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1. 发明申请

WO2012018862A2 MUTATED PROTOPORPHYRINOGEN IX OXIDASE (PPX) GENES 审中-公开
标题翻译：突变的原卟啉IX氧化酶（PPX）基因
公开(公告)号：WO2012018862A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/046330
申请日：2011-08-02
申请人： CIBUS US LLC , CIBUS EUROPE B.V. , GOCAL, Gregory F.W. , BEETHAM, Peter R. , DE SCHOPKE, Aura , DUMM, Sarah , PEARCE, James , SCHOPKE, Christian , WALKER, Keith A.
发明人： GOCAL, Gregory F.W. , BEETHAM, Peter R. , DE SCHOPKE, Aura , DUMM, Sarah , PEARCE, James , SCHOPKE, Christian , WALKER, Keith A.
IPC分类号： A01H5/00
CPC分类号： C12N15/8201 , C12N9/001 , C12N15/8213 , C12N15/8274
摘要： Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resitant.
摘要翻译：提供涉及转基因或非转基因植物中基因和/或蛋白质突变的组合物和方法。在某些实施方案中，本公开涉及原卟啉原IX（PPX）基因中的突变。在一些实施方案中，本公开涉及作为除草剂抗性剂的植物。

2. 发明申请

WO2011063350A3 METHODS AND COMPOSITIONS FOR PRODUCING SQUALENE USING YEAST 审中-公开
公开(公告)号：WO2011063350A3
公开(公告)日：2011-05-26
申请号：PCT/US2010/057668
申请日：2010-11-22
申请人： COH Inc. , WALKER, Keith A. , KNUTH, Mark E. , FONG, Noel M. , BEETHAM, Peter R.
发明人： WALKER, Keith A. , KNUTH, Mark E. , FONG, Noel M. , BEETHAM, Peter R.
IPC分类号： C12R1/73 , C12N15/09 , C12P5/02
摘要： Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.

3. 发明申请

WO2013028188A1 MUTATED PROTOPORPHYRINOGEN IX OXIDASE (PPX) GENES 审中-公开
标题翻译：突变的原生质子IX氧化酶（PPX）基因
公开(公告)号：WO2013028188A1
公开(公告)日：2013-02-28
申请号：PCT/US2011/049007
申请日：2011-08-24
申请人： CIBUS US LLC , CIBUS EUROPE B.V. , GOCAL, Gregory F.W. , BEETHAM, Peter R. , DE SCHOPKE, Aura , DUMM, Sarah , PEARCE, James , SCHOPKE, Christian , WALKER, Keith A.
发明人： GOCAL, Gregory F.W. , BEETHAM, Peter R. , DE SCHOPKE, Aura , DUMM, Sarah , PEARCE, James , SCHOPKE, Christian , WALKER, Keith A.
IPC分类号： A01H5/00 , C12N15/53 , C12N9/02 , C12N15/82
CPC分类号： C12N9/001 , C12N15/8274
摘要： Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resitant.
摘要翻译：提供与转基因植物或非转基因植物中的基因和/或蛋白质突变相关的组合物和方法。在某些实施方案中，本公开涉及原卟啉原IX（PPX）基因中的突变。在一些实施方案中，本公开涉及除草剂除颤剂的植物。

4. 发明申请

WO2012018862A3 MUTATED PROTOPORPHYRINOGEN IX OXIDASE (PPX) GENES 审中-公开
标题翻译：突变的原生质子IX氧化酶（PPX）基因
公开(公告)号：WO2012018862A3
公开(公告)日：2012-05-31
申请号：PCT/US2011046330
申请日：2011-08-02
申请人： CIBUS US LLC , CIBUS EUROPE BV , GOCAL GREGORY F W , BEETHAM PETER R , DE SCHOPKE AURA , DUMM SARAH , PEARCE JAMES , SCHOPKE CHRISTIAN , WALKER KEITH A
发明人： GOCAL GREGORY F W , BEETHAM PETER R , DE SCHOPKE AURA , DUMM SARAH , PEARCE JAMES , SCHOPKE CHRISTIAN , WALKER KEITH A
IPC分类号： A01H5/00
CPC分类号： C12N15/8201 , C12N9/001 , C12N15/8213 , C12N15/8274
摘要： Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resitant.
摘要翻译：提供与转基因植物或非转基因植物中的基因和/或蛋白质突变相关的组合物和方法。在某些实施方案中，本公开涉及原卟啉原IX（PPX）基因中的突变。在一些实施方案中，本公开涉及除草剂除颤剂的植物。

