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1. 发明申请

WO2009106831A3 PHARMACEUTICAL COMPOSITION COMPRISING NALTREXONE 审中-公开
公开(公告)号：WO2009106831A3
公开(公告)日：2009-09-03
申请号：PCT/GB2009/000537
申请日：2009-02-26
申请人： SYNTROPHARMA LIMITED , WEIMANN, Ludwig, Jan
发明人： WEIMANN, Ludwig, Jan
IPC分类号： A61K9/70 , A61K47/14 , A61K31/485 , A61P25/32 , A61P25/36
摘要： The invention provides transdermal patches comprising an adhesive and a composition comprising naltrexone and either methyl oleate or isopropyl myristate, a kit comprising a plurality of such transdermal patches, a composition comprising naltrexone and methyl oleate, such a composition for use as a medicament, and compositions comprising naltrexone and methyl oleate or isopropyl myristate for use in the treatment of alcoholism or opiate addiction.

2. 发明申请

WO2008027203A3 MEDICATED ORTHOPEDIC SUPPORT STRUCTURES FOR TREATMENT OF DAMAGED MUSCULOSKELETAL TISSUE 审中-公开
标题翻译：用于治疗损伤的胶质细胞组织的药物治疗支持结构
公开(公告)号：WO2008027203A3
公开(公告)日：2008-11-06
申请号：PCT/US2007018199
申请日：2007-08-14
申请人： CURE THEREPAUTICS INC , ANG ROBERT , WEIMANN LUDWIG , MURRELL ANTHONY CALVERT
发明人： ANG ROBERT , WEIMANN LUDWIG , MURRELL ANTHONY CALVERT
IPC分类号： A61F13/00
CPC分类号： A61K9/7061 , A61K31/21
摘要： A system and method for treating damaged musculoskeletal tissue includes an orthopedic support structure and a nitroglycerin-containing composition. The orthopedic support structure provides mechanical support to the damaged tissue and maintains the nitroglycerin-containing composition in contact with the skin of a subject wearing using the system. The nitroglycerin- containing composition can be integrated into the orthopedic support structure or the support structure can be configured to contain removable doses of the nitroglycerin-containing composition. The system and method provides relief of pain and improved function of the musculoskeletal tissue.
摘要翻译：用于治疗损伤的肌肉骨骼组织的系统和方法包括矫形支撑结构和含硝酸甘油的组合物。矫形支撑结构为受损组织提供机械支撑，并使含硝酸甘油的组合物与使用该系统的受试者的皮肤接触。含硝酸甘油的组合物可以整合到整形外科支持结构中，或者支持结构可被配置成含有可除去剂量的含有硝酸甘油的组合物。该系统和方法提供减轻疼痛和改善肌肉骨骼组织的功能。

3. 发明申请

WO2007143185A3 TRANSDERMAL TREATMENT OF TENDINOPATHY USING GLYCERYL TRINITRITE 审中-公开
标题翻译：使用谷氨酸TRINITRITE的TENDINOPATHY的透皮治疗
公开(公告)号：WO2007143185A3
公开(公告)日：2008-06-26
申请号：PCT/US2007013117
申请日：2007-06-01
申请人： CURE THERAPEUTICS INC , MURRELL GEORGY ANTHONY CALVERT , ANG ROBERT , WEIMANN LUDWIG , JACOBSON SVEN
发明人： MURRELL GEORGY ANTHONY CALVERT , ANG ROBERT , WEIMANN LUDWIG , JACOBSON SVEN
IPC分类号： A61F13/00 , A61K31/21
CPC分类号： A61K9/0014 , A61K9/7023 , A61K31/21
摘要： The present invention provides methods for treating tendinopathy providing a durability of effect by administering nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies. The use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr.
摘要翻译：本发明提供通过施用硝酸甘油来治疗提供耐久性的腱鞘的方法。这些方法包括减轻与这种腱病相关的疼痛的方法。使用透皮贴片，其配置为以5mcg / hr的速率将硝酸甘油酯输送至约85mcg / hr。

