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1. 发明申请

WO2006061610A3 DIAGNOSIS OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：神经退行性疾病的诊断
公开(公告)号：WO2006061610A3
公开(公告)日：2006-08-10
申请号：PCT/GB2005004700
申请日：2005-12-07
申请人： ELECTROPHORETICS LTD , UNIV LONDON , MEDICAL RES COUNCIL , LEEDS NICOLA LOUISE , WARD MALCOLM ANDREW , MCGREGOR EMMA , TABRIZI SARAH JOANNA , DALRYMPLE ANNETTE , CAMPBELL JAMES , WESTBROKE JULIAN ARTHUR , BYERS HELEN LOUISE
发明人： LEEDS NICOLA LOUISE , WARD MALCOLM ANDREW , MCGREGOR EMMA , TABRIZI SARAH JOANNA , DALRYMPLE ANNETTE , CAMPBELL JAMES , WESTBROKE JULIAN ARTHUR , BYERS HELEN LOUISE
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/52
摘要： The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number : Protein name; P10909 : Clusterin precursor; P00738 : Haptoglobin precursor; P01009 : Alpha- l-antitrypsin precursor; P01024 : Complement C3 precursor; P01620 : 1g kappa chain V-III region; P01834 : 1g kappa chain C region P01842 : 1g lambda chain C regions; P01857 : 1g gamma-1 chain C region; P01859 : Ig gamma-2 chain C region; P01876 : 1g alpha-1 chain C region P02647 : Apolipoprotein A-I precursor; P02649 : Apolipoprotein E precursor; P02652 : Apolipoprotcin A-II precursor; P02655 : Apolipoprotein C-II precursor; P02656 : Apolipoprotein C-III precursor P02671 : Fibrinogen alpha/alpha-E chain precursor; P02763 : Alpha- l-acid glycoprotein 1 precursor; P02766 : Transthyretin precursor; P02768 : Serum albumin precursor; P02787 : Serotransferrin precursor; P04196 : Histidine-rich glycoprotein precursor; P06727 : Apolipoprotein A-IV precursor; P19652 : Alpha- l-acid glycoprotein 2 precursor; P68871/P02042 : Hemoglobin beta chain/Hemoglobin delta chain; P60709 : Beta actin.
摘要翻译：本发明涉及一种在取自人类受试者的有效身体组织的诊断样品中诊断亨廷顿舞蹈病的方法，其包括检测与对照人类受试者的样品相比诊断样品中蛋白质浓度的改变，该蛋白质选自：Swiss Prot登录号：蛋白质名称; P10909：丛生蛋白前体; P00738：触珠蛋白前体; P01009：α-1-抗胰蛋白酶前体; P01024：补体C3前体; P01620：1gκ链V-III区; P01834：1克κ链C区P01842：1克λ链C区; P01857：1gγ-1链C区; P01859：Igγ-2链C区; P01876：1gα-1链C区P02647：载脂蛋白A-I前体; P02649：载脂蛋白E前体; P02652：Apolipoprotcin A-II前体; P02655：载脂蛋白C-II前体; P02656：载脂蛋白C-III前体P02671：纤维蛋白原α/α-E链前体; P02763：α-1酸性糖蛋白1前体; P02766：转甲状腺素蛋白前体; P02768：血清白蛋白前体; P02787：Serotransferrin前体; P04196：富含组氨酸的糖蛋白前体; P06727：载脂蛋白A-IV前体; P19652：α-1酸性糖蛋白2前体; P68871 / P02042：血红蛋白β链/血红蛋白三链; P60709：β肌动蛋白。

