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1. 发明申请

WO2013116798A3 A METHOD FOR THE TREATMENT AND/OR PREVENTION OF ORAL ALLERGIC SYMPTOMS OF THE LIPS DUE TO ORAL CONTACT WITH A FOOD ALLERGEN 审中-公开
公开(公告)号：WO2013116798A3
公开(公告)日：2013-08-08
申请号：PCT/US2013/024528
申请日：2013-02-01
申请人： HARISH, M.D., Ziv , RUBINSTEIN, Isaac , WEINZIMMER, Russ , ARBIT, Ehud
发明人： RUBINSTEIN, Isaac , WEINZIMMER, Russ , ARBIT, Ehud
IPC分类号： A61K31/352 , A61K31/353 , A61K31/40 , A61K9/06 , A61K9/12 , A61P1/02
摘要： A method of applying a topical preparation of at least one of a mast cell stabilizer, an antihistamine, and a leukotriene inhibitor is disclosed for prevention and/or treatment of oral allergy syndrome of the lips, including lip itchiness and/or swelling. For example, topical application of Cromolyn Sodium to the lips can be used to prevent and/or treat allergic reaction to consumption or other contact with raw fruits and/or raw vegetables. The topical administration can be performed by using applicator devices that apply at least one of a mast cell stabilizer and an antihistamine in the form of a liquid, or a gel, or a butter, or a wax-like solid, or a liposome suspension. Applicator devices can include at least one of: a roller, a brush, a sponge, a swab, a tube, a lipstick. The taste of the at least one of a mast cell stabilizer and an antihistamine can be masked by flavors.

2. 发明申请

WO2012092594A3 PREPARATIONS FOR TOPICAL PREVENTION AND/OR TREATMENT OF ORAL ALLERGIC SYMPTOMS DUE TO ORAL CONTACT WITH FRUITS AND/OR VEGETABLES 审中-公开
公开(公告)号：WO2012092594A3
公开(公告)日：2012-07-05
申请号：PCT/US2011/068185
申请日：2011-12-30
申请人： HARISH, Ziv, M.D. , ARBIT, Ehud , RUBINSTEIN, Isaac , WEINZIMMER, Russ
发明人： HARISH, Ziv, M.D. , ARBIT, Ehud , RUBINSTEIN, Isaac , WEINZIMMER, Russ
IPC分类号： A61K31/353 , A61K31/352 , A61K31/40 , A61K9/12 , A61K9/06 , A61P1/02
摘要： A topical preparation of at least one of a mast cell stabilizer and an antihistamine is disclosed for prevention and/or treatment of oral allergy syndrome, or other allergy-related oral inflammatory processes. For example, the topical administration of Cromolyn Sodium prior to ingestion of raw fruits and raw vegetables may be used to prevent oral allergy symptoms. The topical administration can be performed by use of a solution, a powder, an aerosol, a tablet, a chewable tablet, a gel, a melting strip, a mouth rinse, a mouth swab, or a piece of candy, and may be combined with carrier molecules and/or mucoadhesive molecules to enhance efficacy.

