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1. 发明申请

WO2003087399A1 NAD)P)H OXIDASE INHIBITORS FOR INCREASED GLUCOSE UPTAKE AND TREATMENT OF TYPE II DIABETES 审中-公开
标题翻译： NAD）P）H氧化酶抑制剂用于增加葡萄糖摄取和治疗II型糖尿病
公开(公告)号：WO2003087399A1
公开(公告)日：2003-10-23
申请号：PCT/SE2003/000618
申请日：2003-04-16
申请人： BIOVITRUM AB , GRÖNBERG, Alvar , WIKSTRÖM, Per
发明人： GRÖNBERG, Alvar , WIKSTRÖM, Per
IPC分类号： C12Q1/26
CPC分类号： A61K31/255 , A61K31/03 , A61K31/12 , A61K31/265 , A61K31/305 , A61K31/4164 , A61K31/44 , C12Q1/26 , G01N33/66 , G01N33/6893 , G01N2500/04 , G01N2800/042 , Y10S514/866
摘要： The present invention relates to the use of NAD(P)H oxidase inhibitors to increase cellular uptake of glucose and in the treatment and/or prevention of diseases caused by insulin resistance or diseases related thereto, such as type II diabetes. Specifically, the invention relates to a method for identifying an agent useful for the treatment or prophylaxis of a medical condition associated with elevated levels of blood glucose, the method comprising (i) contacting a candidate agent with a mammalian NAD(P)H oxidase or NAD(P)H oxidase complex; and (ii) determining whether said candidate agent inhibits the biological activities of the NAD(P)H oxidase or NAD(P)H oxidase complex.
摘要翻译：本发明涉及NAD（P）H氧化酶抑制剂用于增加葡萄糖的细胞摄取和用于治疗和/或预防由胰岛素抵抗或其相关疾病引起的疾病，例如II型糖尿病。具体地，本发明涉及用于鉴定可用于治疗或预防与血糖水平升高相关的医学病症的药剂的方法，所述方法包括（i）使候选药剂与哺乳动物NAD（P）H氧化酶或 NAD（P）H氧化酶复合物; 和（ii）确定所述候选试剂是否抑制NAD（P）H氧化酶或NAD（P）H氧化酶复合物的生物活性。

2. 发明申请

WO1995014035A1 METHOD FOR PURIFICATION OF A MIXTURE OF HYDROXAMATE DERIVATIZED PROTEIN AND NATIVE PROTEIN 审中-公开
标题翻译：纯化羟脯氨酸衍生蛋白和原蛋白混合物的方法
公开(公告)号：WO1995014035A1
公开(公告)日：1995-05-26
申请号：PCT/SE1994001088
申请日：1994-11-17
申请人： PHARMACIA AB , WIKSTRÖM, Per
发明人： PHARMACIA AB
IPC分类号： C07K07/10
CPC分类号： C07K14/65 , C07K1/22
摘要： The invention relates to a method for purification of a mixture of hydroxamate derivatized protein/proteins and native protein which is characterized by treating the mixture with immobilized metal and thereby adsorbing the hydroxamate derivatized protein/proteins on the immobilized-metal and recovering the native protein. The protein could be IGF-I. It also relates to a process for the production of a native protein which is characterized by expression of the protein as a fusion protein, cleavage of the fusion protein by hydroxylamine, separation of native protein from hydroxamate derivatized protein by adsorbing the hydroxamate derivatized protein on immobilized metal and directly recovering the native protein. The use of immobilized metal affinity chromatography for separation of native protein from hydroxamate derivatized protein is also claimed.
摘要翻译：本发明涉及纯化异羟肟酸衍生化蛋白质/蛋白质和天然蛋白质的混合物的方法，其特征在于用固定化金属处理混合物，从而将固定化金属上的异羟肟酸衍生化蛋白质/蛋白质吸附并回收天然蛋白质。蛋白质可以是IGF-I。它还涉及生产天然蛋白质的方法，其特征在于将蛋白质表达为融合蛋白，通过羟胺切割融合蛋白，通过将固定化的羟肟酸衍生化蛋白质吸附在异羟肟酸衍生化蛋白质上，将天然蛋白质与异羟肟酸衍生化蛋白质分离金属并直接回收天然蛋白质。还要求使用固定化金属亲和层析法将天然蛋白质与异羟肟酸衍生化蛋白质分离。

3. 发明申请

WO2011152783A1 FORMULATIONS PRESERVING BIOACTIVITY AND METHODS OF THEIR PREPARATION 审中-公开
标题翻译：保留生物活性的制剂及其制备方法
公开(公告)号：WO2011152783A1
公开(公告)日：2011-12-08
申请号：PCT/SE2011/050670
申请日：2011-05-30
申请人： RPH PHARMACEUTICALS AB , WIKSTRÖM, Per , BRAMER, Tobias , YACHOH, Lilyan
发明人： WIKSTRÖM, Per , BRAMER, Tobias , YACHOH, Lilyan
IPC分类号： A61K47/36 , A61K9/16 , A61K38/00
CPC分类号： A61K9/5036 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K9/5026 , A61K9/5073 , A61K9/5089 , A61K38/00
摘要： A pharmaceutical composition comprising an alginate hydrogel core where a bioactive agent is entrapped. The water content of the hydrogel is at least 10 % of equilibrium water content. The beads have an enteric coating and are intended for oral administration. The bioactive agent is bioactive proteins, antiboies or viable cells and it is intended to exert its activity in the duodenum and the upper intestines.
摘要翻译：一种药物组合物，其包含生物活性剂被捕获的藻酸盐水凝胶核心。水凝胶的含水量至少为平衡水含量的10％。珠粒具有肠溶衣，旨在口服给药。生物活性剂是生物活性蛋白，抗体或活细胞，其目的是在十二指肠和上肠中发挥其活性。

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