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1. 发明申请

WO1996003129A1 METHOD OF TREATING SWEAT-RELATED CONDITIONS 审中-公开
标题翻译：处理相关条件的方法
公开(公告)号：WO1996003129A1
公开(公告)日：1996-02-08
申请号：PCT/US1995006679
申请日：1995-06-02
申请人： MERCK & CO., INC. , WALDSTREICHER, Joanne
发明人： MERCK & CO., INC.
IPC分类号： A61K31/56
CPC分类号： A61K45/06 , A61K31/00 , A61K31/56 , A61K31/58 , A61K33/08 , A61K31/203 , A61K2300/00
摘要： The instant invention involves methods of treating sweat-related conditions with compounds that are 5 alpha -reductase inhibitors. The 5 alpha -reductase inhibitors may be administered alone or in combination with other active agents to treat conditions such as apocrine gland sweating, hyperhidrosis, and hydradenitis suppurativa.
摘要翻译：本发明涉及用5α-还原酶抑制剂化合物治疗汗液相关病症的方法。 5α-还原酶抑制剂可以单独施用或与其它活性剂组合施用以治疗诸如顶分泌腺出汗，多汗症和嗜酸性细菌性贫血的病症。

2. 发明申请

WO1996012817A1 COMBINATION METHOD FOR ACNE TREATMENT 审中-公开
标题翻译： ACNE治疗的组合方法
公开(公告)号：WO1996012817A1
公开(公告)日：1996-05-02
申请号：PCT/US1995013440
申请日：1995-10-17
申请人： MERCK & CO., INC. , WALDSTREICHER, Joanne
发明人： MERCK & CO., INC.
IPC分类号： C12P33/20
CPC分类号： A61K45/06
摘要： Described is a combination method using selective inhibitors of 5 alpha -reductase 1 and/or 2 including 7 beta -substituted 4-aza-5 alpha -cholestan-3-ones and related 4-aza-5 alpha -androstan-3-one compounds which are useful in the treatment of acne vulgaris in combination with at least one agent selected from an antibacterial, keratolytic, and/or an anti-inflammatory.
摘要翻译：描述了使用5α-还原酶1和/或2的选择性抑制剂的组合方法，包括7β-取代的4-氮杂-5α-胆固醇-3-酮和相关的4-氮杂-5α-雄甾烷-3-酮化合物其可用于治疗寻常痤疮与至少一种选自抗细菌，角质分解和/或抗炎的药物的组合。

3. 发明申请

WO2004017896A2 COMBINATION THERAPY USING A DUAL PPAR ALPHA/GAMMA AGONIST AND AN ANGIOTENSIN II TYPE I RECEPTOR ANTAGONIST 审中-公开
标题翻译：使用双PPAR ALPHA / GAMMA AGONIST和ANGIOTENSIN II I型受体拮抗剂的联合治疗
公开(公告)号：WO2004017896A2
公开(公告)日：2004-03-04
申请号：PCT/US2003/025434
申请日：2003-08-15
申请人： MERCK & CO., INC. , WALDSTREICHER, Joanne , FOX, Jonathan, C. , MERCURI, Michele
发明人： WALDSTREICHER, Joanne , FOX, Jonathan, C. , MERCURI, Michele
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K31/192 , A61K31/35 , A61K31/41 , A61K31/4184 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4709 , A61K31/517 , A61K31/538 , A61K2300/00
摘要： The present invention relates to the treatment of hypertension and type 2 diabetes, Metabolic Syndrome or a pre-diabetic state, by the administration of a therapeutically effective amount of a combination of a dual PPARα/γ agonist and an Angiotensin II type I receptor antagonist, including pharmaceutically acceptable salts and solvates of said active ingredients.
摘要翻译：本发明涉及通过施用治疗有效量的双重PPARα/γ激动剂和血管紧张素II I型受体拮抗剂的组合来治疗高血压和2型糖尿病，代谢综合征或前期糖尿病状态，包括所述活性成分的药学上可接受的盐和溶剂化物。

4. 发明申请

WO0053148A3 METHODS AND COMPOSITIONS FOR TREATING ERECTILE DYSFUNCTION 审中-公开
标题翻译：治疗溃疡性功能障碍的方法和组合
公开(公告)号：WO0053148A3
公开(公告)日：2000-12-14
申请号：PCT/US0005711
申请日：2000-03-03
申请人： MERCK & CO INC , WALDSTREICHER JOANNE , STONER ELIZABETH
发明人： STONER ELIZABETH
IPC分类号： A61K31/00 , A61K31/4164 , A61K31/4985 , A61K31/502 , A61K31/519 , A61K38/12 , A61K38/08 , A61K31/415 , A61K31/505
CPC分类号： A61K31/00 , A61K31/4164 , A61K31/4985 , A61K31/502 , A61K31/519 , A61K38/12 , A61K2300/00
摘要： The present invention provides for a method for the treatment of erectile dysfunction in a male or female human subject in need of such treatment comprising administration of a therapeutically effective amount of an agonist of the melanocortin receptor in combination with a therapeutically effective amount of a cyclic-GMP-specific phosphodiesterase inhibitor or an alpha-adrenergic receptor antagonist. Further, the present invention provides for pharmaceutical compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for treating erectile dysfunction.
摘要翻译：本发明提供了治疗需要这种治疗的男性或女性人类受试者的勃起功能障碍的方法，包括给予治疗有效量的黑皮质素受体的激动剂与治疗有效量的环状 - GMP特异性磷酸二酯酶抑制剂或α-肾上腺素能受体拮抗剂。此外，本发明提供了可用于本发明方法的药物组合物以及用于治疗勃起功能障碍的药物的制备方法。