2. 发明申请

WO2011036059A1 MASS LABELS 审中-公开
标题翻译：质量标签
公开(公告)号：WO2011036059A1
公开(公告)日：2011-03-31
申请号：PCT/EP2010/063191
申请日：2010-09-08
申请人： ELECTROPHORETICS LIMITED , BAUMANN, Christian , BYERS, Helen , SCHULZ-KNAPPE, Peter , WARD, Malcolm
发明人： BAUMANN, Christian , BYERS, Helen , SCHULZ-KNAPPE, Peter , WARD, Malcolm
IPC分类号： C07B59/00 , C07D211/14 , C07D401/12
CPC分类号： G01N33/743 , C07B59/002 , C07D211/14 , C07D401/12 , G01N33/58 , G01N2458/15 , G01N2560/00 , Y10T436/196666 , Y10T436/200833 , Y10T436/24
摘要： A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure: X-L-M-S-Re wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: Formula (I), wherein J is C=O, K is NH, and n is 2 or J and K are both CH2 and n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.
摘要翻译：用于通过质谱法标记用于检测的生物分子的反应性质量标签，该标记包括用于标记巯基或羰基的反应性官能团。还提供了用于通过质谱法标记用于检测的生物分子的反应性质量标签，其中所述质量标签包含以下结构：XLMS-Re，其中X是质量标记物部分，L是可切割接头，M是质量归一化部分 S是包含以下基团的质量系列改性基团：式（I）其中J为C = O，K为NH，n为2或J和K均为CH 2，n为1，m为至少1; 并且Re是用于将质量标签附着到生物分子的反应性官能团。

3. 发明申请

WO2006061610A2 DIAGNOSIS OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：诊断神经源性疾病
公开(公告)号：WO2006061610A2
公开(公告)日：2006-06-15
申请号：PCT/GB2005/004700
申请日：2005-12-07
申请人： ELECTROPHORETICS LIMITED , UNIVERSITY COLLEGE LONDON , MEDICAL RESEARCH COUNCIL , LEEDS, Nicola, Louise , WARD, Malcolm, Andrew , McGREGOR, Emma , TABRIZI, Sarah, Joanna , DALRYMPLE, Annette , CAMPBELL, James , WESTBROKE, Julian, Arthur , BYERS, Helen, Louise
发明人： LEEDS, Nicola, Louise , WARD, Malcolm, Andrew , McGREGOR, Emma , TABRIZI, Sarah, Joanna , DALRYMPLE, Annette , CAMPBELL, James , WESTBROKE, Julian, Arthur , BYERS, Helen, Louise
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/52
摘要： The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number : Protein name; P10909 : Clusterin precursor; P00738 : Haptoglobin precursor; P01009 : Alpha- l-antitrypsin precursor; P01024 : Complement C3 precursor; P01620 : 1g kappa chain V-III region; P01834 : 1g kappa chain C region P01842 : 1g lambda chain C regions; P01857 : 1g gamma-1 chain C region; P01859 : Ig gamma-2 chain C region; P01876 : 1g alpha-1 chain C region P02647 : Apolipoprotein A-I precursor; P02649 : Apolipoprotein E precursor; P02652 : Apolipoprotcin A-II precursor; P02655 : Apolipoprotein C-II precursor; P02656 : Apolipoprotein C-III precursor P02671 : Fibrinogen alpha/alpha-E chain precursor; P02763 : Alpha- l-acid glycoprotein 1 precursor; P02766 : Transthyretin precursor; P02768 : Serum albumin precursor; P02787 : Serotransferrin precursor; P04196 : Histidine-rich glycoprotein precursor; P06727 : Apolipoprotein A-IV precursor; P19652 : Alpha- l-acid glycoprotein 2 precursor; P68871/P02042 : Hemoglobin beta chain/Hemoglobin delta chain; P60709 : Beta actin.
摘要翻译：本发明涉及一种在人受试者的有效身体组织的诊断样本中诊断亨廷顿病的方法，其包括检测诊断样品中蛋白质的浓度变化，与对照人受试者的样品相比，该蛋白质选自：瑞士抗原登录号：蛋白质名称; P10909：聚集蛋白前体; P00738：近红球蛋白前体; P01009：α-抗胰蛋白酶前体; P01024：补体C3前体; P01620：1gκ链V-III区; P01834：1gκ链C区P01842：1gλ链C区; P01857：1gγ-1链C区; P01859：Igγ-2链C区; P01876：1gα-1链C区P02647：载脂蛋白A-1前体; P02649：载脂蛋白E前体; P02652：载脂蛋白A-II前体; P02655：载脂蛋白C-II前体; P02656：载脂蛋白C-III前体P02671：纤维蛋白原α/α-E链前体; P02763：α-酸性糖蛋白1前体; P02766：曲氨酸蛋白前体; P02768：血清白蛋白前体; P02787：血清转铁蛋白前体; P04196：富含组氨酸糖蛋白前体; P06727：载脂蛋白A-IV前体; P19652：α-酸性糖蛋白2前体; P68871 / P02042：血红蛋白β链/血红蛋白三角链; P60709：β肌动蛋白

