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1. 发明申请

WO2010143936A1 COMPOSITION AND METHOD FOR IMPROVING VASCULAR HEALTH 审中-公开
标题翻译：用于改善血管健康的组合物和方法
公开(公告)号：WO2010143936A1
公开(公告)日：2010-12-16
申请号：PCT/MY2010/000096
申请日：2010-06-08
申请人： MALAYSIAN PALM OIL BOARD , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (CSIRO) , ABEYWARDENA, Mahinda , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
发明人： ABEYWARDENA, Mahinda , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
IPC分类号： A61K36/889 , A61P9/06 , A61P9/12 , A61K31/05 , A61P9/10
CPC分类号： A61K36/889 , A23L33/105 , A23V2002/00 , A61K45/06 , A23V2200/326 , A23V2250/21
摘要： The present invention relates to a composition for the use in improving vascular health, including treating and preventing vascular diseases and diseases related thereto, using a botanical extract of oil palm vegetation liquor from the palm oil milling process.
摘要翻译：本发明涉及一种用于改善血管健康的组合物，其包括使用来自棕榈油研磨过程的油棕榈植物液的植物提取物来治疗和预防与之相关的血管疾病和疾病。

2. 发明申请

WO2009014417A3 AN ANTIVIRAL COMPOSITION 审中-公开
标题翻译：抗病毒组合物
公开(公告)号：WO2009014417A3
公开(公告)日：2009-04-02
申请号：PCT/MY2008000075
申请日：2008-07-23
申请人： MALAYSIAN PALM OIL BOARD , SAMBANTHAMURTHI RAVIGADEVI , SUNDRAM KALYANA , ALI TAN YEW , WAHID MOHD BASRI
发明人： SAMBANTHAMURTHI RAVIGADEVI , SUNDRAM KALYANA , ALI TAN YEW , WAHID MOHD BASRI
IPC分类号： A61K31/21 , A61K31/522 , A61K31/56
CPC分类号： A61K36/889 , A61K31/047 , A61K31/192 , A61K31/353
摘要： The present invention relates to a composition enriched in but not confined to phenolic antioxidants obtained from oil palm, and more particularly this invention relates to a composition for promoting immunity in general and most essentially against Human Immunodeficiency Virus (HIV) and HCV related infections. Accordingly, the composition having the said oil palm compounds can effectively inhibit various viruses, further supporting oil palm compounds as one of the broad spectrum antiviral drugs.
摘要翻译：本发明涉及一种富含但不限于从油棕获得的酚类抗氧化剂的组合物，更具体地说，本发明涉及一般用于促进免疫的组合物，最基本上是针对人类免疫缺陷病毒（HIV）和HCV相关感染的组合物。因此，具有所述油棕榈化合物的组合物可以有效地抑制各种病毒，进一步支持作为广谱抗病毒药物之一的油棕榈化合物。

