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1. 发明申请

WO2012112451A1 ESTER DERIVATIVES OF BIMATOPROST COMPOSITIONS AND METHODS 审中-公开
标题翻译：双歧杆菌组合物和方法的酯酶衍生物
公开(公告)号：WO2012112451A1
公开(公告)日：2012-08-23
申请号：PCT/US2012/024881
申请日：2012-02-13
申请人： ALLERGAN, INC. , WOODWARD, David, F. , WANG, Jenny, W. , GARST, Michael, E. , BURK, Robert, M. , GAC, Todd, S. , POLOSO, Neil, J.
发明人： WOODWARD, David, F. , WANG, Jenny, W. , GARST, Michael, E. , BURK, Robert, M. , GAC, Todd, S. , POLOSO, Neil, J.
IPC分类号： C07C405/00 , A61K8/42 , A61Q7/00
CPC分类号： C07C235/34 , A61K8/42 , A61Q7/00 , C07C405/00 , C07C405/0041 , C07C2601/08
摘要： Provided herein, inter alia , are prodrugs of bimatoprost, methods of using the same and compositions including the same.
摘要翻译：本文提供的是比马前列素的前药，其使用方法和包含其的组合物。

2. 发明申请

WO2012003477A2 INHIBITION OF INFLAMMATION BYSIMULTANEOUS BLOCKADE OF MULTIPLE PROSTANOID RECEPTORS 审中-公开
标题翻译：多种前列腺素受体炎性反应性阻滞的抑制作用
公开(公告)号：WO2012003477A2
公开(公告)日：2012-01-05
申请号：PCT/US2011/042851
申请日：2011-07-01
申请人： ALLERGAN, INC. , WANG, Jenny, W. , WOODWARD, David, F. , NI, Ming , MARTOS, Jose, L. , CARLING, William, R.
发明人： WANG, Jenny, W. , WOODWARD, David, F. , NI, Ming , MARTOS, Jose, L. , CARLING, William, R.
IPC分类号： A61P1/16 , A61P7/02
CPC分类号： A61K31/422
摘要： The present invention provides a method for treating inflammation in a patient in need thereof comprising administering to said patient an effective amount of a compound according to formula wherein R is H or lower alkyl, R1 is hydrocarbyl or substituted hydrocarbyl and the broken line represents a saturated or unsaturated bond, i.e a double bond. Preferably, R1 is an alkyl. More preferably, R1 is a n- alkyl or a cycloalkyl-n-alkyl, e.g. a cyclohexyl-n-alkyl, e.g. n- octyl, n-nonyl or cyclohexyl-n-butyl radical and prodrugs, isomers and pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供了治疗有此需要的患者的炎症的方法，包括给所述患者施用有效量的根据下式的化合物其中R是H或低级烷基，R 1是烃基或取代的烃基，虚线表示饱和或不饱和键，即双键。优选地，R1是烷基。更优选地，R 1是正烷基或环烷基 - 正烷基，环己基 - 正烷基，例如环己基正烷基。正辛基，正壬基或环己基正丁基及其前药，异构体和药学上可接受的盐。

3. 发明申请

WO2012106249A3 METHOD OF ENHANCING HAIR GROWTH 审中-公开
标题翻译：增加头发生长的方法
公开(公告)号：WO2012106249A3
公开(公告)日：2014-02-27
申请号：PCT/US2012023148
申请日：2012-01-30
申请人： ALLERGAN INC , WOODWARD DAVID F , WANG JENNY W
发明人： WOODWARD DAVID F , WANG JENNY W
IPC分类号： A61K8/42 , A61K8/49 , A61Q7/00
CPC分类号： A61K8/4953 , A61K8/42 , A61K31/215 , A61K31/505 , A61K2800/592 , A61Q5/00 , A61Q7/00 , Y10S514/88
摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include bimatoprost and minoxidil in a vehicle for topical application to the skin of a mammal, e.g. a human, whereby the combination of bimatoprost and minoxidil produces a faster onset of hair growth in humans or other mammals and wherein said composition brings about a synergestic result of faster onset of hair growth as compared to compositions comprising bimatoprost and minoxidil, alone.
摘要翻译：公开了用于刺激毛发生长的方法和组合物，其中所述组合物包括用于局部施用于哺乳动物皮肤的载体中的比马前列素和米诺地尔。由此，比马前列素和米诺地尔的组合在人或其它哺乳动物中产生更快的头发生长发生，并且与单独包含比马前列素和米诺地尔的组合物相比，所述组合物产生更快发生头发生长的协同作用。