3. 发明申请

WO2010011614A3 GARMENT WITH REGIONALLY VARIED EVAPORATIVE COOLING PROPERTIES 审中-公开
标题翻译：具有区域性蒸发冷却性能的服装
公开(公告)号：WO2010011614A3
公开(公告)日：2010-05-06
申请号：PCT/US2009051182
申请日：2009-07-20
申请人： GOLDMANN RICHARD , WEINZIMMER RUSS , BURUM DOUGLAS P
发明人： GOLDMANN RICHARD , WEINZIMMER RUSS , BURUM DOUGLAS P
IPC分类号： A41D13/005 , A41D13/00 , A41D27/00 , A41D27/20
CPC分类号： A41D13/00 , A41D13/002 , A41D13/0056 , A41D2400/20 , A41D2400/46 , A41D2400/62 , A42B1/008
摘要： A garment, such as a shirt, shorts, socks, or a hat, is disclosed for efficiently cooling an individual by water evaporation, thereby reducing perspiration, dehydration, loss of electrolytes, and discomfort. The garment includes at least one property that is intentionally non-uniform, so as to concentrate and retain applied water in areas where enhanced cooling is desired. Variable properties include structure, density, composition, texture, type and/or quantity of additive substances, included fabric layers, and degree of contact with a user's body. A source of water can be included, for example in an attachable container. The container can be compressed, water can be pumped, or compressed air can push water from the container. A pump can be actuated by hand or by natural movements of a user. A drinking port can be included, and a pouch can hold a removable, water-absorbing and water-releasing insert that can be pre-wetted and/or pre-cooled.
摘要翻译：披露了一种服装，例如衬衫，短裤，袜子或帽子，用于通过水分蒸发有效地冷却个体，由此减少出汗，脱水，电解质损失和不适。该服装包括至少一个有意不均匀的特性，以便在需要增强冷却的区域中集中并保持施用的水。可变性质包括结构，密度，组成，质地，添加剂物质的类型和/或数量，包括织物层和与用户身体的接触程度。水源可以包含在例如可附接的容器中。容器可以被压缩，水可以被泵送，或者压缩空气可以从容器中推出水。泵可以用手或通过使用者的自然运动来启动。可以包括饮用口，并且小袋可以容纳可以预先湿润和/或预冷却的可移除的吸水和放水插入物。

4. 发明申请

WO2010045635A3 SWIMMING ENVIRONMENT WITH MULTIPLE TEMPERATURE REGIONS 审中-公开
公开(公告)号：WO2010045635A3
公开(公告)日：2010-04-22
申请号：PCT/US2009/061151
申请日：2009-10-19
申请人： GOLDMANN, Richard , WEINZIMMER, Russ , BURUM, Douglas, P.
发明人： GOLDMANN, Richard , WEINZIMMER, Russ , BURUM, Douglas, P.
IPC分类号： E04H4/14 , E04H4/00 , E04H4/12
摘要： A swimming environment is disclosed that enables a swimmer to select water of a desired temperature by moving between swimming regions that are separate swimming pools and/or sub-regions of a swimming pool. Pools can be divided into sub-regions by thermally isolating barriers that are sheets or strips hanging from floats, sheets attached to pool boundaries, or solid barriers. Strips can be flexible or rigid, and can be linked by magnets. Barriers can be designed to avoid swimmer injury and absorb wave energy. Swimmers can move past barriers without fully leaving the water by submerging floats, separating strips, moving through a barrier gap, traversing a slide, and/or moving through a door. Doors can be single or double, swinging, sliding, revolving, or pocket. A water temperature control system ensures that none of the regions exceeds 90 degrees Fahrenheit, and can include a heater, cooler, and/or heat pump.

5. 发明申请

WO2009058724A2 DEVICE FOR APPLYING COOLING MIST TO INDIVIDUALS WITHOUT WATER ACCUMULATION 审中-公开
标题翻译：用于将冷却雾应用于个体而不积水的装置
公开(公告)号：WO2009058724A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/081302
申请日：2008-10-27
申请人： GOLDMANN, Richard , WEINZIMMER, Russ , BURUM, Douglas P.
发明人： GOLDMANN, Richard , WEINZIMMER, Russ , BURUM, Douglas P.
IPC分类号： B05B15/00 , F24F6/12
CPC分类号： F24F6/12 , F24F2221/38 , Y10S261/43
摘要： An apparatus and method of use are disclosed for cooling one or more exercising or resting individuals with a water mist while automatically preventing the undesirable accumulation of excess water. In some embodiments, a sensor detects accumulated water on or near an individual, while other embodiments use measured climate parameters to predict water accumulation. The apparatus can be free standing, fixed to the walls or ceiling, or attached to an object on which an individual is resting or exercising. In some preferred embodiments, the apparatus is controlled according to the passing of time and/or one or more measured physiological parameters measured by sensors directed toward or attached to an individual, or embedded in an object on which an individual is resting or exercising. In some embodiments dry air is also applied either simultaneously or alternately with the mist to enhance cooling and further discourage water accumulation.
摘要翻译：公开了一种使用装置和方法，用于利用水雾来冷却一个或多个锻炼或休息的个体，同时自动防止过量水的不希望的积聚。在一些实施例中，传感器检测个体上或附近的积聚的水，而其他实施例使用测量的气候参数来预测水积聚。该设备可以是独立式的，可以固定在墙壁或天花板上，也可以附着在个人休息或锻炼的物体上。在一些优选实施例中，根据时间的推移和/或由传感器测量的一个或多个测量的生理参数来控制该设备，该传感器指向或附接到个体，或嵌入在个体正在休息或锻炼的对象中。在一些实施方式中，干空气也与雾同时或交替地施加以增强冷却并进一步阻止水积聚。

