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1. 发明申请

WO2009044115A1 ENDOCRINE DISRUPTORS 审中-公开
标题翻译：内镜消除
公开(公告)号：WO2009044115A1
公开(公告)日：2009-04-09
申请号：PCT/GB2008/003295
申请日：2008-09-29
申请人： THE UNIVERSITY OF BIRMINGHAM , WARING, Rosemary, Hope , RAMSDEN, David, Boyer
发明人： WARING, Rosemary, Hope , RAMSDEN, David, Boyer
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/136 , C12Q2600/158 , G01N33/74 , G01N2500/02
摘要： A method is provided for assessing the potential of one or more test compounds to disrupt the endocrine system. The method comprises measuring the effect of the test compound(s) on hormone sulphation, oestrogen synthesis, and thyroid hormone and/or growth hormone function. These tests may be carried out sequentially or in parallel. Also provided is a test kit for assessing the endocrine disruption potential of a compound. The kit comprises means for assessing the effect of a compound on hormone sulphation, oestrogen synthesis, and thyroid hormone and/or growth hormone function. The kit may also contain comprise one or more optional control test compounds.
摘要翻译：提供了一种评估一种或多种测试化合物破坏内分泌系统的潜力的方法。该方法包括测量测试化合物对激素硫酸化，雌激素合成和甲状腺激素和/或生长激素功能的影响。这些测试可以顺序或并行进行。还提供了用于评估化合物的内分泌破坏潜力的测试试剂盒。试剂盒包括用于评估化合物对激素硫酸化，雌激素合成和甲状腺激素和/或生长激素功能的影响的方法。试剂盒还可以含有一种或多种任选的对照试验化合物。

2. 发明申请

WO2007010258A2 POLYMORPHISM 审中-公开
标题翻译：多态性
公开(公告)号：WO2007010258A2
公开(公告)日：2007-01-25
申请号：PCT/GB2006/002698
申请日：2006-07-20
申请人： THE UNIVERSITY OF BIRMINGHAM , WARING, Rosemary, Hope , RAMSDEN, David, Boyer , WILKINSON, Lucy, Jane , KIKUCHI, Hugh
发明人： WARING, Rosemary, Hope , RAMSDEN, David, Boyer , WILKINSON, Lucy, Jane , KIKUCHI, Hugh
IPC分类号： C12Q1/68
CPC分类号： A61K38/217 , A61K38/2026 , A61K38/2066 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , A61K2300/00
摘要： The invention relates to the detection and identification of polymorphisms in cysteine dioxygenase (CDO) for the use of that diagnosis to identify a propensity in a patient towards rheumatoid arthritis and/or to have side effects with a number of drugs, to nucleic acid and isolated proteins encoding the polymorphisms, to assays for CDO activity and for the identification of compounds affecting CDO activity, and additionally to use of interferon-y optionally in combination with different compounds, to treat rheumatoid arthritis.
摘要翻译：本发明涉及检测和鉴定半胱氨酸双加氧酶（CDO）中的多态性，以便使用该诊断来确定患者对类风湿性关节炎的倾向和/或具有多种药物的副作用，以核酸和分离编码多态性的蛋白质，CDO活性的测定和影响CDO活性的化合物的鉴定，以及任选地与不同化合物组合使用干扰素-γ治疗类风湿性关节炎。

3. 发明申请

WO2012127213A1 BIOMARKERS 审中-公开
标题翻译：生物标志物
公开(公告)号：WO2012127213A1
公开(公告)日：2012-09-27
申请号：PCT/GB2012/050582
申请日：2012-03-16
申请人： THE UNIVERSITY OF BIRMINGHAM , WARING, Rosemary , HUNTER, John
发明人： WARING, Rosemary , HUNTER, John
IPC分类号： G01N33/62 , G01N33/64 , G01N33/84 , G01N33/98
CPC分类号： G01N33/98 , G01N33/62 , G01N33/64 , G01N33/84 , G01N2800/065
摘要： The invention relates to a method of identifying or monitoring irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD) comprising detecting one or more volatile organic compounds (VOCs) from a sample from a subject. Typically the sample is faecal material or urine. The VOC may be one or more of ethyl esters of propanoic or butanoic acids, propanoic acid, butanoic acid, butanoic acid methyl ester, propanoic acid methyl ester, 3-methyl butanoic acid, 1-butanol, 1-propanol, indole, 2-methyl propanoic acid, 1-pentanol, hydroxy urea, methyl cyclobutane, (R)-(-)-2-amino-1-propanol, 2-hydroxy-propanamide, acetic acid hydrazide, 2-pentanone, pyrrole, 1-butoxy-2-propanol, 2-butanone, dimethyl disulphide, 2-methyl-1,3-dioxolane and sulphur dioxide.
摘要翻译：本发明涉及鉴定或监测肠易激综合征（IBS）或炎性肠病（IBD）的方法，其包括从受试者的样品中检测一种或多种挥发性有机化合物（VOC）。通常，样品是粪便或尿液。丙酸或丁酸，丙酸，丁酸，丁酸甲酯，丙酸甲酯，3-甲基丁酸，1-丁醇，1-丙醇，吲哚，2-丁醇，甲基丙酸，1-戊醇，羟基脲，甲基环丁烷，（R） - （ - ） - 2-氨基-1-丙醇，2-羟基 - 丙酰胺，乙酸酰肼，2-戊酮，吡咯，1-丁氧基 - 2-丙醇，2-丁酮，二甲基二硫化物，2-甲基-1,3-二氧戊环和二氧化硫。

4. 发明申请

WO2007010258A3 POLYMORPHISM IN CYSTEINE DIOXYGENASE 审中-公开
标题翻译： CYSTEINE DIOXYGENASE中的多态性
公开(公告)号：WO2007010258A3
公开(公告)日：2007-05-31
申请号：PCT/GB2006002698
申请日：2006-07-20
申请人： UNIV BIRMINGHAM , WARING ROSEMARY HOPE , RAMSDEN DAVID BOYER , WILKINSON LUCY JANE , KIKUCHI HUGH
发明人： WARING ROSEMARY HOPE , RAMSDEN DAVID BOYER , WILKINSON LUCY JANE , KIKUCHI HUGH
IPC分类号： C12Q1/68 , A61K38/20 , A61K38/21
CPC分类号： A61K38/217 , A61K38/2026 , A61K38/2066 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , A61K2300/00
摘要： The invention relates to the detection and identification of polymorphisms in cysteine dioxygenase (CDO) for the use of that diagnosis to identify a propensity in a patient towards rheumatoid arthritis and/or to have side effects with a number of drugs, to nucleic acid and isolated proteins encoding the polymorphisms, to assays for CDO activity and for the identification of compounds affecting CDO activity, and additionally to use of interferon-y optionally in combination with different compounds, to treat rheumatoid arthritis.
摘要翻译：本发明涉及检测和鉴定半胱氨酸双加氧酶（CDO）中的多态性，以便使用该诊断来确定患者对类风湿性关节炎的倾向和/或具有多种药物的副作用，以核酸和分离编码多态性的蛋白质，CDO活性的测定和影响CDO活性的化合物的鉴别，以及任选地与不同化合物组合使用干扰素-γ治疗类风湿性关节炎。

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