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1. 发明申请

WO2011144640A1 NOVEL C3C EPITOPE, ANTIBODIES BINDING THERETO, AND USE THEREOF 审中-公开
标题翻译：新型C3C抗生素，抗体结合蛋白及其用途
公开(公告)号：WO2011144640A1
公开(公告)日：2011-11-24
申请号：PCT/EP2011/058007
申请日：2011-05-17
申请人： SYDDANSK UNIVERSITET , SKJOEDT, Mikkel, Ole , VITVED, Lars , PALARASAH, Yaseelan
发明人： SKJOEDT, Mikkel, Ole , VITVED, Lars , PALARASAH, Yaseelan
IPC分类号： C07K16/18 , G01N33/564
CPC分类号： C07K16/18 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/472 , C07K2317/33 , C07K2317/34 , G01N33/564 , G01N33/6893 , G01N2333/4716 , G01N2800/122 , G01N2800/24 , G01N2800/26
摘要： Provided are antibodies directed against a novel epitope on the human C3c (complement factor 3 c) and the use and manufacture thereof. Moreover, there is provided a novel immunogen for use in the preparation of the antibodies. The antibodies are in the first place of the monoclonal type.
摘要翻译：提供针对人C3c（补体因子3c）上的新表位的抗体及其使用和制造。此外，提供了用于制备抗体的新型免疫原。抗体位于单克隆型的第一位。

2. 发明申请

WO2009030240A2 METHOD OF DETERMINING FUNCTIONAL DEFICIENCIES IN THE COMPLEMENT SYSTEM 审中-公开
标题翻译：确定补充系统中功能缺陷的方法
公开(公告)号：WO2009030240A2
公开(公告)日：2009-03-12
申请号：PCT/DK2008050221
申请日：2008-09-05
申请人： IMMUNOBOND APS , PALARASAH YASEELAN , OLE SKJOEDT MIKKEL , VITVED LARS , KOCH CLAUS
发明人： PALARASAH YASEELAN , OLE SKJOEDT MIKKEL , VITVED LARS , KOCH CLAUS
IPC分类号： G01N33/564
CPC分类号： G01N33/564
摘要： The present invention relates to a method of in vitro determining functional deficiencies in the lectin pathway of the complement system, the method comprises the steps of (a) diluting a mammalian sample of body fluid with a diluent comprising one or more inhibitors of the activation of the classical and the alternative pathways of the complement system; (b) activating the lectin pathway of the complement system in the sample obtained from (a); and (c) determining in the sample obtained from (b) the activation of one or more of the complement factors C3, C4, or one or more of the components of the C5-C9 complex. The invention furthermore relates to kits for use in connection with the above-mentioned method, the first kit comprises i) a first component comprising a carrier, one or more inhibitors of the classical and the alternative complement pathways and a diluent; and ii) a second component comprising one or more substances for activation of the lectin complement pathway and optionally an inert carrier. The second kit comprises a container comprising a predetermined amount of one or more inhibitors of the classical and the alternative complement pathways and a diluent, wherein the container is adapted for receiving a predetermined amount of sample, so that when the predetermined amount of sample is added, the concentration of the one or more inhibitors is an inhibitory effective concentration of the classical and alternative pathways, but not the lectin pathway.
摘要翻译：本发明涉及体外确定补体系统的凝集素途径中功能缺陷的方法，所述方法包括以下步骤：（a）用稀释剂稀释哺乳动物体液样品，所述稀释剂包含一种或多种补体系统的经典和替代途径; （b）激活从（a）获得的样品中补体系统的凝集素途径; 和（c）确定从（b）获得的样品中一种或多种补体因子C3，C4或C5-C9复合物的一种或多种组分的活化。本发明还涉及与上述方法结合使用的试剂盒，第一试剂盒包含：i）第一组分，其包含载体，一种或多种经典和可选补体途径的抑制剂以及稀释剂; 和ii）第二组分，其包含一种或多种用于激活凝集素补体途径的物质和任选的惰性载体。第二试剂盒包含容器，该容器包含预定量的一种或多种经典补体途径和替代补体途径的一种或多种抑制剂和稀释剂，其中该容器适于接收预定量的样品，从而当添加预定量的样品，一种或多种抑制剂的浓度是经典途径和替代途径的抑制性有效浓度，但不是凝集素途径。

3. 发明申请

WO2009030240A3 METHOD OF DETERMINING FUNCTIONAL DEFICIENCIES IN THE COMPLEMENT SYSTEM 审中-公开
公开(公告)号：WO2009030240A3
公开(公告)日：2009-03-12
申请号：PCT/DK2008/050221
申请日：2008-09-05
申请人： IMMUNOBOND APS , PALARASAH, Yaseelan , OLE SKJØDT, Mikkel , VITVED, Lars , KOCH, Claus
发明人： PALARASAH, Yaseelan , OLE SKJØDT, Mikkel , VITVED, Lars , KOCH, Claus
IPC分类号： G01N33/564
摘要： The present invention relates to a method of in vitro determining functional deficiencies in the lectin pathway of the complement system, the method comprises the steps of (a) diluting a mammalian sample of body fluid with a diluent comprising one or more inhibitors of the activation of the classical and the alternative pathways of the complement system; (b) activating the lectin pathway of the complement system in the sample obtained from (a); and (c) determining in the sample obtained from (b) the activation of one or more of the complement factors C3, C4, or one or more of the components of the C5-C9 complex. The invention furthermore relates to kits for use in connection with the above-mentioned method, the first kit comprises i) a first component comprising a carrier, one or more inhibitors of the classical and the alternative complement pathways and a diluent; and ii) a second component comprising one or more substances for activation of the lectin complement pathway and optionally an inert carrier. The second kit comprises a container comprising a predetermined amount of one or more inhibitors of the classical and the alternative complement pathways and a diluent, wherein the container is adapted for receiving a predetermined amount of sample, so that when the predetermined amount of sample is added, the concentration of the one or more inhibitors is an inhibitory effective concentration of the classical and alternative pathways, but not the lectin pathway.

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