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1. 发明申请

WO2009032235A1 APPARATUS AND METHOD FOR MULTI-MODAL IMAGING 审中-公开
标题翻译：多模式成像的装置和方法
公开(公告)号：WO2009032235A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010304
申请日：2008-09-02
申请人： CARESTREAM HEALTH, INC. , HARDER, John W , ZHENG, Shiying , WANG, Ruizheng , BRINGLEY, Joseph F. , VIZARD, Douglas L. , MCLAUGHLIN, William E. , HALL, Heidi , BRIDGES, Mark E
发明人： HARDER, John W , ZHENG, Shiying , WANG, Ruizheng , BRINGLEY, Joseph F. , VIZARD, Douglas L. , MCLAUGHLIN, William E. , HALL, Heidi , BRIDGES, Mark E
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B6/00 , A61B5/0035 , A61B5/0059 , A61B6/4216 , A61B6/4417 , A61B6/481 , A61B6/508 , A61B2503/40 , A61B2562/0242
摘要： Apparatus for multimodal imaging of an object includes a support stage for receiving an object; an object supported on the stage, the object having been treated with a biocompatible imaging probe comprising nanoparticles carrying targeting moieties and diagnostic components; a light source for producing a beam; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus includes a tiltable filter for filtering light from the source. The apparatus includes a mechanism for directing light through a first filter assembly to produce a first beam of light of a first frequency range for illuminating an object in a first imaging mode or through a second filter assembly to produce a second beam of light of a second frequency range for illuminating an object in a second imaging mode.
摘要翻译：用于物体的多模式成像的装置包括用于接收物体的支撑台; 支撑在舞台上的物体，已经用包含携带靶向部分和诊断部件的纳米颗粒的生物相容性成像探针处理该物体; 用于产生光束的光源; 定位成接收并将光束传递到物体的过滤器; 以及用于捕获对象的图像的镜头和相机系统。该装置包括用于过滤来自源的光的可倾斜滤光器。该装置包括用于引导光通过第一过滤器组件以产生第一频率范围的第一光束的机构，用于以第一成像模式照射物体或通过第二过滤器组件产生第二光束的第二光束用于在第二成像模式中照亮对象的频率范围。

2. 发明申请

WO2010033182A1 ON-PRESS DEVELOPABLE IMAGEABLE ELEMENTS 审中-公开
标题翻译：可压缩可开发的成像元件
公开(公告)号：WO2010033182A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/005157
申请日：2009-09-16
申请人： EASTMAN KODAK COMPANY , MUNNELLY, Heidi M. , WANG, Ruizheng
发明人： MUNNELLY, Heidi M. , WANG, Ruizheng
IPC分类号： G03F7/105 , B41M5/36 , B41C1/10
CPC分类号： G03F7/105 , B41C1/1008 , B41C1/1016 , B41C2201/02 , B41C2201/14 , B41C2210/04 , B41C2210/08 , B41C2210/22 , B41C2210/24 , B41C2210/266 , B41M5/368
摘要： On press developable negative-working, imageable elements have improved printout qualities with an infrared radiation absorbing compound that has a cyanine dye chromophore represented by Structure (CHROMOPHORE):] wherein one or both of Q 1 and Q 2 are independently acyl groups -(C=O)-R 3 ' and -(C=O)-R 4 ' respectively, wherein R 3 ' and R 4 ' are independently alkyl or aryl groups, or they are joined together to form a ring structure, or one of Q 1 and Q 2 is hydrogen and the other is a substituted or unsubstituted acyl group, A and A' are independently -S-, -O-, -NH-, -CH 2 -, or -CR'R"- groups wherein R' and R" are independently substituted or unsubstituted alkyl groups, or R' and R" together can form a cyclic group, Z represents the carbon atoms needed to form a 5- to 7-membered carbocyclic ring, Z 1 and Z 2 are independently benzo or naphtho condensed rings, and R 1 ' and R 2 ' are independently alkyl, cycloalkyl, or aryl groups.
摘要翻译：在可印刷的负性作用下，可成像元件具有改进的具有由结构（CHROMOPHORE）表示的花青染料发色团的红外辐射吸收化合物的打印质量：其中Q1和Q2中的一个或两个独立地为酰基 - （C = O ）-R 3'和 - （C = O）-R 4'，其中R 3'和R 4'独立地是烷基或芳基，或它们连接在一起形成环结构，或者Q1和Q2中的一个是氢，另一个是取代或未取代的酰基，A和A'独立地是-S-，-O-，-NH-，-CH 2 - 或-CR'R“ - 基团，其中R'和R”独立地是取代或未取代的烷基或R'和R“一起可以形成环状基团，Z表示形成5-至7-元碳环所需的碳原子，Z 1和Z 2独立地为苯并或萘并环稠合，R1'和R2 独立地是烷基，环烷基或芳基。

