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1. 发明申请

WO2005065707A3 RECOMBINANT VACCINE AGAINST JAPANESE ENCEPHALITIS VIRUS [JEV] INFECTION AND A METHOD THEREOF 审中-公开
公开(公告)号：WO2005065707A3
公开(公告)日：2005-07-21
申请号：PCT/IN2004/000432
申请日：2004-12-30
申请人： NATIONAL INSTITUTE OF IMMUNOLOGY , VRATI, Sudhanshu
发明人： VRATI, Sudhanshu
IPC分类号： A61K39/12
摘要： The present invention relates to a novel recombinant adenovirus (RAdEs) vaccine against Japanese encephalitis virus (JEV) infection, wherein said vaccine produces secretory JEV envelope protein; an effective and superior method of immunization to JEV infection; also, a method of preparing the recombinant RAdEs vaccine.

2. 发明申请

WO2010137036A2 NOVEL JAPANESE ENCEPHALITIS VACCINE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：新日本精神病毒疫苗及其制造方法
公开(公告)号：WO2010137036A2
公开(公告)日：2010-12-02
申请号：PCT/IN2010/000343
申请日：2010-05-21
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , GALGALKAR, Milind V , MAITHAL, Kapil , VRATI, Sudhanshu
发明人： JAIN, Rajesh , GALGALKAR, Milind V , MAITHAL, Kapil , VRATI, Sudhanshu
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163 , Y02A50/39
摘要： The present invention relates to a novel Japanese encephalitis vaccine and a novel process for making the same. The invention in particular relates to a Japanese encephalitis virus strain P20778 vaccine, wherein the viral adaptation and propagation is carried out in a medium which is free of serum and additives of animal origin. The virus may be propagated particularly in Vero cell line.
摘要翻译：本发明涉及一种新型的日本脑炎疫苗及其制造方法。本发明特别涉及日本脑炎病毒株P20778疫苗，其中病毒适应和繁殖在不含血清和动物来源的添加剂的培养基中进行。病毒可能在Vero细胞系中特别传播。

3. 发明申请

WO2006064519A2 DNAZYMES FOR INHIBITION OF JAPANESE ENCEPHALITIS VIRUS REPLICATION 审中-公开
标题翻译：用于抑制日本脑炎病毒复制的DNAZYMES
公开(公告)号：WO2006064519A2
公开(公告)日：2006-06-22
申请号：PCT/IN2005000423
申请日：2005-12-14
申请人： NAT INST IMMUNOLOGY , VRATI SUDHANSHU , APPAIAHGARI MOHAN BABU
发明人： VRATI SUDHANSHU , APPAIAHGARI MOHAN BABU
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , C12N2310/12 , C12N2310/315 , C12N2310/3519 , C12N2770/24111
摘要： The present invention relates to synthetic catalytic DNA molecules or DNAzymes which specifically cleave the RNA sequences of the Japanese Encephalitis Viral genome and is useful in treating Japanese Encephalitis infection. The DNAzyme comprises of a chemical modification, a catalytic domain and two hybridizing arms. The DNAzymes are 29-45 nucleotides in length. The 3' end of the DNAzyme is tethered to a poly-(G)10 tail and the molecule comprises of at least one chemical modification. The chemical modifications are in the form of sugar modification, nucleic acid base modification, and/or phosphate backbone modification. The catalytic DNA molecule inhibits JEV replication in vitro in cultured cells and in vivo in the mouse brain. The present invention also relates to the method of treatment of Japanese encephalitis comprising the steps of introducing the catalytic DNA molecule or DNAzyme into the infected cells under conditions suitable for cleavage and reduction of viral titres.
摘要翻译：本发明涉及合成的催化DNA分子或DNA酶，其特异性切割日本脑炎病毒基因组的RNA序列并且可用于治疗日本脑炎感染。 DNAzyme包含化学修饰，催化结构域和两个杂交臂。 DNAzyme的长度为29-45个核苷酸。脱氧核糖核酸酶的3'末端连接到聚（G）10尾部，并且该分子包含至少一个化学修饰。化学修饰处于糖修饰，核酸碱基修饰和/或磷酸酯主链修饰的形式。催化DNA分子在体外培养的细胞中和体内小鼠脑中抑制JEV复制。本发明还涉及治疗日本脑炎的方法，包括在适于裂解和降低病毒滴度的条件下将催化性DNA分子或脱氧核糖核酸酶引入感染的细胞中的步骤。

4. 发明申请

WO2005065707B1 RECOMBINANT VACCINE AGAINST JAPANESE ENCEPHALITIS VIRUS [JEV] INFECTION AND A METHOD THEREOF 审中-公开
公开(公告)号：WO2005065707B1
公开(公告)日：2005-10-27
申请号：PCT/IN2004000432
申请日：2004-12-30
申请人： NAT INST IMMUNOLOGY , VRATI SUDHANSHU
发明人： VRATI SUDHANSHU
IPC分类号： A61K39/12 , C07K14/18 , C12N15/861
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , A61K2039/542 , C07K14/005 , C12N2710/10343 , C12N2770/24122 , C12N2770/24134
摘要： The present invention relates to a novel recombinant adenovirus (RAdEs) vaccine against Japanese encephalitis virus (JEV) infection, wherein said vaccine produces secretory JEV envelope protein; an effective and superior method of immunization to JEV infection; also, a method of preparing the recombinant RAdEs vaccine.