4. 发明申请

WO1990013814A1 ULTRASONIC WHEEL TESTING 审中-公开
标题翻译：超声轮测试
公开(公告)号：WO1990013814A1
公开(公告)日：1990-11-15
申请号：PCT/AU1990000172
申请日：1990-05-01
申请人： HAMERSLEY IRON PTY. LIMITED , WARD, Malcolm , WARK, Brian, Alan
发明人： HAMERSLEY IRON PTY. LIMITED
IPC分类号： G01N29/04
CPC分类号： G01N29/27 , G01N29/2493 , G01N2291/0423 , G01N2291/2696
摘要： A method and apparatus for detecting defects in rolling stock wheels by performing an ultrasonic scan of the wheels. The ultrasonic wheel testing facility automatically scans each wheel (12) of a wheel set and comprises two ultrasonic wheel probes (16, 26) for each wheel. A wheel tread probe (26) and a wheel flange probe (16) are mounted on a movable probe platform (28) and each wheel probe comprises a rotatable fluid filled tyre (44) housing one or more ultrasonic transducers. The transducers are oriented to transmit a sound beam into the surface of the wheel at prescribed angles to obtain optimum strength of signals reflected from fatigue defects in the wheel (12). In accordance with the method of the invention, the wheel set is positioned over the probe platform, the probe platform (28) is raised to bring both the wheel tread probe (26) and the wheel flange probe (16) into rolling contact with the wheel (12), and the wheel is then rotated to perform an ultrasonic scan of the wheel. Liquid couplant is sprayed onto the wheel during rotation to ensure acoustic coupling of the ultrasonic signals from the probes into the wheel.
摘要翻译：一种用于通过对车轮执行超声波扫描来检测车辆车轮中的缺陷的方法和装置。超声波轮测试设备自动扫描车轮组的每个车轮（12），并且包括用于每个车轮的两个超声波轮探针（16,26）。轮胎胎面探针（26）和车轮凸缘探针（16）安装在可移动探针平台（28）上，并且每个车轮探针包括容纳一个或多个超声换能器的可旋转流体填充轮胎（44）。传感器被定向为以规定的角度将声束传播到车轮的表面，以获得从车轮（12）中的疲劳缺陷反射的信号的最佳强度。根据本发明的方法，车轮组位于探头平台的上方，探头平台（28）被升高以使车轮胎面探针（26）和车轮凸缘探头（16）都与轮（12），然后旋转车轮以执行车轮的超声波扫描。液体耦合剂在旋转过程中喷洒到车轮上，以确保从探头到车轮的超声信号的声耦合。