5. 发明申请

WO1998025622A1 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING BONE LOSS 审中-公开
标题翻译：预防和治疗骨质疏松的方法和组合物
公开(公告)号：WO1998025622A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022050
申请日：1997-12-05
申请人： MERCK & CO., INC. , FUH, Vivian, L. , KAUFMAN, Keith, D. , WALDSTREICHER, Joanne
发明人： MERCK & CO., INC.
IPC分类号： A61K31/56
CPC分类号： A61K31/58
摘要： The present invention provides for a method of inhibiting bone loss in a subject in need of such treatment comprising administration of a therapeutically effective amount of a compound of structural formula (I) to the subject. The present invention further provides for a method for treating and preventing osteoporosis and osteopenia and other diseases where inhibiting bone loss may be beneficial, including: Paget's disease, malignant hypercalcemia, periodontal disease, joint loosening and metastatic bone disease, comprising administration of therapeutically effective amount of a compound of structural formula (I) to the subject. Further, the present invention provides for compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for inhibiting bone loss and treating or preventing osteoporosis and osteopenia.
摘要翻译：本发明提供了一种抑制需要这种治疗的受试者的骨丢失的方法，包括向受试者施用治疗有效量的结构式（I）化合物。本发明还提供了治疗和预防骨质疏松症和骨质减少症等抑制骨丢失可能有益的疾病的方法，包括：佩吉特氏病，恶性高钙血症，牙周病，关节松动和转移性骨病，包括给予治疗有效量的结构式（I）的化合物。此外，本发明提供了可用于本发明方法的组合物，以及用于抑制骨丢失和治疗或预防骨质疏松症和骨质减少症的药物的制备方法。

6. 发明申请

WO1997041879A1 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE 审中-公开
标题翻译：增强休眠与增长的霍尔米内秘密
公开(公告)号：WO1997041879A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007516
申请日：1997-05-05
申请人： MERCK & CO., INC. , WALDSTREICHER, Joanne
发明人： MERCK & CO., INC.
IPC分类号： A61K38/00
CPC分类号： A61K38/25 , A61K31/438 , A61K31/475 , A61K31/55 , A61K38/05 , A61K38/30 , A61K2300/00
摘要： A growth hormone secretagogue is useful, alone or in combination with other agents, for enhancing and improving the quality of sleep, in particular by increasing sleep efficiency and augmenting sleep maintenance.
摘要翻译：生长激素促分泌素单独或与其他药物组合是有用的，用于增强和改善睡眠质量，特别是通过提高睡眠效率和增加睡眠维持。

7. 发明申请

WO1995010284A1 METHOD OF TREATING ANDROGENIC ALOPECIA WITH 5-ALPHA REDUCTASE INHIBITORS 审中-公开
标题翻译：用5-ALPHA还原酶抑制剂治疗恶变性ALPECIA的方法
公开(公告)号：WO1995010284A1
公开(公告)日：1995-04-20
申请号：PCT/US1994011507
申请日：1994-10-11
申请人： MERCK & CO., INC. , GORMLEY, Glenn, J. , KAUFMAN, Keith, D. , STONER, Elizabeth , WALDSTREICHER, Joanne
发明人： MERCK & CO., INC.
IPC分类号： A61K31/58
CPC分类号： A61Q19/00 , A61K8/63 , A61K31/00 , A61K31/58 , A61K2800/782 , A61Q5/00 , A61Q7/00 , A61Q7/02 , Y10S514/844 , Y10S514/852 , Y10S514/874 , Y10S514/88
摘要： The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by administering to a patient in need of such treatment a 5 alpha -reductase 2 inhibitor, such as finasteride, in a dosage amount under 5 mgs/day.
摘要翻译：本发明涉及通过向需要这种治疗的患者施用5α-还原酶2抑制剂，治疗和/或逆转雄激素性脱发并促进毛发生长的方法，以及治疗寻常性痤疮，皮脂溢和女性多毛症的方法，如非那雄胺，剂量不超过5毫克/日。

