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    • 1. 发明申请
    • SONO-ACTIVE LIPOSOMES AND LIPID PARTICLES AND USE THEREOF AS CONTRAST AGENTS AND ACTIVE-AGENT DELIVERY SYSTEMS
    • SONO活性脂质体和脂质颗粒及其作为对比剂和活性剂递送系统的用途
    • WO2007012962A2
    • 2007-02-01
    • PCT/IB2006/002076
    • 2006-07-29
    • XU, YuhongWEI, Xiaohui
    • XU, YuhongWEI, Xiaohui
    • A61K49/227A61K9/1272A61K41/0028A61K48/00A61K49/1806A61K49/1812A61K49/1821
    • The present invention is directed to a novel class of gas filled liposomal delivery system particles, and to methods of making these particles, including the production of gas filled liposomal delivery system particles via chemical reaction to produce gas bubbles inside the particles. The present invention also includes: gas filled liposomal delivery system particles containing one or more active agents; gas filled liposomal delivery system particles for visualization purposes, e.g., for visualization of structures of the body via ultrasound waves; gas filled liposomal delivery system particles for the targeted delivery of active agent to one or more areas of interest of the body; and, gas filled liposomal delivery system particles for the targeted delivery of active agent to one or more areas of interest of the body, where targeting specificity is enhanced by active targeting to direct the gas filled liposomal delivery system particles to a particular target.
    • 本发明涉及一种新型的气体填充脂质体递送系统颗粒,以及制备这些颗粒的方法,包括通过化学反应生成气体填充的脂质体递送系统颗粒,以在颗粒内产生气泡。 本发明还包括:含有一种或多种活性剂的填充气体的脂质体递送系统颗粒; 用于可视化目的的气体填充脂质体递送系统颗粒,例如用于通过超声波可视化身体的结构; 气体填充的脂质体递送系统颗粒,用于将活性剂靶向递送至身体感兴趣的一个或多个区域; 以及气体填充的脂质体递送系统颗粒,用于将活性剂靶向递送至身体感兴趣的一个或多个区域,其中靶向特异性通过主动靶向来增强气体填充的脂质体递送系统颗粒到特定靶标。
    • 3. 发明申请
    • SONO-ACTIVE LIPOSOMES AND LIPID PARTICLES AND USE THEREOF AS CONTRAST AGENTS AND ACTIVE-AGENT DELIVERY SYSTEMS
    • SONO活性脂质体和脂质颗粒及其用作造影剂和活性剂递送系统
    • WO2007012962A3
    • 2007-06-14
    • PCT/IB2006002076
    • 2006-07-29
    • XU YUHONGWEI XIAOHUI
    • XU YUHONGWEI XIAOHUI
    • A61K9/127A61K49/00A61K49/18A61P43/00
    • A61K49/227A61K9/1272A61K41/0028A61K48/00A61K49/1806A61K49/1812A61K49/1821
    • The present invention is directed to a novel class of gas filled liposomal delivery system particles, and to methods of making these particles, including the production of gas filled liposomal delivery system particles via chemical reaction to produce gas bubbles inside the particles. The present invention also includes: gas filled liposomal delivery system particles containing one or more active agents; gas filled liposomal delivery system particles for visualization purposes, e.g., for visualization of structures of the body via ultrasound waves; gas filled liposomal delivery system particles for the targeted delivery of active agent to one or more areas of interest of the body; and, gas filled liposomal delivery system particles for the targeted delivery of active agent to one or more areas of interest of the body, where targeting specificity is enhanced by active targeting to direct the gas filled liposomal delivery system particles to a particular target.
    • 本发明涉及一类新型充气脂质体递送系统颗粒,以及制备这些颗粒的方法,包括通过化学反应生产充气脂质体递送系统颗粒以在颗粒内部产生气泡。 本发明还包括:含有一种或多种活性剂的充气脂质体递送系统颗粒; 充气脂质体递送系统颗粒,用于可视化目的,例如用于通过超声波可视化身体结构; 充气的脂质体递送系统颗粒,用于将活性剂靶向递送至身体的一个或多个感兴趣区域; 以及充气的脂质体递送系统颗粒,用于将活性剂靶向递送至身体的一个或多个感兴趣的区域,其中靶向特异性通过主动靶向增强以将充气的脂质体递送系统颗粒引导至特定目标。
    • 4. 发明申请
    • AUTONOMIC MONITORING IN A GRID ENVIRONMENT
    • 全球环境中的自动监测
    • WO2005124553A1
    • 2005-12-29
    • PCT/IB2005/001717
    • 2005-06-17
    • PLATFORM COMPUTING CORPORATIONBIGAGLI, DavidWEI, Xiaohui
    • BIGAGLI, DavidWEI, Xiaohui
    • G06F11/30
    • H04L43/00
    • A system for performing autonomic monitoring in a computing grid is described. The system includes a plurality of modules, which when implemented into a computing grid, are operable to analyze objects of the grid and identify exception conditions associated with the objects. The system includes a configuration module for receiving information on specified objects to be monitored and exception conditions for the objects, an information collection module to collect job execution data associated with the objects, and an exception module to evaluate the job execution data associated with the objects and identify existing exception conditions. Related methods of performing autonomic monitoring in a grid system are also described.
    • 描述了用于在计算网格中执行自主监视的系统。 该系统包括多个模块,其在被实现到计算网格中时可操作以分析网格的对象并且识别与对象相关联的异常状况。 该系统包括用于接收关于要监视的指定对象和对象异常条件的信息的配置模块,用于收集与该对象相关联的作业执行数据的信息收集模块以及用于评估与对象相关联的作业执行数据的异常模块 并识别现有的异常情况。 还描述了在网格系统中执行自主监控的相关方法。