3. 发明申请

WO2011084046A1 ANTI-OBESITY AND ANTI-DYSLIPIDEMIC EFFECTS OF OIL PALM PHENOLICS IN PREVENTING ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE 审中-公开
标题翻译：油棕榈酚在预防甲状腺功能亢进和心血管疾病中的抗生素和抗血小板效应
公开(公告)号：WO2011084046A1
公开(公告)日：2011-07-14
申请号：PCT/MY2011/000002
申请日：2011-01-07
申请人： MALAYSIAN PALM OIL BOARD , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
发明人： SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
IPC分类号： A61K36/889 , A61P3/06 , A61K31/05 , A61P9/10
CPC分类号： A61K36/889 , A61K31/05
摘要： Water-soluble phenolics from the oil palm (Elaeis guineensis) possess significant antioxidant and health-promoting properties. This invention documents the effects of administering oil palm phenolics to mice, with the aim of identifying whether these compounds possess significant anti-obesity or anti-dyslipidemics properties for the prevention of atherosclerosis and cardiovascular disease. We first explored the gene expression changes caused by oil palm phenolics in livers of mice given a low-fat normal diet, in which fatty acid beta oxidation genes were up-regulated while five cholesterol biosynthesis genes were down-regulated. In addition, the weight gain of mice given oil palm palm phenolics was delayed, suggesting that oil palm phenolics may play a role in delaying the onset of obesity. Using Illumina microarrays, we found that the atherogenic diet caused oxidative stress, up-regulated the inflammatory response and increased the turnover of metabolites and cells in the liver, spleen and heart. In contrast, we found that oil palm phenolics showed signs of attenuating the effects of the atherogenic diet in mice. The extract increased unfolded protein response in the liver, while attenuated antigen presentation and processing in the spleen. Oil palm phenolics also increased the expression of antioxidant genes in the heart. A majority of the genes regulated by oil palm phenolics in the different organs showed a difference in direction of regulation when compared to the atherogenic diet.
摘要翻译：来自油棕（Elaeis guineensis）的水溶性酚类具有显着的抗氧化和促进健康的性质。本发明记录了给予棕榈油酚醛树脂对小鼠的作用，目的是鉴定这些化合物是否具有显着的抗肥胖症或抗血脂异常特性以预防动脉粥样硬化和心血管疾病。我们首先探讨了脂肪酸β氧化基因在脂肪酸β氧化基因上调，而五种胆固醇生物合成基因下调的小鼠肝脏中油棕酚类物质引起的基因表达变化。此外，给予油棕榈酚酚的小鼠的体重增加被延迟，这表明油棕榈酚可能在延缓肥胖发作中起作用。使用Illumina微阵列，我们发现致动脉粥样化饮食导致氧化应激，上调了炎症反应，增加了肝脏，脾脏和心脏中代谢物和细胞的周转。相比之下，我们发现油棕酚酚酸显示出减弱动脉粥样硬化饮食对小鼠的影响的迹象。提取物增加了肝脏中未折叠的蛋白质反应，同时减弱了脾脏中的抗原呈递和加工。油棕榈酚类也增加了抗氧化基因在心脏中的表达。与致动脉粥样化饮食相比，不同器官中油棕榈酚调节的大多数基因显示出调节方向的差异。

4. 发明申请

WO2010134799A1 COMPOSITIONS COMPRISING COMPOUNDS FROM PALM OIL MILL EFFLUENTS FOR USE IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES 审中-公开
标题翻译：包含来自棕榈油的化合物的组合物用于预防和治疗心血管疾病的用途
公开(公告)号：WO2010134799A1
公开(公告)日：2010-11-25
申请号：PCT/MY2010/000081
申请日：2010-05-18
申请人： MALAYSIAN PALM OIL BOARD , HJ CHE IDRIS, Hjh Che Anishas , BALASUNDRAM, Nagendran , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
发明人： HJ CHE IDRIS, Hjh Che Anishas , BALASUNDRAM, Nagendran , SAMBANTHAMURTHI, Ravigadevi , TAN, Yew Ai , P. MANICKAM, Kalyana Sundram , WAHID, Mohd Basri
IPC分类号： A61K36/889 , A61P9/00 , A61P9/10
CPC分类号： A61K36/889 , A61K31/192 , A61K31/353 , A61K31/355 , A61K2300/00
摘要： The invention provides a composition the prevention and treatment of cardiovascular disease, wherein said composition compounds obtained from palm oil mill effluents, in particular from vegetative liquor from the milling of palm oil fruit.
摘要翻译：本发明提供了预防和治疗心血管疾病的组合物，其中所述从棕榈油研磨废水获得的组合物化合物，特别是来自研磨棕榈油果实的营养液。