6. 发明申请

WO2015070116A2 FORMULATIONS AND METHODS FOR PREVENTION AND TREATMENT OF ORAL ALLERGY SYNDROME 审中-公开
标题翻译：口服过敏综合症的预防和治疗方法及其方法
公开(公告)号：WO2015070116A2
公开(公告)日：2015-05-14
申请号：PCT/US2014/064713
申请日：2014-11-09
申请人： HARISH, Ziv, M.D. , WEINZIMMER, Russ
发明人： HARISH, Ziv, M.D. , WEINZIMMER, Russ
IPC分类号： B02C13/00
CPC分类号： A61K9/006 , A61K31/352
摘要： A method and formulation for the prevention and treatment for Oral Allergy Syndrome (OAS), also referred to as Pollen-associated Food Allergy Syndrome (PFAS), is disclosed. The formulation significantly reduces or prevents symptoms related to Oral Allergy Syndrome while having a superb safety record. It can significantly improve Quality of Life for millions of patients afflicted with OAS.
摘要翻译：披露了一种用于预防和治疗口腔过敏综合征（OAS）的方法和制剂，也被称为花粉相关性食物过敏综合征（PFAS）。该制剂具有极好的安全记录，可显着减少或预防与口腔过敏综合征相关的症状。它可以显着提高数百万患有美洲国家组织的患者的生活质量。

7. 发明申请

WO2013116798A2 A METHOD FOR THE TREATMENT AND/OR PREVENTION OF ORAL ALLERGIC SYMPTOMS OF THE LIPS DUE TO ORAL CONTACT WITH A FOOD ALLERGEN 审中-公开
标题翻译：一种治疗和/或预防口服接触食物过敏原的口服过敏症状的方法
公开(公告)号：WO2013116798A2
公开(公告)日：2013-08-08
申请号：PCT/US2013024528
申请日：2013-02-01
申请人： HARISH M D ZIV , RUBINSTEIN ISAAC , WEINZIMMER RUSS , ARBIT EHUD
发明人： RUBINSTEIN ISAAC , WEINZIMMER RUSS , ARBIT EHUD
CPC分类号： A61K9/006 , A61K31/352 , A61K31/353 , A61K31/40 , A61K45/06 , A61K47/183 , C07D311/24 , A61K2300/00
摘要： A method of applying a topical preparation of at least one of a mast cell stabilizer, an antihistamine, and a leukotriene inhibitor is disclosed for prevention and/or treatment of oral allergy syndrome of the lips, including lip itchiness and/or swelling. For example, topical application of Cromolyn Sodium to the lips can be used to prevent and/or treat allergic reaction to consumption or other contact with raw fruits and/or raw vegetables. The topical administration can be performed by using applicator devices that apply at least one of a mast cell stabilizer and an antihistamine in the form of a liquid, or a gel, or a butter, or a wax-like solid, or a liposome suspension. Applicator devices can include at least one of: a roller, a brush, a sponge, a swab, a tube, a lipstick. The taste of the at least one of a mast cell stabilizer and an antihistamine can be masked by flavors.
摘要翻译：公开了一种施用肥大细胞稳定剂，抗组胺剂和白三烯抑制剂中的至少一种的局部制剂的方法，用于预防和/或治疗唇部的口腔过敏综合征，包括唇痒和/或肿胀。例如，将Cromolyn钠局部施用于唇部可用于预防和/或治疗与生水果和/或生蔬菜的消费或其他接触的过敏反应。局部施用可以通过使用施用器械来进行，所述施用装置应用液体，凝胶或黄油，蜡状固体或脂质体悬浮液形式的肥大细胞稳定剂和抗组胺剂中的至少一种。涂抹器装置可以包括以下至少一种：辊，刷，海绵，拭子，管，口红。肥大细胞稳定剂和抗组织胺中的至少一种的味道可以被香料掩蔽。