3. 发明申请

WO2008140475A3 IMAGING CONTRAST AGENTS USING NANOPARTICLES 审中-公开
标题翻译：使用纳米颗粒成像对比剂
公开(公告)号：WO2008140475A3
公开(公告)日：2009-08-13
申请号：PCT/US2007023044
申请日：2007-11-01
申请人： CARESTREAM HEALTH INC , ZHENG SHIYING , WANG RUIZHENG , CHE WENYI
发明人： ZHENG SHIYING , WANG RUIZHENG , CHE WENYI
IPC分类号： A61K49/00 , A61K9/14 , A61K9/51 , G01N33/543
CPC分类号： A61K49/0093 , A61K49/0032 , A61K49/1881
摘要： The present invention relates to a nanoparticle comprising self- assembled crosslinked, amphiphilic block copolymers and at least one immobilized dye, wherein the sell-assembled, crosslinked, amphiphilic block copolymers comprise a hydrophilic block and a hydrophobic block, wherein the self-assembled, crosslinked, amphiphilic block copolymers are self-assembled to form a core of the nanoparticle comprising a hydrophobic block, wherein the hydrophobic block is derived from at least one pendant multifunctional crosslinked alkoxy silane or amino silane moiety, and an exterior of the nanoparticle comprising a hydrophilic block, and wherein the immobilized dye is immobilized in the core
摘要翻译：本发明涉及包含自组装交联的两亲性嵌段共聚物和至少一种固定染料的纳米颗粒，其中所述销售组装的交联的两亲性嵌段共聚物包含亲水嵌段和疏水嵌段，其中所述自组装交联两亲性嵌段共聚物自组装形成包含疏水嵌段的纳米颗粒的核心，其中所述疏水嵌段衍生自至少一个侧链多官能交联的烷氧基硅烷或氨基硅烷部分，并且所述纳米颗粒的外部包含亲水嵌段，并且其中固定的染料固定在芯中

4. 发明申请

WO2009042041A1 MEMS PRINTHEAD BASED COMPRESSED FLUID PRINTING SYSTEM 审中-公开
标题翻译：基于MEMS PRINTHEAD的压缩流体打印系统
公开(公告)号：WO2009042041A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/010718
申请日：2008-09-15
申请人： EASTMAN KODAK COMPANY , MEHTA, Rajesh Vinodrai , MARCUS, Michael Alan , WANG, Ruizheng , HAWKINS, Gilbert Allen
发明人： MEHTA, Rajesh Vinodrai , MARCUS, Michael Alan , WANG, Ruizheng , HAWKINS, Gilbert Allen
IPC分类号： B41J2/04
CPC分类号： B41J2/015 , B41J2/04
摘要： A method and apparatus for delivering a mixture of compressed fluid and marking material and depositing the marking material in a pattern onto a substrate, includes a high pressure source of a mixture of compressed fluid and marking material. A micro-machined manifold includes a plurality of micro-nozzles, a fluid chamber, and an entrance port with portions of a first surface of the micro-machined manifold defining the entrance port with the entrance port being connected in fluid communication with the fluid chamber. Each of the micro-nozzles has an inlet and an outlet, the inlet being in fluid communication with the fluid chamber and the outlet being located on the second surface of the micro-machined manifold. Each micro-nozzle is shaped to produce a directed beam of the mixture beyond the outlet of the micro-nozzle. A housing is connected with the high pressure source and the entrance port of the micro-machined manifold.
摘要翻译：用于输送压缩流体和标记材料的混合物并将标记材料以图案沉积到基底上的方法和装置包括压缩流体和标记材料的混合物的高压源。微加工歧管包括多个微喷嘴，流体室和入口，其中微加工歧管的第一表面的部分限定入口，入口与流体室流体连通地连接。每个微喷嘴都具有入口和出口，入口与流体室流体连通，出口位于微加工歧管的第二表面上。每个微型喷嘴成形为产生混合物的定向束超过微喷嘴的出口。壳体与高压源和微加工歧管的入口连接。