5. 发明申请

WO2012156665A3 METHODS AND COMPOSITIONS RELATING TO PLATELET SENSITIVITY 审中-公开
标题翻译：与平板敏感性相关的方法和组合
公开(公告)号：WO2012156665A3
公开(公告)日：2013-03-07
申请号：PCT/GB2012000433
申请日：2012-05-11
申请人： KING S COLLEGE LONDON , ELECTROPHORETICS LTD , GOODMAN TIMOTHY WILLIAM , FERRO ALBERT , SCHOFIELD EMMA , WARD MALCOLM ANDREW , FLOYD CHRISTOPHER
发明人： GOODMAN TIMOTHY WILLIAM , FERRO ALBERT , SCHOFIELD EMMA , WARD MALCOLM ANDREW , FLOYD CHRISTOPHER
IPC分类号： G01N33/50
CPC分类号： G01N33/5023 , G01N2333/70557 , G01N2333/91215
摘要： The invention identifies and describes proteins that are differentially expressed in platelets resistant to anti- platelet agents such as aspirin (acetylsalicyclic acid) compared to those platelets that are sensitive to such agents. Methods for determining further such differentially expressed proteins and methods for determining an individual's sensitivity to anti-platelet agents, such as aspirin, prior to administration.
摘要翻译：本发明鉴定并描述了与对这些试剂敏感的那些血小板相比，抗血小板抗性的血小板差异表达的蛋白质，例如阿司匹林（acetylsalicyclic acid）。用于确定进一步的这种差异表达的蛋白质的方法和用于在施用之前确定个体对抗血小板剂如阿司匹林的敏感性的方法。

6. 发明申请

WO2007138357A1 DIAGNOSTIC ASSAY FOR SPONGIFORM ENCEPHALOPATHIES 审中-公开
标题翻译：诊断心脏病的诊断测定
公开(公告)号：WO2007138357A1
公开(公告)日：2007-12-06
申请号：PCT/GB2007/050302
申请日：2007-05-29
申请人： ELECTROPHORETICS LIMITED , MEDICAL RESEARCH COUNCIL , PIKE, Ian Hugo , WARD, Malcolm Andrew , O'BRIEN, Darragh Patrick Willian
发明人： PIKE, Ian Hugo , WARD, Malcolm Andrew , O'BRIEN, Darragh Patrick Willian
IPC分类号： G01N33/68 , C12Q1/37
CPC分类号： G01N33/6896 , C12Q1/37 , G01N2800/2828
摘要： The invention provides a method of diagnosis of a spongiform encephalopathy in a diagnostic sample of a valid body tissue taken from a subject, which comprises detecting an increased proteolytic activity in the diagnostic sample, compared with a sample from a control subject.
摘要翻译：本发明提供了从受试者获取的有效身体组织的诊断样品中的海绵状脑病的诊断方法，其包括检测诊断样品中增加的蛋白水解活性，与来自对照受试者的样品相比。

7. 发明申请

WO2006035237A3 METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：WO2006035237A3
公开(公告)日：2006-04-06
申请号：PCT/GB2005/003756
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING'S COLLEGE LONDON , WESTBROOK, Jules , BYERS, Helen , WARD, Malcolm , LOVESTONE, Simon , HYE, Abdul , LYNHAM, Stephen , JOUBERT, Richard , PREFOT, Petra , KUHN, Karsten , BAUMANN, Christian , SCHAEFER, Juergen , PRINZ, Thorsten , KIENLE, Stefan
发明人： WESTBROOK, Jules , BYERS, Helen , WARD, Malcolm , LOVESTONE, Simon , HYE, Abdul , LYNHAM, Stephen , JOUBERT, Richard , PREFOT, Petra , KUHN, Karsten , BAUMANN, Christian , SCHAEFER, Juergen , PRINZ, Thorsten , KIENLE, Stefan
IPC分类号： G01N33/68 , A61P25/28
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

