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1. 发明申请

WO2010033168A2 AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：酰胺化合物，组合物及其应用
公开(公告)号：WO2010033168A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/005119
申请日：2009-09-14
申请人： RENOVIS, INC. , WEI, Zhi-Liang , GOWLUGARI, Sumithra , KAUB, Carl , WANG, Zhan , CAO, Yeyu , KINCAID, John
发明人： WEI, Zhi-Liang , GOWLUGARI, Sumithra , KAUB, Carl , WANG, Zhan , CAO, Yeyu , KINCAID, John
IPC分类号： C07D213/40 , C07D213/56 , C07D239/26 , C07D401/12 , C07D401/14 , C07D413/12 , C07C255/50 , A61P25/00 , A61K31/506 , A61K31/44
CPC分类号： C07D213/40 , A61K31/166 , A61K31/40 , C07C233/69 , C07C233/70 , C07C255/57 , C07D213/56 , C07D227/04 , C07D227/087 , C07D239/26 , C07D295/04 , C07D295/10 , C07D401/12 , C07D401/14 , C07D413/12
摘要： Compounds are provided according to formula (I), where A, B, W, X', L, R 1, R 3 , R 4b , and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
摘要翻译：根据式（I）提供化合物，其中A，B，W，X'，L，R 1，R 3，R 4b和m'如本文所定义。提供的化合物及其药物组合物可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例的疼痛，炎症，认知障碍，焦虑，抑郁等。

2. 发明申请

WO2007100758A3 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及使用该组合物的方法
公开(公告)号：WO2007100758A3
公开(公告)日：2007-11-29
申请号：PCT/US2007004912
申请日：2007-02-22
申请人： RENOVIS INC , KELLY MICHAEL G , KAUB CARL J , KINCAID JOHN , JANAGANI SATYANARAYANA , WU GUOXIAN , WEI ZHI-LIANG , SAHASRABUDHE KIRAN , DUNCTON MATTHEW , UPASANI RAVINDRA B , FANG YUNFENG , COX MATTHEW
发明人： KELLY MICHAEL G , KAUB CARL J , KINCAID JOHN , JANAGANI SATYANARAYANA , WU GUOXIAN , WEI ZHI-LIANG , SAHASRABUDHE KIRAN , DUNCTON MATTHEW , UPASANI RAVINDRA B , FANG YUNFENG , COX MATTHEW
IPC分类号： A01N37/18 , A61K31/16
CPC分类号： C07D209/08 , C07D209/48 , C07D209/50 , C07D215/06 , C07D215/38 , C07D217/02 , C07D217/22 , C07D231/56 , C07D235/06 , C07D235/08 , C07D237/28 , C07D241/42 , C07D263/58 , C07D265/16 , C07D265/36 , C07D267/14 , C07D277/46 , C07D277/64 , C07D295/088 , C07D295/13 , C07D317/52 , C07D317/58 , C07D319/18 , C07D333/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D491/052 , C07D498/04
摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的化学式的化合物：式（I）。所述化合物可制备成药物组合物，并且可用于预防和治疗包括人在内的哺乳动物的各种病症，包括非限制性实例，疼痛，炎症，创伤性损伤等。

3. 发明申请

WO2004024939A2 LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR, AND METHODS OF USE THEREOF 审中-公开
标题翻译：过氧化物酶体增殖物激活受体的配体及其使用方法
公开(公告)号：WO2004024939A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028931
申请日：2003-09-12
申请人： GEORGETOWN UNIVERSITY , KOZIKOWSKI, Alan, P. , GLAZER, Robert, I. , PETUKHOV, Pavel , WEI, Zhi-Liang
发明人： KOZIKOWSKI, Alan, P. , GLAZER, Robert, I. , PETUKHOV, Pavel , WEI, Zhi-Liang
IPC分类号： C12Q
CPC分类号： C07D471/04 , C07D261/08 , C07D413/06 , C07D413/12
摘要： One aspect of the present invention relates to compounds that are active at a peroxisome proliferator-activated receptor (PPAR). In certain embodiments, the compound has a isoxazole or indole core. Another aspect of the present invention relates to a method of treating a mammal afflicted with cancer or non-insulin-dependent (type II) diabetes by administering a therapeutic amount of the compounds of the invention. In certain embodiments, the invention relates to a method of treating prostrate, stomach, or breast cancer. Another aspect of the invention relates to a method of identifying ligands active at a PPAR subtype using X-ray structural information. In certain embodiments, the method of identifying the ligand comprises using molecular modeling approaches including: in silico screening of chemical databases, de novo /rational drug design in which the ligand will be created computationally, and/or in silico screening of virtual combinatorial libraries.
摘要翻译：本发明的一个方面涉及对过氧化物酶体增殖物激活受体（PPAR）有活性的化合物。在某些实施方案中，该化合物具有异恶唑或吲哚核心。本发明的另一个方面涉及通过施用治疗量的本发明化合物治疗患有癌症或非胰岛素依赖性（II型）糖尿病的哺乳动物的方法。在某些实施方案中，本发明涉及治疗前列腺癌，胃癌或乳腺癌的方法。本发明的另一方面涉及使用X射线结构信息鉴定在PPAR亚型上有活性的配体的方法。在某些实施方案中，鉴定配体的方法包括使用分子建模方法，包括：在计算机化学数据库筛选中，从头/合理的药物设计，其中配体将是在计算机上创建和/或虚拟组合库的计算机筛选。