5. 发明申请

WO2009014417A2 AN ANTIVIRAL COMPOSITION 审中-公开
标题翻译：抗病毒组合物
公开(公告)号：WO2009014417A2
公开(公告)日：2009-01-29
申请号：PCT/MY2008/000075
申请日：2008-07-23
申请人： MALAYSIAN PALM OIL BOARD , SAMBANTHAMURTHI, Ravigadevi , SUNDRAM, Kalyana , ALI, Tan Yew , WAHID, Mohd Basri
发明人： SAMBANTHAMURTHI, Ravigadevi , SUNDRAM, Kalyana , ALI, Tan Yew , WAHID, Mohd Basri
IPC分类号： A61K31/21 , A61K31/52 , A61K31/56
CPC分类号： A61K36/889 , A61K31/047 , A61K31/192 , A61K31/353
摘要： The present invention relates to a composition enriched in but not confined to phenolic antioxidants obtained from oil palm, and more particularly this invention relates to a composition for promoting immunity in general and most essentially against Human Immunodeficiency Virus (HIV) and HCV related infections. Accordingly, the composition having the said oil palm compounds can effectively inhibit various viruses, further supporting oil palm compounds as one of the broad spectrum antiviral drugs.
摘要翻译：本发明涉及一种富含但不限于从油棕得到的酚类抗氧化剂的组合物，更具体地说，本发明涉及一种用于促进免疫的组合物，该组合物用于一般和最基本的抗人类免疫缺陷病毒 HIV）和HCV相关感染。因此，具有所述油棕榈化合物的组合物可以有效地抑制各种病毒，进一步支持油棕榈化合物作为广谱抗病毒药物之一。

6. 发明申请

WO2012067491A2 COMPOSITIONS COMPRISING EXTRACTS OBTAINED FROM OIL PALM BASED MATERIALS FOR PROVIDING ANTI -INFLAMMATORY EFFECTS AND METHOD OF PRODUCING THEREOF 审中-公开
标题翻译：包含从用于提供抗炎效果的油棕基材料中提取的提取物的组合物及其制备方法
公开(公告)号：WO2012067491A2
公开(公告)日：2012-05-24
申请号：PCT/MY2011000234
申请日：2011-11-16
申请人： MALAYSIAN PALM OIL BOARD , KANG HYUN , RHA CHOKYUN , SAMBANTHAMURTHI RAVIGADEVI , J SINSKEY ANTHONY , TAN YEW AI , MANICKAM KALYANA SUNDRAM , WAHID MOHD BASRI
发明人： KANG HYUN , RHA CHOKYUN , SAMBANTHAMURTHI RAVIGADEVI , J SINSKEY ANTHONY , TAN YEW AI , MANICKAM KALYANA SUNDRAM , WAHID MOHD BASRI
IPC分类号： A61K36/889 , A61K9/20 , A61K9/48 , A61P29/00
CPC分类号： A61K36/889 , A61K31/192 , A61K31/216 , A61K2300/00
摘要： The present invention provides compositions and method for production of a composition used to provide anti-inflammatory effects on microglial cells in the brain. The composition comprises extracts obtained from oil palm based materials.
摘要翻译：本发明提供了用于生产用于对大脑中的小神经胶质细胞提供抗炎作用的组合物的组合物和方法。该组合物包含从油棕基材料获得的提取物。

7. 发明申请

WO2009035314A3 A BOTANICAL EXTRACT FROM THE AQUEOUS STREAM OF THE PALM OIL MILLING PROCESS FOR THE PREVENTION AND INHIBITION OF OXIDATIVE STRESS AND HAEMOLYSIS IN HUMAN RED BLOOD CELLS 审中-公开
公开(公告)号：WO2009035314A3
公开(公告)日：2009-03-19
申请号：PCT/MY2008/000100
申请日：2008-09-11
申请人： MALAYSIAN PALM OIL BOARD , BALASUNDRAM, Nagendran , SAMBANTHAMURTHI, Ravigadevi , YEW ALI, Tan , SUNDRAM, Kalyana , WAHID, Mohd Basri , SAMMAN, Samir , AGAR, Nihal S.
发明人： BALASUNDRAM, Nagendran , SAMBANTHAMURTHI, Ravigadevi , YEW ALI, Tan , SUNDRAM, Kalyana , WAHID, Mohd Basri , SAMMAN, Samir , AGAR, Nihal S.
IPC分类号： A61K36/889 , A61K36/18
摘要： The invention provides a composition for the prevention and inhibition of oxidative stress and haemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling ( palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.