5. 发明申请

WO2007120579A3 LOADED LATEX OPTICAL MOLECULAR IMAGING PROBES 审中-公开
公开(公告)号：WO2007120579A3
公开(公告)日：2008-06-12
申请号：PCT/US2007008638
申请日：2007-04-04
申请人： EASTMAN KODAK CO , LEON JEFFREY WADE , HARRISON WILLIAM JAMES , KELLEY BRIAN JOSEPH , BENNETT JAMES R , STEGMAN DAVID ALAN , WANG RUIZHENG , HARDER JOHN WILLIAM
发明人： LEON JEFFREY WADE , HARRISON WILLIAM JAMES , KELLEY BRIAN JOSEPH , BENNETT JAMES R , STEGMAN DAVID ALAN , WANG RUIZHENG , HARDER JOHN WILLIAM
IPC分类号： C08F220/28 , A61B5/00 , A61K49/00 , G01N33/58
CPC分类号： A61K49/0093 , A61K49/0021 , A61K49/0032 , A61K49/0036 , A61K49/0058 , B82Y5/00 , C08F212/36 , C08F220/26 , C08F220/28 , C08F222/1006 , Y10T436/143333 , C08F212/08
摘要： The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least two ethylenically unsaturated chemical functionalities; Z is at least one polyethylene glycol macromonomer with an average molecular weight of between 300 and 10,000; W is an ethylenic monomer different from X, Y, or Z; and X is at least one water insoluble, alkoxethyl containing monomer; and m, n, o, and p are the respective weight percentages of each monomer. The particle may be loaded with a fluorescent dye.
摘要翻译：本发明涉及一种负载的胶乳颗粒，其包含由式（X）m-（Y）n-（Z）o-（W）p表示的混合物制成的胶乳材料，其中Y是至少一种具有至少一个两种烯属不饱和化学官能团; Z是至少一种平均分子量在300和10,000之间的聚乙二醇大分子单体; W是不同于X，Y或Z的烯属单体; X为至少一种不溶于水的含烷氧基乙基单体; m，n，o和p分别为各单体的重量百分比。颗粒可以装载荧光染料。

6. 发明申请

WO2015003046A1 YELLOW THERMOCHROMIC DYES, INKS COMPOSITION AND LEVEL INDICATORS 审中-公开
标题翻译：黄色热变性染料，墨水组合物和水平指示剂
公开(公告)号：WO2015003046A1
公开(公告)日：2015-01-08
申请号：PCT/US2014/045224
申请日：2014-07-02
申请人： CHROMATIC TECHNOLOGIES INC. , WANG, Ruizheng , DU, Yu , OWEN, Timothy, J. , ABRAHA, Medhanei , CLAYTON, Terrill, Scott , SMALL, Lyle
发明人： WANG, Ruizheng , DU, Yu , OWEN, Timothy, J. , ABRAHA, Medhanei , CLAYTON, Terrill, Scott , SMALL, Lyle
IPC分类号： C09D11/50
CPC分类号： C09D11/50 , B41M5/287 , B41M5/327 , B41M5/3335 , C08K5/053 , C08K5/09 , C08K5/3445 , C09B11/08 , C09B11/22 , C09B11/26 , C09B57/00 , C09B57/008 , C09D11/00
摘要： A new leuco dye produces a yellow color while demonstrating also exceptional light and thermal stability under light.
摘要翻译：新的无色染料产生黄色，同时在光照下也表现出特别的光和热稳定性。

7. 发明申请

WO2008140475A2 IMAGING CONTRAST AGENTS USING NANOPARTICLES 审中-公开
标题翻译：使用纳米颗粒成像对比剂
公开(公告)号：WO2008140475A2
公开(公告)日：2008-11-20
申请号：PCT/US2007/023044
申请日：2007-11-01
申请人： CARESTREAM HEALTH, INC. , ZHENG, Shiying , WANG, Ruizheng , CHE, Wenyi
发明人： ZHENG, Shiying , WANG, Ruizheng , CHE, Wenyi
IPC分类号： A61K49/00 , A61K9/14 , A61K9/51 , G01N33/543
CPC分类号： A61K49/0093 , A61K49/0032 , A61K49/1881
摘要： The present invention relates to a nanoparticle comprising self- assembled crosslinked, amphiphilic block copolymers and at least one immobilized dye, wherein the sell-assembled, crosslinked, amphiphilic block copolymers comprise a hydrophilic block and a hydrophobic block, wherein the self-assembled, crosslinked, amphiphilic block copolymers are self-assembled to form a core of the nanoparticle comprising a hydrophobic block, wherein the hydrophobic block is derived from at least one pendant multifunctional crosslinked alkoxy silane or amino silane moiety, and an exterior of the nanoparticle comprising a hydrophilic block, and wherein the immobilized dye is immobilized in the core
摘要翻译：本发明涉及包含自组装交联的两亲性嵌段共聚物和至少一种固定染料的纳米颗粒，其中所述销售组装的交联的两亲性嵌段共聚物包含亲水嵌段和疏水嵌段，其中所述自组装交联两亲性嵌段共聚物自组装形成包含疏水嵌段的纳米颗粒的核心，其中所述疏水嵌段衍生自至少一个侧链多官能交联烷氧基硅烷或氨基硅烷部分，并且所述纳米颗粒的外部包含亲水嵌段，并且其中固定的染料固定在芯中