4. 发明申请

WO2010033168A3 MODULATORS OF P2X3 RECEPTOR ACTIVITY 审中-公开
标题翻译： P2X3受体活性的调节剂
公开(公告)号：WO2010033168A3
公开(公告)日：2010-11-18
申请号：PCT/US2009005119
申请日：2009-09-14
申请人： RENOVIS INC , WEI ZHI-LIANG , GOWLUGARI SUMITHRA , KAUB CARL , WANG ZHAN , CAO YEYU , KINCAID JOHN
发明人： WEI ZHI-LIANG , GOWLUGARI SUMITHRA , KAUB CARL , WANG ZHAN , CAO YEYU , KINCAID JOHN
IPC分类号： C07D213/40 , A61K31/44 , A61K31/506 , A61P25/00 , C07C255/50 , C07D213/56 , C07D239/26 , C07D401/12 , C07D401/14 , C07D413/12
CPC分类号： C07D213/40 , A61K31/166 , A61K31/40 , C07C233/69 , C07C233/70 , C07C255/57 , C07D213/56 , C07D227/04 , C07D227/087 , C07D239/26 , C07D295/04 , C07D295/10 , C07D401/12 , C07D401/14 , C07D413/12
摘要： Compounds are provided according to formula (I), where A, B, W, X', L, R1, R3, R4b, and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
摘要翻译：根据式（I）提供化合物，其中A，B，W，X'，L，R 1，R 3，R 4b和m'如本文所定义。提供的化合物及其药物组合物可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，认知障碍，焦虑，抑郁等。

5. 发明申请

WO2006093832A3 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及其使用方法
公开(公告)号：WO2006093832A3
公开(公告)日：2007-03-22
申请号：PCT/US2006006615
申请日：2006-02-24
申请人： RENOVIS INC , KELLY MICHAEL , KINCAID JOHN , DUNCTON MATTHEW , SAHASRABUDHE KIRAN , JANAGANI SATYNARAHANA , UPASANI RAVINDRA , WU GUOXIAN , FANG YUNFENG , WEI ZHI-LIANG
发明人： KELLY MICHAEL , KINCAID JOHN , DUNCTON MATTHEW , SAHASRABUDHE KIRAN , JANAGANI SATYNARAHANA , UPASANI RAVINDRA , WU GUOXIAN , FANG YUNFENG , WEI ZHI-LIANG
IPC分类号： A61K31/538 , A61K31/4709 , C07D405/14 , C07D413/02
CPC分类号： C07D209/08 , C07D209/48 , C07D209/50 , C07D215/06 , C07D215/38 , C07D217/02 , C07D217/22 , C07D231/56 , C07D235/06 , C07D235/08 , C07D237/28 , C07D241/42 , C07D263/58 , C07D265/16 , C07D265/36 , C07D267/14 , C07D277/46 , C07D277/64 , C07D295/088 , C07D295/13 , C07D317/52 , C07D317/58 , C07D319/18 , C07D333/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D491/052 , C07D498/04
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有下列化学式的化合物：化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的多种病症，包括作为非限制性实例的疼痛，炎症，创伤性损伤等。

6. 发明申请

WO2009110985A2 AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：酰胺化合物，组合物及其用途
公开(公告)号：WO2009110985A2
公开(公告)日：2009-09-11
申请号：PCT/US2009001249
申请日：2009-02-27
申请人： RENOVIS INC , WEI ZHI-LIANG , GOWLUGARI SUMITHRA , KAUB CARL , WANG ZHAN , CAO YEYU , KINCAID JOHN
发明人： WEI ZHI-LIANG , GOWLUGARI SUMITHRA , KAUB CARL , WANG ZHAN , CAO YEYU , KINCAID JOHN
IPC分类号： C07D205/04 , C07D213/56 , C07D213/61 , C07D215/12 , C07D231/12 , C07D231/16
CPC分类号： C07D213/64 , C07C69/78 , C07C233/69 , C07C317/32 , C07D205/04 , C07D207/06 , C07D213/56 , C07D213/61 , C07D213/643 , C07D215/12 , C07D231/12 , C07D231/16 , C07D239/26 , C07D239/34 , C07D239/47 , C07D241/12 , C07D249/08 , C07D263/56 , C07D265/36 , C07D277/28 , C07D277/30 , C07D295/104 , C07D317/48 , C07D333/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D489/04
摘要： Compounds are provided according to formula (1 ) : where A, B, W, X', L, R1, R3, R4b, and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
摘要翻译：根据式（1）提供化合物：其中A，B，W，X'，L，R 1，R 3，R 4b和m'如本文所定义。提供的化合物及其药物组合物可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，认知障碍，焦虑，抑郁等。