8. 发明申请

WO2006035237A2 METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE 审中-公开
标题翻译：有关阿尔茨海默病的方法和组合物
公开(公告)号：WO2006035237A2
公开(公告)日：2006-04-06
申请号：PCT/GB2005003756
申请日：2005-09-29
申请人： PROTEOME SCIENCES PLC , KING S COLLEGE LONDON , WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEVEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
发明人： WESTBROOK JULES , BYERS HELEN , WARD MALCOLM , LOVESTONE SIMON , HYE ABDUL , LYNHAM STEVEN , JOUBERT RICHARD , PREFOT PETRA , KUHN KARSTEN , BAUMANN CHRISTIAN , SCHAEFER JUERGEN , PRINZ THORSTEN , KIENLE STEFAN
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译：提供了与阿尔茨海默病有关的方法和组合物。具体而言，提供了相对于其在正常状态中的表达而在阿尔茨海默病状态中差异表达的蛋白质。确定并描述与阿尔茨海默病有关的蛋白质。还提供了使用差异表达蛋白诊断阿尔茨海默病的方法，以及用于预防和治疗阿尔茨海默病的化合物的鉴定和治疗用途的方法。

9. 发明申请

WO2006021810A1 METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE 审中-公开
标题翻译：关于阿尔茨海默病的方法和组合
公开(公告)号：WO2006021810A1
公开(公告)日：2006-03-02
申请号：PCT/GB2005/003366
申请日：2005-08-26
申请人： PROTEOME SCIENCES PLC , WARD, Malcolm , PATEL, Vaksha , MCGREGOR, Emma , LEEDS, Nicola , BYERS, Helen , CAMPBELL, James , LEUNG, Kit-Yi , WESTBROOK, Jules
发明人： WARD, Malcolm , PATEL, Vaksha , MCGREGOR, Emma , LEEDS, Nicola , BYERS, Helen , CAMPBELL, James , LEUNG, Kit-Yi , WESTBROOK, Jules
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2500/00 , G01N2800/2821
摘要： Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided are methods, particularly experimental paradigms, for the identification of differential expressed proteins that are potential molecular targets for compounds to treat or prevent Alzheimer's disease. Also provided are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译：提供了与阿尔茨海默病相关的方法和组合物，包括与正常状态相比在阿尔茨海默氏病中差异表达的蛋白质。还提供了用于鉴定作为治疗或预防阿尔茨海默病的化合物的潜在分子靶标的差异表达蛋白质的方法，特别是实验范例。还提供了用于鉴定和治疗用于预防和治疗阿尔茨海默病的化合物的方法。

10. 发明申请

WO2005001114A2 SCREENING METHODS 审中-公开
标题翻译：筛选方法
公开(公告)号：WO2005001114A2
公开(公告)日：2005-01-06
申请号：PCT/GB2004/002739
申请日：2004-06-25
申请人： PROTEOME SCIENCES PLC , KING'S COLLEGE LONDON , ANDERTON, Brian , HANGER, Diane , WARD, Malcolm , BYERS, Helen
发明人： ANDERTON, Brian , HANGER, Diane , WARD, Malcolm , BYERS, Helen
IPC分类号： C12Q1/00
CPC分类号： G01N33/573 , C12Q1/42 , C12Q1/485 , G01N33/6896 , G01N2333/4709 , G01N2333/9121 , G01N2500/02
摘要： Methods for screening for substances capable of modulating the phosphorylation of tau protein are disclosed, and in particular paired helical filament (PHF) tau, and the use of such modulators in the treatment of tauopathies. The assays and screening methods are based on the identification of new phosphorylation sites in PHF tau and new kinases and combinations of kinases as therapeutic targets, in particular the identification of casein kinase 1 as a kinase which phosphorylates tau protein.
摘要翻译：筛选能够调节τ蛋白磷酸化的物质的方法，特别是成对螺旋丝（PHF）tau，以及这些调节剂在治疗tau蛋白病中的用途。测定和筛选方法基于鉴定PHF tau中新的磷酸化位点以及新激酶和激酶组合作为治疗靶标，特别是鉴定酪蛋白激酶1作为磷酸化τ蛋白的激酶。

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