4. 发明申请

WO2013101598A1 COMPOUNDS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE 审中-公开
标题翻译：在多种PROSTAGLANDIN受体上起作用的化合物产生一般的抗炎反应
公开(公告)号：WO2013101598A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/070664
申请日：2012-12-19
申请人： ALLERGAN, INC. , KANGASMETSA, Jussi J. , CARLING, William R. , MARTOS, Jose L. , WOODWARD, David F. , WANG, Jenny W.
发明人： KANGASMETSA, Jussi J. , CARLING, William R. , MARTOS, Jose L. , WOODWARD, David F. , WANG, Jenny W.
IPC分类号： C07D231/14 , C07D231/38 , A61K31/415 , A61P11/00
CPC分类号： C07D231/38 , C07D231/12 , C07D231/14
摘要： The present invention provides a compound that is represented by the following general formula (A): wherein R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , X, W, X and Y are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, TP and/or EP4 receptor mediated diseases or conditions.
摘要翻译：本发明提供由以下通式（A）表示的化合物：其中R1，R2，R4，R5，R6，R7，X，W，X和Y如说明书中所定义。可以施用化合物以治疗DP1，FP，EP1，TP和/或EP4受体介导的疾病或病症。

5. 发明申请

WO2012003414A1 COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE 审中-公开
标题翻译：多种PROSTAGLANDIN受体的化合物作用产生一般的抗炎反应
公开(公告)号：WO2012003414A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042729
申请日：2011-07-01
申请人： ALLERGAN, INC. , WOODWARD, David, F. , MARTOS, Jose, L. , WANG, Jenny, W. , KANGASMETSA, Hussi, J. , CARLING, William, C.
发明人： WOODWARD, David, F. , MARTOS, Jose, L. , WANG, Jenny, W. , KANGASMETSA, Hussi, J. , CARLING, William, C.
IPC分类号： C07D231/12 , A61K31/415 , A61P29/00
CPC分类号： C07D231/12 , A61K31/415
摘要： The present invention provides a compound, that is a 1-[(2-{[(alkyl or aryl)methyl]oxy}halo or haloalkyl substituted-phenyl)alkyl]-5-hydrocarbyl or substituted hydrocarbyl-1H-pyrazole carboxylic acid or alkylenylcarboxylic acid or a hydrocarbyl or substituted hydrocarbyl sulfonamide of said carboxylic acid or said alkylenylcarboxylic acid, provided however said compound is not a 3-carboxylic acid, a sulfonamide thereof, or a 3-methylenylcarboxylic acid. The compound may be represented by the following formula (I). Wherein R1, R2, R3, R4, R5, R6, X, W, X and Y are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, TP and/or EP4 receptor mediated diseases or conditions.
摘要翻译：本发明提供了化合物，即1 - [（2 - {[（烷基或芳基）甲基]氧基}卤代或卤代烷基取代的 - 苯基）烷基] -5-烃基或取代的烃基-1H-吡唑羧酸或亚烷基羧酸或所述羧酸或所述烷基烯基羧酸的烃基或取代的烃基磺酰胺，但是所述化合物不是3-羧酸，其磺酰胺或3-甲基烯基羧酸。化合物可以由下式（I）表示。其中R1，R2，R3，R4，R5，R6，X，W，X和Y如说明书中所定义。可以施用化合物以治疗DP1，FP，EP1，TP和/或EP4受体介导的疾病或病症。

6. 发明申请

WO2012100238A3 COMPOUNDS AND METHODS FOR ENHANCING HAIR GROWTH 审中-公开
标题翻译：用于增加头发生长的化合物和方法
公开(公告)号：WO2012100238A3
公开(公告)日：2014-07-03
申请号：PCT/US2012022133
申请日：2012-01-21
申请人： ALLERGAN INC , WANG JENNY W , WOODWARD DAVID F
发明人： WANG JENNY W , WOODWARD DAVID F
IPC分类号： A61Q7/00 , A61K8/46 , A61K31/5575 , A61K31/575 , A61P17/14
CPC分类号： A61K31/5575 , A61K8/46 , A61K31/575 , A61Q7/00
摘要： The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase hair growth and one or more properties selected from the group consisting of luster, sheen, brilliance, gloss, glow, shine or patina of hair associated with the follicles or increasing one or more of: length, thickness, number, and density, of eyelash hair or eyebrow hair comprising applying to the skin of a patient a composition comprising an effective amount of an EP3 agonist or an EP4 agonist prodrug or a mixture thereof. Such compositions which are used in treating the skin or scalp of a human or non-human animal may comprise an effective amount of 3, 7 or 3 and 7 thia prostanoic acid. A mixture of 3,7-dithia PGE1 and 3,7- dithiaPGEl-isopropyl ester is preferred for this treatment.
摘要翻译：本发明提供了一种用于刺激哺乳动物物种的毛发生长或将us毛或中间毛发转化为末梢毛或刺激毛囊以增加毛发生长的方法以及选自光泽，光泽，光泽，光泽的一种或多种性质，与毛囊相关的头发，发光或光泽的毛发，或增加睫毛或眉毛的长度，厚度，数量和密度中的一种或多种，其包括向患者的皮肤施用包含有效量的 EP3激动剂或EP4激动剂前药或其混合物。用于治疗人或非人动物的皮肤或头皮的这种组合物可以包含有效量的3,7或3和7以及前列腺酸。这种处理优选3,7-二硫键PGE1和3,7-二硫代磷酸异丙酯的混合物。

