD, Robert, A. , GREENLEE, Charles
发明人： WITTE, Russell, S. , MONTILLA, Leonardo, Gabriel , OLAFSSON, Ragnar , INGRAM, Charles, M. , WANG, Zhaohui , NORWOOD, Robert, A. , GREENLEE, Charles
IPC分类号： G01N21/17
CPC分类号： G01S7/52017 , A61B5/0093 , A61B5/0095 , A61B5/7257 , A61B8/08 , A61B8/0825 , G01N21/1702 , G01N29/0672 , G01N29/2418 , G01N2291/02475 , G01S7/52 , G01S15/02
摘要： Devices are disclosed for obtaining data of a sample, particularly data capable of being processed to produce an image of a region of the sample. An exemplary device includes a light-beam source, an acoustic-wave source, an optical element, and an acoustic detector. The optical element is transmissive to a light beam produced by the light-beam source and reflective to acoustic waves produced by the acoustic-wave source. The optical element is situated to direct the transmitted light beam and reflected acoustic wave simultaneously along an optical axis to be incident at a situs in or on a sample to cause the sample to produce acoustic echoes from the incident acoustic waves while also producing photoacoustic waves from the incident light beam photoacoustically interacting with the situs. The acoustic detector is placed to receive and detect the acoustic echoes and the photoacoustic waves from the situs. The acoustic detector can comprise one or more hydrophones exploiting the acousto-electric effect.
摘要翻译：公开了用于获取样本数据的装置，特别是能够被处理以产生样本区域的图像的数据。示例性装置包括光束源，声波源，光学元件和声学检测器。光学元件对由光束源产生的光束是透射的，并且对由声波源产生的声波进行反射。光学元件被定位成沿着光轴同时引导透射光束和反射声波，以入射到样品中或样本上的位置，以使样本从入射的声波产生声学回波，同时还产生来自入射光束与地势光声学相互作用。声学检测器被放置以接收和检测来自地点的声学回声和光声波。声学检测器可以包括利用声电效应的一个或多个水听器。

3. 发明申请

WO2008115521A1 PHOTOACOUSTIC INDICATORS 审中-公开
标题翻译：摄影指标
公开(公告)号：WO2008115521A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/003608
申请日：2008-03-19
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ASHKENAZI, Shai , KOPELMAN, Raoul , WITTE, Russell S. , HORVATH, Tom , KIM, Gwangseong
发明人： ASHKENAZI, Shai , KOPELMAN, Raoul , WITTE, Russell S. , HORVATH, Tom , KIM, Gwangseong
IPC分类号： G01J3/30
CPC分类号： G01N21/6408 , G01N21/1702 , G01N21/6428 , G01N29/2418 , G01N2021/6432
摘要： A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point.
摘要翻译：一种测量荧光团激发态寿命的方法，包括在染料处引发激发激光脉冲，以将染料的染料分子从基态激发至激发态，并在染料分子处引发探测脉冲，从而产生第一组光声波第一时间延迟导致第一强度点。可以重复该过程，可选地引入第二激发激光脉冲，以在第二时间延迟产生第二组光声波，从而产生第二强度点。可以分析数据以确定第一强度点和第二强度点之间的斜率。