7. 发明申请

WO2008130481A1 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： 2-氰基苯基熔融杂环化合物及其组合物及其用途
公开(公告)号：WO2008130481A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004208
申请日：2008-03-31
申请人： RENOVIS, INC. , WEI, Zhi-Liang , DUNCTON, Matthew, Alexander, James , KINCAID, John , KELLY, Michael G. , O'MAHONY, Donogh , WANG, Zhan
发明人： WEI, Zhi-Liang , DUNCTON, Matthew, Alexander, James , KINCAID, John , KELLY, Michael G. , O'MAHONY, Donogh , WANG, Zhan
IPC分类号： A01N43/90 , A61K31/517 , C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： Fused heterocyclic compounds are provided according to formula (1): where R 1 , R 2 , R 3 , and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
摘要翻译：根据式（1）提供稠合的杂环化合物：其中R 1，R 2，R 3和M如本文所定义。提供的化合物及其药物组合物可用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例的疼痛，炎症，认知障碍，焦虑，抑郁等。

8. 发明申请

WO2007100758A2 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 审中-公开
标题翻译：作为离子通道配体和药物组合物的酰胺衍生物及其使用方法
公开(公告)号：WO2007100758A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/004912
申请日：2007-02-22
申请人： RENOVIS, INC. , KELLY, Michael, G. , KAUB, Carl, J. , KINCAID, John , JANAGANI, Satyanarayana , WU, Guoxian , WEI, Zhi-Liang , SAHASRABUDHE, Kiran , DUNCTON, Matthew , UPASANI, Ravindra, B. , FANG, Yunfeng , COX, Matthew
发明人： KELLY, Michael, G. , KAUB, Carl, J. , KINCAID, John , JANAGANI, Satyanarayana , WU, Guoxian , WEI, Zhi-Liang , SAHASRABUDHE, Kiran , DUNCTON, Matthew , UPASANI, Ravindra, B. , FANG, Yunfeng , COX, Matthew
CPC分类号： C07D209/08 , C07D209/48 , C07D209/50 , C07D215/06 , C07D215/38 , C07D217/02 , C07D217/22 , C07D231/56 , C07D235/06 , C07D235/08 , C07D237/28 , C07D241/42 , C07D263/58 , C07D265/16 , C07D265/36 , C07D267/14 , C07D277/46 , C07D277/64 , C07D295/088 , C07D295/13 , C07D317/52 , C07D317/58 , C07D319/18 , C07D333/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D491/052 , C07D498/04
摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的式的化合物：式（I）。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

9. 发明申请

WO2005066171A1 BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF 审中-公开
标题翻译：二氯化铝化合物作为离子通道配体及其用途
公开(公告)号：WO2005066171A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043456
申请日：2004-12-23
申请人： RENOVIS, INC. , KELLY, Michael, G. , JANAGANI, Satyanarayana , WU, Guoxian , KINCAID, John , LONERGAN, David , FANG, Yunfeng , WEI, Zhi-Liang
发明人： KELLY, Michael, G. , JANAGANI, Satyanarayana , WU, Guoxian , KINCAID, John , LONERGAN, David , FANG, Yunfeng , WEI, Zhi-Liang
IPC分类号： C07D471/14
CPC分类号： C07D471/04
摘要： Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下列化学式表示的式的胺化合物：该化合物可以制备成药物组合物，并且可以用于预防和治疗哺乳动物包括人的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

10. 发明申请

WO2005000806A3 LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTORS, AND METHODS OF MAKING AND USING THEM 审中-公开
公开(公告)号：WO2005000806A3
公开(公告)日：2005-01-06
申请号：PCT/US2004/018340
申请日：2004-06-09
申请人： GEORGETOWN UNIVERSITY , KOZIKOWSKI, Alan, P. , MUSACHIO, John, L. , KELLAR, Kenneth, J. , XIAO, Yingxian , WEI, Zhi-Liang
发明人： KOZIKOWSKI, Alan, P. , MUSACHIO, John, L. , KELLAR, Kenneth, J. , XIAO, Yingxian , WEI, Zhi-Liang
IPC分类号： A61K31/439
摘要： One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. The present invention also relates to the use of a compound of the invention for treating a mammal suffering from Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism or trichtillomania.

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