7. 发明申请

WO2013101733A1 COMPOUNDS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE 审中-公开
标题翻译：在多种PROSTAGLANDIN受体上起作用的化合物产生一般的抗炎反应
公开(公告)号：WO2013101733A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/071232
申请日：2012-12-21
申请人： ALLERGAN, INC. , CARLING, William R. , MARTOS, Jose L. , KANGASMETSA, Jussi J. , WANG, Jenny W. , WOODWARD, David F.
发明人： CARLING, William R. , MARTOS, Jose L. , KANGASMETSA, Jussi J. , WANG, Jenny W. , WOODWARD, David F.
IPC分类号： C07D231/14 , A61K31/415 , A61P11/00
CPC分类号： C07D231/14
摘要： The present invention provides a compound, that is wherein Y, W, Z, R1, R2, R4, R5 and R6 are as defined in the specification. The compounds may be administered to treat DP, FP, EP1, TP and/or EP4 receptor-mediated diseases or conditions.
摘要翻译：本发明提供化合物，其中Y，W，Z，R 1，R 2，R 4，R 5和R 6如说明书中所定义。可以施用化合物以治疗DP，FP，EP1，TP和/或EP4受体介导的疾病或病症。

8. 发明申请

WO2012100238A2 COMPOUNDS AND METHODS FOR ENHANCING HAIR GROWTH 审中-公开
标题翻译：用于增加头发生长的化合物和方法
公开(公告)号：WO2012100238A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/022133
申请日：2012-01-21
申请人： ALLERGAN, INC. , WANG, Jenny W. , WOODWARD, David F.
发明人： WANG, Jenny W. , WOODWARD, David F.
IPC分类号： A61K31/216 , A61K31/192 , A61K31/381 , A61K31/343 , A61P17/14
CPC分类号： A61K31/5575 , A61K8/46 , A61K31/575 , A61Q7/00
摘要： The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase hair growth and one or more properties selected from the group consisting of luster, sheen, brilliance, gloss, glow, shine or patina of hair associated with the follicles or increasing one or more of: length, thickness, number, and density, of eyelash hair or eyebrow hair comprising applying to the skin of a patient a composition comprising an effective amount of an EP3 agonist or an EP4 agonist prodrug or a mixture thereof. Such compositions which are used in treating the skin or scalp of a human or non-human animal may comprise an effective amount of 3, 7 or 3 and 7 thia prostanoic acid. A mixture of 3,7-dithia PGE1 and 3,7- dithiaPGEl-isopropyl ester is preferred for this treatment.
摘要翻译：本发明提供了一种用于刺激哺乳动物物种的毛发生长或将us毛或中间毛发转化为末梢毛或刺激毛囊以增加毛发生长的方法以及选自光泽，光泽，光泽，光泽的一种或多种性质，与毛囊相关的头发，发光或光泽的毛发，或增加睫毛或眉毛的长度，厚度，数量和密度中的一种或多种，其包括向患者的皮肤施用包含有效量的 EP3激动剂或EP4激动剂前药或其混合物。用于治疗人或非人动物的皮肤或头皮的这种组合物可以包含有效量的3,7或3和7以及前列腺酸。这种处理优选3,7-二硫键PGE1和3,7-二硫代磷酸异丙酯的混合物。

9. 发明申请

WO2010135404A1 EP2 RECEPTOR AGONIST FROM NON-PROSTANOID STRUCTURES DESIGNED AS PGE2 ANTAGONISTS 审中-公开
标题翻译： EP2受体激动剂来自非特异性结构域，被设计为PGE2拮抗剂
公开(公告)号：WO2010135404A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035366
申请日：2010-05-19
申请人： ALLERGAN, INC. , WOODWARD, David F. , WANG, Jenny W.
发明人： WOODWARD, David F. , WANG, Jenny W.
IPC分类号： C07C235/60 , A61K31/166 , A61P27/02
CPC分类号： A61K31/192 , C07C235/60
摘要： An EP2-receptor agonist of the following structure is disclosed (I) which is useful in the treatment of pain, inflammation and lowering intraocular pressure.
摘要翻译：公开了以下结构的EP2受体激动剂（I），其可用于治疗疼痛，炎症和降低眼内压。

10. 发明申请

WO2012145737A8 FATTY ACID AMIDE HYDROLASE INHIBITORS FOR TREATING PAIN 审中-公开
标题翻译：脂肪酸酰胺水解酶抑制剂治疗疼痛
公开(公告)号：WO2012145737A8
公开(公告)日：2014-01-03
申请号：PCT/US2012034626
申请日：2012-04-23
申请人： ALLERGAN INC , WOODWARD DAVID F , MARTOS JOSE L , CARLING WILLIAM R , POLOSO NEIL J , WANG JENNY W
发明人： WOODWARD DAVID F , MARTOS JOSE L , CARLING WILLIAM R , POLOSO NEIL J , WANG JENNY W
IPC分类号： C07D413/04 , A61K31/422 , A61P25/00
CPC分类号： C07D413/04 , C07D413/14
摘要： Compounds of Formula 1 are described herein. These compounds may be administered to a patient for treatment of suffering from pain or other FAAH mediated conditions.
摘要翻译：式1的化合物在本文中描述。这些化合物可以施用于患者以治疗患有疼痛或其它FAAH介导的病症。

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