5. 发明申请

WO2011063350A2 METHODS AND COMPOSITIONS FOR PRODUCING SQUALENE USING YEAST 审中-公开
标题翻译：使用酵母生产S烯的方法和组合物
公开(公告)号：WO2011063350A2
公开(公告)日：2011-05-26
申请号：PCT/US2010057668
申请日：2010-11-22
申请人： CIBUS OILS LLC , WALKER KEITH A , KNUTH MARK E , FONG NOEL M , BEETHAM PETER R
发明人： WALKER KEITH A , KNUTH MARK E , FONG NOEL M , BEETHAM PETER R
IPC分类号： C12N1/00
CPC分类号： C12N15/815 , C12N15/52 , C12P5/007 , C12P5/026 , C12R1/73
摘要： Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
摘要翻译：本文提供了用于生产类异戊二烯，包括角鲨烯的组合物和方法。在某些方面和实施方案中提供了遗传转化的酵母并因此使用。在一些方面和实施方案中，遗传转化的酵母产生类异戊二烯，优选角鲨烯。还提供了使用遗传转化的酵母或非遗传转化的酵母生产角鲨烯的方法。本发明还提供由基因转化的酵母或非基因转化的酵母产生的角鲨烯。

6. 发明申请

WO2009143490A1 PRODUCTION OF SQUALENE USING YEAST 审中-公开
标题翻译：使用YEAST生产SQUALENE
公开(公告)号：WO2009143490A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/045080
申请日：2009-05-22
申请人： CIBUS INTERNATIONAL, L.P. , WALKER, Keith, A. , KNUTH, Mark, E. , FONG, Noel, M. , BEETHAM, Peter, R.
发明人： WALKER, Keith, A. , KNUTH, Mark, E. , FONG, Noel, M. , BEETHAM, Peter, R.
IPC分类号： C12P5/02
CPC分类号： C12P5/007
摘要： Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically altered yeast and uses therefore. In some aspects and embodiments, the genetically altered yeast produce isoprenoids, preferably squalene. The genetically altered yeast may have alterations in the expression or activity of enzymes involved in squalene production, for example, acetyl-CoA carboxylase (or "ACCase"), HMG-CoA reductase, squalene epoxidase, and squalene synthase. One or more genes of a genetically altered yeast may be modified by gene repair oligonucleobases. Also are provided methods of producing squalene using a genetically altered yeast. The invention also provides squalene produced by genetically altered yeast.
摘要翻译：提供用于产生类异戊二烯（包括角鲨烯）的组合物和方法。在某些方面和提供的实施方案是经遗传改变的酵母并因此使用。在一些方面和实施方案中，遗传改变的酵母产生类异戊二烯，优选角鲨烯。遗传改变的酵母可能具有改变参与角鲨烯生产的酶的表达或活性，例如乙酰辅酶A羧化酶（或“ACCase”），HMG-CoA还原酶，角鲨烯环氧酶和角鲨烯合酶。遗传改变的酵母的一个或多个基因可以通过基因修复寡核苷酸修饰。还提供了使用遗传改变的酵母生产角鲨烯的方法。本发明还提供由遗传改变的酵母产生的角鲨烯。

7. 发明申请

WO2009085033A1 ALKYLESTER FATTY ACID BLENDS AND USES THEREFOR 审中-公开
标题翻译： ALKYLESTER脂肪酸混合物及其用途
公开(公告)号：WO2009085033A1
公开(公告)日：2009-07-09
申请号：PCT/US2007/026410
申请日：2007-12-27
申请人： CIBUS LLC , KNUTH, Mark, E. , BEETHAM, Peter, R. , WALKER, Keith, A. , KUEBITZ, Bernhard, D.
发明人： KNUTH, Mark, E. , BEETHAM, Peter, R. , WALKER, Keith, A. , KUEBITZ, Bernhard, D.
IPC分类号： C07D317/00 , C10L1/00
CPC分类号： C10L1/026 , C10G2300/1011 , Y02E50/13 , Y02P30/20 , Y02T50/678
摘要： Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.
摘要翻译：本文提供的是包含超过50％的中链脂肪酸或其脂肪酸烷基酯并具有低熔点的混合油或脂肪酸。这种共混物可用作燃料或作为用于生产例如生物柴油的原料。还提供遗传改变或修饰的植物，被修饰，使得植物产生的中链脂肪酸的量增加。进一步提供了一种预测脂肪酸甲酯共混物的熔点的方法，以及用于鉴定适合用作例如生物柴油的共混物的方法。