5. 发明申请

WO1996003508A1 DNA ENCODING OVINE ADENOVIRUS (OAV287) AND ITS USE AS A VIRAL VECTOR 审中-公开
标题翻译： DNA编码OVINE ADENOVIRUS（OAV287）及其用作病毒载体
公开(公告)号：WO1996003508A1
公开(公告)日：1996-02-08
申请号：PCT/AU1995000453
申请日：1995-07-26
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , BOTH, Gerald, Wayne , BOYLE, David, Bernard , VRATI, Sudhanshu
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： C12N15/34
CPC分类号： C07K14/005 , C07K14/43554 , C07K14/43577 , C12N15/86 , C12N2710/10122 , C12N2710/10143 , C12N2720/12334
摘要： The invention relates to an isolated DNA molecule comprising the genome of ovine adenovirus OAV287, functionally equivalent DNA molecules or portions thereof. The invention also relates to plasmids and viral vectors including the DNA molecules. The invention also relates to methods for delivering non-adenoviral DNA molecules encoding a polypeptide or polypeptides to animals and in particular to grazing animals.
摘要翻译：本发明涉及分离的DNA分子，其包含绵羊腺病毒OAV287的基因组，功能上等效的DNA分子或其部分。本发明还涉及包括DNA分子的质粒和病毒载体。本发明还涉及将编码多肽或多肽的非腺病毒DNA分子递送到动物，特别是放牧动物的方法。

6. 发明申请

WO2010137036A3 JAPANESE ENCEPHALITIS VACCINE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：日本ENCEPHALITIS疫苗及其制造方法
公开(公告)号：WO2010137036A3
公开(公告)日：2011-05-26
申请号：PCT/IN2010000343
申请日：2010-05-21
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , GALGALKAR MILIND V , MAITHAL KAPIL , VRATI SUDHANSHU
发明人： JAIN RAJESH , GALGALKAR MILIND V , MAITHAL KAPIL , VRATI SUDHANSHU
IPC分类号： A61K39/12 , C12N5/00 , C12N7/06
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , C12N2770/24134 , C12N2770/24151 , C12N2770/24163
摘要： The present invention relates to a novel Japanese encephalitis vaccine and a novel process for making the same. The invention in particular relates to a Japanese encephalitis virus strain P20778 vaccine, wherein the viral adaptation and propagation is carried out in a medium which is free of serum and additives of animal origin. The virus may be propagated particularly in Vero cell line.
摘要翻译：本发明涉及一种新型的日本脑炎疫苗及其制造方法。本发明特别涉及日本脑炎病毒株P20778疫苗，其中病毒适应和繁殖在不含血清和动物来源的添加剂的培养基中进行。病毒可能在Vero细胞系中特别传播。

7. 发明申请

WO2006064519A3 DNAZYMES FOR INHIBITION OF JAPANESE ENCEPHALITIS VIRUS REPLICATION 审中-公开
公开(公告)号：WO2006064519A3
公开(公告)日：2006-06-22
申请号：PCT/IN2005/000423
申请日：2005-12-14
申请人： NATIONAL INSTITUTE OF IMMUNOLOGY , VRATI, Sudhanshu , APPAIAHGARI, Mohan Babu
发明人： VRATI, Sudhanshu , APPAIAHGARI, Mohan Babu
IPC分类号： C12N15/11 , A61K31/7125
摘要： The present invention relates to synthetic catalytic DNA molecules or DNAzymes which specifically cleave the RNA sequences of the Japanese Encephalitis Viral genome and is useful in treating Japanese Encephalitis infection. The DNAzyme comprises of a chemical modification, a catalytic domain and two hybridizing arms. The DNAzymes are 29-45 nucleotides in length. The 3' end of the DNAzyme is tethered to a poly-(G)10 tail and the molecule comprises of at least one chemical modification. The chemical modifications are in the form of sugar modification, nucleic acid base modification, and/or phosphate backbone modification. The catalytic DNA molecule inhibits JEV replication in vitro in cultured cells and in vivo in the mouse brain. The present invention also relates to the method of treatment of Japanese encephalitis comprising the steps of introducing the catalytic DNA molecule or DNAzyme into the infected cells under conditions suitable for cleavage and reduction of viral titres.

8. 发明申请

WO2005065707A2 RECOMBINANT VACCINE AGAINST JAPANESE ENCEPHALITIS VIRUS [JEV] INFECTION AND A METHOD THEREOF 审中-公开
标题翻译：重组疫苗对日本ENCEPHALITIS病毒感染及其方法
公开(公告)号：WO2005065707A2
公开(公告)日：2005-07-21
申请号：PCT/IN2004000432
申请日：2004-12-30
申请人： NAT INST IMMUNOLOGY , VRATI SUDHANSHU
发明人： VRATI SUDHANSHU
IPC分类号： A61K39/12 , C07K14/18 , C12N15/861
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , A61K2039/542 , C07K14/005 , C12N2710/10343 , C12N2770/24122 , C12N2770/24134
摘要： The present invention relates to a novel recombinant adenovirus (RAdEs) vaccine against Japanese encephalitis virus (JEV) infection, wherein said vaccine produces secretory JEV envelope protein; an effective and superior method of immunization to JEV infection; also, a method of preparing the recombinant RAdEs vaccine.
摘要翻译：本发明涉及针对日本脑炎病毒（JEV）感染的新型重组腺病毒（RADE）疫苗，其中所述疫苗产生分泌型JEV包膜蛋白; 有效和优越的免疫JEV感染方法; 也是制备重组RADE疫苗的方法。

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