8. 发明申请

WO2009131864A3 APPARATUS AND METHOD FOR FLEXIBLY AND EFFICIENTLY VARYING AIR TEMPERATURES IN MULTIPLE ROOMS 审中-公开
标题翻译：装置和方法在多个房间中灵活和有效地改变空气温度
公开(公告)号：WO2009131864A3
公开(公告)日：2010-01-07
申请号：PCT/US2009040406
申请日：2009-04-13
申请人： GOLDMANN RICHARD , WEINZIMMER RUSS , BURUM DOUGLAS P
发明人： GOLDMANN RICHARD , WEINZIMMER RUSS , BURUM DOUGLAS P
IPC分类号： F24F3/147 , F24F3/052 , F25B30/00
CPC分类号： F24F12/003 , F24F3/052 , F24F2221/08 , F24F2221/38 , Y02B30/52 , Y02B30/563
摘要： The invention enables coordinated, flexible, agile, and energy efficient temperature variation among a plurality of rooms, as found in a hotel, apartment building, or group of exercise rooms, by transferring heat between the rooms. Air can be moved by fans and/or heat can be transferred by heat pump. Heat transfer between exercise rooms can be powered partly by exertion of individuals in the rooms. Rapid air exchange can quickly equalize temperatures in adjacent rooms. Embodiments exchange heat between rooms and interior and/or exterior reservoirs of warmer and cooler air and/or water, and some embodiments move air from the reservoirs into and out of the rooms. Heat can be pumped into or out of the system, and air and/or water can be added or extracted from the reservoirs. In some embodiments heat is moved sequentially through a variable series of rooms, creating a monotonic variation of temperatures.
摘要翻译：本发明通过在房间之间传递热量来实现多个房间之间的协调，灵活，灵活和节能的温度变化，如在酒店，公寓楼或一组健身房中所发现的。空气可以通过风扇移动和/或热量可以通过热泵传递。运动室之间的热量传递部分可以通过在房间中的个人进行运动。快速空气交换可以快速平衡相邻房间的温度。实施例在房间和较暖和较冷空气和/或水的内部和/或外部储存器之间交换热量，并且一些实施例将空气从储存器移入和移出房间。可以将热量泵入或流出系统，并且可以从储存器中添加或提取空气和/或水。在一些实施例中，热量顺序地通过可变系列的房间移动，产生温度的单调变化。