8. 发明申请

WO2008130216A1 COMPOUNDS EXTRACTED FROM PALM OIL MILL EFFLUENT FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH 审中-公开
标题翻译：从棕榈油提取的化合物用于治疗癌症的组合物及其组合物及其方法
公开(公告)号：WO2008130216A1
公开(公告)日：2008-10-30
申请号：PCT/MY2008/000034
申请日：2008-04-23
申请人： MALAYSIAN PALM OIL BOARD , SUNDRAM, Kalyana a/I P. Manickam , RAVIGADEVI a/p Sambathamurthi , TAN, Yew, Ai , BIN WAHID, Mohd, Basri , LEOW, Soon, Sen
发明人： SUNDRAM, Kalyana a/I P. Manickam , RAVIGADEVI a/p Sambathamurthi , TAN, Yew, Ai , BIN WAHID, Mohd, Basri , LEOW, Soon, Sen
IPC分类号： A61K36/889 , A61K31/704 , A61P35/00
CPC分类号： A61K36/889 , A23L33/105 , A23V2002/00 , A61K31/355 , A61K31/704 , A61K45/06
摘要： The present invention describes a composition and methods for prevention and treatment of cancer comprising compounds extracted from Palm oil mill effluent. Also, the invention describes effective therapeutic dosages of the compounds and their combinations. The present invention can be prepared independently or as a combination product.
摘要翻译：本发明描述了一种用于预防和治疗癌症的组合物和方法，包括从棕榈油磨出料中提取的化合物。此外，本发明描述了化合物及其组合的有效治疗剂量。本发明可以单独制备或作为组合产品制备。

9. 发明申请

WO2010087693A1 COMPOSITION COMPRISING OIL PALM PHENOLICS FOR USE IN PROVIDING NEUROPROTECTIVE EFFECTS AND COGNITIVE-ENHANCEMENT 审中-公开
标题翻译：包含油棕榈酚的组合物用于提供神经保护作用和认知增强
公开(公告)号：WO2010087693A1
公开(公告)日：2010-08-05
申请号：PCT/MY2010/000019
申请日：2010-01-29
申请人： MALAYSIAN PALM OIL BOARD , SAMBANTHAMURTHI, Ravigadevi , LEOW, Soon-Sen , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
发明人： SAMBANTHAMURTHI, Ravigadevi , LEOW, Soon-Sen , TAN, Yew Ai , P. MANICKAM, Kalyana, Sundram , WAHID, Mohd, Basri
IPC分类号： A61K36/889 , A61K31/05 , A61P25/28 , A61P25/16
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2250/21
摘要： The present invention relates to a composition comprising oil palm phenolics for use in providing neuroprotective effects and improving cognitive and motor functions abilities.
摘要翻译：本发明涉及包含油棕酚类的组合物，其用于提供神经保护作用并改善认知和运动功能。

10. 发明申请

WO2009035314A2 A BOTANICAL EXTRACT FROM THE AQUEOUS STREAM OF THE PALM OIL MILLING PROCESS FOR THE PREVENTION AND INHIBITION OF OXIDATIVE STRESS AND HAEMOLYSIS IN HUMAN RED BLOOD CELLS 审中-公开
标题翻译：棕榈油研磨过程中的植物提取物抑制人红细胞氧化应激和溶血作用的研究
公开(公告)号：WO2009035314A2
公开(公告)日：2009-03-19
申请号：PCT/MY2008000100
申请日：2008-09-11
申请人： MALAYSIAN PALM OIL BOARD , BALASUNDRAM NAGENDRAN , SAMBANTHAMURTHI RAVIGADEVI , YEW ALI TAN , SUNDRAM KALYANA , WAHID MOHD BASRI , SAMMAN SAMIR , AGAR NIHAL S
发明人： BALASUNDRAM NAGENDRAN , SAMBANTHAMURTHI RAVIGADEVI , YEW ALI TAN , SUNDRAM KALYANA , WAHID MOHD BASRI , SAMMAN SAMIR , AGAR NIHAL S
IPC分类号： A61K36/889 , A61K36/18
CPC分类号： A61K36/889
摘要： The invention provides a composition for the prevention and inhibition of oxidative stress and haemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling ( palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.
摘要翻译：本发明提供了一种用于预防和抑制人红细胞中的氧化应激和溶血的组合物，其中所述组合物化合物从棕榈油碾磨的含水物流（棕榈油植物液）获得，特别是来自棕榈碾磨的营养液油果。

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