8. 发明申请

WO2004017896A3 COMBINATION THERAPY USING A DUAL PPAR ALPHA/GAMMA AGONIST AND AN ANGIOTENSIN II TYPE I RECEPTOR ANTAGONIST 审中-公开
标题翻译：联合治疗使用双重PPAR ALPHA / GAMMA激动剂和血管紧张素II I型受体拮抗剂
公开(公告)号：WO2004017896A3
公开(公告)日：2004-07-08
申请号：PCT/US0325434
申请日：2003-08-15
申请人： MERCK & CO INC , WALDSTREICHER JOANNE , FOX JONATHAN C , MERCURI MICHELE
发明人： WALDSTREICHER JOANNE , FOX JONATHAN C , MERCURI MICHELE
IPC分类号： A61K31/35 , A61K31/42 , A61K31/517 , A61K31/538 , A61K45/06
CPC分类号： A61K45/06 , A61K31/192 , A61K31/35 , A61K31/41 , A61K31/4184 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4709 , A61K31/517 , A61K31/538 , A61K2300/00
摘要： The present invention relates to the treatment of hypertension and type 2 diabetes, Metabolic Syndrome or a pre-diabetic state, by the administration of a therapeutically effective amount of a combination of a dual PPARalpha/gamma agonist and an Angiotensin II type I receptor antagonist, including pharmaceutically acceptable salts and solvates of said active ingredients.
摘要翻译：本发明涉及通过给予治疗有效量的双重PPARα/γ激动剂和血管紧张素II I型受体拮抗剂的组合治疗高血压和2型糖尿病，代谢综合征或糖尿病前期状态，包括所述活性成分的药学上可接受的盐和溶剂化物。

9. 发明申请

WO1998025623A1 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING BONE LOSS 审中-公开
标题翻译：预防和治疗骨质疏松的方法和组合物
公开(公告)号：WO1998025623A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022344
申请日：1997-12-05
申请人： MERCK & CO., INC. , FUH, Vivian, L. , KAUFMAN, Keith, D. , WALDSTREICHER, Joanne
发明人： MERCK & CO., INC.
IPC分类号： A61K31/56
CPC分类号： A61K31/568 , A61K45/06
摘要： The present invention provides for a method of inhibiting bone loss in a subject in need of such treatment comprising administration of a therapeutically effective amount of the 5 alpha -reductase type 2 inhibitor finasteride to the subject. The present invention further provides for a method for treating and preventing osteoporosis and osteopenia and other diseases where inhibiting bone loss may be beneficial, including: Paget's disease, malignant hypercalcemia, periodontal disease, joint loosening and metastatic bone disease, comprising administration of therapeutically effective amount of the 5 alpha -reductase type 2 inhibitor finasteride to the subject. Further, the present invention provides for compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for inhibiting bone loss and treating or preventing osteoporosis and osteopenia.
摘要翻译：本发明提供了一种在需要这种治疗的受试者中抑制骨丢失的方法，包括向受试者施用治疗有效量的5α-还原酶2型抑制剂非那雄胺。本发明还提供了治疗和预防骨质疏松症和骨质减少症等抑制骨丢失可能有益的疾病的方法，包括：佩吉特氏病，恶性高钙血症，牙周病，关节松动和转移性骨病，包括给予治疗有效量的5α-还原酶2型抑制剂非那雄胺。此外，本发明提供了可用于本发明方法的组合物，以及用于抑制骨丢失和治疗或预防骨质疏松症和骨质减少症的药物的制备方法。

10. 发明申请

WO1998025463A1 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING BONE LOSS 审中-公开
标题翻译：预防和治疗骨质疏松的方法和组合物
公开(公告)号：WO1998025463A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022045
申请日：1997-12-05
申请人： MERCK & CO., INC. , FUH, Vivian, L. , KAUFMAN, Keith, D. , WALDSTREICHER, Joanne
发明人： MERCK & CO., INC.
IPC分类号： A01N43/42
CPC分类号： C07D401/06 , C07D221/18 , C07D401/12 , C07D403/12 , C07D413/12 , C07J73/005
摘要： The present invention provides for a method of inhibiting bone loss in a subject in need of such treatment comprising administration to the subject of a therapeutically effective amount of a compound of structural formula (I). The present invention further provides for a method for treating and preventing osteoporosis and osteopenia and other diseases where inhibiting bone loss may be beneficial, including: Paget's disease, malignant hypercalcemia, periodontal disease, joint loosening and metastatic bone disease, comprising administration of therapeutically effective amount of a compound of structural formula (I) to the subject. Further, the present invention provides for compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for inhibiting bone loss and treating or preventing osteoporosis and osteopenia.
摘要翻译：本发明提供一种抑制需要这种治疗的受试者的骨丢失的方法，其包括向受试者施用治疗有效量的结构式（I）的化合物。本发明还提供了治疗和预防骨质疏松症和骨质减少症等抑制骨丢失可能有益的疾病的方法，包括：佩吉特氏病，恶性高钙血症，牙周病，关节松动和转移性骨病，包括给予治疗有效量的结构式（I）的化合物。此外，本发明提供了可用于本发明方法的组合物，以及用于抑制骨丢失和治疗或预防骨质疏松症和骨质减少症的药物的制备方法。

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