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1. 发明申请

WO1991013089A1 PEPTIDE DERIVATIVES AND PRODUCTION THEREOF 审中-公开
标题翻译：肽衍生物及其生产
公开(公告)号：WO1991013089A1
公开(公告)日：1991-09-05
申请号：PCT/JP1991000165
申请日：1991-02-12
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. , WAKIMASU, Mitsuhiro , KIKUCHI, Takashi , KUBO, Kazuki
发明人： TAKEDA CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07K07/10
CPC分类号： C07K14/57536 , A61K38/00
摘要： Disclosed are a peptide derivative represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein A, B, C, D, E, and F each represent amino acid residues, and satisfy any one condition of (i) A=Ser, C=Ser, D=Leu, E=Met and F=Phe, (ii) A=Ser, B=Ser, C=Ser, D=Trp, E=Leu and F=Phe, and (iii) A=Thr, B=Phe, C=Thr, D=Tyr, E=Lys and F=Tyr; and W, X, Y and Z each represent amino acid residues, and satisfy any one condition of (i) at least one of W and Y is an amino acid residue other than an L-alanine residue or other than an L-cysteine residue, (ii) X is an amino acid residue other than an L-lysine residue, and (iii) Z is an amino acid residue other than an L-aspartic acid residue; (2) a method for producing the peptide derivative function mainly comprising the peptide derivate or the salt thereof; and (3) an agent for improving a circulatory function mainly comprising the peptide derivative or the salt thereof, such as a vasodilator or a vasoconstrictor.
摘要翻译：公开了由式（I）表示的肽衍生物或其药学上可接受的盐，其中A，B，C，D，E和F各自表示氨基酸残基，并且满足（i）A = Ser， C = Ser，D = Leu，E = Met和F = Phe，（ii）A = Ser，B = Ser，C = Ser，D = Trp，E = Leu和F = Phe，和（iii）A = Thr ，B = Phe，C = Thr，D = Tyr，E = Lys和F = Tyr; 并且W，X，Y和Z各自表示氨基酸残基，并且满足（i）W和Y中的至少一个是L-丙氨酸残基或L-半胱氨酸残基以外的氨基酸残基的任何一个条件，（ii）X是除L-赖氨酸残基以外的氨基酸残基，（iii）Z是除了L-天冬氨酸残基以外的氨基酸残基; （2）生成主要含有肽衍生物或其盐的肽衍生物功能的方法; 和（3）主要由肽衍生物或其盐例如血管扩张剂或血管收缩剂改善循环功能的药剂。

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