8. 发明申请

WO2008002643A4 FATTY ACID BLENDS AND USES THEREFOR 审中-公开
公开(公告)号：WO2008002643A4
公开(公告)日：2008-01-03
申请号：PCT/US2007/015017
申请日：2007-06-27
申请人： CIBUS LLC , KNUTH, Mark, E. , BEETHAM, Peter, R. , WALKER, Keith, A. , GOCAL, Gregory, Francis William
发明人： KNUTH, Mark, E. , BEETHAM, Peter, R. , WALKER, Keith, A. , GOCAL, Gregory, Francis William
IPC分类号： C07B53/00 , C07C53/00
摘要： Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.

9. 发明申请

WO2008002643A2 FATTY ACID BLENDS AND USES THEREFOR 审中-公开
标题翻译：脂肪酸混合物及其用途
公开(公告)号：WO2008002643A2
公开(公告)日：2008-01-03
申请号：PCT/US2007015017
申请日：2007-06-27
申请人： CIBUS LLC , KNUTH MARK E , BEETHAM PETER R , WALKER KEITH A , GOCAL GREGORY FRANCIS WILLIAM
发明人： KNUTH MARK E , BEETHAM PETER R , WALKER KEITH A , GOCAL GREGORY FRANCIS WILLIAM
IPC分类号： A01H5/00
CPC分类号： C10L1/026 , A23D9/00 , C10L2200/0476 , C11C1/08 , C11C3/003 , C12N9/0083 , C12N15/8247 , Y02E50/13
摘要： Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.
摘要翻译：本文提供的是包含超过50％的中链脂肪酸或其脂肪酸烷基酯并具有低熔点的混合油或脂肪酸。这种共混物可用作燃料或作为用于生产例如生物柴油的原料。还提供遗传改变或修饰的植物，被修饰，使得植物产生的中链脂肪酸的量增加。进一步提供了一种预测脂肪酸甲酯共混物的熔点的方法，以及用于鉴定适合用作例如生物柴油的共混物的方法。

10. 发明申请

WO2008002643A3 FATTY ACID BLENDS AND USES THEREFOR 审中-公开
标题翻译：脂肪酸混合物及其用途
公开(公告)号：WO2008002643A3
公开(公告)日：2008-11-27
申请号：PCT/US2007015017
申请日：2007-06-27
申请人： CIBUS LLC , KNUTH MARK E , BEETHAM PETER R , WALKER KEITH A , GOCAL GREGORY FRANCIS WILLIAM
发明人： KNUTH MARK E , BEETHAM PETER R , WALKER KEITH A , GOCAL GREGORY FRANCIS WILLIAM
IPC分类号： C07B53/00 , C07C53/00
CPC分类号： C10L1/026 , A23D9/00 , C10L2200/0476 , C11C1/08 , C11C3/003 , C12N9/0083 , C12N15/8247 , Y02E50/13
摘要： Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the production of, for example, a biodiesel. Also provided genetically altered or modified plants, modified such that the amount of medium chain fatty acids generated by the plant are increased. Further provided is a method of predicting the melting point of a blend of fatty acid methyl esters and the use of such a method for identifying blends suitable for use as, for example, a biodiesel.
摘要翻译：本文提供了包含超过50％中链脂肪酸或其脂肪酸烷基酯并具有低熔点的混合油或脂肪酸。这种共混物可用作燃料或作为生产例如生物柴油的起始材料。还提供了基因改变或修饰的植物，其经过修饰使得植物产生的中链脂肪酸的量增加。进一步提供了预测脂肪酸甲酯混合物熔点的方法以及使用这种方法来鉴定适合用作例如生物柴油的混合物。

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