9. 发明申请

WO2014205008A1 SUBLINGUAL IMMUNOTHERAPY WITH REDUCED ORAL ITCHINESS 审中-公开
标题翻译：具有减少口服功能的次生免疫治疗
公开(公告)号：WO2014205008A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/042813
申请日：2014-06-17
申请人： HARISH, Ziv , WEINZIMMER, Russ
发明人： HARISH, Ziv , WEINZIMMER, Russ
IPC分类号： A61K39/35 , A61K47/06 , A61K9/20 , A61K9/28 , A61P37/00
CPC分类号： A61K47/22 , A61K9/006 , A61K9/209 , A61K31/352 , A61K31/353 , A61K31/40 , A61K39/35 , A61K39/36 , A61K45/06 , A61K2039/545 , A61K2300/00
摘要： Sublingual immunotherapy (SLIT) with reduced oral itchiness is disclosed. The improved sublingual immunotherapy combines a monotonically increasing dose of allergen, along with a constant dose of mast cell stabilizer, thereby substantially avoiding the oral itchiness and other uncomfortable adverse reactions typically experienced with SLIT, which can improve patient compliance. An antihistamine and/or a leukotriene inhibitor can also be added along with the mast cell stabilizer. Multi-layer and/or coated tablets, and flexible paired ampoules with special features to advantageously time the dose of the allergen relative to the dose of the mast cell stabilizer, have been provided to effectively administer the improved sublingual immunotherapy in a highly convenient manner. Methods, preparations, and apparatuses for administration of SLIT, apparatus for sequentially dispensing, methods for producing a sequence of allergen doses with reduced adverse reactions, methods for producing a stock solution for dilution, and methods for producing cooperative pre-filled vials are also disclosed.
摘要翻译：披露了口服瘙痒减轻的舌下免疫治疗（SLIT）。改进的舌下免疫治疗结合了单调增加剂量的变应原，以及恒定剂量的肥大细胞稳定剂，从而基本上避免了口服发痒和其它通常经历的不适反应，其可以改善患者依从性。还可以与肥大细胞稳定剂一起添加抗组胺药和/或白三烯抑制剂。已经提供了多层和/或包衣片剂和具有特殊特征的柔性配对安瓿，以有利地相对于肥大细胞稳定剂的剂量来计时变应原剂量，以便以非常方便的方式有效地施用改进的舌下免疫治疗。还公开了用于施用SLIT的方法，制剂和装置，用于顺序分配的装置，用于产生具有减少的不良反应的变应原剂量序列的方法，用于制备用于稀释的储备溶液的方法，以及用于生产协同预填充小瓶的方法。

10. 发明申请

WO2012135537A2 PALM-CONTROLLED INJECTORS 审中-公开
标题翻译：棕榈控制注射器
公开(公告)号：WO2012135537A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/031286
申请日：2012-03-29
申请人： HARISH, Ziv , RUBINSTEIN, Isaac , ARBIT, Ehud , WEINZIMMER, Russ
发明人： HARISH, Ziv , RUBINSTEIN, Isaac , ARBIT, Ehud , WEINZIMMER, Russ
IPC分类号： A61M5/24 , A61M5/20 , A61M5/14
CPC分类号： A61M5/2033 , A61M5/19 , A61M5/3234 , A61M5/326 , A61M5/3287 , A61M5/422 , A61M2005/2013 , A61M2005/206 , A61M2005/2073
摘要： A palm-controlled device is disclosed for injection of a substance into an organism. The device includes a palm-receiving surface for receiving a palm of a hand, the palm receiving surface being shaped so that the palm is substantially parallel to a surface of an injection site of the organism while operating the device. The palm receiving surface can also be shaped so that the palm is substantially perpendicular to a surface of the injection site. The device also includes an injector having at least one pre-filled syringe, the palm-receiving surface being cooperative with the injector such that when pressure is applied to the palm-receiving surface, the injector is actuated so as to inject contents of the at least one pre-filled syringe. Actuation of the injector is by gradual pressure; not sudden motion. Single or multiple doses of same or different medications can be included in a single injector.
摘要翻译：公开了一种用于将物质注射到生物体中的手掌控制装置。该装置包括用于接纳手掌的手掌接收表面，手掌接收表面被成形为使得手掌在操作装置时基本上平行于生物体的注射部位的表面。手掌接收表面也可以被成形为使得手掌基本垂直于注射部位的表面。该装置还包括具有至少一个预填充注射器的注射器，手掌接收表面与注射器配合，使得当压力施加到手掌接收表面时，注射器被致动以便注射注射器的内容物至少一个预充注射器。喷射器的驱动是通过逐渐的压力来实现的; 不是突然的动作。单次注射器可以包含一次或多次相同或不同的药物。

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