4. 发明申请

WO2008094448A1 HIGH-RESOLUTION MAPPING OF BIO-ELECTRIC FIELDS 审中-公开
标题翻译：生物电场的高分辨率映射
公开(公告)号：WO2008094448A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/000962
申请日：2008-01-25
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WITTE, Russell, S. , OLAFSSON, Ragnar , O'DONNELL, Matthew
发明人： WITTE, Russell, S. , OLAFSSON, Ragnar , O'DONNELL, Matthew
IPC分类号： A61B8/00 , H04R17/00
CPC分类号： A61B5/0093 , A61B5/04 , A61B5/05 , A61B5/4064 , A61B5/4094
摘要： A current source density mapping system includes an ultrasound transducer emitting an ultrasound wave traveling along an ultrasound beam directed at a mapping field in a region of living tissue and an ultrasound pulser delivering a transmit pulse to said ultrasound transducer. The system includes a timing device producing controlled excitation of the transmit pulse; a plurality of recording electrodes positioned in contact with the living tissue detecting an acoustoelectric voltage signal generated at a bioelectric current source and within a focal zone of said ultrasound beam. An amplifier operatively connected to the recording electrodes amplifying the acoustoelectric voltage signal at a predetermined gain; and an analyzing component comprising a digitizer, a sampling device, a signal processor and a display unit operatively connected to the amplifier determining the location of the bioelectric current source by analyzing the acoustoelectric voltage signal detected by the recording electrodes in response to an interaction between the ultrasound wave and the presence of a current source in the mapping field.
摘要翻译：电流源密度映射系统包括发射超声波的超声波换能器，所述超声波沿着指向生物体组织区域中的映射场的超声波以及向所述超声换能器递送发射脉冲的超声脉冲发生器传播。该系统包括产生发射脉冲的受控激励的定时装置; 多个记录电极，其与生物体组织接触，检测在生物电流源处产生的声电压信号，并且在所述超声波束的聚焦区域内。可操作地连接到记录电极的放大器，以预定增益放大声电压信号; 以及包括数字转换器，采样装置，信号处理器和显示单元的分析部件，所述数字转换器，采样装置，信号处理器和显示单元，其可操作地连接到所述放大器，通过分析响应于所述记录电极之间的相互作用而由所述记录电极检测的声电压信号超声波和映射场中电流源的存在。

5. 发明申请

WO2008042424A3 THERMAL STRAIN IMAGING OF TISSUE 审中-公开
标题翻译：组织的热应变成像
公开(公告)号：WO2008042424A3
公开(公告)日：2008-05-29
申请号：PCT/US2007021280
申请日：2007-10-03
申请人： UNIV MICHIGAN , KIM KANG , HUANG SHENG-WEN , WITTE RUSSELL S , O'DONNELL MATTHEW
发明人： KIM KANG , HUANG SHENG-WEN , WITTE RUSSELL S , O'DONNELL MATTHEW
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B8/587
摘要： Thermal strain imaging can be used to identify vascular plaques. Methods include heating and imaging with ultrasound to identify vulnerable plaques, which typically consist of a large lipid-rich core, in peripheral arteries of a patient. Lipid-bearing tissue has a negative temperature dependence of sound speed, whereas water-based tissue has a positive one, allowing thermal strain imaging to differentiate the two different types of tissues with high contrast to characterize plaque composition. Apparatus and methods of the present teachings allow noninvasive and reliable plaque identification.
摘要翻译：热应变成像可用于鉴定血管斑块。方法包括用超声波进行加热和成像，以鉴定在患者的外周动脉中通常由大的富脂质核心组成的易损斑块。脂质组织具有声速的负温度依赖性，而水基组织具有阳性组织，允许热应变成像区分具有高对比度的两种不同类型的组织以表征斑块组成。本发明的装置和方法允许非侵入性和可靠的斑块鉴定。

6. 发明申请

WO2008042424A2 THERMAL STRAIN IMAGING OF TISSUE 审中-公开
标题翻译：组织的热应变成像
公开(公告)号：WO2008042424A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/021280
申请日：2007-10-03
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , KIM, Kang , HUANG, Sheng-Wen , WITTE, Russell, S. , O'DONNELL, Matthew
发明人： KIM, Kang , HUANG, Sheng-Wen , WITTE, Russell, S. , O'DONNELL, Matthew
IPC分类号： A61B8/12
CPC分类号： A61B8/0858 , A61B8/587
摘要： Thermal strain imaging can be used to identify vascular plaques. Methods include heating and imaging with ultrasound to identify vulnerable plaques, which typically consist of a large lipid-rich core, in peripheral arteries of a patient. Lipid-bearing tissue has a negative temperature dependence of sound speed, whereas water-based tissue has a positive one, allowing thermal strain imaging to differentiate the two different types of tissues with high contrast to characterize plaque composition. Apparatus and methods of the present teachings allow noninvasive and reliable plaque identification.
摘要翻译：可以使用热应变成像来识别血管斑块。方法包括用超声波加热和成像以识别患者外周动脉中的脆性斑块，其通常由富含大量脂质的核心组成。含脂质的组织对声速具有负温度依赖性，而水基组织具有正的温度依赖性，允许热应变成像以高对比度区分两种不同类型的组织以表征斑块组成。本教导的装置和方法允许无创和可靠的牙斑识别。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式