4. 发明申请

WO2007092284A3 LOW DOSE NO DONOR-CONTAINING TRANSDERMAL PATCH 审中-公开
标题翻译：低剂量不含复合透皮贴片
公开(公告)号：WO2007092284A3
公开(公告)日：2008-07-03
申请号：PCT/US2007002835
申请日：2007-02-02
申请人： CURE THERAPEUCTICS INC , ANG ROBERT , JACOBSON SVEN , WEIMANN LUDWIG
发明人： ANG ROBERT , JACOBSON SVEN , WEIMANN LUDWIG
IPC分类号： A61F13/02 , A61F13/00
CPC分类号： A61K9/7061 , A61K31/21 , A61K47/10
摘要： The present invention is drawn to a transdermal patch for the delivery of a nitroglycerin or other NO donor. The patch can comprise a backing layer, and a nitroglycerin-containing composition or other NO donor-containing composition which is supported at least in part by the backing layer. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 µg/hour to about 70 µg/hour. In one embodiment, the transdermal patch can provide a delivery rate at the drug delivery zone of from about 1 µg/cm2/day to about 600 µg/cm2/day. In another embodiment, the transdermal patch can contain from 6 wt% to 18 wt% of the nitric oxide donor, e.g., nitroglycerin. In each embodiment, the patch can contain at least 450 µg/cm2 of nitroglycerin.
摘要翻译：本发明涉及用于递送硝酸甘油或其他NO供体的透皮贴片。贴剂可以包含背衬层和含硝酸甘油的组合物或至少部分由背衬层支撑的含NO供体的组合物。透皮贴剂可以具有由组合物接触完整的人皮肤部位的区域限定的药物递送区，并且透皮贴剂可以配制成以约5μg/小时至约约1μg/小时递送一氧化氮供体，例如硝酸甘油 70μg/小时。在一个实施方案中，透皮贴剂可以在药物递送区域提供约1μg/ cm 2 /天至约600μg/ cm 2 /天的递送速率。在另一个实施方案中，透皮贴剂可含有6重量％至18重量％的一氧化氮供体，例如硝酸甘油。在每个实施方案中，贴剂可含有至少450μg/ cm 2的硝酸甘油。

5. 发明申请

WO2004060447A3 TRANSDERMAL DELIVERY USING ENCAPSULATED AGENT ACTIVATED BY ULTRASOUND AND/OR HEAT 审中-公开
标题翻译：使用由超声波和/或热激活的封装剂进行超导传送
公开(公告)号：WO2004060447A3
公开(公告)日：2005-12-08
申请号：PCT/US0341850
申请日：2003-12-31
申请人： ULTRA SONIC TECHNOLOGIES L L C , WEIMANN LUDWIG J
发明人： WEIMANN LUDWIG J
IPC分类号： A61B17/20 , A61F2/00 , A61F13/00 , A61F13/02 , A61K9/00 , A61K9/22 , A61K9/48 , A61K9/66 , A61K9/70 , A61L15/16 , A61M20060101 , A61M37/00 , A61N1/30
CPC分类号： A61K9/0009 , A61K9/0014 , A61K9/7084 , A61K9/7092 , A61M37/00 , A61M37/0092 , A61N1/30
摘要： A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.
摘要翻译：通过在用于保持微胶囊的介质（150）内通过在预定尺寸的微胶囊中提供物质来输送物质通过至少一个真皮层的方法; 将用于保持微胶囊的介质放置在与人或动物的皮肤（320）相邻的贴片（100）的表面上; 并且将能量（200）施加到贴剂上，该能量具有干扰微胶囊完整性的特征，从而导致物质从微胶囊中释放出来。可以选择性地施加能量以在期望的时间释放物质。该物质可以是药物或其它活性剂。

6. 发明申请

WO2009106831A2 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2009106831A2
公开(公告)日：2009-09-03
申请号：PCT/GB2009000537
申请日：2009-02-26
申请人： SYNTROPHARMA LTD , WEIMANN LUDWIG JAN
发明人： WEIMANN LUDWIG JAN
IPC分类号： A61K9/70 , A61K31/485 , A61K47/14 , A61P25/32 , A61P25/36
CPC分类号： A61K31/485 , A61K9/7084 , A61K47/14
摘要： The invention provides transdermal patches comprising an adhesive and a composition comprising naltrexone and either methyl oleate or isopropyl myristate, a kit comprising a plurality of such transdermal patches, a composition comprising naltrexone and methyl oleate, such a composition for use as a medicament, and compositions comprising naltrexone and methyl oleate or isopropyl myristate for use in the treatment of alcoholism or opiate addiction.
摘要翻译：本发明提供透皮贴剂，其包含粘合剂和包含纳曲酮和油酸甲酯或肉豆蔻酸异丙酯的组合物，包含多个这种透皮贴剂的试剂盒，包含纳曲酮和油酸甲酯的组合物，这种用作药物的组合物和组合物包括纳曲酮和油酸甲酯或肉豆蔻酸异丙酯，用于治疗酒精中毒或鸦片成瘾。

7. 发明申请

WO2008027203A2 MEDICATED ORTHOPEDIC SUPPORT STRUCTURES FOR TREATMENT OF DAMAGED MUSCULOSKELETAL TISSUE 审中-公开
标题翻译：药物支架结构治疗损伤的肌肉骨骼组织
公开(公告)号：WO2008027203A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018199
申请日：2007-08-14
申请人： CURE THEREPAUTICS, INC , ANG, Robert , WEIMANN, Ludwig , MURRELL, Anthony, Calvert
发明人： ANG, Robert , WEIMANN, Ludwig , MURRELL, Anthony, Calvert
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7061 , A61K31/21
摘要： A system and method for treating damaged musculoskeletal tissue includes an orthopedic support structure and a nitroglycerin-containing composition. The orthopedic support structure provides mechanical support to the damaged tissue and maintains the nitroglycerin-containing composition in contact with the skin of a subject wearing using the system. The nitroglycerin- containing composition can be integrated into the orthopedic support structure or the support structure can be configured to contain removable doses of the nitroglycerin-containing composition. The system and method provides relief of pain and improved function of the musculoskeletal tissue.
摘要翻译：治疗受损肌肉骨骼组织的系统和方法包括整形外科支撑结构和含硝酸甘油的组合物。整形外科支撑结构为受损组织提供机械支撑并使含有硝酸甘油的组合物与使用该系统佩戴的受试者的皮肤接触。含硝化甘油的组合物可以整合到整形外科支撑结构中，或者支撑结构可以构造成含有可移除剂量的含硝化甘油的组合物。该系统和方法减轻了疼痛并改善了肌肉骨骼组织的功能。