8. 发明申请

WO2007120579A2 LOADED LATEX OPTICAL MOLECULAR IMAGING PROBES 审中-公开
公开(公告)号：WO2007120579A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008638
申请日：2007-04-04
申请人： EASTMAN KODAK COMPANY , LEON, Jeffrey, Wade , HARRISON, William, James , KELLEY, Brian, Joseph , BENNETT, James, R. , STEGMAN, David, Alan , WANG, Ruizheng , HARDER, John, william
发明人： LEON, Jeffrey, Wade , HARRISON, William, James , KELLEY, Brian, Joseph , BENNETT, James, R. , STEGMAN, David, Alan , WANG, Ruizheng , HARDER, John, william
IPC分类号： C08F220/26 , C08F212/08 , C09D11/00 , B41M3/14
CPC分类号： A61K49/0093 , A61K49/0021 , A61K49/0032 , A61K49/0036 , A61K49/0058 , B82Y5/00 , C08F212/36 , C08F220/26 , C08F220/28 , C08F222/1006 , Y10T436/143333 , C08F212/08
摘要： The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least two ethylenically unsaturated chemical functionalities; Z is at least one polyethylene glycol macromonomer with an average molecular weight of between 300 and 10,000; W is an ethylenic monomer different from X, Y, or Z; and X is at least one water insoluble, alkoxethyl containing monomer; and m, n, o, and p are the respective weight percentages of each monomer. The particle may be loaded with a fluorescent dye.
摘要翻译：本发明涉及一种负载的胶乳颗粒，其包含由式（X）m-（Y）n-（Z）o-（W）p表示的混合物制成的胶乳材料，其中Y是至少一种具有至少一个两种烯属不饱和化学官能团; Z是至少一种平均分子量在300和10,000之间的聚乙二醇大分子单体; W是不同于X，Y或Z的烯属单体; X为至少一种不溶于水的含烷氧基乙基单体; m，n，o和p分别为各单体的重量百分比。颗粒可以装载荧光染料。

9. 发明申请

WO2006011879A1 PROCESS FOR FORMING AN AROMATIC AMINE COMPOUND 审中-公开
标题翻译：形成芳族胺化合物的方法
公开(公告)号：WO2006011879A1
公开(公告)日：2006-02-02
申请号：PCT/US2004/021137
申请日：2004-06-30
申请人： EASTMAN KODAK COMPANY , MC GARRY, Lynda, Woedy , SPARA, Paul, Patrick , WANG, Ruizheng
发明人： MC GARRY, Lynda, Woedy , SPARA, Paul, Patrick , WANG, Ruizheng
IPC分类号： C07C209/10
CPC分类号： C07C209/08 , C07C209/10 , C07C211/54 , C07C211/57
摘要： A process for forming an aromatic amine product comprises the steps of (a) combining an aromatic primary or secondary initial amine with an aromatic halide compound in the presence of a palladium complex and a phosphine compound catalyst to form a mixture; (b) heating the mixture to a first temperature of at least 60°C; (c) adding a base material to the heated mixture; and (d) maintaining the temperature of the mixture at or above the first temperature for a period of time sufficient to form as a product an aromatic substituted form of the aromatic primary or secondary initial amine. The process provides products of high purity in good yields.
摘要翻译：形成芳族胺产物的方法包括以下步骤：（a）在钯络合物和膦化合物催化剂的存在下将芳族伯或仲初始胺与芳族卤化物化合物混合以形成混合物; （b）将混合物加热至至少60℃的第一温度; （c）将基材添加到加热的混合物中; 和（d）将混合物的温度保持在或高于第一温度一段足以形成芳族取代形式的芳族伯或仲初始胺的产物。该方法以高产率提供了高纯度的产品。

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