8. 发明申请

WO2007143185A2 TREATMENT OF PERSISTENT ACTIVE TENDINOPATHY USING TRANSDERMAL GLYCERYL TRINITRATE PROVIDING DURABILITY OF EFFECT 审中-公开
标题翻译：使用透皮葡萄糖酸转铁蛋白治疗持续性活动性TENDINOPATHY提供效果的耐久性
公开(公告)号：WO2007143185A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/013117
申请日：2007-06-01
申请人： CURE THERAPEUTICS, INC. , MURRELL, Georgy Anthony, Calvert , ANG, Robert , WEIMANN, Ludwig , JACOBSON, Sven
发明人： MURRELL, Georgy Anthony, Calvert , ANG, Robert , WEIMANN, Ludwig , JACOBSON, Sven
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/0014 , A61K9/7023 , A61K31/21
摘要： The present invention provides methods for treating tendinopathy providing a durability of effect by administering nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies. The use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr.
摘要翻译：本发明提供通过施用硝酸甘油来治疗提供耐久性的腱鞘的方法。这些方法包括减轻与这种腱病相关的疼痛的方法。使用透皮贴片，其配置为以5mcg / hr的速率将硝酸甘油酯输送至约85mcg / hr。

9. 发明申请

WO2007092284A2 LOW DOSE NO DONOR-CONTAINING TRANSDERMAL PATCH 审中-公开
标题翻译：低剂量不含复合透皮贴片
公开(公告)号：WO2007092284A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/002835
申请日：2007-02-02
申请人： CURE THERAPEUCTICS, INC. , ANG, Robert , JACOBSON, Sven , WEIMANN, Ludwig
发明人： ANG, Robert , JACOBSON, Sven , WEIMANN, Ludwig
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7061 , A61K31/21 , A61K47/10
摘要： The present invention is drawn to a transdermal patch for the delivery of a nitroglycerin or other NO donor. The patch can comprise a backing layer, and a nitroglycerin-containing composition or other NO donor-containing composition which is supported at least in part by the backing layer. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 μg/hour to about 70 μg/hour. In one embodiment, the transdermal patch can provide a delivery rate at the drug delivery zone of from about 1 μg/cm2/day to about 600 μg/cm2/day. In another embodiment, the transdermal patch can contain from 6 wt% to 18 wt% of the nitric oxide donor, e.g., nitroglycerin. In each embodiment, the patch can contain at least 450 μg/cm2 of nitroglycerin.
摘要翻译：本发明涉及用于递送硝酸甘油或其他NO供体的透皮贴片。贴剂可以包含背衬层和含硝酸甘油的组合物或至少部分由背衬层支撑的含NO供体的组合物。透皮贴剂可以具有由组合物接触完整的人皮肤部位的区域限定的药物递送区域，并且可以配制透皮贴片，以约5μg/小时至约约5μg/小时递送一氧化氮供体，例如硝酸甘油 70μg/小时。在一个实施方案中，透皮贴剂可以在药物递送区域提供约1μg/ cm 2 /天至约600μg/ cm 2 /天的递送速率。在另一个实施方案中，透皮贴剂可含有6重量％至18重量％的一氧化氮供体，例如硝酸甘油。在每个实施方案中，贴剂可含有至少450μg/ cm 2的硝酸甘油。

10. 发明申请

WO2004060447A2 TRANSDERMAL DELIVERY USING ENCAPSULATED AGENT ACTIVATED BY ULTRASOUND AND/OR HEAT 审中-公开
标题翻译：使用由超声波和/或热激活的封装剂进行超导传送
公开(公告)号：WO2004060447A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/041850
申请日：2003-12-31
申请人： ULTRA-SONIC TECHNOLOGIES, L.L.C. , WEIMANN, Ludwig, J.
发明人： WEIMANN, Ludwig, J.
IPC分类号： A61M
CPC分类号： A61K9/0009 , A61K9/0014 , A61K9/7084 , A61K9/7092 , A61M37/00 , A61M37/0092 , A61N1/30
摘要： A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.
摘要翻译：通过在用于保持微胶囊的介质（150）内通过在预定尺寸的微胶囊中提供物质来输送物质通过至少一个真皮层的方法; 将用于保持微胶囊的介质放置在与人或动物的皮肤（320）相邻的贴片（100）的表面上; 并且将能量（200）施加到贴剂上，该能量具有干扰微胶囊完整性的特征，从而导致物质从微胶囊中释放出来。可以选择性地施加能量以在期望的时间释放物质。该物质可以是药物或其它活性剂。

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